Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI(376 views visite) Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
CIRPeB, Department of Biological Chemistry, University of Naples Federico II, Via Mezzocannone, 6, Naples, 1-80134, Italy Department of Chemistry, University of Naples Federico II, Via Cynthia, Naples, 1-80126, Italy
References Riferimenti: Weissleder, R., Mahmood, U., (2001) Mol. Imaging Radiol., 219, p. 31
Aime, S., Cabella, C., Colombatto, S., Geninatti Crich, S., Gianolio, E., Maggioni, F., (2002) J. Magn. Reson. Imaging, 16, p. 394
Glogard, C., Stensrud, G., Hovland, R., Fossheim, S.L., Klaveness, J., (2002) Int. J. Pharm., 233, p. 131
Morel, S., Terreno, E., Ugazio, E., Aime, S., Gasco, M.R., (1998) Eur. J. Pharm. Biopharm., 45, p. 157
Aloj, L., Carraro, C., Zannetti, A., Del Vecchio, S., Tesauro, D., DeLuca, S., Panico, M., Salvatore, M.J., (2004) Nucl. Med., 45 (3). , in press
Aime, S., Gianolio, E., Morelli, G., Tesauro, D., De Luca, S., Anelli, P.L., Manuscript in preparationChang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: New York
Arai, H., Murata, M.J., (1973) J. Colloid Interface Sci., 44, p. 475
Stilbs, P., (1987) NMR Spectrosc., 19, p. 1
Infelta, P.P., Gratzel, M., Thomas, J.K., (1975) J. Phys. Chem., 78, p. 190
Tachiya, M., (1975) Chem. Phys. Lett., 33, p. 289
Gehlen, M.H., De Schryver, F.C., (1993) Chem. Rev., 93, p. 199
Turro, N.J., Yekta, A., (1978) J. Am. Chem. Soc., 100, p. 5951
McNeil, R., Thomas, J.K., (1981) J. Colloid Interface Sci., 83, p. 57
Banci, L., Bertini, I., Luchinat, C., (1991) Nuclear and Electronic Relaxation, p. 91. , VCH: Weinheim
Berti, D., Pini, F., Baglioni, P., Teixeira, J., (1999) J. Phys. Chem. B, 103, p. 1738
Hayter, J.B., Penfold, J., (1983) J. Colloid Polym. Sci., 261, p. 1072
Hayter, J.B., Hansen, J.B., (1991) Mol. Phys., 42, p. 651
Ragone, R., De Luca, S., Tesauro, D., Pedone, C., Morelli, G., (2001) Biopolymers, 56, p. 47
Jonstromer, M., Jonsson, B., Lindman, B., (1991) J. Phys. Chem., 95, p. 3293
Powell, D.H., Ni Dhubhghaill, O.M., Pubanz, D., Helm, L., Lebedev, Y.S., Schlaepfer, W., Merbach, A.E., (1996) J. Am. Chem. Soc., 118, p. 9333
Tanford, C., (1974) J. Phys. Chem., 78, p. 3293
Hannak, R.B., Färber, G., Konrat, R., Kräutler, B., (1997) J. Am. Chem. Soc., 119, p. 2313
Anelli, P. L., Lattuada, L., Lorusso, V., Schneider, M., Tournier, H., Uggeri, F., (2001) Magn. Reson. Mater. Phys. Biol. Med., 12, p. 114
Wiener, E. C., Brechbiel, M. W., Brothers, H., Magin, R. L., Gansow, O. A., Tomalia, D. A., Lauterbur, P. C., (1994) Magn. Reson. Med., 3, p. 1
Bligh, S. W., Harding, C. T., Sadler, P. J., Bulman, R. A., Bydder, G. M., Pennock, J. M., Kelly, J. D., Marriott, J. A., (1991) Magn. Reson. Med., 17, p. 516
Liu, S., Edward, D. S., (1999) Chem. Rev., 99, p. 2235
Torchilin, V. P., (2002) Adv. Drug Delivery, 54, p. 235
Andre, J. P., Toth, E., Fischer, H., Seelig, A., Macke, H. R., Merbach, A. E., (1999) Chem. Eur. J., 5, p. 2977
Wank, S. A., (1995) Am. J. Physiol., 269, pp. G628
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res., 57, p. 1377
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjugate Chem., 10, p. 137
Infelta, P. P., Gratzel, M., Thomas, J. K., (1975) J. Phys. Chem., 78, p. 190
Gehlen, M. H., De Schryver, F. C., (1993) Chem. Rev., 93, p. 199
Turro, N. J., Yekta, A., (1978) J. Am. Chem. Soc., 100, p. 5951
Hayter, J. B., Penfold, J., (1983) J. Colloid Polym. Sci., 261, p. 1072
Hayter, J. B., Hansen, J. B., (1991) Mol. Phys., 42, p. 651
Powell, D. H., Ni Dhubhghaill, O. M., Pubanz, D., Helm, L., Lebedev, Y. S., Schlaepfer, W., Merbach, A. E., (1996) J. Am. Chem. Soc., 118, p. 9333
Hannak, R. B., F rber, G., Konrat, R., Kr utler, B., (1997) J. Am. Chem. Soc., 119, p. 2313
Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI
New amphiphilic molecules containing a bioactive peptide or a claw moiety have been prepared in order to obtain mixed micelles as target-specific contrast agents in magnetic resonance imaging. The first molecule, C 18H37CONH(AdOO)2-G-CCK8 (C18CCK8), contains a C18 hydrophobic moiety bound to the C-terminal cholecystokinin octapeptide amide (CCK 26-33 or CCK8). The second amphiphilic compound, C18H 37CONHLys(DTPAGlu)CONH2 (C18DTPAGlu) or its gadolinium complex, (C18DTPAGlu(Gd)), contains the same C18 hydrophobic moiety bound, through a lysine residue, to the DTPAGlu chelating agent. The mixed aggregates as well as the pure C18DTPAGlu aggregate, in the presence and absence of Gd, have been fully characterized by surface tension measurements, FT-PGSE-NMR, fluorescence quenching, and small-angle neutron scattering measurements. The structural characterization of the mixed aggregates C18DTPAGlu(Gd)-C18CCK8 indicates a spherical arrangement of the micelles with an external shell of ∼21 Å and an inner core of ∼20 Å. Both the DTPAGlu(Gd) complexes and the CCK8 peptides point toward the external surface. The measured values for relaxivity in saline medium at 20 MHz proton Larmor frequency and 25 °C are 18.7 mM-1 s-1. These values show a large enhancement in comparison with the isolated DTPAGlu(Gd) complex.
Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI
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626 Records (589 escludendo Abstract e Conferenze). Impact factor totale: 2174.463 (2073.948 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2273.137 (2169.152 escludendo Abstract e Conferenze).
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