Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes(313 visite) Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Parole chiave: Autoimmunity, Islet Cell Antibodies, Metabolic Control, Type 1 Diabetes, Urinary Neopterin, Pancreas Islet Cell Antibody, Adolescent, Adult, Article, Controlled Study, Diagnosis, Disease Course, Etiology, Female, Human, Immunofluorescence Test, Insulin Dependent Diabetes Mellitus, Metabolic Regulation, Priority Journal, School Child, Sex Difference, Urinalysis, Autoantibodies, Biopterin, Insulin-Dependent, Hemoglobin A, Glycosylated, Islets Of Langerhans, Probability, Reference Values, Regression Analysis, Time Factors,
Universita Cattolica, Istituto di Clinica Medica, Largo A. Gemelli, 8, 00168 Roma, Italy
Neopterin is specifically produced by interferon-activated macrophages, and it may be considered a marker of cellular immunity. In 40 newly diagnosed and 38 longer standing type 1 (insulin-dependent) diabetics the relationship between urinary neopterin levels and islet cell antibodies (ICA) was investigated. Raised urinary neopterin levels were found in 30 ICA positive (mean ± SD: 729.8±602.1μmol/mol creatinine, p=0.0001) and 10 ICA negative (433.4±191.2μmol/mol creatinine, p=0.0005) diabetics at onset of disease compared with age-matched control subjects (118.1±33.2μmol/mol creatinine). No significant difference in urinary neopterin levels was observed between diabetic groups. After the first stages of disease (>5 months from onset), a significant difference (p=0.0002) in urinary neopterin excretion was found between longer standing ICA positive patients and controls, but not between ICA negative diabetics and controls. In longer standing diabetics, neopterin levels were significantly higher in ICA positive patients than in ICA negative patients (544.6±341.3 versus 201.7±180μmol/mol creatinine, p=0.0002). No correlation between newly diagnosed or longer standing patients and HbA(1c) levels was found. Our results suggest that increased neopterin excretion in type 1 diabetes seems to be a sensitive indicator for the activation of cell-mediated immunity even when ICA are undetectable.
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(144 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
110 Records (105 escludendo Abstract e Conferenze). Impact factor totale: 449.816 (441.629 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 478.381 (468.574 escludendo Abstract e Conferenze).