High Superoxide Dismutase Activity Of A Novel, Intramolecularly Imidazolato-Bridged Asymmetric Dicopper(ii) Species; Design, Synthesis, Structure And Magnetism Of Cu(ii) Complexes With A Mixed Pyrazole-Imidazole Donor Set
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High Superoxide Dismutase Activity Of A Novel, Intramolecularly Imidazolato-Bridged Asymmetric Dicopper(ii) Species; Design, Synthesis, Structure And Magnetism Of Cu(ii) Complexes With A Mixed Pyrazole-Imidazole Donor Set (77 visite)

Tabbì G, Driessen WL, Reedijk J, Bonomo RP, Veldman N, Spek AL

Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1997; 36(6): 1168-1175.

Tipo di articolo: Journal Article,

Impact factor: 2.736

Impact factor a 5 anni: 4.04


Parole chiave: Non disponibili.

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0000398260&partnerID=40&md5=b63422991f285039f36a6974dfc70f1e

A new dinucleating ligand 1, 5-bis (l-pyrazolyl) -3- [bis (2-imidazolyl) methyl] azapentane (Hbpzbiap), containing pyrazoles and imidazoles has been designed and synthesized. The synthesis and characterization of the copper complexes with the ligand Hbpzbiap and its dehydronated form are described. This study is aimed at modeling the active site of copper-zinc Superoxide dismutase (SOD). Single crystals of the imidazolato-bridged complex [Cu2fbpzbiap) Cl3] (1) and non-imidazolato-bridged complex [Cu2 (Hbpzbiap) Cl4] (2) were obtained and their structures determined by X-ray diffraction. Both structures show two copper centers in two different coordination environments: a distorted square pyramid and a distorted tetrahedron. The Cu-nitrogen bond lengths range from 1. 919 (4) to 2. 039 (3) and are as expected. The copper-copper distances from 5. 566 (1) to 6. 104 (1) being only slightly shorter than that found in bovine erythrocyte SOD. Temperature-dependent magnetic susceptibility study of 1 shows antiferromagnetic behavior with -2J = 96 cm-1. From pH-dependent electron paramagnetic resonance and electronic spectra, [Cu2 (bpzbiap) Cl3] has been demonstrated to be stable over a quite wide pH range including the physiological pH values. A low concentration of this complex (1) catalyzes the dismutation of Superoxide at biological pH. Voltammetric studies indicate a quasi-reversible redox behavior in aqueous solution at pH 7. These results clearly indicate that complex 1 is a good model for Superoxide dismutase
Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P. O. Box 9502, 2300 RA Leiden, Netherlands

Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy

Bijvoet Ctr. for Biomol. Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands
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Merlino F, Brancaccio D, Yousif AM, Piras L, Campiglia P, Gomez-monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Carotenuto A, Grieco P
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2016; N/D: N/D-N/D.
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* Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1, 2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines (68 visite)
Desplat V, Vincenzi M, Lucas R, Moreau S, Savrimoutou S, Pinaud N, Lesbordes J, Peyrilles E, Marchivie M, Routier S, Sonnet P, Rossi F, Ronga L, Guillon J
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2016; 113: 214-227.
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* The effect of digestive activity of pig gastro-intestinal tract on zeolite-rich rocks: An in vitro study (52 visite)
Mercurio M, Cappelletti P, De Gennaro B, De Gennaro M, Bovera F, Iannaccone F, Grifa C, Langella A, Monetti V, Esposito  L
Microporous And Mesoporous Materials (ISSN: 1387-1811), 2016; 225: 133-136.
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* Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke (52 visite)
Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH
J Cereb Blood Flow Metab (ISSN: 1559-7016electronic, 0271-678xlinking), 2015 Nov; 35(11): 1711-1721.
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* Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool (85 visite)
Scudiero O, Nigro E, Cantisani M, Colavita I, Leone M, Mercurio FA, Galdiero M, Pessi A, Daniele A, Salvatore F, Galdiero S
Int J Nanomedicine (ISSN: 1178-2013electronic, 1176-9114linking), 2015 Oct 15; 10: 6523-6539.
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* An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (200 visite)
Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2015 Apr 22; 13(17): 4859-4868.
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* Copper (II) ions modulate Angiogenin activity in human endothelial cells (98 visite)
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
Int J Biochem Cell Biol International Journal Of Biochemistry And Cell Biology (ISSN: 1878-5875, 1357-7272, 1357-2725), 2015 Mar; 60: 185-196.
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* Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (84 visite)
Mucci A, Dima D, Soricelli A, Volpe U, Bucci P, Frangou S, Prinster A, Salvatore M, Galderisi S, Maj M
Psychol Med (ISSN: 1469-8978), 2015 Jan 12; N/D: 1-14.
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* A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (112 visite)
GrassoG, Satriano C, Milardi D
Biophysical Chemistry (ISSN: 0301-4622), 2015; 203-204: 33-40.
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* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (124 visite)
Roviello GN, Musumeci D, Roviello V
Int J Pharm International Journal Of Pharmaceutics (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
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* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (86 visite)
Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
Mol Immunol Molecular Immunology (ISSN: 0161-5890), 2015; 63(2): 166-175.
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* Platinum(II) Complexes with O, S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding (65 visite)
Mügge C, Marzo T, Massai L, Hildebrandt J, Ferraro G, Rivera-Fuentes P, Metzler-Nolte N, Merlino A, Messori L, Weigand W
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2015; 54(17): 8560-8570.
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* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (95 visite)
Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
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* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (101 visite)
Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
Acs Chem Biol (ISSN: 1554-8929, 1554-8937electronic, 1554-8929linking), 2015; 10(4): 965-969.
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* A Chaperone Enhances Blood Alpha-Glucosidase Activity In Pompe Disease Patients Treated With Enzyme Replacement Therapy (61 visite)
Parenti G, Fecarotta S, la Marca G, Rossi B, Ascione S, Donati MA, Morandi LO, Ravaglia S, Pichiecchio A, Ombrone D, Sacchini M, Pasanisi MB, De Filippi P, Danesino C, Della Casa R, Romano A, Mollica C, Rosa M, Agovino T, Nusco E, Porto C, Andria G
Molecular Therapy, 2014 Nov; 22(11): 2004-2012.
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* Effect of p53 Activity on the Sensitivity of Human Glioblastoma Cells to PARP-1 Inhibitor in Combination with Topoisomerase I Inhibitor or Radiation (74 visite)
Sabbatino F, Fusciello C, Somma D, Pacelli R, Poudel R, Pepin D, Leonardi A, Carlomagno C, Della Vittoria Scarpati G, Ferrone S, Pepe S
Cytometry Part A (ISSN: 1552-4922), 2014 Nov; 85A(11): 953-961.
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* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (84 visite)
Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2014 Sep 6; 136(31): 10838-10841.
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* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (92 visite)
Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
Antimicrobial Agents And Chemotherapy (ISSN: 1098-6596, 0066-4804), 2014 Sep; 58(9): 5280-5290.
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* Compounds modulators of VEGF activity and uses thereof (65 visite)
D'Andrea LD, Pedone C, Turco MC
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2014 Jun 3; N/D: N/D-N/D.
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* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (102 visite)
Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2014 Mar; 1844(3): 632-640.
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* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (116 visite)
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
Bioorg Med Chem (ISSN: 1464-3391, 0968-0896, 1464-3391electronic), 2014 Feb 1; 22(3): 960-966.
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* Simulation of surface EMG for the analysis of muscle activity during whole body vibratory stimulation (78 visite)
Fratini A, Bifulco P, Romano  M, Clemente F, Cesarelli M
Comput Methods Programs Biomed (ISSN: 0169-2607, 1872-7565electronic, 0169-2607linking), 2014 Jan; 113(1): 314-322.
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* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (98 visite)
Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
Rsc Advances (ISSN: 2046-2069), 2014; 4(93): 51353-51361.
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* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (113 visite)
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
Antimicrobial Agents And Chemotherapy (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
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* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (112 visite)
Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
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* Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders (66 visite)
Vitagliano L, Zaccaro L, Morelli G, Martegani E
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Jun 11; N/D: N/D-N/D.
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* A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (108 visite)
Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2013 Apr 2; 52(14): 3926-3930.
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* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (103 visite)
Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
Antimicrobial Agents And Chemotherapy (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
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* Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy (111 visite)
Stelitano V, Brandt A, Fernicola S, Franceschini S, Giardina G, Pica A, Rinaldo S, Sica F, Cutruzzola F
Nucleic Acids Res (ISSN: 0305-1048, 0305-5104, 1362-4962), 2013 Apr; 41(7): e79-e79.
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* EFFECTS OF SLEEP APNEA ON CARDIAC SYMPATHETIC ACTIVITY IN PATIENTS WITH SEVERE SYSTOLIC HEART FAILURE: A (123)MIBG SCINTIGRAPHIC STUDY (61 visite)
Scala O, Paolillo S, Rengo G, Pagano G, Formisano R, Pellegrino T, De Michele F, Starace A, Cirillo A, Vitagliano A, Formisano T, Leosco D, Cuocolo A, Perrone-Filardi P
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): N/D-N/D.
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* Evidence of brown fat activity in constitutional leanness (69 visite)
Pasanisi F, Pace L, Fonti R, Marra M, Sgambati D, De Caprio C, De Filippo E, Vaccaro A, Salvatore M, Contaldo F
Journal Of Clinical Endocrinology And Metabolism (ISSN: 1945-7197, 0021-972x), 2013 Mar; 98(3): 1214-1218.
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* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (72 visite)
Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
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* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (97 visite)
D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
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* Cholesterol modulates the fusogenic activity of a membranotropic domain of the FIV glycoprotein gp36 (63 visite)
Vitiello G, Fragneto G, Petruk AA, Falanga A, Galdiero S, D'Ursi A, Merlino A, D'Errico G
(ISSN: 1744-683x), 2013; 9(28): 6442-6456.
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* Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity (170 visite)
Musumeci D, Roviello GN, Montesarchio D, Sapio R, Valente M, Anr V, Bucci EM
Rsc Advances (ISSN: 2046-2069), 2013; 3(30): 12176-12184.
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* Metal ions affect insulin-degrading enzyme activity (85 visite)
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
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* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (79 visite)
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
Molecular Biology Of The Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
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* Evidence of Brown Adipose Tissue Activity Assessed by 18F-FDG-PET/CT in Females with Constitutional Leanness (56 visite)
Fonti R, Sgambati D, Vaccaro A, Pasanisi F, De Caprio C, Pace L, Contaldo F, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
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* High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity (98 visite)
Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2012 Sep; 40(16): 8119-8128.
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* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (102 visite)
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2012 May 7; 7(5): e35774-e35774.
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* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (111 visite)
Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
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* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (97 visite)
Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
J Pharmacol Exp Ther Journal Of Pharmacology And Experimental Therapeutics (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
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* Identification of an active dimeric intermediate populated during the unfolding process of the cambialistic superoxide dismutase from Streptococcus mutans (87 visite)
Merlino A, Russo Krauss I, Rossi B, De Vendittis A, Marco S, De Vendittis E, Vergara A, Sica F
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 Mar; 94(3): 768-775.
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* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (76 visite)
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
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* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (82 visite)
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
Cell Death Dis (ISSN: 2041-4889), 2012; 3(12): N/D-N/D.
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* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (106 visite)
Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
Int J Nanomedicine (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
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* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (128 visite)
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
J Biol Chem Journal Of Biological Chemistry (ISSN: 1083-351x, 0021-9258), 2011 Dec 2; 286(48): 41680-41691.
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* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (96 visite)
Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
J Pept Sci (ISSN: 1099-1387, 1075-2617, 1075-2617print), 2011 Dec 2; 17(5): 348-352.
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* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (75 visite)
D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
Biochim Biophys Acta (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
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* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (106 visite)
Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
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* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (80 visite)
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
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* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (63 visite)
Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
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* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (84 visite)
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
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* RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (72 visite)
Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2011 Apr 14; 54(7): 2095-2101.
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* A Heme-Peptide Metalloenzyme Mimetic with Natural Peroxidase-Like Activity (89 visite)
Nastri F, Lista L, Ringhieri P, Vitale R, Faiella M, Andreozzi C, Travascio P, Maglio O, Lombardi A, Pavone V
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Apr; 17(16): 4444-4453.
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* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (156 visite)
Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
Faseb Journal (ISSN: 0892-6638), 2011 Apr; 25(4): 1230-1243.
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* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (100 visite)
Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
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* Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the enzyme isolated from Pseudoalteromonas haloplanktis (101 visite)
Merlino A, Russo Krauss I, Castellano I, De Vendittis E, Rossi B, Conte M, Vergara A, Sica F
Journal Of Structural Biology (ISSN: 1047-8477), 2010 Dec; 172(3): 343-352.
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* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (66 visite)
Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
British Journal Of Haematology (ISSN: 0007-1048, 0007-1048linking), 2010 Oct; 151(2): 195-197.
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* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (86 visite)
Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
Cell Mol Life Sci Cellular And Molecular Life Sciences (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
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* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (102 visite)
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
Antimicrobial Agents And Chemotherapy (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
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* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (176 visite)
Castellano I, Merlino A, Rossi M, La Cara F
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
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* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (92 visite)
Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
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* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (104 visite)
Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
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* Synthetic Analogs Of Human Beta-Defensins Display A More Effective Antimicrobial Activity Than Wild-Type Peptides (72 visite)
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Galdiero M, D'Isanto M, Naclerio G, Pedone C, Castaldo G, Salvatore F
Antimicrob Agents Chemother, 2010; 54: 2312-2322.
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* An artificial di-iron oxo-protein with phenol oxidase activity (70 visite)
Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
Nature Chemical Biology (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
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* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (76 visite)
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
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* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (83 visite)
Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
Plos One (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
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* Synthesis, structure and reactivity of amino-benzodifurane derivatives (71 visite)
Caruso U, Panunzi B, Roviello GN, Roviello GN, Tingoli M, Tuzi A
Comptes Rendus Chimie (ISSN: 1631-0748), 2009 May; 12(5): 622-634.
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* The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study (76 visite)
Grasso G, Rizzarelli E, Spoto G
J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1096-9888, 1076-5174), 2009 May; 44(5): 735-741.
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* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (79 visite)
Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
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* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (56 visite)
De Rosa V, Alan D, Alain F, Thierry D, Walid R
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
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* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (106 visite)
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
J Mol Biol Journal Of Molecular Biology (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
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* Copper(II) complexes with an avian prion N-terminal region and their potential SOD-like activity (109 visite)
La Mendola D, Bonomo RP, Caminati S, Di Natale G, Emmi SS, Hansson O, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2009 Feb; 103(2): 195-204.
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A MINIMALLY-INVASIVE SYSTEM FOR FREE-LIVING ACTIVITY MONITORING IN HOME CARE (70 visite)
Clemente F, Manna C
World Biomater Congr (ISSN: 9781-6156), 2009; 3: 1938-1941.
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* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (71 visite)
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
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* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (50 visite)
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
Febs J, 2009; 276: 6158-6171.
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* Monomers of beta-amyloid protein are endowed with neuroprotective activity (89 visite)
Giuffrida M, Caraci F, Molinaro G, Cataldo S, Pignataro B, Bruno V, De Bona P, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2009; 39: N/D-N/D.
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New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins (38 visite)
Lanza V, Vecchio G
Journal Of Inorganic Biochemistry, 2009; 103(3): 381-388.
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* Sub-femtomolar activity of a new cell migration inhibitor (51 visite)
Pavone V, Lista L, Maglio O, Longanesi-cattani I, Bifulco K, Arra C, V , Carriero M
Biopolymers, 2009; 92: 350-350.
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Synthesis of Superoxide Dismutase (SOD) enzyme mimetics: A bioinorganic laboratory experiment (39 visite)
Vecchio G, Lanza V
Journal Of Chemical Education, 2009; 86(12): 1419-1421.
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* The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension (79 visite)
Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari
Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Nov; 1784(11): 1601-1606.
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* Assessment of Metabolic Activity by PET-CT with F-18-FDG in patients with T-cell Lymphoma (68 visite)
Storto G, Di Giorgio E, Pellegrino T, Erra P, Nardelli A, Perna F, Castaldi E, Ortosecco G, Speranza A, De Renzo A, Salvatore M, Rotoli B, Pace L
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
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* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (88 visite)
Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
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* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (85 visite)
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
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* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (77 visite)
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
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* Crystallization and preliminary x-ray diffraction studies of a psychrophilic iron superoxide dismutase from Pseudoalteromonas haloplanktis (53 visite)
Merlino A, Russo Krauss I, Castellano I, De Vendittis E, Vergara A, Sica F
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2008; 15(4): 415-418.
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* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (86 visite)
Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
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* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (61 visite)
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
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* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (84 visite)
Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
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* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (77 visite)
Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
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* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (76 visite)
Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
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* Excited state properties of sizable molecules in solution: From structure to reactivity (70 visite)
Santoro F, Barone V, Benzi C, Improta R
Theor Chem Acc (ISSN: 1432-881x), 2007 May; 117(5-6): 1073-1084.
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* Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task (87 visite)
Landmann C, Dehaene S, Pappata S, Jobert A, Bottlaender M, Roumenov D, Le Bihan D
Cereb Cortex (ISSN: 1047-3211), 2007 Apr; 17(4): 749-759.
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* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (72 visite)
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
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* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (66 visite)
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
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* Crystallization and preliminary X-ray diffraction analysis of PD-L1, a highly glycosylated ribosome inactivating protein with DNase activity (59 visite)
Ruggiero A, Chambery A, Di Maro A, Mastroianni A, Parente A, Berisio R
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2007; 14(4): 407-409.
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* Modelling IAPP's membrane interaction: Conformational preferences and membrane activity of IAPP17-29 peptide derivatives (82 visite)
Pappalardo G, Milardi D, Magna A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(4): N/D-N/D.
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* Structure-activity relationships in peptides: From modelling to rational drug design (84 visite)
Benedetti E, Pedone C, Saviano M
Front Drug Des And Discov (ISSN: 1574-0889), 2007; 3(1): 539-558.
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* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (158 visite)
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
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* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (77 visite)
Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
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* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (92 visite)
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
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* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (140 visite) (PDF 108 visite)
Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
J Neuroimaging (ISSN: 1051-2284), 2006 Jul; 16(3): 224-235.
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* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (95 visite)
Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
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* Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (72 visite)
Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
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* Activity Threshold Determining Cumulative Aderse-Effects In Patients Undergoing Peptide Receptor Radionuclide Therapy With Y-90 Octreotate (78 visite)
Storto G, Speranza A, Pellegrino T, Panico M, Cella L, Nardelli A, Russo AA, Klain M, Soricelli A, Pace L, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006; 33: 338-338.
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* Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity (74 visite)
Mai A, Rotili D, Ornaghi P, Tosi F, Vicidomini C, Sardella G, Nebbioso A, Altucci L, Filatici P
Arkivoc (ISSN: 1424-6376), 2006; 6(VIII): 24-37.
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* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (81 visite)
Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
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* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (87 visite)
Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
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* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (74 visite)
Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
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* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (88 visite)
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2005 May 6; 280(18): 17953-17960.
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* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (80 visite)
Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
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* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (81 visite)
Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
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* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (66 visite)
Puglisi A, Tabbì G, Vecchio G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
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* New antitumour cyclic astin analogues: Synthesis, conformation and bioactivity (75 visite)
Rossi F, Zanotti G, Saviano M, Iacovino R, Palladino P, Saviano G, Amodeo P, Tancredi T, Laccetti P, Corbier C, Benedetti E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 Feb; 10(2): 92-102.
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* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (79 visite)
Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
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Functional Mimics Of Cu, Zn-Superoxide Dismutase Enzymes, In Metal-Ligand Interactions In Nano-, Micro-, And Macro-Systems In Complex Environments (66 visite)
Bonomo RP, Impellizzeri G, La Mendola D, Maccarone G, Pappalardo G, Santoro A, Tabbì G, Vecchio G, Rizzarelli E
In Complex Environmentsmetal Ligand Interactions (ISSN: 1568-2609, 1568-8260), 2003 Jan; 116: 41-63.
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* Functional mimics of Cu, Zn-superoxide dismutase enzymes (87 visite)
Bonomo RP, Impellizzeri G, La Mendola D, Maccarone G, Pappalardo G, Santoro A, Tabbì G, Vecchio G, Rizzarelli E
In Complex Environmentsmetal Ligand Interactions (ISSN: 1568-2609, 1568-8260), 2003; 116: 41-63.
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* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (79 visite)
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
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* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (65 visite)
Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
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* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (97 visite)
Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
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* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (76 visite)
Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
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* Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (207 visite)
Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF
Nat Neurosci (ISSN: 1097-6256), 2002 Mar; 5(3): 267-271.
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* Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity (64 visite)
Ferro A, Salvatore M, Cuocolo A
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001 Sep; 8(6): 669-676.
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* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (89 visite)
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
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* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (86 visite)
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
Free Radic Biol Med Free Radical Biology And Medicine (ISSN: 0891-5849, 0891-5849linking), 2001 Feb 1; 30(3): 268-276.
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* Comparison Of Three Fungal Laccases From Rigidoporus Lignosus And Pleurotus Ostreatus: Correlation Between Conformation Changes And Catalytic Activity (72 visite)
Bonomo RP, Cennamo G, Purrello R, Santoro AM, Zappala R
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Jan 1; 83(1): 67-75.
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Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (77 visite)
Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic), 2000 Dec; 18(3): 353-362.
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Technetium 99m furifosmin regional myocardial uptake in patients with previous myocardial infarction: Relation to thallium-201 activity and left ventricular function (68 visite)
Cuocolo A, Rubini G, Acampa W, Nicolai E, Florimonte L, DiGiovine G, D'Addabbo A, Salvatore M
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 May; 7(3): 235-241.
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Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (84 visite)
Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
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Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (79 visite)
Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
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Antioxidant activity of virgin olive oil phenolic compounds in a micellar system (73 visite)
Fogliano V, Ritieni A, Monti SM, Gallo M, Della Medaglia D, Ambrosino ML, Sacchi R
Journal Of The Science Of Food And Agriculture (ISSN: 0022-5142), 1999 Oct; 79(13): 1803-1808.
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Viscosity Does Not Represent An Important Mechanism Of The Hypoglycemic Activity Of Dietary Fibre (61 visite)
Mansueto G, Clemente G, Giacco R, Mancini M, D'Avanzo A, Lasorella G, Spagnuolo M, Rivellese AA, Riccardi G
6th Meeting Of The Mediterranean Group For The Study Of Diabetes Rome, 1998 Sep; N/D: 67-67.
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Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction (101 visite)
Petretta M, Cuocolo A, Nicolai E, Acampa W, Salvatore M, Bonaduce D
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Jul; 5(4): 378-386.
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Prognostic value of combined assessment of left ventricular function and regional myocardial thallium-201 activity in patients with chronic ischemic left ventricular dysfunction (62 visite)
Cuocolo A, Petretta M, Nicolai E, Acampa W, Varrone A, Bonaduce D, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): N/D-N/D.
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A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase (60 visite)
Tabbì G, Nauser T, Koppenol WH, Reedijk J
European Journal Of Inorganic Chemistry (ISSN: 1434-1948), 1998; (12): 1939-1943.
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Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (106 visite)
Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
N/D (ISSN: 0300-9246), 1998; (22): 3851-3857.
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Tyrosinase Models. Synthesis, Structure, Catechol Oxidase Activity, And Phenol Monoxygenase Activity Of A Dinuclear Copper Complex Derived From A Triamino Pentabenzimidazole Ligand (63 visite)
Monzani E, Quinti L, Perrotti A, Casella L, Gullotti M, Randaccio L, Geremia S, Nardin G, Faleschini P, Tabbì G
Inorg Chem, 1998; 37: 553-562.
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Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (50 visite)
Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 1997 Apr 25; 272(17): 11147-11151.
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Effects of superoxide on nitric oxide-dependent n-nitrosation reactions (55 visite)
Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB
Free Radic Res Free Radical Research (ISSN: 1071-5762), 1995 Oct; 23(4): 379-390.
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INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (90 visite)
Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
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Structural requirements for antagonist activity at tachykinin NK2 receptor in a series of bicyclic hexapeptides (49 visite)
L , Q , Fabbri G, Patacchini R, A , Maggi C, Astolfi M, D'Auria G, Maglio O, Lombardi A, Pedone C, Pavone V
Peptides, 1994; N/D: 591-592.
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New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (77 visite)
Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
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Determination of superoxide dismutase-like activity of copper(II) complexes. Relevance of the speciation for the correct interpretation of in vitro O2 - scavenger activity (83 visite)
Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Jun; 50(4): 273-281.
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Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (103 visite)
Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
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Cerebrovascular Reactivity By Transcranial Doppler Ultrasonography In Insulin-Dependent Diabetic Patients (53 visite)
De Simone C, Mancini M, Vaccaro O, Riccardi G, Gallotta LA, Ferrara G, Cicerano U, Postiglione A
Cerebrovasc Dis, 1993; 3(2): 111-115.
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Thermodynamic and Spectroscopic Characterization, and in vitro O2- Scavenger Activity of Copper(II) Complexes with Glycyl-L-histidyl-glycyl-L-histidine (70 visite)
Bonomo RP, Bonsignore F, Conte E, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E
J Chem Soc (ISSN: 1364-5447), 1993; 8: 1295-1300.
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Deficiency of 5'-deoxy-5'-methylthioadenosine phosphorylase activity in malignancy. Absence of the protein in human enzyme-deficient cell lines (54 visite)
Della Ragione F, Oliva A, Palumbo R, Russo GL, Gragnaniello V, Zappia V
Biochem J (ISSN: 0264-6021print, 0264-6021linking, 1470-8728electronic), 1992 Jan 15; 281(Pt2): 533-538.
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Chronobiological Evaluation Of Cardiovascular Reactivity (58 visite)
Ferrara LA, Soro S, Marotta T, Mancini M
Atherosclerosis And Cardiovascular Disease Descovich G C Gaddi A Magri Gl Lenzi S, 1989; 4(a): 10-10.
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The Adrenergic Nervous System Reactivity: A Chronobiological Study (61 visite)
Marotta T, Soro S, Mancini M, Ferrara LA
7th International Meeting On Atherosclerosis And Cardiovascular Disease Bologna, 1989; N/D: 27-27.
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TRANSCRANIAL DOPPLER EVALUATION OF CEREBROVASCULAR REACTIVITY TO ACETAZOLAMIDE IN NORMAL SUBJECTS (73 visite)
Mancini M, De Chiara S, Ferrara LA, Gallotta G, Postiglione A
15th World Congress Angiology Rome, 1989; 20(4): 284-284.
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Effects of sodium intake on blood pressure and adrenergic vascular reactivity (53 visite)
Ferrara LA, Pisanti N, Fasano ML, Mancini M
J Clin Hypertens (ISSN: 0748-450x), 1986; 2(4): 315-321.
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Sulphinpyrazone-Induced Decrease In Antihypertensive Activity Of Beta-Blockers (46 visite)
Ferrara LA, Marotta T, Mancini Marcello, Fasano ML, Pasanisi F, Mancini M
Second European Meeting On Hypertension Milan, 1985 Dec; N/D: 171-171.
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Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (64 visite)
Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
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Effects of ionizing radiations on the activity of valyl tRNA synthetase isolated from rat liver and from Morris hepatoma 7777 (53 visite)
 Romano M, Cerra M, Salvatore M, Onorati A
Tumori (ISSN: 0300-8916, 0300-8916print), 1974 Jul; 60(4): 301-306.
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173 Records (149 escludendo Abstract e Conferenze).
Impact factor totale: 590.63 (529.05 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 607.779 (538.319 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Superoxide" OR [btitle] "Dismutase" OR [btitle] "Activity" OR [btitle] "Intramolecularly" OR [btitle] "Imidazolato") AND NOT [id] = 10674)







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