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Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non-Small Cell Lung Cancer Detected by (18)F-fluorothymidine (56 visite)

Iommelli F, De Rosa V, Terlizzi C, Monti M, Panico M, Fonti R, Del Vecchio S

Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jul 1; 24(13): 3126-3136.

Tipo di articolo: Journal Article

Impact factor: 10.199

Impact factor a 5 anni: 6.646


Parole chiave: Non disponibili.

Url: Non disponibile.


Purpose: Our aim was to test whether imaging with (18)F-fluorothymidine ((18)F-FLT) PET/CT was able to detect the combined effects of EGFR and MET inhibitors in oncogene-driven non-small cell lung cancer (NSCLC) and to elucidate the mechanisms underlying the enhanced efficacy of drug combination.Experimental Design: NSCLC cells bearing MET amplification (H1993 and H820) were treated with EGFR and MET inhibitors either alone or in combination and then tested for cell viability and inhibition of signaling. Nude mice bearing H1993 tumors underwent (18)F-FLT PET/CT scan before and after treatment with erlotinib and crizotinib alone or in combination (1:1 ratio) and posttreatment changes of (18)F-FLT uptake in tumors were determined. The role of inositol trisphosphate receptor type 3 (IP3R3) in mediating the combined action of EGFR and MET inhibitors was tested by transfecting NSCLC cells with IP3R3-targeted siRNA.Results: Imaging studies showed a significant reduction of (18)F-FLT uptake in response to combined treatment with EGFR and MET inhibitors that was higher than that obtained with single agents (ANOVA, F-ratio = 6.215, P = 0.001). Imaging findings were confirmed by analysis of surgically excised tumors. Levels of IP3R3 were significantly reduced in both cells and tumors after treatment with crizotinib, whereas EGFR inhibitors caused a reduction of IP3R3 interaction with K-Ras mainly through dephosphorylation of serine residues of K-Ras.Conclusions: Our findings indicate that (18)F-FLT PET/CT is able to detect the enhanced efficacy of EGFR and MET inhibitors in oncogene-driven NSCLC and that such enhancement is mediated by IP3R3 through its interaction with K-Ras. Clin Cancer Res; 24(13); 3126-36. (c)2018 AACR.
*** IBB - CNR ***

Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy., CEINGE-Advanced Biotechnologies, Naples Italy., Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy., Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy. delvecc@unina.it.,
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* Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays (44 visite)
Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2018 Jan 12; N/D: N/D-N/D.
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* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (46 visite)
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
Neuropharm (ISSN: 0028-3908linking), 2018 Jan; 128: 301-313.
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* Enhancement of Peroxidase Activity in Artificial Mimochrome VI Catalysts through Rational Design (27 visite)
Caserta G, Chino M, Firpo V, Zambrano G, Leone L, D'Alonzo D, Nastri F, Maglio O, Pavone V, Lombardi A
Chembiochem, 2018; 19: 1823-1826.
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* Inositol trisphosphate receptor type 3-mediated enhancement of EGFR and MET co-targeting efficacy in non-small cell lung cancer detected by 18F-fluorothymidine (49 visite)
Iommelli F, De Rosa V, Terlizzi C, Monti M, Panico M, Fonti R, Del Vecchio S
Clin Cancer Res, 2018; N/D: N/D-N/D.
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* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (48 visite)
Caraci F, Nicoletti F, Copani A
Curr Opin Pharmacol (ISSN: 1471-4973electronic, 1471-4892linking), 2017 Dec 23; 38: 1-7.
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* The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors (42 visite)
Mercurio FA, Di Natale C, Pirone L, Iannitti R, Marasco D, Pedone EM, Palumbo R, Leone M
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2017 Dec 12; 7(1): 17474-17474.
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* Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications (57 visite)
Calvanese L, Caporale A, Foca G, Iaccarino E, Sandomenico A, Doti N, Apicella I, Incisivo GM, De Falco S, Falcigno L, D'Auria G, Ruvo M
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2017 Dec 2; N/D: N/D-N/D.
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* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (224 visite) (PDF 78 visite)
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
Aging Cell (ISSN: 1474-9726electronic, 1474-9718linking), 2017 Nov 01; N/D: N/D-N/D.
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* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (59 visite)
Doti N, Ruvo M
Neural Regen Res (ISSN: 1673-5374print, 1673-5374linking), 2017 Sep; 12(9): 1428-1429.
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* Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain? (42 visite)
Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M
Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking, 0005-2728), 2017 Jun 06; 1865(9): 1095-1104.
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* Aptamer-mediated impairment of EGFR-integrin alphavbeta3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers (48 visite) (PDF 81 visite)
Camorani S, Crescenzi E, Gramanzini M, Fedele M, Zannetti A, Cerchia L
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2017 Apr 20; 7: 46659-46659.
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* Advances in molecular preclinical therapy mediated by imaging (50 visite) (PDF 69 visite)
Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
Q J Nucl Med Mol Imaging (ISSN: 1827-1936electronic, 1824-4785linking), 2017 Mar; 61(1): 76-94.
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* Early 18F-FDG uptake as a reliable imaging biomarker of T790M-mediated resistance but not MET amplification in non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors (80 visite)
De Rosa V, Iommelli F, Monti M, Mainolfi CG, Fonti R, Del Vecchio S
Ejnmmi Res, 2016 Dec; 6(1): 74-74.
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* Insulin, insulin receptors, and cancer (44 visite)
Vigneri R, Goldfine ID, Frittitta L
J Endocrinol Invest (ISSN: 1720-8386electronic, 0391-4097linking), 2016 Dec; 39(12): 1365-1376.
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* The Sam Domain of EphA2 receptor and its relevance to cancer: a novel challenge for drug discovery? (71 visite)
Mercurio F, Leone M
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2016 Nov 01; N/D: N/D-N/D.
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* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (59 visite) (PDF 94 visite)
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
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* Miniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response (59 visite)
De Rosa L, Finetti F, Diana D, Di Stasi R, Auriemma S, Romanelli A, Fattorusso R, Ziche M, Morbidelli L, D'Andrea LD
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2016 Aug 08; 6: 31295-31295.
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* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (96 visite) (PDF 184 visite)
Pelagalli A, Nardelli A, Fontanella R, Zannetti A
Int J Mol Sci (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2016 Jul 11; 17(7): N/D-N/D.
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* Structural identification of an HER2 receptor model binding pocket to optimize lead compounds: a combined experimental and computational approach (101 visite)
Langella E, Calce E, Saviano M, De Luca S
Mol Biosyst (ISSN: 1742-2051electronic, 1742-2051linking, 1742-206x), 2016 Jun 21; 12(7): 2159-2167.
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* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (58 visite)
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
Neuropharmacology (ISSN: 1873-7064electronic, 0028-3908linking), 2016 Apr 30; N/D: N/D-N/D.
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* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (51 visite)
Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
Frontiers In Medicinal Chemistry, 2016; 9: 130-160.
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* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (106 visite)
Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 159: 149-158.
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* Development of Targeting Ligands for HER2 Receptor: Simplified Receptor Model Employed for Selecting Highly Specific Molecules (52 visite)
Calce E, Saviano M, De Luca S
International Journal Of Peptide Research And Therapeutics, 2015 Dec; N/D: N/D-N/D.
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* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (519 visite) (PDF 147 visite)
Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
Cancer Lett (ISSN: 1872-7980electronic, 0304-3835linking), 2015 Oct 27; 370(1): 100-107.
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* Early 18F-FDG uptake as a reliable imaging biomarker of T790M-mediated resistance but not MET amplification in NSCLC (161 visite)
De Rosa V, Iommelli F, Monti M, Mainolfi C, Fonti R, Del Vecchio S
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2015 Oct; 42: N/D-N/D.
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* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (146 visite)
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
Frontiers In Cellular Neuroscience (ISSN: 1662-5102electronic, 1662-5102linking), 2015 Aug 7; 9(AUGUST): 297-297.
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* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (236 visite)
Calce E, Monfregola L, Saviano M, De Luca S
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2015 May 20; 22(21): 2525-2538.
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* An investigation into the origin of the biased agonism associated with the urotensin II receptor activation (134 visite)
Brancaccio D, Merlino F, Limatola A, Yousif AM, Gomez-Monterrey I, Campiglia P, Novellino E, Grieco P, Carotenuto A
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2015 Feb 19; 21(5): 392-399.
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* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (120 visite)
Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
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* A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands (147 visite)
di Villa Bianca R, Mitidieri E, Donnarumma E, Fusco F, Longo N, Rosa GD, Novellino E, Grieco P, Mirone V, Cirino G, Sorrentino R
Asian J Androl Asian Journal Of Andrology (ISSN: 1008-682x, 1745-7262electronic), 2015 Jan; 17(1): 81-85.
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* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (107 visite)
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
Int J Mol Sci (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2015; 16(6): 12159-12173.
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* Cyclization of the urokinase receptor-derived Ser-Arg-Ser-Arg-Tyr peptide generates a potent inhibitor of trans-endothelial migration of monocytes (101 visite)
Yousif AM, Minopoli M, Bifulco K, Ingangi V, Di Carluccio G, Merlino F, Motti ML, Grieco P, Carriero MV
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2015; 10(5): N/D-N/D.
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* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (106 visite)
Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
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* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (109 visite)
Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
Int J Pharm International Journal Of Pharmaceutics (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
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* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (163 visite)
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking), 2014 Sep 15; 20(18): 4806-4815.
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* Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (139 visite)
Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2014 Jul 24; 57(14): 5965-5974.
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* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (94 visite)
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
International Journal Of Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
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* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (119 visite)
Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
Mol Cancer Ther Molecular Cancer Therapeutics (ISSN: 1538-8514electronic, 1535-7163linking), 2014 May; 13(5): 1092-1104.
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* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (158 visite)
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
Int J Nanomedicine (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2014 Mar 27; 9(1): 1537-1557.
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* Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans (106 visite)
Federico A, Zappavigna S,  Romano M, Grieco P, Luce A, Marra M, Gravina AG, Stiuso P, D'Armiento FP, Vitale G, Tuccillo C, Novellino E, Loguercio C, Caraglia M
European Journal Of Clinical Investigation (ISSN: 0014-2972, 1365-2362), 2014 Mar; 44(3): 285-294.
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* Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization (139 visite)
Hayafune M, Berisio R, Marchetti R, Silipo A, Kayama M, Desaki Y, Arima S, Squeglia F, Ruggiero A, Tokuyasu K, Molinaro A, Kaku H, Shibuya N
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Jan 21; 111(3): E404-E404.
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* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (110 visite)
Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2014; 46(5): 1197-1206.
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* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (123 visite)
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
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* Copper promotes TFF1-mediated Helicobacter pylori colonization (95 visite)
Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2013 Nov 13; 8(11): e79455-e79455.
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* An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis (113 visite)
Zhou JS, Sandomenico A, Burton O, Oettgen HC, Ruvo M
Molecular Biosystems (ISSN: 1742-206x), 2013 Nov; 9(11): 2853-2859.
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* Selective alpha v beta 3 receptor peptide antagonist for therapeutic and diagnostic applications (82 visite)
Del Gatto A, Zaccaro L, Pedone C, Saviano M
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Oct 1; N/D: N/D-N/D.
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* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (99 visite)
Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
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* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (114 visite)
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
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* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (214 visite)
Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
Bmc Medical Imaging (ISSN: 1471-2342), 2013 Sep 12; 13: 31-31.
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* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (104 visite)
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
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* New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide (122 visite)
Carotenuto A, Auriemma L, Merlino F, Limatola A, Campiglia P, Gomez-monterrey I, Di Villa Bianca R, Brancaccio D, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
J Pept Sci (ISSN: 1075-2617, 1099-1387electronic), 2013 May; 19(5): 293-300.
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* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (118 visite)
Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
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* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (85 visite)
Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
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* Cations as switches of amyloid-mediated membrane disruption mechanisms: Calcium and IAPP (133 visite)
Sciacca MFM, Milardi D, Messina GML, Marletta G, Brender JR, Ramamoorthy A, La Rosa C
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jan 8; 104(1): 173-184.
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* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (110 visite)
Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
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* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (95 visite)
Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
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* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (88 visite)
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
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* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (89 visite)
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
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* F-18 FDG PET/CT metabolic tumor volume correlates with epidermal grow factor receptor expression in patients with NSCLC (72 visite)
Nappi A, Giacomobono S, Improta G, Nardelli A, Gallicchio R, Soscia E, Leggiadro F, Zupa A, Giudice G, Capacchione D, Vita G, Lequaglie C, Storto G
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
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* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (133 visite)
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
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* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (101 visite)
Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
Biochem Biophys Res Commun Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
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* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (91 visite)
Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
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* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (205 visite)
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
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* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (144 visite)
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
Journal Of Nuclear Medicine (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
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* Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor (89 visite)
Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
Diabetesdiabetes (ISSN: 0012-1797), 2012; 61(3): 692-701.
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* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (97 visite)
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
Cell Death Dis (ISSN: 2041-4889), 2012; 3(12): N/D-N/D.
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* Monomeric beta-amyloid activities relay on specific receptor engagement (88 visite)
Giuffrida M, Tomasello F, Caraci F, Pandini G, Chiechio S, Pappalardo G, Vigneri R, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2012; 42: N/D-N/D.
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* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (116 visite)
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
Int J Nanomedicine (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
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* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (143 visite)
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
J Biol Chem Journal Of Biological Chemistry (ISSN: 1083-351x, 0021-9258), 2011 Dec 2; 286(48): 41680-41691.
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* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (144 visite)
Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
Hum Brain Mapp (ISSN: 1065-9471), 2011 Oct; 32(10): 1626-1636.
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* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (91 visite)
Sandomenico A, Monti SM, Palumbo R, Ruvo M
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
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* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (135 visite)
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
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* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (105 visite)
Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
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* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (110 visite)
Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
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* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (229 visite)
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
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* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of yttrium-90 (127 visite)
Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2011 Jan; 69(1): 52-55.
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* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (112 visite)
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
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* D-Amphetamine decreases [C-11]AZ10419369 receptor binding in the monkey brain (68 visite)
Finnema SJ, Varrone A, Farde L, Halldin C
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
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* Quantitative measurement of [C-11]ORM-13070 receptor binding in the monkey brain using a bolus-infusion protocol (68 visite)
Finnema SJ, Nakao R, Haaparanta-solin M, Varrone A, Stepanov V, Solin O, Ingman K, Sallinen J, Scheinin M, Farde L, Halldin C
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
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* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (100 visite)
Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
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* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (94 visite)
Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
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* Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (102 visite)
Finnema SJ, Varrone A, Hwang TJ, Gulyas B, Pierson ME, Halldin C, Farde L
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
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* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (81 visite)
Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
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* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (96 visite)
Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
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* PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (100 visite)
Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
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* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (166 visite)
Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
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* Peptide modified nanocarriers for selective targeting of bombesin receptors (78 visite)
Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
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* Design, synthesis, and functional characterization of new cyclepeptides inhibitors for C-X-C chemokine receptor-4 (CXCR4) (73 visite)
Scala S, Portella L, Napolitano M, Consales C, Polimeno MN, D'Alterio C,  Palma G, Arra C, Vitale R, Amodeo P,  De Luca S, Monfrecola L, Castello G
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2010 Apr; 51: N/D-N/D.
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* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (81 visite)
Monfregola L, Saviano M, De Luca S
International Journal Of Peptide Research And Therapeutics (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
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* Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop (62 visite)
Severino V, Chambery A, Vitiello M, Cantisani M, Galdiero S, Galdiero M, Malorni L, Di Maro A, Parente A
J Proteome Res Journal Of Proteome Research (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
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* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (84 visite)
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
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* CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES (89 visite)
Amodeo P, Castello G, De Luca S, Scala S, Siani A, Vitale RM
Patent, 2010; PctWo2011092575: Pct-Pct.
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* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (86 visite)
D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
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* A SPR strategy for high-throughput ligand screenings based on synthetic peptides mimicking a selected subdomain of the target protein: A proof of concept on HER2 receptor (100 visite)
Monfregola L, Vitale RM, Amodeo P, De Luca S
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2009 Oct 1; 17(19): 7015-7020.
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* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of Yttrium-90 (91 visite)
Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pellegrino T, Pace L, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
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* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (119 visite)
Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
Mol Cancer Ther Molecular Cancer Therapeutics (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
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* Peptides targeting angiogenesis related growth factor receptors (13849 visite)
D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
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* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (92 visite)
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
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* [18F]Flumazenil binding to central benzodiazepine receptor studies by PET. - Quantitative analysis and comparisons with [11C]flumazenil (94 visite)
Odano I, Halldin C, Karlsson P, Varrone A, Airaksinen AJ, Krasikova RN, Farde L
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2009 Apr 15; 45(3): 891-902.
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* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (93 visite)
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
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* Changes in cortical dopamine D1 receptor binding associated with cognitive training (114 visite)
Mcnab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T
Science (ISSN: 0036-8075), 2009 Feb 6; 323(5915): 800-802.
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* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (87 visite)
Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
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* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (99 visite)
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Dec 5; 283(49): 34250-34259.
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* Efficacy and Toxicity of Peptide Receptor Radionuclide Therapy (PRRT) using medium-high activities of Y-90-DOTA-Octreotate (Y-90-DOTATATE) in patients with tumours expressing somatostatin receptors (SSTR) (84 visite)
Storto G, Erra P, Pellegrino T, Nardelli A, Milone F, Di Giorgio E, Faggiano A, Castaldi E, Ortosecco G, Speranza A, Klain M, Colao A, Salvatore M, Pace L
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
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* Imaging of lung cancer resistance to EGFR tyrosine kinase inhibitors through Bcl-2/Bcl-x(L) modulation of inositol trisphosphate receptor type (84 visite)
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Bianco R, Tortora G, Salvatore M, Del Vecchio S
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
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* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (149 visite)
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking), 2008 Sep 15; 14(16): 5209-5219.
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* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (78 visite)
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
Neuropharmacology (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
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* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (78 visite)
Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (94 visite)
Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
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* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (90 visite)
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
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* An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor (63 visite)
Bifulco K, Longanesi-cattani I, Gargiulo L, Maglio O, Cataldi M, De Rosa M, Stoppelli MP, Pavone V, Carriero MV
Febs Lett (ISSN: 0014-5793print, 0014-5793linking, 1873-3468electronic), 2008 Apr 2; 582(7): 1141-1146.
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* In vivo imaging of neurotransmission and brain receptors in dementia (105 visite) (PDF 123 visite)
Pappata S, Salvatore E, Postiglione A
J Neuroimaging (ISSN: 1051-2284), 2008 Apr; 18(2): 111-124.
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* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (110 visite)
Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
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* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1059 visite)
Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
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* Imaging Of Lung Cancer Resistance To Egfr Tyrosine Kinase Inhibitors Trough Bcl-2/Bcl-Xl Modulation Of Inositol Trisphosphate Receptor Type (85 visite)
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Bianco R, Tortora G, Salvatore M, Del Vecchio S
Eur J Nucl Med, 2008; suppl2: N/D-N/D.
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* PNA-mediated alteration of mRNA splicing (77 visite)
Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
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* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (99 visite)
Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
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* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (73 visite)
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
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The Rapid Growth Of Multimodality Imaging In Europe Multimodality (mm) Imaging: Enhancement Through Interlacing (60 visite)
Cuocolo A
European Journal Of Nuclear Medicine And Molecular Imaging, 2008; 35: 1221-1229.
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* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (112 visite)
Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
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* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (92 visite)
De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
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* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (98 visite)
Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jun 29; 282(26): 19029-19041.
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* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (127 visite)
Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
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* Integrin Receptor Family: Promising Target For Therapeutic And Diagnostic Applications (73 visite)
Zaccaro L, Del Gatto A, Pedone C, Saviano M
Current Topics In Biochemical Research (ISSN: 0972-4583), 2007; 9(2): 45-56.
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* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (96 visite)
De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
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* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (155 visite)
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
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* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (126 visite)
De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
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* Triphasic helical CT in Budd-Chiari syndrome: Patterns of enhancement in acute, subacute and chronic disease (109 visite)
Camera L, Mainenti PP, Di Giacomo A, Romano M, Rispo A, Alfinito F, Imbriaco M, Soscia E, Salvatore M
Clin Radiol (ISSN: 0009-9260), 2006 Apr; 61(4): 331-337.
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* Activity Threshold Determining Cumulative Aderse-Effects In Patients Undergoing Peptide Receptor Radionuclide Therapy With Y-90 Octreotate (91 visite)
Storto G, Speranza A, Pellegrino T, Panico M, Cella L, Nardelli A, Russo AA, Klain M, Soricelli A, Pace L, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006; 33: 338-338.
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* Bombesin receptors and transplanted stem cells in rat brain: High-resolution scan with 99mTc BN1 (100 visite)
Scopinaro F, Paschali E, Di Santo G, Antonellis T, Massari R, Trotta C, Gourni H, Bouziotis P, David V, Soluri A, Varvarigou AD
Nuclear Instruments And Methods In Physics Research Section A, 2006; 569(2SPEC.ISS.): 525-528.
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* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (83 visite)
Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
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* Novel and selective alpha v beta 3 receptor peptide antagonist: Design, synthesis and biological behaviour (92 visite)
Del Gatto A, Zaccaro L, Zannetti A, Del Vecchio S, Benedetti E, Salvatore M, Pedone C, Saviano M
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006; 12: N/D-N/D.
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* SPECT study of GABAA/BZD receptors and cerebral blood flow in mild cognitive impairment (MCI) (87 visite)
Pappata S, Varrone A, Milan G, Sansone V, Iavarone A, Panico M, Quarantelli M, Mollica C, De Falco C, Lore E, Postiglione A, Salvatore M
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2006; 31: N/D-N/D.
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* Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease (95 visite)
Pellegrino T, Storto G, Filardi PP, Sorrentino AR, Silvestro A, Petretta M, Brevetti G, Chiariello M, Salvatore M, Cuocolo A
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2005 Dec; 46(12): 1997-2002.
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* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (99 visite)
Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
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* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (102 visite)
Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
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* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (89 visite)
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
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* Relation between coronary flow reserve and flow mediated dilation index in patients with peripheral artery disease (59 visite)
Perrone-Filardi P, Silvestro A, Pellegrino T, Brevetti G, Corrado L, Cafiero M, Chiariello M, Cuocolo A
European Heart Journal (ISSN: 0195-668x), 2005 Sep; 26: N/D-N/D.
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* Relation Between Tc-99m Sestamibi Estimated Coronary Flow Reserve and Flow Mediated Dilation Index in Patients with Peripheral Artery Disease (60 visite)
Pellegrino T, Storto G, Sorrentino AR, Filardi PP, Silvestri A, Petretta M, Brevetti G, Cuocolo A
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
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* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (144 visite)
Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
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* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (88 visite)
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
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* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (93 visite)
Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
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* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (97 visite)
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
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* Structural features of the inactive and active states of the melanin-concentrating hormone receptors: Insights from molecular simulations (149 visite)
Vitale RM, Pedone C, De Benedetti PG, Fanelli F
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Sep 15; 56(3): 430-448.
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* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (115 visite)
Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
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* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (152 visite)
Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
Journal Of Nuclear Medicine (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
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* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (96 visite)
Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
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* A cyclic and branched peptide as a new selective ligand for the CCKA receptor (151 visite)
Benedetti E, Morelli G, Della Moglie R, De Luca S, Saviano M, Aloj L
Peptide Revolution, 2004; N/D: N/D-N/D.
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* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (103 visite)
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
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* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (107 visite)
De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
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* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (99 visite)
Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
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* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (106 visite)
Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
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* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (96 visite)
Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
Peptide Revolution, 2003 Apr; 10(2): 133-138.
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* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (88 visite)
De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
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* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (85 visite)
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
Molecular Pharmacology, 2003; 64: 1295-1308.
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* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (95 visite)
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
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* The Simultaneous Separation Of Different Enantiomeric Pairs In Capillary Electrophoresis By Mixing Different Hemispherodextrins, A Very Versatile Class Of Receptors (94 visite)
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M
J Chromatogr A (ISSN: 0021-9673), 2002 Dec 6; 979(1-2): 137-145.
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* Radiolabeling approaches for cholecystokinin B receptor imaging (127 visite)
Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
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* Targeting VEGF Receptors Using Designed Polypeptide (72 visite)
D’Andrea LD, Fattorusso R, Carannante C, Pedone C
Peptides 2002, 2002; ConferenceBook: 454-455.
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* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (83 visite)
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D,  De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
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* N-terminal myristylation of HBV preS1 domain enhances receptor recognition (100 visite)
De Falco S, Ruvo M, Verdoliva A, Scarallo A, Raimondo D, Raucci A, Fassina G
(ISSN: 1397-002x), 2001 May; 57(5): 390-400.
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Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (96 visite)
Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
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Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (105 visite)
Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
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Urokinase receptor interacts with alpha(v)beta(5) vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (106 visite)
Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli M
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1999 Oct 15; 59(20): N/D-N/D.
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Neuronorm is a potent and water soluble neurokinin A receptor antagonist (68 visite)
Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 1998 Jul 7; 8(13): 1735-1740.
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A novel super-potent neurokinin A receptor antagonist containing dehydroalanine (90 visite)
Lombardi A, D'Agostino B, Nastri F, D'Andrea LD, Filippelli A, Falciani M, Rossi F, Pavone V
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894xprint, 0960-894xlinking), 1998 May 19; 8(10): 1153-1156.
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Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (85 visite)
Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Eur J Endocrinol (ISSN: 0804-4643), 1997 Oct; 137(4): 410-414.
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Nitric oxide enhancement of melphalan-induced cytotoxicity (82 visite)
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Br J Cancer British Journal Of Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
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Vitronectin binding to urokinase receptor in human breast cancer (101 visite)
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking), 1997 Sep; 3(8): 1299-1308.
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Benzodiazepine receptor distribution in Alzheimer's disease with (123)I-iomazenil by SPECT (89 visite)
Varrone A, Soricelli A, Postiglione A, Salvatore M, Lassen N
Textbook Of Spect In Neurology And Psychiatry, 1997; N/D: N/D-N/D.
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The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (93 visite)
Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
Arch Biochem Biophys (ISSN: 0003-9861), 1996 Jul 15; 331(2): 241-248.
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Somatostatin receptor scintigraphy (SRS) with technetium-99m labeled synthetic peptides in melanoma (73 visite)
Lastoria S, Muto P, Acampa W, Caraco C, Vergara E, Varrella P, Pezzullo L, Ionna F, Mozzillo N, ListerJames J, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
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Design and structure of a novel Neurokinin A receptor antagonist cyclo(-Met1-Asp2-Trp3-Phe4-Dap 5-Leu6-)cyclo(2β-5β) (89 visite)
Pavone V, Lombardi A, Nastri F, Saviano M, Maglio O, D'Auria G, Quartara L, Maggi CA, Pedone C
(ISSN: 1472-779x), 1995; (5): 987-993.
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Tc-99m labeled somatostatin analogs to image tumors expressing specific receptors (65 visite)
Muto P, Lastoria S, Vergara E, Caraco C, Varrella P, Bernardy JD, Acampa W, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995; 36(5SUPPL.): N/D-N/D.
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Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (90 visite)
Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
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IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (82 visite)
Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Nuclear Medicine And Biology (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
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IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (66 visite)
LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
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Comparative distribution of urokinase receptor and urokinase in human breast cancer (72 visite)
Carriero MV, Stoppelli MP, Del Vecchio S, Franco P, Massa O, Fonti R, Salvatore M
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1994; 35(0): N/D-N/D.
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IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (83 visite)
LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
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Structural requirements for antagonist activity at tachykinin NK2 receptor in a series of bicyclic hexapeptides (67 visite)
L , Q , Fabbri G, Patacchini R, A , Maggi C, Astolfi M, D'Auria G, Maglio O, Lombardi A, Pedone C, Pavone V
Peptides, 1994; N/D: 591-592.
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CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (89 visite)
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cancer Immunology Immunotherapy (ISSN: 0340-7004), 1993 Sep; 37(3): 150-156.
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Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (77 visite)
Del Vecchio S, Stoppelli MP, Carriere MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1993 Jul 1; 53(13): 3198-3206.
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EPIDERMAL GROWTH-FACTOR (EGFR) AND TRANSFERRIN (TRFR) RECEPTOR UP-REGULATION IS INDUCED BY ARABINOSIDE CYTOSINE (ARA-C) ON HUMAN TUMOR-CELLS (80 visite)
Caraglia M, Correale P, Genua G, Pepe S, Del Vecchio S, Esposito G, Bianco AR, Tagliaferri P
(ISSN: 0361-090x), 1993; 17(2): 337-338.
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Structural and functional studies of insulin receptors in human breast cancer (87 visite)
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
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Urokinase and urokinase receptor overexpression in breast carcinoma as compared to benign lesions (72 visite)
Del Vecchio S, Stoppelli P, Fonti R, Carriero MV, Li P, Salvatore M
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1993; 34(0): N/D-N/D.
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Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (66 visite)
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
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Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (71 visite)
Trischitta V,  Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
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Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (69 visite)
Pezzino V, Papa V, Trischitta V,  Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
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Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (72 visite)
Trischitta V, Wong KY,  Brunetti A, Scalisi R, Vigneri R, Goldfine ID
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 1989 Mar 25; 264(9): 5041-5046.
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Study With The Competitive 5 Ht2 Receptor Antagonist Ketanserin (66 visite)
Ferrara LA, Fasano ML, Rubba P, Soro S, Marotta G, Mancini M
Journal Of Cardiovascular Pharmacology, 1985; 7: 159-160.
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190 Records (157 escludendo Abstract e Conferenze).
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Impact factor a 5 anni totale: 759.031 (650.244 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Inositol" OR [btitle] "Trisphosphate" OR [btitle] "Receptor" OR [btitle] "mediated" OR [btitle] "Enhancement") AND NOT [id] = 53828)







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