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Combined evaluation of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the identification of viable myocardium in patients with chronic coronary artery disease (98 visite)

Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Vezzuto P, Varrone A, Crisci T, Cuocolo A, Dellegrottaglie S, Piscione F, Chiariello M, Salvatore M

Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1998 Jul; 25(7): 744-750.

Tipo di articolo: Journal Article, , Impact factor: 2.564, Impact factor a 5 anni: 3.983, Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-7344264987&partnerID=40&md5=c3f37c4f1345b027d1b7a5a8e83a2047

Parole chiave: Discriminant Analysis, Dobutamine Echocardiography, Thallium-201, Viable Myocardium, Thallium 201, Adult, Aged, Article, Clinical Article, Clinical Trial, Controlled Study, Coronary Artery Disease, Diagnostic Accuracy, Female, Heart Muscle, Heart Muscle Revascularization, Human, Intermethod Comparison, Tomography, Adrenergic Beta-Agonists, Coronary Disease, Middle Aged, Myocardial Revascularization, Regression Analysis, Stroke Volume, Thallium Radioisotopes,

Affiliazioni: Cattedra di Medicina Nucleare, Istituto di Scienze Radiologiche, Università Federico II, Napoli, Italy
Ctro. C.N.R. per la Med. Nucleare, Napoli, Italy
Cattedra di Cardiologia, Ist. Med. Int.-Cardiol. C., Università Federico II, Napoli, Italy
trav. priv. Sanseverino 5/A, I-80128 Napoli, Italy
Ctro. C. N. R. per la Med. Nucleare, Napoli, Italy


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The purpose of this study was to evaluate whether combined evaluation by discriminant analysis of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the accuracy in identifying viable myocardium in patients with chronic coronary artery disease. Rest-redistribution 201Tl has high sensitivity but low specificity in identifying viable myocardium, while the opposite is true for low-dose dobutamine echocardiography. Forty-six patients underwent low-dose dobutamine echocardiography and rest redistribution 201Tl tomography on the same day. Rest echocardiography was repeated at least 30 days (mean 40 ± 20) after myocardial revascularization. Discriminant analysis was applied to the results of 201Tl tomography and dobutamine echocardiography to classify a/dyskinetic segments as viable or non-viable. In 92 a/dyskinetic segments that were revascularized, rest-redistribution 201Tl tomography yielded an accuracy of 75%, while the accuracy of dobutamine echocardiography was 70% (P < 0.05). When discriminant analysis was used, the combined evaluation gave an accuracy of 83% (P < 0.05 vs both tests). These findings demonstrate that low-dose dobutamine echocardiography and 201Tl imaging are useful and complementary techniques for identifying viable myocardium in patients with chronic coronary artery disease. Combined evaluation by discriminant anal analysis significantly improves accuracy, although the cost-effectiveness of such an approach remains to be determined.
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Squame F, Imbriaco M, Trimarco B, Salvatore M
ENHANCED DETECTION OF VIABLE MYOCARDIUM BY TECHNETIUM-99M-MIBI IMAGING AFTER NITRATE ADMINISTRATION IN CHRONIC CORONARY-ARTERY DISEASE (104 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): 1945-1952.
Impact Factor: 3.491
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Nicolai E, Cuocolo A, Pace L, Maurea S, Nappi A, Imbriaco M, Morisco C, Argenziano L, Salvatore M
Assessment of systolic wall thickening using technetium-99m methoxyisobutylisonitrile in patients with coronary artery disease: relation to thallium-201 scintigraphy with re-injection (127 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1995 Sep; 22(9): 1017-1022.
Impact Factor: 2.692
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Cuocolo A, Pace L, Maurea S, Nappi A, Nicolai E, Imbriaco M, Sullo P, Cardei S, Salvatore M
Morpho-functional diagnostic imaging in the assessment of viable myocardium in patients with ischemic heart disease. Correlations between myocardial perfusion and regional function of the left ventricle (94 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1995 Jun; 89(6): 870-875.
Impact Factor: 0.967
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Maurea S, Cuocolo A, Nicolai E, Salvatore M
Improved detection of viable myocardium with thallium-201 reinjection in chronic coronary artery disease: comparison with technetium-99m-MIBI imaging (98 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Apr; 35(4): 621-624.
Impact Factor: 3.491
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Cuocolo A, Pace L, Maurea S, Ricciardelli B, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Enhanced thallium-201 uptake after reinjection: Relation to regional ventricular function, myocardial perfusion and coronary anatomy (75 visite)
J Nucl Med Allied Sci, 1994 Mar; 38(1): 6-13.
Impact Factor: 0
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Left ventricular dysfunction in coronary artery disease: Comparison between rest-redistribution thallium 201 and resting technetium 99m methoxyisobutyl isonitrile cardiac imaging (111 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1994 Jan; 1(1): 65-71.
Impact Factor: 1.878
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Cuocolo A, Maurea S, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Resting technetium-99m methoxyisobutylisonitrile cardiac imaging in chronic coronary artery disease: comparison with rest-redistribution thallium-201 scintigraphy (103 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Dec; 20(12): 1186-1192.
Impact Factor: 2.692
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Pace L, Cuocolo A, Maurea S, Nicolai E, Imbriaco M, Nappi A, Morisco C, Chiariello M, Trimarco B, Salvatore M
Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function (119 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1993 Oct; 34(10): 1688-1692.
Impact Factor: 3.491
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Morisco C, Chiariello M, Trimarco B, Salvatore M
Rest-injected thallium-201 redistribution and resting technetium-99m methoxyisobutylisonitrile uptake in coronary artery disease: relation to the severity of coronary artery stenosis (94 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Jun; 20(6): 502-510.
Impact Factor: 2.692
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41 Records (29 escludendo Abstract e Conferenze).
Impact factor totale: 123.379 (74.23 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 184.806 (106.306 escludendo Abstract e Conferenze).







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