[Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure](107 visite) Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Jul; 96(1-2): 68-72.
Tipo di articolo: Journal Article,
Impact factor: 0.967, Impact factor a 5 anni: 1.448
Url: Non disponibile.
Parole chiave: Adult, Aged, Female, Heart Failure, Physiopathology, Humans, Middle Aged, Myocardial Contraction, Time Factors, Ventricular Function,
Affiliazioni:
Dipartimento di Scienze Radiologiche, Facolta di Medicina, Universita Federico II, Napoli.,
Riferimenti:
Non disponibile.
INTRODUCTION: The asynchrony of the left ventricle--i.e., its nonuniform contraction and relaxation--is an important factor for left ventricular function. Heart failure is often related to abnormal systolic function, sometimes associated with a diastolic dysfunction. We studied the relationship of left ventricular asynchrony to left ventricular function in patients with nonischemic heart failure. MATERIAL AND METHODS: Radionuclide angiography at rest was performed in 25 patients with nonischemic heart failure and in 26 age and sex matched normal subjects. In addition to ejection fraction and peak filling rate, two indices of left ventricular asynchrony were calculated: the coefficient of variation of regional time to end systole and the coefficient of variation of regional time to peak filling rate. These factors indicate how disperse are the regional values of time to end systole and of time to peak filling rate. In fact, the higher the value, the greater the asynchrony. RESULTS: A significant (r = .46, p < .05) inverse correlation was found between the ejection fraction and the coefficient of variation of regional time to end systole in both the normal subjects and the heart failure patients, while the ejection fraction correlated significantly (r = .46, p < .05) with the coefficient of variation of regional time to peak filling rate only in the patients. Moreover, the peak filling rate was inversely correlated (r = .57, p < .05) with the coefficient of variation of regional time to peak filling rate in the heart failure patients but not in the normal subjects. CONCLUSIONS: These results suggest that left ventricular systolic and diastolic asynchrony may contribute to impair left ventricular systolic and diastolic function in patients with nonischemic heart failure.
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580 Records (543 escludendo Abstract e Conferenze). Impact factor totale: 1870.17 (1739.688 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2032.978 (1878.589 escludendo Abstract e Conferenze).
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