Giuffrida ML, Copani A, Rizzarelli E

A promising connection between BDNF and Alzheimer's disease
Aging (ISSN: 1945-4589linking), 2018 Aug 6; 10(8): 1791-1792.

Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S

Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.

Lanza V, Milardi D, Di Natale G, Pappalardo G

Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.

Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G

Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.

Caraci F, Nicoletti F, Copani A

Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.

D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M

VEGF mimic peptides: Potential applications in central nervous system therapeutics
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.

Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A

Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.

Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S

Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.

Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C

Copper (II) ions modulate Angiogenin activity in human endothelial cells
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.

Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A

Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.

Milardi D, Pappalardo M

Molecular dynamics: New advances in drug discovery
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 91: 1-3.

Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium

Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting
Neuroimage-Clin (ISSN: 2213-1582), 2014 Oct 24; 6: 445-454.

Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A

A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia
J Alzheimers Dis (ISSN: 1387-2877), 2014; 41(3): 709-714.

Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M

Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.

Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E

Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.

Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A

Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.

Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E

Metal ions affect insulin-degrading enzyme activity
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.

Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W

Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.

Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC

Decreased carbon-11-flumazenil binding in early Alzheimer's disease
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.

Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.

Grasso G, Giuffrida ML, Rizzarelli E

Metallostasis And Amyloid Beta-Degrading Enzymes
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.

Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E

The inorganic perspectives of neurotrophins and Alzheimer's disease
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.

Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A

Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.

Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.

Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E

Neuroprotective features of carnosine in oxidative driven diseases
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.

Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I

Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.

Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.

Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL

Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.

Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F

Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.

Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E

Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.

Varrone A, Halldin C

Molecular imaging of the dopamine transporter
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.

Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M

SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.

Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G

Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.

Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A

The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.

Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ

EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.

Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Nagren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K

EANM procedure guidelines for PET brain imaging using [18F]FDG, version
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.

Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA

Nitric oxide in cell survival: a janus molecule
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864), 2009 Nov; 11(11): 2717-2739.

Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G

Copper-triggered aggregation of ubiquitin
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2009 Sep 16; 4(9): e7052-e7052.

Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D

New SPECT and PET dementia tracers
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.

Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E

Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.

Pappata S, Salvatore E, Postiglione A

In vivo imaging of neurotransmission and brain receptors in dementia
J Neuroimaging (ISSN: 1051-2284), 2008 Apr; 18(2): 111-124.

Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A

Frontal Behavioural Inventory in the differential diagnosis of dementia
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.

Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA

The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.

Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.

Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F

The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death
Bba-Mol Basis Dis (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.

Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E

Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.

Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L

Mild cognitive impairment. Survey of attitudes of specialists and general physicians
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.

Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R

The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.

Esposito L, Pedone C, Vitagliano L

Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.

Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F

Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.

Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.

Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S

Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.

Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D

Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.

Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M

Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.

Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B

Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): 260-266.

Varrone A, Soricelli A, Postiglione A, Salvatore M

Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.

Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M

Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic), 1998 Mar; 39(3): 497-499.

Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A

Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.

Postiglione A, Soricelli, Salvatore M, Lassen NA

123I-iomazenil as a clinical tool for studying neuronal loss [4]
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.

Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N

Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 1996 Nov; 201: N/D-N/D.

Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N

Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.