Neuronorm is a potent and water soluble neurokinin A receptor antagonist(325 views visite) Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Keywords Parole chiave: Men 10627, Neurokinin 2 Receptor Antagonist, Neuronorm, Substance P, Tachykinin, Unclassified Drug, Animal Tissue, Article, Controlled Study, Drug Potency, Drug Solubility, Drug Synthesis, Guinea Pig, Nonhuman, Peptide Synthesis, Proton Nuclear Magnetic Resonance, Respiratory Tract Inflammation, Smooth Muscle Contraction, Structure Analysis, Trachea, Vas Deferens, Cyclic,
Affiliations Affiliazioni: Ctro. Interuniveristario di R., Universita di Napoli Federico II, via Mezzocannone 4, 80134 Napoli, Italy Ist. di Farmacologia e Tossicologia, Seconda Università di Napoli, via Costantinopoli 16, 80131 Napoli, Italy Ist. di Biochim. delle Macromolecule, Seconda Università di Napoli, via Costantinopoli 16, 80131 Napoli, Italy
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Neuronorm is a potent and water soluble neurokinin A receptor antagonist
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
Neuronorm is a potent and water soluble neurokinin A receptor antagonist
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