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Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (268 visite) (PDF 67 visite)
Theranostics (ISSN: 1838-7640electronic, 1838-7640linking), 2017 Aug 22; 7(14): 3595-3607.
Tipo di articolo: Journal Article,
Impact factor: 8.766
Impact factor a 5 anni: 9.222
Parole chiave: Bone Marrow-Derived Mesenchymal Stem Cells, Aptamer, Platelet-Derived Growth Factor Receptor Beta, Triple-Negative Breast Cancer.,
Url: Non disponibile.
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor progression by establishing a favorable tumor microenvironment (TME) that promote metastasis through a cytokine networks. However, the mechanism of homing and recruitment of BM-MSCs into tumors and their potential role in malignant tissue progression is poorly understood and controversial. Here we show that BM-MSCs increase aggressiveness of triple-negative breast cancer (TNBC) cell lines evaluated as capability to migrate, invade and acquire stemness markers. Importantly, we demonstrate that the treatment of BM-MSCs with a nuclease-resistant RNA aptamer against platelet-derived growth factor receptor beta (PDGFRbeta) causes the inhibition of receptor-dependent signaling pathways thus drastically hampering BM-MSC recruitment towards TNBC cell lines and BM-MSCs trans-differentiation into carcinoma-associated fibroblast (CAF)-like cells. Moreover, in vivo molecular imaging analysis demonstrated the aptamer ability to prevent BM-MSCs homing to TNBC xenografts. Collectively, our results indicate the anti-PDGFRbeta aptamer as a novel therapeutic tool to interfere with BM-MSCs attraction to TNBC providing the rationale to further explore the aptamer in more complex pre-clinical settings.
*** IBB - CNR ***
Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy., Ceinge, Advanced Biotechnology, Scarl, Naples, Italy., Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., IRCCS SDN, Naples, Italy.,
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