A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein
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A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (308 visite)

La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E

Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.

Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,

Impact factor: 5.476

Impact factor a 5 anni: 5.477


Parole chiave: Copper, Doppel Proteins, Helical Structures, Peptides, Prions, Amino Acid Residues, Aqueous Solutions, Asparagine Residue, Aspartates, Carboxylate Groups, Cd Measurements, Cd Spectra, Coordination Environment, Copper Complexes, Copper Ions, Epr Parameters, Helical Conformation, Helix Peptide, Histidine Residues, Loop Regions, Metal Binding, Metal-Binding Sites, N-Terminal Domains, Neurotoxicity, Peptide Conformation, Peptide Fragments, Physiological Ph Range, Potentiometric Titrations, Prion Protein, Protein Domains, Protein Functions, Secondary Structures, Spectroscopic Measurements, Spectroscopic Parameters, Spectroscopic Studies, Stability Constants, Transgenic Mice, Uv Region, Binding Energy, Biochemistry, Carboxylation, Complexation, Coordination Reactions, Data Storage Equipment, Electron Spin Resonance Spectroscopy, Metal Complexes, Metal Ions, Organic Acids, Ph Effects, Phosphatases, Plants (botany), Spectroscopic Analysis, Synthesis (chemical), Copper Compounds, Glycosylphosphatidylinositol Anchored Protein, Prnd Protein, Human, Amino Acid Sequence, Article, Circular Dichroism, Protein Binding, Protein Secondary Structure, Thermodynamics, Ultraviolet Spectrophotometry, Gpi-Linked Proteins, Protein Structure,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952728882&partnerID=40&md5=bfa042f2e7a6f2bdbe61b2849a22f99d

The doppel protein (Dpi) is the first homologue of the prion protein (PrP C) to be discovered; it is overexpressed in transgenic mice that lack the prion gene, resulting in neurotoxicity. The whole prion protein is able to inhibit Dpi neurotoxicity, and its N-terminal domain is the determinant part of the protein function. This region represents the main copper(II) binding site of PrP C. Dpi is able to bind at least one copper ion, and the specific metalbinding site has been identified as the histidine residue at the beginning of the third helical region. However, a reliable characterization of copper(II) coordination features has not been reported. In a previous paper, we studied the copper(II) interaction with a peptide that encompasses only the loop region potentially involved in metal binding. Nevertheless, we did not find a complete match between the EPR spectroscopic parameters of the copper(II) complexes formed with the synthesized peptide and those reported for the copper(II) binding sites of the whole protein. Herein, the synthesis of the human Dpi peptide fragment hDpl(122-139) (Ac-KPDNKLHQQVLWRLVQEL-NH 2) and its copper(II) complex species are reported. This peptide encompasses the third a helix and part of the loop linking the second and the third helix of human doppel protein. The single-point-mutated peptide, hDpl(122-139)D124N, in which aspartate 124 replaces an asparagine residue, was also synthesized. This peptide was used to highlight the role of the carboxylate group on both the conformation preference of the Dpi fragment and its copper(II) coordination features. NMR spectroscopic measurements show that the hDpl( 122-139) peptide fragment is in the prevailing ahelix conformation. It is localized within the 127-137 amino acid residue region that represents a reliable conformational mimic of the related protein domain. A comparison with the singlepoint-mutated hDpl(122-139)D124N reveals the significant role played by the aspartic residue in addressing the peptide conformation towards a helical structure. It is further confirmed by CD measurements. Potentiometric titrations were carried out in aqueous solutions to obtain the stability constant values of the species formed by copper(II) with the hDpl peptides. Spectroscopic studies (EPR, NMR, CD, UV/Vis) were performed to characterize the coordination environments of the different metal complexes. The EPR parameters of the copper(II) complexes with hDpl( 122-139) match those of the previously reported copper(II) binding sites of the whole hDpl. Addition of the copper(II) ion to the peptide fragment does not alter the helical conformation of hDpl(122-139), as shown by CD spectra in the far-UV region. The aspartate-driven preorganized secondary structure is not significantly modified by the involvement of Aspl24 in the copper(II) complex species that form in the physiological pH range. To elaborate on the potential role of copper(II) in the recently reported interaction between the PrP C and Dpi, the affinity of the copper(II) complexes towards the prion N terminus domain and the binding site of Dpi was reported. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
*** IBB - CNR ***

Dipartimento di Scienze Chimiche, Università Degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy

Istituto di Biostrutlure e Bioimmagini, CNR, c/o Dipartimento di Scienze Chimiche Viale A. Doria 6, 95125 Catania, Italy

Department of Chemistry, University of Gothenburg, PO Box 462, SE-405 30 Gothenburg, Sweden

Istituto Nazionale di Biostrutture e Biosistemi, Consorzio Interuniversitario, Viale Medaglie d'oro 305, 00136 Roma, Italy

Département de Biochimie, Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada

D partement de Biochimie, Universit de Montr al, C. P. 6128 Succursale Centre-Ville, Montr al, QC, H3C 3J7, Canada
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Mol Biosyst (ISSN: 1742-2051electronic, 1742-2051linking, 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
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* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (114 visite)
Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
Biochemistry (ISSN: 1520-4995electronic, 0006-2960linking), 2015 Sep 15; 54(36): 5646-5656.
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* Cullin3 - BTB interface: A novel target for stapled peptides (139 visite)
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2015 Apr 7; 10(4): e0121149-e0121149.
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* Antimicrobial peptides as an opportunity against bacterial diseases (152 visite)
Galdiero S, Falanga A, Berisio R, Grieco P, Morelli G, Galdiero M
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2015 Mar 11; 22(14): 1665-1677.
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* gH625: A milestone in understanding the many roles of membranotropic peptides (117 visite)
Galdiero S, Falanga A, Morelli G, Galdiero M
Biochim Biophys Acta (ISSN: 0005-2736, 0006-3002, 0925-4439), 2015 Jan; 1848(PA): 16-25.
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* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (112 visite)
Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
Biotechnology Journal (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
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* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (113 visite)
Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
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* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (124 visite)
Roviello GN, Musumeci D, Roviello V
Int J Pharm International Journal Of Pharmaceutics (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
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* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (90 visite)
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
Int J Mol Sci (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2015; 16(6): 12159-12173.
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* Insect gut symbiont susceptibility to host antimicrobial peptides caused by alteration of the bacterial cell envelope (118 visite)
Kim JK, Son DW, Kim C-H, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2015; 290(34): 21042-21053.
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* Investigating the inclusion properties of aromatic amino acids complexing beta-cyclodextrins in model peptides (86 visite)
Caso JV, Russo L, Palmieri M, Malgieri G, Galdiero S, Falanga A, Isernia C, Iacovino R
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; N/D: N/D-N/D.
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* On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides (92 visite)
Tomasello MF, Sinopoli A, Pappalardo G
J Diabetes Res (ISSN: 2314-6745print, 2314-6753online), 2015; articleID918573: 918573-918573.
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* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (94 visite)
Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
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* Synthetic and structural routes for the rational conversion of peptides into small molecules (122 visite)
Scognamiglio PL, Morelli G, Marasco D
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
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* The renaissance era of peptides in drug discovery at the 14th Naples workshop on bioactive peptides (71 visite)
Morelli G, Saviano M, Grieco P
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2015; 21(5): 321-322.
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* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (255 visite)
Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2014 Jun 23; 81: 442-455.
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* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (85 visite)
Accardo A, Ringhieri P, Palumbo R, Morelli G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Apr; 101(4): 304-312.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (140 visite)
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
Int J Nanomedicine (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2014 Mar 27; 9(1): 1537-1557.
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* Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (129 visite)
Avitabile C, D'Andrea LD, Romanelli A
Sci Rep (ISSN: 2045-2322, 2045-2322electronic), 2014 Mar 12; 4: 4293-4293.
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* The Copper (ii) And Zinc (ii) Coordination Mode Of Hexxh And Hxxeh Motif In Small Peptides: The Role Of Carboxylate Location And Hydrogen Bonding Network (93 visite)
GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
J Chem Res (ISSN: 1873-3344electronic, 0162-0134linking, 0162-0134print), 2014 Jan; 130(1): 92-102.
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* Adsorption of NGF and BDNF derived peptides on gold surfaces (124 visite)
Forte G, Travaglia A, Magrì A, Satriano C, La Mendola D
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(4): 1536-1544.
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* Conformational Disorder In Phosphopeptides: Solution Studies By Cd And Nmr Techniques (80 visite)
Leone M, Mercurio FA, Vincenzi M, Accardo A, Ringhieri P, Tesauro D, Carrière F, Rossi F
Peptidomics, 2014; 1: 14-21.
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* Lipidated Peptides Via Post-Synthetic Thioalkylation Promoted By Molecular Sieves (98 visite)
Calce E, Leone M, Monfregola L, De Luca S
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(8): 1899-1905.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Conformational modifications of gB from herpes simplex virus type 1 analyzed by synthetic peptides (100 visite)
Cantisani M, Falanga A, Incoronato N, Russo L, De Simone A, Morelli G, Berisio R, Galdiero M, Galdiero S
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8366-8376.
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* The effect of non-coordinating side chains on the metal binding affinities of peptides of histidine (111 visite)
Turi I, DSanna D, Garribba E, Pappalardo G, Sóvágó I
Polyhedron (ISSN: 0277-5387), 2013 Oct 7; 62: 7-17.
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* Synthesis of a thymine-functionalized nucleoamino acid for the solid phase assembly of cationic nucleopeptides (91 visite)
Roviello GN, Musumeci D, D'Alessandro C, Pedone C
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2013 Oct; 45(4): 779-784.
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* New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide (103 visite)
Carotenuto A, Auriemma L, Merlino F, Limatola A, Campiglia P, Gomez-monterrey I, Di Villa Bianca R, Brancaccio D, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
J Pept Sci (ISSN: 1075-2617, 1099-1387electronic), 2013 May; 19(5): 293-300.
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* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (120 visite)
Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 240-245.
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* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (100 visite)
Autiero I, Langella E, Saviano M
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
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* α-Helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes (118 visite)
Pannuzzo M, Raudino A, Milardi D, La Rosa C, Karttunen M
Sci Rep (ISSN: 2045-2322, 2045-2322electronic), 2013; 3: N/D-N/D.
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* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (86 visite)
Accardo A, Ringhieri P, Tesauro D, Morelli G
New Journal Of Chemistry (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
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* Shared and distinct features of beta-amyloid peptides (74 visite)
Giuffrida M, Caraci F, Tomasello F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2013; 43: N/D-N/D.
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* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (87 visite)
Roviello GN, Musumeci D, Bucci EM, Pedone C
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
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* Postsynthetic modification of peptides via chemoselective N-alkylation of their side chains (96 visite)
Monfregola L, Leone M, Calce E,  de Luca S
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2012 Apr 6; 14(7): 1664-1667.
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* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (101 visite)
Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
Biochemical Journal, 2012 Apr 1; 443: 231-240.
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* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (134 visite)
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
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* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (106 visite)
Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
Int J Nanomedicine (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
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* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (96 visite)
Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
J Pept Sci (ISSN: 1099-1387, 1075-2617, 1075-2617print), 2011 Dec 2; 17(5): 348-352.
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* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (99 visite)
Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
Biochim Biophys Acta (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
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* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (80 visite)
Roviello GN, Musumeci D, Bucci EM, Pedone C
Int J Pharm International Journal Of Pharmaceutics (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
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* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (119 visite)
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
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* Mimetic peptides of suppressor of cytokine signaling (SOCS)1 impair inflammatory responses of epidermal keratinocytes in vitro and in a mouse skin model of allergic contact dermatitis (63 visite)
Madonna S, Scarponi C, Sestito R, Doti N, Carbone T, Nasorri F, Marasco D, Cavani A, Albanesi C
Journal Of Investigative Dermatology (ISSN: 0022-202x), 2011 Sep; 131: N/D-N/D.
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* Nucleobase-containing peptides: a spectroscopic study of their properties and nucleic acids recognition ability (77 visite)
Roviello GN, Musumeci D, Bucci EM, Pedone C
Eur Biophys J (ISSN: 0175-7571, 1432-1017), 2011 Sep; 40: N/D-N/D.
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* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (128 visite)
Ruvo M, Sandomenico A, Tudisco L, De Falco S
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
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* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (123 visite)
Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
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* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (88 visite)
Roviello GN, Musumeci D, Bucci EM, Pedone C
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (101 visite)
Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
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* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (114 visite)
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
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* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (122 visite)
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
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* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (101 visite)
Barile E, Leone M, Barile E, Dahl R, Pellecchia M
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
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* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of yttrium-90 (108 visite)
Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2011 Jan; 69(1): 52-55.
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* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (109 visite)
Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
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* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (80 visite)
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Nucleobase-containing peptides: An overview of their characteristic features and applications (121 visite)
Roviello GN, Benedetti E, Pedone C, Bucci EM
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jun; 39(1): 45-57.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Design, synthesis, and functional characterization of new cyclepeptides inhibitors for C-X-C chemokine receptor-4 (CXCR4) (59 visite)
Scala S, Portella L, Napolitano M, Consales C, Polimeno MN, D'Alterio C,  Palma G, Arra C, Vitale R, Amodeo P,  De Luca S, Monfrecola L, Castello G
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2010 Apr; 51: N/D-N/D.
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* Are fibril growth and membrane damage linked processes? An experimental and computational study of IAPP(12-18) and IAPP(21-27) peptides (80 visite)
Sciacca MFM, Pappalardo M, Attanasio F, Milardi D, La Rosa C, Grasso DM
New Journal Of Chemistry (ISSN: 1144-0546), 2010; 34(2): 200-207.
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* CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES (73 visite)
Amodeo P, Castello G, De Luca S, Scala S, Siani A, Vitale RM
Patent, 2010; PctWo2011092575: Pct-Pct.
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* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (76 visite)
Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
Journal Of Chemical Physics, 2010; 114: 13830-13838.
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* Synthetic Analogs Of Human Beta-Defensins Display A More Effective Antimicrobial Activity Than Wild-Type Peptides (72 visite)
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Galdiero M, D'Isanto M, Naclerio G, Pedone C, Castaldo G, Salvatore F
Antimicrob Agents Chemother, 2010; 54: 2312-2322.
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* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (74 visite)
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
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* A SPR strategy for high-throughput ligand screenings based on synthetic peptides mimicking a selected subdomain of the target protein: A proof of concept on HER2 receptor (83 visite)
Monfregola L, Vitale RM, Amodeo P, De Luca S
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2009 Oct 1; 17(19): 7015-7020.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of Yttrium-90 (76 visite)
Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pellegrino T, Pace L, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

* Peptides targeting angiogenesis related growth factor receptors (13831 visite)
D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
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* Maldi, Ap/Maldi And Esi Techniques For The Ms Detection Of Amyloid Beta-Peptides (97 visite)
Grasso G, Mineo P, Rizzarelli E, Spoto G
Int J Mass Spectrom (ISSN: 1387-3806), 2009 Apr 15; 282(1-2): 50-55.
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* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (127 visite)
De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
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* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (87 visite)
Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
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* Peptides for tumour therapy and diagnosis: current status and future directions (156 visite)
Zaccaro L, Del Gatto A, Pedone C, Saviano M
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
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* Self-assembling properties of ionic-complementary peptides (102 visite)
D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
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* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (149 visite)
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
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* ONE-STEP SYNTHESIS OF 18F LABELED [18F]-N-SUCCINIMIDYL 4-FLUOROBENZOATE FOR A20 AND A20-36 PEPTIDES LABELING (91 visite)
Panico M, Lang L, Larobina M, Greco A, Gargiulo S, Iaccino E, Palmieri C, Scala G, Alfano B, Salvatore M
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2009; 52: N/D-N/D.
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* Peptides binding the type E immunoglobulins (75 visite)
Sandomenico A, Marasco D, Monti SM, Saviano M, Pedone C, Benedetti E, Ruvo M
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 573-574.
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* Sterochemistry And Thermodynamics Of The Inclusion Of Aliphatic And Aromatic Anionic Guests In A Tetracationic Calix [4] Arene In Acidic And Neutral Aqueous Solutions (54 visite)
Sgarlata C, Bonaccorso C, Gulino FG, Zito V, Arena G, Sciotto D
New Journal Of Chemistry, 2009; 33: 991-991.
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* Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation (89 visite)
Di Natale G, Damante CA, Nagy Z, Osz K, Pappalardo G, Rizzarelli E, Sóvágó I
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2008 Nov; 102(11): 2012-2019.
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* An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA15: implications for the development of peptides-specific antagonist (78 visite)
Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A, Miele C, Pedone C, Ruvo M
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (86 visite)
De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (65 visite)
Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
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* Synthesis and in vitro and in vivo characterization of NGF mimetic peptides (64 visite)
Sarmientos P, Morelli G, Alberghina L, Colangelo A, Martegani E, Vitagliano L, Papa M, Tornesello AL
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours (78 visite)
Saviano M, De Luca S, Morelli G, Tesauro D, Pedone C
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2008 Feb 12; N/D: N/D-N/D.
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* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (77 visite)
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
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* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (69 visite)
Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
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* Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (86 visite)
Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
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* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (75 visite)
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
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* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (92 visite)
Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
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* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (91 visite)
Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 83-90.
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* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (87 visite)
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
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* NMR structure and CD titration with metal cations of human prion α2-helix-related peptides (97 visite)
Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
Bioinorg Chem Appl (ISSN: 1565-3633), 2007; 2007: N/D-N/D.
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* Structure-activity relationships in peptides: From modelling to rational drug design (84 visite)
Benedetti E, Pedone C, Saviano M
Front Drug Des And Discov (ISSN: 1574-0889), 2007; 3(1): 539-558.
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* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (87 visite)
Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
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* The prion protein: structural features and related toxic peptides (78 visite)
Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
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* Transition metal complexes of terminally protected peptides containing histidyl residues (95 visite)
Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
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* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (73 visite)
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
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* Engineering Peptides In Angiogenesis (74 visite)
Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
Biopolymers, 2006; 0: 215-216.
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* Peptides reproducing the ApoA-I 141-164 region: Studies on Hpt recognition (61 visite)
D'Andrea LD, Spagnuolo M, De Stefano A, Morra M, Carlucci A, Del Gatto A, Caso P, Pedone C, Abrescia P, Benedetti E
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
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* Radiolabeled peptides as CXCR4 ligands (56 visite)
Benedetti E, Morelli G, Della Moglie R,  De Luca S, Aloj L, Ciarmiello A, Lastoria S, Arra C, D'Alessio A, Tarallo L
Understanding Biology Using Peptides, 2006; 80(4): N/D-N/D.
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* Copper(II) interaction with unstructured prion domain outside the octarepeat region: Speciation, stability, and binding details of copper(II) complexes with PrP106-126 peptides (96 visite)
Di Natale G, Grasso G, Impellizzeri G, La Mendola D, Micera G, Mihala N, Nagy Z, Osz K, Pappalardo G, Rigó V, Rizzarelli E, Sanna D, Sóvágó I
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2005 Oct 3; 44(20): 7214-7225.
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* New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides (89 visite)
De Luca S, Della Moglie R, De Capua A, Morelli G
Tetrahedron Letters (ISSN: 0040-4039), 2005 Sep 26; 46(39): 6637-6640.
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* Conformational Analysis Of Novel Heparin Binding Peptides (104 visite)
Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
Biomaterials (ISSN: 0142-9612, 1878-5905electronic), 2005 Jun; 26(16): 3207-3214.
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* Understanding Electron Transfer across Negatively-Charged Aib Oligopeptides (141 visite)
Improta R, Antonello S, Formaggio F, Maran F, Rega N, Barone V
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2005 Jan 20; 109(2): 1023-1033.
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* Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues (62 visite)
Zubrzak P, Banas A, Kaczmarek K, Leplawy MT, Sochacki M, Kowalski ML, Szkudlinska B, Zabrocki J, Di Lello P, Isernia C, Saviano M, Pedone C, Benedetti E
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(2-3): 347-356.
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* Anti-HIV C-terminal SDF-1 derived peptides: a conformational study (60 visite)
Falcigno L, D'Auria G, Vacatello M, Fasano G, Dettin M, Pasquato A, Di Bello C, Paolillo L
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
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* Metal ion driven turn conformation in two histidine-containing short peptides (86 visite)
Pappalardo G, Campagna T, Di Natale G, Grasso G, Impellizzeri G, Rizzarelli E
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
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* Imino acids and collagen triple helix stability: Characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (77 visite)
Berisio R, Granata V, Vitagliano L, Zagari A
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Sep 22; 126(37): 11402-11403.
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* Imino acids and collagen triple helix stability: characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (79 visite)
Berisio R, Granata V, Vitagliano L, Zagari A
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking), 2004 Sep 22; 126(37): 11402-11403.
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* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (82 visite)
Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
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* Assesing the reliability of density functional methods in the conformational study of polypeptides: The treatment of intraresidue nonbonding interactions (67 visite)
Improta R, Barone V
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2004; 25(11): 1333-1341.
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* Conformation and bioactive properties of novel osteoblast-adhesive peptides for biomaterial design (67 visite)
Vacatello M, D'Auria G, Falcigno L, Oliva R, Bevilacqua C, Dettin M, Conconi MT, Gambaretto R, Di Bello C, Paolillo L
Peptide Revolution, 2004; N/D: N/D-N/D.
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* Copper(II) binding of prion protein's octarepeat model peptides (101 visite)
Pappalardo G, Impellizzeri G, Campagna T
Inorg Chim Acta (ISSN: 0020-1693), 2004; 357(1): 185-194.
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* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (76 visite)
Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
Peptide Revolution, 2004; N/D: N/D-N/D.
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* Electron transfer to and conformational preferences of Aib oligo-peptides (70 visite)
Barone V, Formaggio F, Improta R, Polo F, Maran F
Proc Electrochem Soc, 2004; 10: 29-32.
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* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (85 visite)
Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
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* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (96 visite)
Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
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* Synthetic peptides mimicking the interleukin-6/gp130 interaction: a two-helix bundle system. Design and conformational studies (85 visite)
Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Feb; 9(2): 105-105.
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* Folding of peptides characterized by c3Val, a highly constrained analogue of valine (81 visite)
Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
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* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (106 visite)
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
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* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (84 visite)
Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
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* Understanding the role of stereoelectronic effects in determining collagen stability. 2. A quantum mechanical/molecular mechanical study of (Proline-Proline-Glycine)n polypeptides (68 visite)
Improta R, Mele F, Crescenzi O, Benzi C, Barone V
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Jul 3; 124(26): 7857-7865.
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* Nitroxyl peptides as catalysts of enantioselective oxidations (92 visite)
Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
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* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (68 visite)
Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
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* Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry (67 visite)
Monti SM, Gallo M, Ferracane R, Borrelli RC, Ritieni A, Greco ML, Graniti A, Fogliano V
Rapid Commun Mass Spectrom (ISSN: 0951-4198), 2001; 15(8): 623-628.
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* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (78 visite)
Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
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Conformational behavior of C(α, α)-diphenyl glycine: Extended conformation in tripeptides containing consecutive Dφg residues (74 visite)
Pavone V, Lombardi A, Saviano M, De Simone G, Nastri F, Maglio O, Omote Y, Yamanaka Y, Yamada T
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 161-168.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (79 visite)
Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (109 visite)
Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
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Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (87 visite)
Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
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Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (106 visite)
Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
N/D (ISSN: 0300-9246), 1998; (22): 3851-3857.
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Conformational Behaviour Of C-Alpha-Alpha-Diphenylglicine. Folded Versus Extended Structures In Dfg-Containing Tripeptides (68 visite)
Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
Journal Of Peptide Science, 1998; 4: 21-32.
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Conformational Characterization Of Peptides Rich In The Cycloaliphatic C Alpha, Alpha-Disubstituted Glycine 1-Aminocyclononane-1-Carboxylic Acid (86 visite)
Gatos M, Formaggio F, Crisma M, Valle G, Toniolo C, Bonora GM, Saviano M, Iacovino R, Menchise V, Galdiero S, Pedone C, Benedetti E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1997 Sep; 3(5): 367-382.
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β-Amino acid residues: Conformational characterization of an N- and C-protected homo-β-(S)-leucine (58 visite)
Benedetti E, Iacovino R, Pedone C, Rossi F, Saviano M, Isernia C, Montesarchio D, DeNapoli L, Piccialli G
International Journal Of Peptide Research And Therapeutics (ISSN: 0929-5666, 1573-3149), 1997 Jun; 4(3): 129-134.
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Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (73 visite)
Cucinotta V, Grasso D, Grasso G, Milardi D
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
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Unusual conformational preferences of β-alanine containing cyclic peptides. VII (85 visite)
Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
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Somatostatin receptor scintigraphy (SRS) with technetium-99m labeled synthetic peptides in melanoma (57 visite)
Lastoria S, Muto P, Acampa W, Caraco C, Vergara E, Varrella P, Pezzullo L, Ionna F, Mozzillo N, ListerJames J, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
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Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (111 visite)
Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
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Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (74 visite)
Bonomo RP, Marchelli R, Tabbì G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
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Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (75 visite)
Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Biopolymers (ISSN: 0006-3525print, 0006-3525linking), 1995 Oct; 26(12): 453-460.
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CONFORMATIONAL STUDIES OF HETEROCHIRAL PEPTIDES WITH DIASTEREOISOMERIC RESIDUES - CRYSTAL AND MOLECULAR-STRUCTURES OF LINEAR DIPEPTIDES DERIVED FROM LEUCINE, ISOLEUCINE, AND ALLO-ISOLEUCINE (93 visite)
Di Blasio B, Saviano M, Del Duca V, De Simone G, Rossi F, Pedone C, Benedetti E, Lorenzi GP
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Oct; 36(4): 401-408.
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SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (86 visite)
Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
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ACID CATALYSIS IN THE FORMATION OF DIOXOPIPERAZINES FROM PEPTIDES CONTAINING TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AT POSITION-2 (61 visite)
CAPASSO S, SICA F, MAZZARELLA L, BALBONI G, GUERRINI R, SALVADORI S
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print), 1995 Jun; 45(6): 567-573.
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Design of metal ion binding peptides (105 visite)
Fattorusso R, Morelli G, Lombardi A, Nastri F,  maglio O, D'Auria G, Pedone C, Pavone V
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
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Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe (67 visite)
Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Dec; 34(12): 1595-1604.
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β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (77 visite)
Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
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BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (73 visite)
Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
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Structural requirements for antagonist activity at tachykinin NK2 receptor in a series of bicyclic hexapeptides (49 visite)
L , Q , Fabbri G, Patacchini R, A , Maggi C, Astolfi M, D'Auria G, Maglio O, Lombardi A, Pedone C, Pavone V
Peptides, 1994; N/D: 591-592.
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BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (85 visite)
Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
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Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (84 visite)
Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
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Pt(II) Complexes of Amino Acids and Peptides. III. X-Ray Diffraction Study of trans-[Cl-(Ph3P)-Pt-(H-Aib-O-)] (60 visite)
Lombardi A, Maglio O, Pavone B, Di Blasio V, Saviano M, Nastri F, Pedone C, Benedetti E
Inorg Chim Acta, 1993; 204: 87-92.
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BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (81 visite)
DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
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β-Alanine containing peptides: A novel molecular tool for the design of γ-turns (88 visite)
Pavone V, Lombardi A, D'Auria G, Saviano M, Nastri F, Paolillo L, Di Blasio B, Pedone C
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1992 Feb; 32(2): 173-184.
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Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (69 visite)
Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Inorg Chim Acta, 1992; 196: 241-246.
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Thermodynamic and 1H-NMR Study of Proton Complex Formation of Histidine-Containing Cyclodipeptides in Aqueous Solution (67 visite)
Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
J Chem Soc, 1992; N/D: 371-376.
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Bioactive peptides: Solid-state and solution conformation of cyclolinopeptide (67 visite)
Blasio BD, Rossi F, Benedetti E, Pavone V, Pedone C, Temussi PA, Zanotti G, Tancredi T
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1989; 111(25): 9089-9098.
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Solid-state conformations of aminosuccinyl peptides: crystal structure of tert-butyloxycarbonyl-L-leucyl-L-aminosuccinyl-L-phenylalaninami de (65 visite)
Capasso S, Mazzarella L, Sica F, Zagari A
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989; 28(1): 139-147.
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Studies on gliadin related peptides. I. Synthesis, purification and 1H n. m. r. characterization of the pentapeptide H-Tyr-(Gln)3-Pro-OH (69 visite)
Pavone V, Rossi F, Pucci P, Andini S, Ferrara L, Di Blasio B, Pedone C
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print), 1983 Oct; 22(4): 482-488.
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171 Records (151 escludendo Abstract e Conferenze).
Impact factor totale: 490.246 (442.982 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 517.906 (466.893 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Doppel Proteins" OR [btitle] "Helical Structures" OR [btitle] "Peptides" OR [btitle] "Amino Acid Residues" OR [btitle] "Aqueous Solutions") AND NOT [id] = 8838)







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