Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease(295 views visite) Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Dipto. di Diagnostica per Immagini, AORN San Sebastiano, Caserta, Italy U.O. di Neurologia, AORN San Sebastiano, Caserta, Italy IBB-CNR, Università Federico II, Napoli, Italy U. O. di Neurologia, AORN San Sebastiano, Caserta, Italy IBB-CNR, Universit Federico II, Napoli, Italy
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Gelb, D. J., Olivier, E., Gilman, S., Diagnostic criteria for Parkinson's disease (1999) Arch Neurol, 56, pp. 33-39
Hughes, A. J., Daniel, S. E., Ben-Shlomo, Y., The accuracy of the clinical diagnosis of parkinsonian syndromes in a specialist movement disorder service (2002) Brain, 125, pp. 861-870
Brooks, D. J., Neuroimaging in movement disorders (1997) Movement Disorders: Neurologic Principles and Practice, pp. 31-48. , Watts RL, Koeller WC (eds). McGraw-Hill, New York
Raiput, A. H., Rozdilsky, B., Rajput, A., Accuracy of clinical diagnosis in parkinsonism. A prospective study (1991) Can J Neurol Sci, 18, pp. 275-278
Bower, J. H., Maraganoe, D. M., McDonnel, S. K., Influence of strict, intermediate, and broad diagnostic criteria on the age- and sex-specific incidence of Parkinson's disease (2000) Mov Disord, 15, pp. 19-25
Gilman, S., Low, P. A., Quinn, N., Consensus statement on the diagnosis of multiple system atrophy (1999) J Neurol Sci, 163, pp. 94-98
Marek, K. L., Seibyl, J. P., Zoghbi, S. S., [123I] beta-CIT SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease (1996) Neurology, 46, pp. 231-237
Benamer, H. T. S., Patterson, J., Grosset, D. G., Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I] -FP-CIT SPECT imaging: The [123I] -FP-CIT study group (2000) Mov Disord, 15, pp. 503-510
Berendse, H. W., Booij, J., Francot, C. M., Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patient's relatives with a decreased sense of smell (2001) Ann Neurol, 50, pp. 34-31
Rubenstain, L. M., Chrischilles, E. A., Voelker, M. D., The impact of Parkinson's disease in Europe: A collaborative study of population-based cohorts (1997) Pharmacoeconomics, 12, pp. 486-498. , Neurologic Diseases in the Elderly Research Group
Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease
PURPOSE: Here we report our experience in a general hospital setting using [(123)I]-FP-CIT SPECT to diagnose patients with suspect Parkinson's disease (PD). MATERIALS AND METHODS: Thirty consecutive patients (19M, 11W, mean age: 61+/-13 years) were prospectively studied. Patients underwent MRI (27) at 1.5T or CT (3) when MRI was contraindicated, to rule out focal brain abnormalities. Motor and cognitive function were evaluated by neurologists with UPDRS and Hoehn e Yahr Scale. [(123)I]-FP-CIT striatal uptake, assessed with SPECT, was classified as normal, non-diagnostic, abnormal (unilateral or bilateral). Imaging results (SPECT+MRI) were correlated with the neurological findings. RESULTS: In 5 patients the [(123)I]-FP-CIT brain SPECT was normal, suggesting that their symptoms could be related to a benign disorder such as essential tremor. Two patients had non-diagnostic [(123)I]-FP-CIT brain SPECT, with MRI/CT findings compatible with subcortical cerebrovascular disease. In the remaining 23 patients abnormal striatal [(123)I]-FP-CIT uptake correlated with neurological findings, significantly increasing the probability of Parkinson's disease. In these patients MRI/CT scans were normal, or showed a mild BA, or mild cerebral vascular disease (mild CVD). CONCLUSIONS: Our results suggest that [(123)I]-FP-CIT scan could be used routinely in clinical practice to support the diagnosis of PD and to differentiate between other conditions. Moreover, FP-CIT could significantly impact treatment selection and follow-up of these patients.
Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease
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