OPTIMAL DETERMINATION OF RIGHT-VENTRICULAR FILLING DYNAMICS IN SYSTEMIC HYPERTENSION(272 views visite) Cittadini A, Fazio S, Strömer H, Cuocolo A, Sabatini D, Imbriaco M, Saccá L, Douglas PS
American Heart Journal (ISSN: 0002-8703), 1995 Nov; 130(5): 1074-1082.
Keywords Parole chiave: Adult, Aged, Article, Clinical Article, Controlled Study, Female, Heart Left Ventricle Enddiastolic Volume, Heart Left Ventricle Filling, Heart Right Ventricle Function, Heart Right Ventricle Volume, Heart Ventricle Filling, Human, Hypertension, Priority Journal, Echocardiography, Doppler, Gated Blood-Pool Imaging, Heart Rate, Middle Age, Stroke Volume, Support, Non-U.S. Gov, Ventricular Function, Non-U. S. Gov,
Affiliations Affiliazioni: Department of Internal Medicine, Federico II University Medical School Naples, Italy Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Department of Medicine (Cardiovascular Division) of Beth Israel Hospital and Harvard Medical School, Boston, Mass., USA
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OPTIMAL DETERMINATION OF RIGHT-VENTRICULAR FILLING DYNAMICS IN SYSTEMIC HYPERTENSION
To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r=0.34; LV, r=0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r=0.87; LV, r=0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios (E/A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or EIA in evaluating RV and LV filling dynamics.
OPTIMAL DETERMINATION OF RIGHT-VENTRICULAR FILLING DYNAMICS IN SYSTEMIC HYPERTENSION
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