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Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (70 views) (PDF public 23 views)

Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A

Theranostics (ISSN: 1838-7640electronic, 1838-7640linking), 2017 Aug 22; 7(14): 3595-3607.

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor progression by establishing a favorable tumor microenvironment (TME) that promote metastasis through a cytokine networks. However, the mechanism of homing and recruitment of BM-MSCs into tumors and their potential role in malignant tissue progression is poorly understood and controversial. Here we show that BM-MSCs increase aggressiveness of triple-negative breast cancer (TNBC) cell lines evaluated as capability to migrate, invade and acquire stemness markers. Importantly, we demonstrate that the treatment of BM-MSCs with a nuclease-resistant RNA aptamer against platelet-derived growth factor receptor beta (PDGFRbeta) causes the inhibition of receptor-dependent signaling pathways thus drastically hampering BM-MSC recruitment towards TNBC cell lines and BM-MSCs trans-differentiation into carcinoma-associated fibroblast (CAF)-like cells. Moreover, in vivo molecular imaging analysis demonstrated the aptamer ability to prevent BM-MSCs homing to TNBC xenografts. Collectively, our results indicate the anti-PDGFRbeta aptamer as a novel therapeutic tool to interfere with BM-MSCs attraction to TNBC providing the rationale to further explore the aptamer in more complex pre-clinical settings.

Affiliations ▼
*** IBB - CNR Affiliation

Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy., Ceinge, Advanced Biotechnology, Scarl, Naples, Italy., Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., IRCCS SDN, Naples, Italy.,

Details ▼
Impact factor: 8.712, 5-year impact factor: 0

Paper type: Journal Article,

Keywords: Bone Marrow-Derived Mesenchymal Stem Cells, Aptamer, Platelet-Derived Growth Factor Receptor Beta, Triple-Negative Breast Cancer.,

Url: Not available.

References ▼
Not available.

Related activities ▼
Clinical Oncology (199 views)

Related papers ▼
Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer. (public domain) (23 views)

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* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (46 views) (PDF 4 views)
Pelagalli A, Nardelli A, Fontanella R, Zannetti A
Int J Mol Sci (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2016 Jul 11; 17(7): N/D-N/D.

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* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (473 views) (PDF 108 views)
Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
Cancer Lett (ISSN: 1872-7980electronic, 0304-3835linking), 2015 Oct 27; 370(1): 100-107.

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2 Records (2 excluding Abstracts and Conferences).
Total impact factor: 7.96 (7.96 excluding Abstracts and Conferences).
Total 5-year impact factor: 7.679 (7.679 excluding Abstracts and Conferences).

Your bibliography query: (([btitle, keywords, abstract] BONE AND [btitle, keywords, abstract] MARROW AND [btitle, keywords, abstract] DERIVED AND [btitle, keywords, abstract] MESENCHYMAL AND [btitle, keywords, abstract] STEM AND [btitle, keywords, abstract] CELLS)) AND NOT [id] = 53593

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