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Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (130 visite)

Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S

J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.

Tipo di articolo: Journal Article, , Impact factor: 1.342, Impact factor a 5 anni: 3.382, Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0027537966&partnerID=40&md5=ced621a6c704a82704ea551c82fbb586

Parole chiave: Copper Complex, Cytostatic Agent, Cytotoxic Agent, Animal Cell, Article, Cell Strain Kb, Cell Transformation, Controlled Study, Cytotoxicity, Fibroblast, Human, Human Cell, In Vitro Study, Melanoma Cell, Mouse, Nonhuman, Species Difference, Squamous Cell Carcinoma, Acetates, Amino Acids, Antineoplastic Agents, Cell Death, Cell Division, Imidazoles, Experimental, Mouth Neoplasms, Support, Non-U.S. Gov, Tumor Cells, Cultured, Non-U. S. Gov,

Affiliazioni: Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, Italy
Istituto di Fisiologia, Universita' di Catania, Catania, Italy
Istituto per lo Studio delle Sostanze Naturali di Interesse Alimentare e Chimico-farmaceutico, C.N.R., Catania, Italy


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The cytotoxicity of some copper(II) compounds against the mouse cancer cell line B16, murine L929, human KB cells, and fibroblasts was investigated. All the copper(II) systems tested were shown to have pronounced toxicity against transformed cells and a cytostatic effect against untransformed cells, i.e., human fibroblasts. A careful speciation of the actual in vitro conditions reveals that copper(II) is essentially present as mixed complexes formed with the amino acids of the culture medium, [Cu(glutamine)(histidine)] being the main species. It was found that the cytotoxic activity is related to the amount of copper(II) contained in the tested compounds. © 1993.
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (53 visite)
Metallomics (ISSN: 1756-591xelectronic, 1756-5901linking), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.099
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Vagliasindi LI, Arena G, Bonomo RP, Pappalardo G, Tabbì G
* Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein (124 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Mar 21; 40(11): 2441-2450.
Impact Factor: 3.838
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (136 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Monzani E, Quinti L, Perrotti A, Casella L, Gullotti M, Randaccio L, Geremia S, Nardin G, Faleschini P, Tabbì G
Tyrosinase Models. Synthesis, Structure, Catechol Oxidase Activity, And Phenol Monoxygenase Activity Of A Dinuclear Copper Complex Derived From A Triamino Pentabenzimidazole Ligand (87 visite)
Inorg Chem, 1998; 37: 553-562.
Impact Factor: 0
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (94 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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5 Records (5 escludendo Abstract e Conferenze).
Impact factor totale: 11.149 (11.149 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 11.358 (11.358 escludendo Abstract e Conferenze).







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