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Progetti in evidenza
 INCIPIT ISTAPCA Fondo Europeo Pesca Euro-BioImaging Fondazione Veronesi LightDyNAmics INMiND Instruct-IT PRIN eHealthNet Ponrec MFAG Grant MERITCollegamenti
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 Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (160 visite) Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810. Tipo di articolo: Journal Article, Impact factor: 3.467, Impact factor a 5 anni: 2.37 Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879407175&partnerID=40&md5=912cf792ada2b1d55289ed44b3a8ca3a Parole chiave: Carbon Disulfide Hydrolase, Carbonic Anhydrase, Carbonyl Sulfide Hydrolase, Coumarin, Dithiocarbamate, Ester, Hydroxamate, Natural Product, Phenol, Polyamine, Sulfocoumarin, Sulfonamide, X-Ray Crystallography, Benzenesulfonohydroxamic Acid, Carbon Dioxide, Carbonate Dehydratase Iii, Carbonate Dehydratase Inhibitor, Carbonate Dehydratase Xii, Hydroxamic Acid Derivative, N Methoxybenzenesulfonamide, Unclassified Drug, Binding Site, Catalysis, Chemical Structure, Drug Design, Drug Structure, Enzyme Inhibition, Hydrophilicity, Hydrophobicity, Priority Journal, Review, X Ray Crystallography, Carbonic Anhydrase Inhibitors, Humans, Hydrophobic And Hydrophilic Interactions, Models, Molecular, Structure-Activity Relationship, Affiliazioni: *** IBB - CNR *** Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy Università Degli Studi di Firenze, NEUROFARBA Department, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy Universit Degli Studi di Firenze, NEUROFARBA Department, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy Riferimenti: Alterio, V., Di Fiore, A., D'Ambrosio, K., Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (2012) Chem Rev, 112, pp. 4421-446 Smeulders, M.J., Barends, T.R., Pol, A., Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon (2011) Nature, 478, pp. 412-416 Ogawa, T., Noguchi, K., Saito, M., Carbonyl sulfide hydrolase from Thiobacillus thioparus strain THI115 is one of the b-carbonic anhydrase family enzymes (2013) J Am Chem Soc, 135, pp. 3818-3825 Supuran, C.T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat Rev Drug Discov, 7, pp. 168-181 Smith, K.S., Jakubzick, C., Whittam, T.S., Ferry, J.G., Carbonic anhydrase is an ancient enzyme widespread in prokaryotes (1999) Proc Natl Acad Sci USA, 96, pp. 15184-15189 Xu, Y., Feng, L., Jeffrey, P.D., Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms (2008) Nature, 452, pp. 56-61 Neri, D., Supuran, C.T., Interfering with pH regulation in tumours as a therapeutic strategy (2011) Nat Rev Drug Discov, 10, pp. 767-777 Eriksson, A.E., Jones, T.A., Liljas, A., Refined structure of human carbonic anhydrase II at 2.0 A resolution (1988) Proteins, 4, pp. 274-282 Supuran, C.T., Bacterial carbonic anhydrases as drug targets: Towards novel antibiotics? (2011) Front Pharmacol, 2, p. 34 Bertucci, A., Moya, A., Tambutté, S., Carbonic anhydrases in anthozoan corals-A review (2013) Bioorg Med Chem, 21, pp. 1437-1450 Monti, S.M., De Simone, G., Dathan, N.A., Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis (2013) Bioorg Med Chem Lett, 23, pp. 1626-1630 Alterio, V., Langella, E., Viparelli, F., Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (2012) Biochimie, 94, pp. 1232-1241 Supuran, C.T., Scozzafava, A., Casini, A., Carbonic anhydrase inhibitors (2003) Med Res Rev, 23, pp. 146-189 Aggarwal, M., McKenna, R., Update on carbonic anhydrase inhibitors: A patent review 2008-2011) (2012) Expert Opin Ther Pat, 22, pp. 903-915 De Simone, G., Supuran, C.T., (In)organic anions as carbonic anhydrase inhibitors (2012) J Inorg Biochem, 111, pp. 117-129 Supuran, C.T., Structure-based drug discovery of carbonic anhydrase inhibitors (2012) J Enzyme Inhib Med Chem, 27, pp. 759-772 Covarrubias, A.S., Bergfors, T., Jones, T.A., Hogbom, M., Structural mechanics of the pH-dependent activity of the beta-carbonic anhydrase from Mycobacterium tuberculosis (2006) J Biol Chem, 281, pp. 4993-4999 Schlicker, C., Hall, R.A., Vullo, D., Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans (2009) J Mol Biol, 385, pp. 1207-1220 Pacchiano, F., Carta, F., Vullo, D., Inhibition of beta-carbonic anhydrases with ureido-substituted benzenesulfonamides (2010) Bioorg Med Chem Lett, 20, pp. 102-105 Domsic, J.F., Avvaru, B.S., Kim, C.U., Entrapment of carbon dioxide in the active site of carbonic anhydrase II (2008) J Biol Chem, 283, pp. 30766-30771 Briganti, F., Mangani, S., Orioli, P., Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes i and II with histamine (1997) Biochemistry, 36, pp. 10384-10392 Temperini, C., Scozzafava, A., Vullo, D., Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L-and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton transfer processes within the active site of an enzyme (2006) Chemistry (Easton), 12, pp. 7057-7066 Maupin, C.M., Castillo, N., Taraphder, S., Chemical rescue of enzymes: Proton transfer in mutants of human carbonic anhydrase II (2011) J Am Chem Soc, 133, pp. 6223-6234 Alterio, V., Hilvo, M., Di Fiore, A., Crystal structure of the extracellular catalytic domain of the tumor-associated human carbonic anhydrase IX (2009) Proc Natl Acad Sci USA, 106, pp. 16233-16238 Di Fiore, A., Monti, S.M., Hilvo, M., Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (2009) Proteins, 74, pp. 164-175 Di Fiore, A., Truppo, E., Supuran, C.T., Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (2010) Bioorg Med Chem Lett, 20, pp. 5023-5026 Whittington, D.A., Waheed, A., Ulmasov, B., Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001) Proc Natl Acad Sci USA, 98, pp. 9545-9550 Whittington, D.A., Grubb, J.H., Waheed, A., Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: Implications for selective inhibition of membrane-associated isozymes (2004) J Biol Chem, 279, pp. 7223-7228 Aggarwal, M., Boone, C.D., Kondeti, B., McKenna, R., Structural annotation of human carbonic anhydrases (2013) J Enzyme Inhib Med Chem, 28, pp. 267-277 Liljas, A., Kannan, K.K., Bergstén, P.C., Crystal structure of human carbonic anhydrase C (1972) Nat New Biol, 235, pp. 131-137 Peña, K.L., Castel, S.E., De Araujo, C., Structural basis of the oxidative activation of the carboxysomal g-carbonic anhydrase, CcmM (2010) Proc Natl Acad Sci USA, 107, pp. 2455-2460 Weber, A., Casini, A., Heine, A., Unexpected nanomolar inhibition of carbonic anhydrase by COX-2 selective celecoxib: New pharmacological opportunities due to related binding site recognition (2004) J Med Chem, 47, pp. 550-557 Di Fiore, A., Pedone, C., D'Ambrosio, K., Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib (2006) Bioorg Med Chem Lett, 16, pp. 437-442 Kohler, K., Hillebrecht, A., Schulze Wischeler, J., Saccharin inhibits carbonic anhydrases: Possible explanation for its unpleasant metallic aftertaste (2007) Angew Chem Int Ed Engl, 46, pp. 7697-7699 Hilvo, M., Innocenti, A., Monti, S.M., Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (2008) Curr Pharm des, 14, pp. 672-678 Woo, L.W., Ganeshapillai, D., Thomas, M.P., Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495) (2011) ChemMedChem, 6, pp. 2019-2034 Kolayli, S., Karahalil, F., Sahin, H., Characterization and inhibition studies of an a-carbonic anhydrase from the endangered sturgeon species Acipenser gueldenstaedti (2011) J Enzyme Inhib Med Chem, 26, pp. 895-900 Carta, F., Aggarwal, M., Maresca, A., Dithiocarbamates: A new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations (2012) Chem Commun (Camb), 48, pp. 1868-1870 Maresca, A., Carta, F., Vullo, D., Supuran, C.T., Dithiocarbamates strongly inhibit the beta-class carbonic anhydrases from Mycobacterium tuberculosis (2013) J Enzyme Inhib Med Chem, 28, pp. 407-411 Pan, P., Vermelho, A.B., Capaci Rodrigues, G., Cloning, characterization, and sulfonamide and thiol inhibition studies of an alpha-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease (2013) J Med Chem, 56, pp. 1761-1771 Almajan, G.L., Innocenti, A., Puccetti, L., Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1, 3, 4-thiadiazole-and 1, 2, 4-triazole-thiols (2005) Bioorg Med Chem Lett, 15, pp. 2347-2352 Di Fiore, A., Maresca, A., Supuran, C.T., De Simone, G., Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (2012) Chem Commun (Camb), 48, pp. 8838-8840 Scozzafava, A., Supuran, C.T., Carbonic anhydrase and matrix metalloproteinase inhibitors: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes (2000) J Med Chem, 43, pp. 3677-3687 Nair, S.K., Ludwig, P.A., Christianson, D.W., Two-site binding of phenol in the active site of human carbonic anhydrase II: Structural implications for substrate association (1994) J Am Chem Soc, 116, pp. 3659-3660 Davis, R.A., Innocenti, A., Poulsen, S.A., Supuran, C.T., Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes i and II from a natural product-based phenolic library (2010) Bioorg Med Chem, 18, pp. 14-18 Martin, D.P., Cohen, S.M., Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors (2012) Chem Commun (Camb), 48, pp. 5259-5261 Carta, F., Temperini, C., Innocenti, A., Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule (2010) J Med Chem, 53, pp. 5511-5522 Davis, R.A., Hofmann, A., Osman, A., Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases (2011) J Med Chem, 54, pp. 1682-1692 Tars, K., Vullo, D., Kazaks, A., Sulfocoumarins (1, 2-benzoxathiine-2, 2-dioxides): A class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases (2013) J Med Chem, 56, pp. 293-300 Maresca, A., Temperini, C., Vu, H., Non-zinc mediated inhibition of carbonic anhydrases: Coumarins are a new class of suicide inhibitors (2009) J Am Chem Soc, 131, pp. 3057-3062 Touisni, N., Maresca, A., McDonald, P.C., Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors (2011) J Med Chem, 54, pp. 8271-8277 McDonald, P.C., Winum, J.Y., Supuran, C.T., Dedhar, S., Recent developments in targeting carbonic anhydrase IX for cancer therapeutics (2012) Oncotarget, 3, pp. 84-97 Davis, R.A., Vullo, D., Maresca, A., Natural product coumarins that inhibit human carbonic anhydrases (2013) Bioorg Med Chem, 21, pp. 1539-1543 Simonsson, I., Jonsson, B.H., Lindskog, S., Phenol, a competitive inhibitor of CO2 hydration catalyzed by carbonic anhydrase (1982) Biochem Biophys Res Commun, 108, pp. 1406-1412 Buchieri, M.V., Riafrecha, L.E., Rodríguez, O.M., Inhibition of the b-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: Identification of the first inhibitor with anti-mycobacterial activity (2013) Bioorg Med Chem Lett, 23, pp. 740-743 Ekinci, D., Karagoz, L., Ekinci, D., Carbonic anhydrase inhibitors: In vitro inhibition of a isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids (2013) J Enzyme Inhib Med Chem, 28, pp. 283-288 Sahin, H., Can, Z., Yildiz, O., Inhibition of carbonic anhydrase isozymes i and II with natural products extracted from plants, mushrooms and honey (2012) J Enzyme Inhib Med Chem, 27, pp. 395-402 Lopez, M., Vu, H., Wang, C.K., Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors (2011) J Am Chem Soc, 133, pp. 18452-18462 Kazancioǧlu, E.A., Güney, M., Şentürk, M., Supuran, C.T., Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity (2012) J Enzyme Inhib Med Chem, 27, pp. 880-885 Innocenti, A., Supuran, C.T., Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of a-but not of b-, g-and z-carbonic anhydrases (2010) Bioorg Med Chem Lett, 20, pp. 6208-6212 Innocenti, A., Scozzafava, A., Parkkila, S., Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (2008) Bioorg Med Chem Lett, 18, pp. 2267-2271 Cavdar, H., Ekinci, D., Talaz, O., A-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters (2012) J Enzyme Inhib Med Chem, 27, pp. 148-154 Carta, F., Maresca, A., Scozzafava, A., Supuran, C.T., 5-and 6-membered (thio) lactones are prodrug type carbonic anhydrase inhibitors (2012) Bioorg Med Chem Lett, 22, pp. 267-270 Huang, S., Hainzl, T., Grundstrom, C., Structural studies of beta-carbonic anhydrase from the green alga Coccomyxa: Inhibitor complexes with anions and acetazolamide (2011) PLoS ONE, 6, pp. e28458 Casini, A., Scozzafava, A., Mincione, F., Carbonic anhydrase inhibitors: Water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects (2000) J Med Chem, 43, pp. 4884-4892 Scozzafava, A., Menabuoni, L., Mincione, F., Supuran, C.T., Carbonic anhydrase inhibitors. A general approach for the preparation of water soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long lasting, topical intraocular pressure lowering properties (2002) J Med Chem, 45, pp. 1466-1476 Fabrizi, F., Mincione, F., Somma, T., A new approach to antiglaucoma drugs: Carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology (2012) J Enzyme Inhib Med Chem, 27, pp. 138-147 Svastová, E., Hulíková, A., Rafajová, M., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Lett, 577, pp. 439-445 Ahlskog, J.K.J., Dumelin, C.E., Trüssel, S., In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives (2009) Bioorg Med Chem Lett, 19, pp. 4851-4856 Lou, Y., McDonald, P.C., Oloumi, A., Targeting tumor hypoxia: Suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors (2011) Cancer Res, 71, pp. 3364-3376 Carta, F., Supuran, C.T., Scozzafava, A., Novel therapies for glaucoma: A patent review 2007-2011 (2012) Expert Opin Ther Pat, 22, pp. 79-88 Steele, R.M., Benedini, F., Biondi, S., Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma (2009) Bioorg Med Chem Lett, 19, pp. 6565-6570 Mincione, F., Benedini, F., Biondi, S., Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action (2011) Bioorg Med Chem Lett, 21, pp. 3216-3221 Alterio, V., Vitale, R.M., Monti, S.M., Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (2006) J Am Chem Soc, 128, pp. 8329-8335 Alterio, V., De Simone, G., Monti, S.M., Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (2007) Bioorg Med Chem Lett, 17, pp. 4201-4207 Wagner, J., Avvaru, B.S., Robbins, A.H., Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: Solution and crystallographic investigations (2010) Bioorg Med Chem, 18, pp. 4873-4878 Biswas, S., Aggarwal, M., Guzel, O., Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms (2011) Bioorg Med Chem, 19, pp. 3732-3738 Pacchiano, F., Aggarwal, M., Avvaru, B.S., Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido- benzenesulfonamides and correlate to inhibitor potency (2010) Chem Commun (Camb), 46, pp. 8371-8373 Carta, F., Garaj, V., Maresca, A., Sulfonamides incorporating 1, 3, 5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms i and II: Solution and X-ray crystallographic studies (2011) Bioorg Med Chem, 19, pp. 3105-3119 Hen, N., Bialer, M., Yagen, B., Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII and XIV (2011) J Med Chem, 54, pp. 3977-81 Güzel, O., Innocenti, A., Scozzafava, A., Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl-and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors (2009) Bioorg Med Chem Lett, 19, pp. 3170-3173 Garaj, V., Puccetti, L., Fasolis, G., Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating 1, 2, 4-triazine moieties (2004) Bioorg Med Chem Lett, 14, pp. 5427-5433 Pastorekova, S., Parkkila, S., Pastorek, J., Supuran, C.T., Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects (2004) J Enzyme Inhib Med Chem, 19, pp. 199-229 Zimmerman, S., Innocenti, A., Casini, A., Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides (2004) Bioorg Med Chem Lett, 14, pp. 6001-6006 Jude, K.M., Banerjee, A.L., Haldar, M.K., Ultrahigh resolution crystal structures of human carbonic anhydrases i and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity (2006) J Am Chem Soc, 128, pp. 3011-3018 Kim, C.Y., Chandra, P.P., Jain, A., Christianson, D.W., Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II (2001) J Am Chem Soc, 123, pp. 9620-9627 De Simone, G., Vitale, R.M., Di Fiore, A., Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (2006) J Med Chem, 49, pp. 5544-5551 Avvaru, B.S., Wagner, J.M., Maresca, A., Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors (2010) Bioorg Med Chem Lett, 20, pp. 4376-4381 Biswas, S., Carta, F., Scozzafava, A., Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition (2013) Bioorg Med Chem, 21, pp. 2314-2318 Whittaker, M., Floyd, C.D., Brown, P., Gearing, A.J.H., Design and therapeutic application of matrix metalloproteinase inhibitors (1999) Chem Rev, 99, pp. 2735-2776 Scolnick, L.R., Clements, A.M., Liao, J., Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase II (1997) J Am Chem Soc, 119, pp. 850-851 Fisher, S.Z., Aggarwal, M., Kovalevsky, A.Y., Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding (2012) J Am Chem Soc, 134, pp. 14726-14729 Capasso, C., Supuran, C.T., Anti-infective carbonic anhydrase inhibitors: A patent and literature review (2013) Expert Opin Ther Pat, , published online 14 March 2013 doi:10.1517/13543776.2013.778245 Smeulders, M. J., Barends, T. R., Pol, A., Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon (2011) Nature, 478, pp. 412-416 Supuran, C. T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat Rev Drug Discov, 7, pp. 168-181 Smith, K. S., Jakubzick, C., Whittam, T. S., Ferry, J. G., Carbonic anhydrase is an ancient enzyme widespread in prokaryotes (1999) Proc Natl Acad Sci USA, 96, pp. 15184-15189 Eriksson, A. E., Jones, T. A., Liljas, A., Refined structure of human carbonic anhydrase II at 2. 0 A resolution (1988) Proteins, 4, pp. 274-282 Supuran, C. T., Bacterial carbonic anhydrases as drug targets: Towards novel antibiotics? (2011) Front Pharmacol, 2, p. 34 Monti, S. M., De Simone, G., Dathan, N. A., Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis (2013) Bioorg Med Chem Lett, 23, pp. 1626-1630 Supuran, C. T., Scozzafava, A., Casini, A., Carbonic anhydrase inhibitors (2003) Med Res Rev, 23, pp. 146-189 Supuran, C. T., Structure-based drug discovery of carbonic anhydrase inhibitors (2012) J Enzyme Inhib Med Chem, 27, pp. 759-772 Covarrubias, A. S., Bergfors, T., Jones, T. A., Hogbom, M., Structural mechanics of the pH-dependent activity of the beta-carbonic anhydrase from Mycobacterium tuberculosis (2006) J Biol Chem, 281, pp. 4993-4999 Domsic, J. F., Avvaru, B. S., Kim, C. U., Entrapment of carbon dioxide in the active site of carbonic anhydrase II (2008) J Biol Chem, 283, pp. 30766-30771 Maupin, C. M., Castillo, N., Taraphder, S., Chemical rescue of enzymes: Proton transfer in mutants of human carbonic anhydrase II (2011) J Am Chem Soc, 133, pp. 6223-6234 Whittington, D. A., Waheed, A., Ulmasov, B., Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001) Proc Natl Acad Sci USA, 98, pp. 9545-9550 Pe a, K. L., Castel, S. E., De Araujo, C., Structural basis of the oxidative activation of the carboxysomal g-carbonic anhydrase, CcmM (2010) Proc Natl Acad Sci USA, 107, pp. 2455-2460 Woo, L. W., Ganeshapillai, D., Thomas, M. P., Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495) (2011) ChemMedChem, 6, pp. 2019-2034 Almajan, G. L., Innocenti, A., Puccetti, L., Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1, 3, 4-thiadiazole-and 1, 2, 4-triazole-thiols (2005) Bioorg Med Chem Lett, 15, pp. 2347-2352 Nair, S. K., Ludwig, P. A., Christianson, D. W., Two-site binding of phenol in the active site of human carbonic anhydrase II: Structural implications for substrate association (1994) J Am Chem Soc, 116, pp. 3659-3660 Davis, R. A., Innocenti, A., Poulsen, S. A., Supuran, C. T., Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes i and II from a natural product-based phenolic library (2010) Bioorg Med Chem, 18, pp. 14-18 Martin, D. P., Cohen, S. M., Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors (2012) Chem Commun (Camb), 48, pp. 5259-5261 Davis, R. A., Hofmann, A., Osman, A., Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases (2011) J Med Chem, 54, pp. 1682-1692 McDonald, P. C., Winum, J. Y., Supuran, C. T., Dedhar, S., Recent developments in targeting carbonic anhydrase IX for cancer therapeutics (2012) Oncotarget, 3, pp. 84-97 Davis, R. A., Vullo, D., Maresca, A., Natural product coumarins that inhibit human carbonic anhydrases (2013) Bioorg Med Chem, 21, pp. 1539-1543 Buchieri, M. V., Riafrecha, L. E., Rodr guez, O. M., Inhibition of the b-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: Identification of the first inhibitor with anti-mycobacterial activity (2013) Bioorg Med Chem Lett, 23, pp. 740-743 Kazancio lu, E. A., G ney, M., ent rk, M., Supuran, C. T., Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity (2012) J Enzyme Inhib Med Chem, 27, pp. 880-885 Svastov, E., Hul kov, A., Rafajov, M., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Lett, 577, pp. 439-445 Ahlskog, J. K. J., Dumelin, C. E., Tr ssel, S., In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives (2009) Bioorg Med Chem Lett, 19, pp. 4851-4856 Steele, R. M., Benedini, F., Biondi, S., Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma (2009) Bioorg Med Chem Lett, 19, pp. 6565-6570 G zel, O., Innocenti, A., Scozzafava, A., Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl-and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors (2009) Bioorg Med Chem Lett, 19, pp. 3170-3173 Jude, K. M., Banerjee, A. L., Haldar, M. K., Ultrahigh resolution crystal structures of human carbonic anhydrases i and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity (2006) J Am Chem Soc, 128, pp. 3011-3018 Kim, C. Y., Chandra, P. P., Jain, A., Christianson, D. W., Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II (2001) J Am Chem Soc, 123, pp. 9620-9627 Avvaru, B. S., Wagner, J. M., Maresca, A., Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors (2010) Bioorg Med Chem Lett, 20, pp. 4376-4381 Scolnick, L. R., Clements, A. M., Liao, J., Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase II (1997) J Am Chem Soc, 119, pp. 850-851 Fisher, S. Z., Aggarwal, M., Kovalevsky, A. Y., Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding (2012) J Am Chem Soc, 134, pp. 14726-14729 doi: 10. 1517/13543776. 2013. 778245 Introduction: Carbonic anhydrases (CAs, EC 4.2.1.1) exist as five genetically distinct families (α, β, γ, δ and ζ) in organisms all over the phylogenetic tree. Due to the ubiquity of such enzymes, the selective inhibition and polypharmacology of inhibitors is an important aspect of all drug design campaigns. There are several classes of CA inhibitors (CAIs): i) metal ion binders (sulfonamides and their isosteres [sulfamates/sulfamides], dithiocarbamates, mercaptans and hydroxamates); ii) compounds anchoring to the zinc-coordinated water molecule/hydroxide ion (phenols, carboxylates, polyamines, esters and sulfocoumarins) and iii) coumarins and related compounds which apparently bind even further away from the metal ion. Areas covered: The authors rationalize the drug design strategies of inhibitors belonging to the first two classes, based on recent X-ray crystallographic data. More precisely, this is achieved by analyzing how the hydrophobic and hydrophilic halves of the enzyme active site interact with inhibitors. This task has been eased by the recent report of β-CA-like enzymes possessing carbon disulfide and carbonyl sulfide hydrolase activities, respectively, allowing the authors to propose a general approach of structure-based drug design of CAIs. Expert opinion: Although amazing progress has been made in the structure-based drug design of CAIs, this field is still in progress, with many constantly emerging new findings. Indeed, several new such enzymes were discovered and characterized recently and novel chemotypes were explored for finding compounds with a better inhibition profile. It is anticipated that this will continue to be one of the main frontiers in the search of pharmacologically relevant enzyme inhibitors. © 2013 Informa UK, Ltd.
Buemi MR, Di Fiore A, De Luca L, Angeli A, Mancuso F, Ferro S, Monti SM, Buonanno M, Russo E, De Sarro G, De Simone G, Supuran CT, Gitto R * Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety (26 visite) Eur J Med Chem (ISSN: 1768-3254electronic, 0223-5234linking), 2018 Dec 1; 163: 443-452. Impact Factor: 2.882 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G * Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2, 4, 6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor (263 visite) J Enzyme Inhib Med Chem (ISSN: 1475-6374electronic, 1475-6366linking), 2018 Dec; 33(1): 151-157. Impact Factor: 4.293 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, Meccariello A, Ceruso M, Szafranski K, Slawinski J, Supuran CT * Inhibition studies of Brucella suis beta-carbonic anhydrases with a series of 4-substituted pyridine-3-sulphonamides (92 visite) J Enzyme Inhib Med Chem (ISSN: 1475-6374electronic, 1475-6366linking), 2018 Dec; 33(1): 255-259. Impact Factor: 2.332 Dettagli Esporta in BibTeX Esporta in EndNote Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT * The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (28 visite) Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265. Impact Factor: 3.929 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Angeli A, Bozdag M, Supuran CT, Winum JY, Monti SM, Alterio V * Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding (42 visite) Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Sep 11; 54(73): 10312-10315. Impact Factor: 6.169 Dettagli Esporta in BibTeX Esporta in EndNote Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM * Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (87 visite) Cell Mol Life Sci, 2018 Sep; 75: 3283-3296. Impact Factor: 6.721 Dettagli Esporta in BibTeX Esporta in EndNote Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G * Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (45 visite) Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836. Impact Factor: 8.29 Dettagli Esporta in BibTeX Esporta in EndNote Mishra CB, Kumari S, Angeli A, Bua S, Buonanno M, Monti SM, Tiwari M, Supuran CT * Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal (12 visite) Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254electronic), 2018 Aug 5; 156: 430-443. Impact Factor: 4.816 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Monti DM, Scaloni A, De Simone G, Monti SM * Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance (46 visite) Oxid Med Cell Longev (ISSN: 1942-0994linking), 2018 Aug 5; 2018:2018306: 2018306-2018306. Impact Factor: 4.936 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G * Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (12 visite) Expert Opinion On Therapeutic Patents (ISSN: 1744-7674electronic, 1354-3776linking), 2018 Jun; N/D: 1-6. Impact Factor: 4.626 Dettagli Esporta in BibTeX Esporta in EndNote Buonanno M, Di Fiore A, Langella E, D’ambrosio K, Supuran CT, Monti SM, De Simone G * The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior (46 visite) Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2018 May; 19(6): 19-24. Impact Factor: 3.687 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, Supuran CT, De Simone G * Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases? (9 visite) Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Mar 26; N/D: N/D-N/D. Impact Factor: 4.63 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Langella E, Esposito D, Supuran CT, Monti SM, Winum JY, Alterio V * Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations (86 visite) J Enzyme Inhib Med Chem (ISSN: 1475-6374electronic, 1475-6366linking), 2017 Dec; 32(1): 1002-1011. Impact Factor: 4.293 Dettagli Esporta in BibTeX Esporta in EndNote Monti DM, De Simone G, Langella E, Supuran CT, Di Fiore A, Monti SM * Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage (119 visite) J Enzyme Inhib Med Chem (ISSN: 1475-6374electronic, 1475-6366linking), 2017 Dec; 32(1): 5-12. Impact Factor: 4.293 Dettagli Esporta in BibTeX Esporta in EndNote Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL * Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion (54 visite) Bioorg Med Chem (ISSN: 1464-3391electronic, 0968-0896linking), 2017 Nov 1; 25(21): 6049-6059. Impact Factor: 2.822 Dettagli Esporta in BibTeX Esporta in EndNote Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D * New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (103 visite) Eur J Med Chem (ISSN: 1768-3254electronic, 0223-5234linking), 2017 Jun 19; 138: 115-127. Impact Factor: 4.519 Dettagli Esporta in BibTeX Esporta in EndNote Brunò E, Buemi MR, Di Fiore A, De LucaL, Ferro S, Angeli A, Cirilli R, Sadutto D, Alterio V, Monti SM, Supuran CT, De Simone G, Gitto R * Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides (98 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2017 May 25; 60(10): 4316-4326. Impact Factor: 6.259 Dettagli Esporta in BibTeX Esporta in EndNote Merlino A, Marzo T, Messori L * Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy (39 visite) Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2017 May 23; 23(29): 6942-6947. Impact Factor: 5.476 Dettagli Esporta in BibTeX Esporta in EndNote Buonanno M, Langella E, Zambrano N, Succoio M, Sasso E, Alterio V, Di Fiore A, Sandomenico A, Supuran CT, Scaloni A, Monti SM, De Simone G * Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements (87 visite) Acs Chem Biol (ISSN: 1554-8937electronic, 1554-8929linking), 2017 Apr 19; N/D: N/D-N/D. Impact Factor: 4.995 Dettagli Esporta in BibTeX Esporta in EndNote Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Tiwari M, Supuran CT * Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment (69 visite) J Med Chem (ISSN: 1520-4804electronic, 0022-2623linking, 0022-2623print), 2017 Mar 23; 60(6): 2456-2469. Impact Factor: 6.259 Dettagli Esporta in BibTeX Esporta in EndNote Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT * Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (68 visite) Bioorg Med Chem (ISSN: 1464-3391electronic, 0968-0896linking), 2017 Feb 15; 25(4): 1456-1464. Impact Factor: 2.93 Dettagli Esporta in BibTeX Esporta in EndNote Angapelly S, Ramya PV, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M * Discovery of 4-sulfamoyl-phenyl-beta-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (77 visite) Bioorg Med Chem (ISSN: 1464-3391electronic, 0968-0896linking), 2017 Jan 15; pii:S0968-0896(16): 539-544. Impact Factor: 2.923 Dettagli Esporta in BibTeX Esporta in EndNote Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M * Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (4 visite) Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2017; 25(2): 539-544. Impact Factor: 2.822 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Cadoni R, Esposito D, Vullo D, Fiore AD, Monti SM, Caporale A, Ruvo M, Sechi M, Dumy P, Supuran CT, De Simone G, Winum JY * Benzoxaborole as a new chemotype for carbonic anhydrase inhibition (102 visite) Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2016 Sep 29; 52(80): 11983-11986. Impact Factor: 6.319 Dettagli Esporta in BibTeX Esporta in EndNote Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M * Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (90 visite) Acs Med Chem Lett (ISSN: 1948-5875print, 1948-5875linking), 2016 Sep 26; 7(12): 1145-1150. Impact Factor: 3.12 Dettagli Esporta in BibTeX Esporta in EndNote Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F * Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1, 6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors (73 visite) Bioorg Med Chem (ISSN: 1464-3391electronic, 0968-0896linking), 2016 Aug 15; 24(16): 3643-3648. Impact Factor: 2.93 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, De Simone G, Alterio V, Riccio V, Winum JY, Carta F, Supuran CT * The anticonvulsant sulfamide JNJ-26990990 and its S, S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies (93 visite) Org Biomol Chem (ISSN: 1477-0520linking, 1477-0539electronic), 2016 Jun 07; 14(21): 4853-4858. Impact Factor: 3.564 Dettagli Esporta in BibTeX Esporta in EndNote Del Prete S, De Luca V, De Simone G, Supuran CT, Capasso C * Cloning, expression and purification of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum (96 visite) J Enzyme Inhib Med Chem (ISSN: 1475-6374electronic, 1475-6366linking), 2016 Jun; 31(sup4): 54-59. Impact Factor: 4.293 Dettagli Esporta in BibTeX Esporta in EndNote Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G * A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases (115 visite) Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2016 Jan 4; 22(1): 97-100. Impact Factor: 5.317 Dettagli Esporta in BibTeX Esporta in EndNote Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Prakash A, Tiwari M, Supuran CT * Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1, 3, 4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors (90 visite) J Enzyme Inhib Med Chem, 2016; 17: 1-6. Impact Factor: 3.428 Dettagli Esporta in BibTeX Esporta in EndNote Mollica A, Locatelli M, Macedonio G, Carradori S, Sobolev AP, De Salvador RF, Monti SM, Buonanno M, Zengin G, Angeli A, Supuran CT * Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars (101 visite) J Enzyme Inhib Med Chem, 2016; 31(sup4): N/D-N/D. Impact Factor: 3.428 Dettagli Esporta in BibTeX Esporta in EndNote Pica A, Chi M-C, Chen Y-Y, D'Ischia M, Lin L-L, Merlino A * The maturation mechanism of γ-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies (98 visite) Biochim Biophys Acta (ISSN: 1570-9639, 0925-4439, 0006-3002), 2016; 1864(2): 195-203. Impact Factor: 2.773 Dettagli Esporta in BibTeX Esporta in EndNote La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, Pan P, Parkkila S, Supuran CT, Rossello A, Silvestri R * Discovery of 1, 1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors (131 visite) J Med Chem (ISSN: 1520-4804electronic, 0022-2623linking, 0022-2623print), 2015 Nov 12; 58(21): 8564-8572. Impact Factor: 5.589 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Vergara A, Caterino M, Alterio V, Monti SM, Ombouma J, Dumy P, Vullo D, Supuran CT, Winum JY, De Simone G * Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors (147 visite) (PDF 134 visite) Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2015 Jul 2; 51(57): 11519-11522. Impact Factor: 6.567 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A * Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense (109 visite) Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2015 May 1; 25(9): 2002-2006. Impact Factor: 2.486 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT * X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor (149 visite) Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2015 Apr 7; 13(13): 4064-4069. Impact Factor: 3.559 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Di Fiore A, Capasso C, Supuran CT * The zinc coordination pattern in the eta-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families (233 visite) Bioorg Med Chem Lett (ISSN: 1464-3405electronic, 0960-894xlinking), 2015 Apr 1; 25(7): 1385-1389. Impact Factor: 2.486 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Langella E, De Simone G, Monti SM * Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (161 visite) Marine Drugs (ISSN: 1660-3397electronic, 1660-3397linking), 2015 Apr; 13(4): 1688-1697. Impact Factor: 3.345 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, Supuran CT, De Simone G * DPP-4 inhibitors: a patent review (2012 - 2014) (108 visite) Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic, 1354-3776linking), 2015 Feb; 25(2): 209-236. Impact Factor: 4.626 Dettagli Esporta in BibTeX Esporta in EndNote Supuran CT, Capasso C, De Simone G * Carbonic Anhydrase II as Target for Drug Design (105 visite) Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 51-90. Impact Factor: 0 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, Supuran CT, De Simone G, Di Fiore A * Carbonic Anhydrase VII (81 visite) Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 151-168. Impact Factor: 0 Dettagli Esporta in BibTeX Esporta in EndNote Supuran CT, De Simone G Carbonic Anhydrases: An Overview (90 visite) Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 3-13. Impact Factor: 0 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, De Simone G, Supuran CT * Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution (95 visite) Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 17-30. Impact Factor: 0 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G * Out of the active site binding pocket for carbonic anhydrase inhibitors (157 visite) (PDF 134 visite) Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305. Impact Factor: 6.567 Dettagli Esporta in BibTeX Esporta in EndNote Ceruso M, Carta F, Osman SM, Alothman Z, Monti SM, Supuran CT * Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties (134 visite) Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2015; 23(15): 4181-4187. Impact Factor: 2.923 Dettagli Esporta in BibTeX Esporta in EndNote Messori L, Marzo T, Merlino A * Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts (98 visite) J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D. Impact Factor: 3.205 Dettagli Esporta in BibTeX Esporta in EndNote Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A * Recent developments of carbonic anhydrase inhibitors as potential drugs (124 visite) Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2015; 2015: 174178-174178. Impact Factor: 2.134 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K * Thermostable carbonic anhydrases in biotechnological applications (139 visite) Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2015; 16(7): 15456-15480. Impact Factor: 3.257 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G * Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (149 visite) Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2014 Feb; 97(1): 114-120. Impact Factor: 2.963 Dettagli Esporta in BibTeX Esporta in EndNote Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM * Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (132 visite) J Enzyme Inhib Med Chem (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504. Impact Factor: 2.332 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V * Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors (118 visite) Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 523210-523210. Impact Factor: 1.579 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G * The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (134 visite) Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778. Impact Factor: 2.385 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Monti SM, De Simone G * Thermal-stable carbonic anhydrases: a structural overview (157 visite) Subcell Biochem (ISSN: 0306-0225), 2014; 75: 387-404. Impact Factor: 33.116 Dettagli Esporta in BibTeX Esporta in EndNote Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY * Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (181 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520. Impact Factor: 5.48 Dettagli Esporta in BibTeX Esporta in EndNote Di Salle F, Cantone E, Savarese MF, Aragri A, Prinster A, Nicolai E, Sarnelli G, Iengo M, Buyckx M, Cuomo R * Effect Of Carbonation On Brain Processing Of Sweet Stimuli In Humans (111 visite) Gastroenterology (ISSN: 0016-5085), 2013 Sep; 145(3): 537-539. Impact Factor: 18.392 Dettagli Esporta in BibTeX Esporta in EndNote Ronda L, Merlino A, Bettati S, Verde C, Balsamo A, Mazzarella L, Mozzarelli A, Vergara A * Role of tertiary structures on the Root effect in fish hemoglobins (132 visite) Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(9): 1885-1893. Impact Factor: 3.191 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, Supuran CT, De Simone G * Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (146 visite) Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749. Impact Factor: 3.441 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Capasso C, De Luca V, Monti SM, Carginale V, Supuran CT, Scozzafava A, Pedone C, Rossi M, De Simone G * X-ray structure of the first 'extremo-alpha-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 (120 visite) Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jun; 69(6): 1150-1159. Impact Factor: 7.232 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, De Simone G, Dathan NA, Ludwig M, Vullo D, Scozzafava A, Capasso C, Supuran CT * Kinetic And Anion Inhibition Studies Of A Beta-Carbonic Anhydrase (fbica 1) From The C-4 Plant Flaveria Bidentis (143 visite) Bioorg Med Chem Lett (ISSN: 0960-894x), 2013 Mar 15; 23(6): 1626-1630. Impact Factor: 2.331 Dettagli Esporta in BibTeX Esporta in EndNote Giallauria F, Acampa W, Ricci F, Vitelli A, Torella G, Lucci R, Del Prete G, Zampella E, Assante R, Rengo G, Leosco D, Cuocolo A, Vigorito C * Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function (155 visite) Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Feb; 40(3): 315-324. Impact Factor: 5.217 Dettagli Esporta in BibTeX Esporta in EndNote Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N * Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (123 visite) J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292. Impact Factor: 5.001 Dettagli Esporta in BibTeX Esporta in EndNote Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM * Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (122 visite) Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348. Impact Factor: 2.689 Dettagli Esporta in BibTeX Esporta in EndNote Giallauria F, Acampa W, Ricci F, Gallicchio R, Xhoxhi E, Vitelli A, D'Agostino M, Lucci R, Vigorito C, Cuocolo A * Effects of exercise training started within 2 weeks after acute myocardial infarction on myocardial perfusion and left ventricular function: A gated SPECT imaging study (159 visite) Eur J Prev Cardiol (ISSN: 2047-4873, 2047-4881), 2012 Dec; 19(6): 1410-1419. Impact Factor: 2.675 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G * Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (145 visite) Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468. Impact Factor: 41.298 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Supuran CT * (In)organic anions as carbonic anhydrase inhibitors (134 visite) J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129. Impact Factor: 3.197 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM * Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (151 visite) Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1232-1241. Impact Factor: 3.142 Dettagli Esporta in BibTeX Esporta in EndNote Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S * 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (237 visite) J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450. Impact Factor: 5.774 Dettagli Esporta in BibTeX Esporta in EndNote Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S * 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (175 visite) J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450. Impact Factor: 5.774 Dettagli Esporta in BibTeX Esporta in EndNote Russo Krauss I, Sica F, Mattia CA, Merlino A * Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (138 visite) Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800. Impact Factor: 2.464 Dettagli Esporta in BibTeX Esporta in EndNote Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM * Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (102 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564. Impact Factor: 2.338 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, Supuran CT, De Simone G * Carbonic anhydrase IX as a target for designing novel anticancer drugs (185 visite) Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830. Impact Factor: 4.07 Dettagli Esporta in BibTeX Esporta in EndNote Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L * Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (118 visite) Journal Of Structural Biology (ISSN: 1047-8477), 2012 Feb; 177(2): 506-512. Impact Factor: 3.361 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G * Editorial: Zinc Metallo-Enzymes As Target For Drug Design (116 visite) Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012. Impact Factor: 4.07 Dettagli Esporta in BibTeX Esporta in EndNote Monti SM, Maresca A, Viparelli F, Carta F, De Simone G, Muehlschlegel FA, Scozzafava A, Supuran CT * Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata (121 visite) Bioorg Med Chem Lett (ISSN: 0960-894x), 2012 Jan 15; 22(2): 859-862. Impact Factor: 2.338 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT * Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (134 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783. Impact Factor: 5.614 Dettagli Esporta in BibTeX Esporta in EndNote Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G * Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (116 visite) Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136. Impact Factor: 6.873 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Maresca A, Supuran CT, De Simone G * Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (101 visite) Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840. Impact Factor: 6.378 Dettagli Esporta in BibTeX Esporta in EndNote Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F * Improving Protein Crystal Quality by the Without-Oil Microbatch Method: Crystallization and Preliminary X-ray Diffraction Analysis of Glutathione Synthetase from Pseudoalteromonas haloplanktis (137 visite) Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2011 Sep; 12(9): 6312-6319. Impact Factor: 2.598 Dettagli Esporta in BibTeX Esporta in EndNote Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F * Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (267 visite) Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626. Impact Factor: 4.883 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (109 visite) Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(42): 11636-11638. Impact Factor: 6.169 Dettagli Esporta in BibTeX Esporta in EndNote Avila FF, Improta R, Santoro F, Barone V * Computing the inhomogeneous broadening of electronic transitions in solution: A first-principle quantum mechanical approach (92 visite) Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2011; 13(38): 17007-17012. Impact Factor: 3.573 Dettagli Esporta in BibTeX Esporta in EndNote Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT * Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (134 visite) Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Sep 15; 20(16): 4745-4748. Impact Factor: 2.661 Dettagli Esporta in BibTeX Esporta in EndNote Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano M * Synthesis of a l-lysine-based alternate alpha, epsilon-peptide: A novel linear polycation with nucleic acids-binding ability (135 visite) Int J Pharm (ISSN: 0378-5173, 1873-3476), 2010 Sep 15; 397(1-2): 179-183. Impact Factor: 3.607 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G * The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (126 visite) Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533. Impact Factor: 3.451 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G * Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (98 visite) Bioorg Med Chem Lett (ISSN: 0960-894x), 2010 Sep 1; 20(17): 5023-5026. Impact Factor: 2.661 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT * Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (100 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605. Impact Factor: 2.661 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Supuran CT * Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (161 visite) Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409. Impact Factor: 2.773 Dettagli Esporta in BibTeX Esporta in EndNote Guler OO, De Simone G, Supuran CT * Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (201 visite) Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526. Impact Factor: 4.63 Dettagli Esporta in BibTeX Esporta in EndNote Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G * Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (120 visite) Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2010; 16(29): 3246-3254. Impact Factor: 4.774 Dettagli Esporta in BibTeX Esporta in EndNote Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A * Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (121 visite) Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125. Impact Factor: 2.605 Dettagli Esporta in BibTeX Esporta in EndNote Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L * The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (99 visite) Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008. Impact Factor: 3.085 Dettagli Esporta in BibTeX Esporta in EndNote Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT * The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors (84 visite) Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2009 Oct 15; 19(20): 5825-5828. Impact Factor: 2.65 Dettagli Esporta in BibTeX Esporta in EndNote Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT * Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (165 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2009 Oct 8; 52(19): 5990-5998. Impact Factor: 4.802 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G * Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (203 visite) Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238. Impact Factor: 9.432 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Scozzafava A, Supuran CT * Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (113 visite) Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321. Impact Factor: 2.473 Dettagli Esporta in BibTeX Esporta in EndNote Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A * Ribosome's mode of function: Myths, facts and recent results (111 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 122-130. Impact Factor: 1.807 Dettagli Esporta in BibTeX Esporta in EndNote Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E * Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (101 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160. Impact Factor: 1.807 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G * Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (105 visite) Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Jan; 74(1): 164-175. Impact Factor: 3.085 Dettagli Esporta in BibTeX Esporta in EndNote Hilvo M, De Simone G, Supuran CT, Parkkila S * Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV (111 visite) Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 273-283. Impact Factor: 1.156 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Supuran CT * Drug Design of Antiobesity Carbonic Anhydrase Inhibitors (126 visite) Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; 66(DECEMBERSPEC.I): 241-254. Impact Factor: 1.156 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G * X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (124 visite) Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138. Impact Factor: 1.156 Dettagli Esporta in BibTeX Esporta in EndNote Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S * Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (139 visite) J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Oct 10; 283(41): 27799-27809. Impact Factor: 5.52 Dettagli Esporta in BibTeX Esporta in EndNote Woo LWL, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, Potter BVL * Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography (124 visite) Mol Cancer Ther Molecular Cancer Therapeutics (ISSN: 1535-7163, 1538-8514electronic), 2008 Sep; 7(8): 2435-2444. Impact Factor: 5.003 Dettagli Esporta in BibTeX Esporta in EndNote Merlino A, Sica F, Mazzarella L, Zagari A, Vergara A * Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)(10) (105 visite) Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2008 Sep; 137(1): 24-27. Impact Factor: 2.362 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT * Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (145 visite) J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237. Impact Factor: 4.898 Dettagli Esporta in BibTeX Esporta in EndNote Supuran CT, Di Fiore A, De Simone G * Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (132 visite) Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392. Impact Factor: 3.08 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G * Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors (109 visite) Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic), 2008 Apr 15; 18(8): 2669-2674. Impact Factor: 2.531 Dettagli Esporta in BibTeX Esporta in EndNote Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (82 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271. Impact Factor: 2.531 Dettagli Esporta in BibTeX Esporta in EndNote Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL * Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (130 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308. Impact Factor: 4.898 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Di Fiore A, Supuran CT * Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (122 visite) Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660. Impact Factor: 4.399 Dettagli Esporta in BibTeX Esporta in EndNote D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G * Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (155 visite) Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477. Impact Factor: 3.15 Dettagli Esporta in BibTeX Esporta in EndNote Supuran CT, De Simone G Carbonic anhydrases--an overview (114 visite) Curr Pharm Des, 2008; 14(7): 603-614. Impact Factor: 0 Dettagli Esporta in BibTeX Esporta in EndNote Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (113 visite) Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678. Impact Factor: 4.399 Dettagli Esporta in BibTeX Esporta in EndNote Improta R, Scalmani G, Frisch MJ, Barone V * Toward effective and reliable fluorescence energies in solution by a new state specific polarizable continuum model time dependent density functional theory approach (90 visite) J Chem Phys (ISSN: 0021-9606, 0897-690online), 2007 Sep 21; 127(7): N/D-N/D. Impact Factor: 3.044 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT * Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (117 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207. Impact Factor: 2.604 Dettagli Esporta in BibTeX Esporta in EndNote Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G * Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (122 visite) Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158. Impact Factor: 2.662 Dettagli Esporta in BibTeX Esporta in EndNote Santoro F, Lami A, Improta R, Barone V * Effective method to compute vibrationally resolved optical spectra of large molecules at finite temperature in the gas phase and in solution (88 visite) J Chem Phys (ISSN: 0021-9606, 0897-690online), 2007 May 14; 126(18): 184102-184102. Impact Factor: 3.044 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G * Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (126 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731. Impact Factor: 2.604 Dettagli Esporta in BibTeX Esporta in EndNote Santoro F, Improta R, Lami A, Bloino J, Barone V * Effective method to compute Franck-Condon integrals for optical spectra of large molecules in solution (94 visite) J Chem Phys (ISSN: 0021-9606, 0897-690online), 2007 Feb 28; 126(8): 084509-084509. Impact Factor: 3.044 Dettagli Esporta in BibTeX Esporta in EndNote Galdiero S, Galdiero M, Pedone C * Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (103 visite) Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82. Impact Factor: 3.259 Dettagli Esporta in BibTeX Esporta in EndNote Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F * Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (143 visite) Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 83-90. Impact Factor: 3.259 Dettagli Esporta in BibTeX Esporta in EndNote Improta R, Barone V, Santoro F * Ab initio calculations of absorption spectra of large molecules in solution: Coumarin C153 (96 visite) Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2007; 46(3): 405-408. Impact Factor: 10.031 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Supuran CT * Antiobesity carbonic anhydrase inhibitors (158 visite) Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884. Impact Factor: 4.325 Dettagli Esporta in BibTeX Esporta in EndNote Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL * 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (308 visite) J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696. Impact Factor: 5.115 Dettagli Esporta in BibTeX Esporta in EndNote Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (109 visite) Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208. Impact Factor: 2.538 Dettagli Esporta in BibTeX Esporta in EndNote Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D * Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (138 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835. Impact Factor: 1.801 Dettagli Esporta in BibTeX Esporta in EndNote Improta R, Barone V, Scalmani G, Frisch MJ * A state-specific polarizable continuum model time dependent density functional theory method for excited state calculations in solution (102 visite) J Chem Phys (ISSN: 0021-9606, 0897-690online), 2006 Sep 7; 125(5): N/D-N/D. Impact Factor: 3.166 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT * Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (142 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551. Impact Factor: 5.115 Dettagli Esporta in BibTeX Esporta in EndNote Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT * Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (120 visite) J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335. Impact Factor: 7.696 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT * Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (115 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442. Impact Factor: 2.538 Dettagli Esporta in BibTeX Esporta in EndNote Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ * Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (107 visite) J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571. Impact Factor: 3.574 Dettagli Esporta in BibTeX Esporta in EndNote De Luca S, Della Moglie R, De Capua A, Morelli G * New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides (144 visite) Tetrahedron Lett (ISSN: 0040-4039), 2005 Sep 26; 46(39): 6637-6640. Impact Factor: 2.477 Dettagli Esporta in BibTeX Esporta in EndNote Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT * Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (141 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727. Impact Factor: 4.926 Dettagli Esporta in BibTeX Esporta in EndNote De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT * Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (117 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320. Impact Factor: 2.478 Dettagli Esporta in BibTeX Esporta in EndNote Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT * Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (146 visite) Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942. Impact Factor: 2.478 Dettagli Esporta in BibTeX Esporta in EndNote Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A * Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (121 visite) J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477. Impact Factor: 5.359 Dettagli Esporta in BibTeX Esporta in EndNote Ambrosino P, Fresa R, Fogliano V, Monti SM, Ritieni A Extraction of azadirachtin a from neem seed kernels by supercritical fluid and its evaluation by HPLC and LC/MS (137 visite) J Agric Food Chem (ISSN: 0021-8561), 1999 Dec; 47(12): 5252-5256. Impact Factor: 1.453 Dettagli Esporta in BibTeX Esporta in EndNote Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (80 visite) Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092. Impact Factor: 1.972 Dettagli Esporta in BibTeX Esporta in EndNote 138 Records (133 escludendo Abstract e Conferenze). Impact factor totale: 594.521 (577.108 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 575.412 (557.637 escludendo Abstract e Conferenze). Esporta in BibTeX Esporta in EndNote Ultima modifica di Giuseppina De Simone in data Monday 06 July 2015, 15:10:59 160 visite. Ultima visita in data Tuesday 19 February 2019, 18:34:43 |
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 Post Doctoral fellowship w2019 award Fondazione Umberto Veronesi  Innova S@lute 2017Bambini Liberi progetto coordinato dal Cnr, vince il premio Innova S@lute 2017 (161 visite)  Sperimentato su pazienti pediatrici un esoscheletro personalizzato progettato da ricercatori Cnr (485 visite)SmartCity Radio24-Sole 24 Ore Intervista il Dott. Alessandro Soluri sulla Pocket Gamma Camera (272 visite) Accordo cooperazione tra IBB ed il Dipartimento di Ingegneria Biomedica dell’Università di Pechino (567 visite) Archivio Notizie>>> (766 visite) Post Doctoral fellowship w2019 award Fondazione Umberto Veronesi Innova S@lute 2017Bambini Liberi progetto coordinato dal Cnr, vince il premio Innova S@lute 2017 (161 visite) Sperimentato su pazienti pediatrici un esoscheletro personalizzato progettato da ricercatori Cnr (485 visite)SmartCity Radio24-Sole 24 Ore Intervista il Dott. Alessandro Soluri sulla Pocket Gamma Camera (272 visite) Accordo cooperazione tra IBB ed il Dipartimento di Ingegneria Biomedica dell’Università di Pechino (567 visite) Archivio Notizie>>> (766 visite) Post Doctoral fellowship w2019 award Fondazione Umberto Veronesi Innova S@lute 2017Bambini Liberi progetto coordinato dal Cnr, vince il premio Innova S@lute 2017 (161 visite) Sperimentato su pazienti pediatrici un esoscheletro personalizzato progettato da ricercatori Cnr (485 visite)SmartCity Radio24-Sole 24 Ore Intervista il Dott. Alessandro Soluri sulla Pocket Gamma Camera (272 visite) Accordo cooperazione tra IBB ed il Dipartimento di Ingegneria Biomedica dell’Università di Pechino (567 visite) Archivio Notizie>>> (766 visite) Concorsi
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