Unusual conformational preferences of β-alanine containing cyclic peptides. VII(392 views visite) Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Keywords Parole chiave: Conformations, Hydrogen Bonds, Molecular Structure, Single Crystals, Synthesis (chemical), X Ray Analysis, Conformational Preferences, Cyclic Peptides, Intramolecular Hydrogen Bond, Proteins, Beta Alanine, Cyclopeptide, Pentapeptide, Article, Peptide Synthesis, Protein Conformation, X Ray Crystallography, Amino Acid Sequence, Beta-Alanine, Molecular Sequence Data,
Affiliations Affiliazioni: CNR and CEINGE, Centro Interdipartimentale, University of Naples Federico II, via Mezzocannone 4, 80134 Napoli, Italy
References Riferimenti: Not available. Non disponibili.
Unusual conformational preferences of β-alanine containing cyclic peptides. VII
In the present paper we describe the synthesis, purification, and single crystal x-ray analysis of the cyclic pentapeptide cyclo-(Pro-Phe-Phe-β-Ala- β-Ala). This compound crystallizes in the orthorhombic space group P212121 from methanol and adopts in the solid state an unusual conformation characterized by a cis β-Ala5-Pro1 peptide bond and by an intramolecular hydrogen bond stabilizing a C11- and a C12-ring structure. The C11 structure contains the Phe3 and the β-Ala4 at the corner position of the turn; it is the first observation of a type II β-turn enlargement due to the insertion of an extra methylene group of the β- alanine residue. The rest of the molecule participates in a newly characterized C12-ring structure, which incorporates a β-Ala residue at position i of the turn.
Unusual conformational preferences of β-alanine containing cyclic peptides. VII
205 Records (203 escludendo Abstract e Conferenze). Impact factor totale: 789.731 (784.193 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 840.999 (835.284 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:15:15 392 views visite. Last view on Ultima visita in data Friday 22 January 2021, 23:53:24