Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease(257 views visite) Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Cuocolo A, Varrone A, Vezzuto P, Crisci T, Soricelli A, Piscione F, Chiariello M, Salvatore M
Affiliations Affiliazioni: Cattedra di Medicina Nucleare, Istituto di Scienze Radiologiche, Università Federico II, Napoli, Italy Cardiologia, Istituto di Scienze Radiologiche, Università Federico II, Napoli, Italy Ctro. C.N.R. per la Med. Nucleare, Napoli, Italy Sanseverino 5/A, 80128, Napoli, Italy Ctro. C. N. R. per la Med. Nucleare, Napoli, Italy
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Liu, P., Burns, R. J., Easy come, easy go: Time to pause and put thallium reverse redistribution in perspective (1993) J Nucl Med, 34, pp. 1692-1694
Marin-Neto, J. A., Dilsizian, V., Arrighi, J. A., Freedman, N., Perrone-Filardi, P., Bacharach, S. L., Thallium reinjection demonstrates viable myocardium in regions with reverse redistribution (1993) Circulation, 88, pp. 1736-1745
Soufer, R., Dey, H. M., Lawson, A. J., Wackers, F. J. Th., Zaret, B. L., Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: A correlative PET study (1995) J Nucl Med, 36, pp. 180-187
Schiller, N. B., Shaha, P. M., Crawford, M., DeMaria, A., Deveroux, R., Feigenbaum, H., Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echocardiogr, 2, pp. 358-367
Udelson, J. E., Coleman, P. S., Metherall, J., Pandian, N. G., Gomez, A. R., Griffith, J. L., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201-T1 and 99m-Tc-sestamibi (1994) Circulation, 89, pp. 2552-2561
Melin, J. A., Becker, L. C., Bulkley, B. H., Differences in Tl-201 uptake in reperfused and non-reperfused myocardial infarction (1983) Circ Res, 53, pp. 414-419
Moore, C. A., Cannon, J., Watson, D. D., Kaul, S., Beller, G. A., Thallium-201 kinetics in stunned myocardium characterized by severe post-ischemic systolic dysfunction (1990) Circulation, 81, pp. 1622-1632
Tatum, J. L., Rehr, R. B., DiSciascio, G., Romhilt, D. W., Fratkin, M. J., Thallium-201/technetium-99m-RP-30A disparity in the course of myocardial infarction after attempted reperfusion (1988) J Nucl Med, 29, pp. 1283-1286
Gallagher, K. P., Osakada, G., Matsuzaki, M., Miller, M., Kemper, W. S., Ross Jr., J., Nonuniformity of inner and outer systolic wall thickening in conscious dogs (1985) Am J Physiol, 18, pp. H241-H248
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease
Objectives. There is growing evidence that myocardial segments with reverse redistribution are viable in patients with chronic coronary artery disease. The aim of this study was to assess the effects of myocardial revascularization on systolic function and thallium-201 uptake in such segments. Methods. Rest-redistribution thallium-201 tomography before and after myocardial revascularization was performed in 47 patients with chronic coronary artery disease. Regional function was evaluated by two-dimensional echocardiography before and after revascularization according to a 3-point scale (1 = normal, 2 = hypokinetic, 3 = a/dyskinetic). Improvement of dysfunctional segments was defined when systolic function score decreased ≤ 1 after revascularization. Reverse redistribution was defined as ≤ 8% decrease in relative thallium-201 uptake between rest and redistribution images. Results. Reverse redistribution was found in 27 (57%) of 47 patients, corresponding to 60 (11%) of 564 myocardial segments. Of such segments, 24 (40%) had normal systolic function, 19 (32%) were hypokinetic, and 17 (28%) were a/dyskinetic. Thirty-six segments underwent myocardial revascularization, and reverse redistribution was no longer present in 86% of them subsequent to the procedure. Of 26 dyssynergic segments with reverse redistribution subjected to revascularization, 18 (69%) improved at follow-up. Conclusions. The findings of the present study indicate that reverse redistribution is a reversible phenomenon and is often associated with improvement of systolic function following revascularization in patients with chronic coronary artery disease.
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease
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