Parole chiave: Apoptosis, Cd95 Apo1 Fas, Flavonoid, Hpb-All Cell Line, Quercetin, Monoclonal Antibody, Acute Lymphoblastic Leukemia, Article, Cancer Cell, Cell Viability, Controlled Study, Human, Human Cell, Leukemia Cell, Membrane Potential, Priority Journal, Signal Transduction, Thymoma, Antigens, Caspase 3, Cell Division, Dna Fragmentation, Dose-Response Relationship, Drug, Flow Cytometry, Immunoblotting, Mitochondria, Reactive Oxygen Species, Time Factors, Tumor Cells, Cultured,
Affiliazioni:
Inst. of Food Science and Technology, CNR, Via Roma 52 A/C, 83100, Avellino, Italy
Riferimenti:
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Several malignant cell lines are resistant to CD95(Apo1/Fas)-mediated apoptosis, even when the CD95 receptor is highly expressed. Sensitivity to CD95-induced apoptosis can be restored using different molecules. In this study, we showed that quercetin, a naturally occurring flavonoid, in association with the agonistic anti-CD95 monoclonal antibody, increases DNA fragmentation and caspase-3 activity in HPB-ALL cells. These cells have been selected for their known resistance to CD95-induced apoptosis. At molecular level, quercetin lowers the level of intracellular reactive oxygen species, reduces mitochondrial transmembrane potential, thereby leaving the expression of CD95 receptor unchanged. Copyright (C) 1999 Federation of European Biochemical Societies.
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(81 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(168 visite) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 DettagliEsporta in BibTeXEsporta in EndNote
156 Records (137 escludendo Abstract e Conferenze). Impact factor totale: 695.703 (623.734 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 728.264 (644.906 escludendo Abstract e Conferenze).