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Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (185 views) (PDF public 44 views)

Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A

Theranostics (ISSN: 1838-7640electronic, 1838-7640linking), 2017 Aug 22; 7(14): 3595-3607.

Abstract
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor progression by establishing a favorable tumor microenvironment (TME) that promote metastasis through a cytokine networks. However, the mechanism of homing and recruitment of BM-MSCs into tumors and their potential role in malignant tissue progression is poorly understood and controversial. Here we show that BM-MSCs increase aggressiveness of triple-negative breast cancer (TNBC) cell lines evaluated as capability to migrate, invade and acquire stemness markers. Importantly, we demonstrate that the treatment of BM-MSCs with a nuclease-resistant RNA aptamer against platelet-derived growth factor receptor beta (PDGFRbeta) causes the inhibition of receptor-dependent signaling pathways thus drastically hampering BM-MSC recruitment towards TNBC cell lines and BM-MSCs trans-differentiation into carcinoma-associated fibroblast (CAF)-like cells. Moreover, in vivo molecular imaging analysis demonstrated the aptamer ability to prevent BM-MSCs homing to TNBC xenografts. Collectively, our results indicate the anti-PDGFRbeta aptamer as a novel therapeutic tool to interfere with BM-MSCs attraction to TNBC providing the rationale to further explore the aptamer in more complex pre-clinical settings.

Affiliations ▼
*** IBB - CNR Affiliation

Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy., Ceinge, Advanced Biotechnology, Scarl, Naples, Italy., Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., IRCCS SDN, Naples, Italy.,

Details ▼
Impact factor: 8.766, 5-year impact factor: 9.222

Paper type: Journal Article,

Keywords: Bone Marrow-Derived Mesenchymal Stem Cells, Aptamer, Platelet-Derived Growth Factor Receptor Beta, Triple-Negative Breast Cancer.,

Url: Not available.

References ▼
Not available.

Related activities ▼
Clinical Oncology (210 views)

Related papers ▼
Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer. (public domain) (44 views)

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* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (4 views) (PDF 44 views)
Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
Theranostics (ISSN: 1838-7640electronic, 1838-7640linking), 2017 Aug 22; 7(14): 3595-3607.

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1 Records (1 excluding Abstracts and Conferences).
Total impact factor: 8.766 (8.766 excluding Abstracts and Conferences).
Total 5-year impact factor: 9.222 (9.222 excluding Abstracts and Conferences).



Your bibliography query: (([btitle, keywords, abstract] BONE AND [btitle, keywords, abstract] MARROW AND [btitle, keywords, abstract] DERIVED AND [btitle, keywords, abstract] MESENCHYMAL AND [btitle, keywords, abstract] STEM AND [btitle, keywords, abstract] CELLS AND [btitle, keywords, abstract] APTAMER AND [btitle, keywords, abstract] PLATELET AND [btitle, keywords, abstract] GROWTH)) AND NOT [id] = 53593



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