Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (299 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Tipo di articolo: Journal Article, Abstract, Conference,
Impact factor: 6.044, Impact factor a 5 anni: 6.044
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871250346&partnerID=40&md5=bd670025334313e76f1c52cd79ff9401
Parole chiave: Breast Cancer, Cell Signaling, Growth Factors And Receptors, Oncogenes, Tumor Promotion And Progression, Epidermal Growth Factor Receptor 2, Insulin Receptor Substrate 1, Liposome, Mitogen Activated Protein Kinase 1, P 1257, Phosphatidylinositol 3 Kinase, Phosphatidylinositol 3 Kinase Inhibitor, Phosphopeptide 1257, Protein P85, Trastuzumab, Unclassified Drug, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antineoplastic Activity, Apoptosis, Article, Cancer Cell Culture, Cell Death, Cell Proliferation, Controlled Study, Drug Efficacy, Electroporation, Enzyme Activity, Enzyme Inhibition, Enzyme Phosphorylation, Female, Gene Overexpression, Human, Human Cell, Human Tissue, In Vitro Study, In Vivo Gene Transfer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Function, Protein Protein Interaction, Protein Targeting, Treatment Response, Tumor Growth, Tumor Volume, Antineoplastic Agents, Breast Neoplasms, Catalytic Domain, Down-Regulation, Enzyme Inhibitors, Insulin Receptor Substrate Proteins, Scid, Phosphatidylinositol 3-Kinases, Protein Binding, Proto-Oncogene Proteins C-Akt, Erbb-3,
Affiliazioni:
*** IBB - CNR ***
Department of Experimental Oncology, Regina National Elena Cancer Institute, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro 156, 0158 Rome, Italy
Regina Elena National Cancer Institute, SAFU, Via delle Messi d'Oro 156, Rome, Italy
Department of Pathology, Regina Elena Cancer Institute, Via E. Chianesi 54, Rome, Italy
Department of Biological Sciences, CIRPeB, University of Naples 'Federico II' and IBB CNR, Via Giovanni Paladino 39, Naples, Italy
Department of Oncology, Regina Elena Cancer Institute, Via E. Chianesi 54, Rome, Italy
Riferimenti:
Liu, P., Cheng, H., Roberts, T.M., Zhao, J.J., Targeting the phosphoinositide 3-kinase pathway in cancer (2009) Nat Rev Drug Discov, 8, pp. 627-64
Engelman, J.A., Targeting signaling in cancer: Opportunities, challenges and limitation (2009) Nat Rev Cancer, 9, pp. 550-562
Yuan, T.L., Canntley, L.C., PI3K pathway alteration in cancer: Variation on a theme (2008) Oncogene, 27, pp. 5497-5510
Willems, L., Tamburini, J., Chapuis, N., Lacombe, C., Mayeux, P., Bouscary, D., PI3K and mTOR signaling pathways in cancer: New data on targeted therapies (2012) Curr Oncol Rep, 14, pp. 129-138
Lou, J., Manning, B.D., Cantley, L.C., Targeting the PI3K-Akt pathway in human cancer: Rationale and promise (2003) Cancer Cell, 4, pp. 257-262
Arteaga, C.L., Sliwkowski, M.X., Osborne, C.K., Perez, E.A., Puglisi, F., Gianni, L., Treatment of HER2-positive breast cancer: Current status and future prospective (2011) Nat Rev Clin Oncol, 9, pp. 16-32
Di Fiore, P.P., Pierce, J.H., Kraus, M.H., Segatto, O., King, C.R., Aaronson, S.A., ErbB-2 is a potent oncogene when overexpressed in NIH73T3 cells (1987) Science, 237, pp. 178-182
Slamon, D.J., Clark, G.M., Wong, S.G., Levin, W.J., Ullrich, A., McGuire, W.L., Human breast cancer: Correlation of relapse and survival with amplified HER-2/neu oncogene (1987) Science, 235, pp. 177-182
Slamon, D.J., Godolphin, W., Jones, L.A., Holt, J.A., Wong, S.G., Keith, D.E., Studies of HER2/neu proto-oncogene in human breast and ovarian cancer (1989) Science, 244, pp. 707-712
Segatto, O., Lonardo, F., Helin, K., Wexler, D., Fazioli, F., Rhee, S.G., ErbB-2 autophosphorylation is required for mitogenic action and high affinity substrate coupling (1992) Oncogene, 7, pp. 1339-1346
Cho, H.S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney Jr., D.W., Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab (2003) Nature, 421, pp. 756-760
Molina, M.A., Codony-Servat, J., Albanell, J., Rojo, F., Arribas, J., Baselga, J., Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells (2001) Cancer Res, 61, pp. 4744-4749
Hudis, C.A., Trastuzumab-mechanism of action and use in clinical practice (2007) N Engl J Med, 357, pp. 39-51
Slamon, D.J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpress HER2 (2001) N Engl J Med, 344, pp. 783-792
Marty, M., Cognetti, F., Maraninchi, D., Snyder, R., Mauriac, L., Tubiana-Hulin, M., Randomized phase II Trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with epidermal growth factor-2-positive metastatic breast cancer administrated as first line treatment: The M77001 Study Group (2005) J Clin Oncol, 23, pp. 4265-4274
Oakman, C., Sapino, C., Marchiò, C., Pestrin, M., Biganzoli, L., Di Leo, A., Chemotherapy with and without trastuzumab (2010) Ann Oncol, 21, pp. vii112-vii119
Normanno, N., Bianco, C., De Luca, A., Maiello, M.R., Salomon, D.S., Target-based agents against ErbB receptors and their ligands: A novel approach to cancer treatment (2003) Endocr Relat Cancer, 10, pp. 1-21
Yarden, Y., Sliwkowski, M.X., Untangling the ErbB signaling network (2001) Nat. Rev. Mol Cell Biol, 2, pp. 127-137
Wallasch, C., Weiss, F.U., Nierderfellner, G., Jallal, B., Issing, W., Ullrich, A., Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3 (1995) EMBO J, 14, pp. 4267-4275
Hellyer, N.J., Cheng, K., Koland, J.G., ErbB3 (HER3) interaction with the p85 regolatory subunit of phosphoinositide3-kinase (1988) Biochem J, 333, pp. 757-763
Sergina, N.V., Rausch, M., Wang, D., Blair, J., Hann, B., Shokat, K.M., Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 (2007) Nature, 445, pp. 347-441
Berns, K., Horlings, H.M., Hennessy, B.T., Madiredjo, M., Hijmans, E.M., Beelen, K., A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer (2007) Cancer Cell, 12, pp. 395-402
Hynes, N.E., Lane, H.A., ERBB receptors and cancer: The complexity of targeted inhibitors (2005) Nat Rev Cancer, 5, pp. 341-354
Holbro, T., Beerli, R.R., Maurer, F., Koziczak, M., Barbas III, C.F., Hynes, N.E., The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB-2 requires ErbB3 to drive breast cancer tumor cell proliferation (2003) Proc Natl Acad Sci USA, 100, pp. 8933-8938
Siegel, P.M., Ryan, E.D., Cardiff, R.D., Muller, W.J., Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer (1999) EMBO J, 18, pp. 2149-2164
Cook, R.S., Garrett, R.T., Sanchez, V., Stanford, J.C., Young, C., Chakrabarty, A., ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis (2011) Cancer Res, 71, pp. 3941-3951
Folgiero, V., Avetrani, P., Bon, G., Di Carlo, S.E., Fabi, A., Nisticò, C., Induction of ErbB-3 expression by a6b4 integrin contributes to Tamoxifen resistance in ERb1-negative breast carcinoma (2008) PLoS ONE, 3, pp. e1592
Vivanco, I., Sawyers, C.L., The phosphatydilinositol 3-kinase Akt pathway in human cancer (2002) Nat Rev Cancer, 2, pp. 489-551
Engelman, J.A., Luo, J., Cantley, L.C., The evolution of phosphatidilinositol 3-kinase of growth and metabolism (2006) Nat Rev Cancer, 7, pp. 606-619
Suenaga, A., Takada, N., Hatakeyama, M., Ichikawa, M., Yu, X., Tomii, K., Novel Mechanism of interaction of p85 subunit of phosphatidylinositol 3-kinase and ErbB3 receptor-derived phosphotyrosyl peptides (2005) J Biol Chem, 280, pp. 1321-1326
Songyang, Z., Shoelson, S.E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W.G., SH2 domains recognize specific phosphopeptide sequences (1993) Cell, 72, pp. 767-778
Damiano, V., Garofalo, S., Rosa, R., Bianco, R., Caputo, R., Gelardi, T., A novel toll-like receptor agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action (2009) Clin Cancer Res, 15, pp. 6921-6930
Defazio, A., Chiew, Y.E., Sini, R.L., Janes, P.W., Sutherland, R.L., Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cancer cell lines (2000) Int J Cancer, 87, pp. 487-498
Folgiero, V., Bachelder, R.E., Bon, G., Sacchi, A., Falcioni, R., Mercurio, A.M., The alpha6beta4 integrin can regulate ErbB-3 expression: Implications for alpha6beta4 signaling and function (2007) Cancer Res, 67, pp. 1645-1652
Saal, L.H., Holm, K., Maurer, M., Memeo, L., Su, T., Wang, X., PIK3CA mutations correlate with hormone receptor, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast cancer (2005) Cancer Res, 65, pp. 2554-2559
Huang, X., Gao, L., Wang, S., McManaman, J.L., Thor, A.D., Yang, X., Heterodimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-I receptor in breast cancer cells resistant to Trastuzumab (2010) Cancer Res, 70, pp. 1204-1214
Zhang, S., Huang, W.C., Li, P., Guo, H., Poh, S.B., Brady, S.W., Combating Trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways (2001) Nature Med, 17, pp. 461-470
Zhu, S., Lee, D.A., Li, S., IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors (2010) J Immunol, 184, pp. 2348-2354
Sanchez, C.G., Ma, C.X., Crowder, R.J., Guintoli, T., Phommaly, C., Gao, F., Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer (2011) Breast Cancer Res, 13, pp. R21
Engelman, J. A., Targeting signaling in cancer: Opportunities, challenges and limitation (2009) Nat Rev Cancer, 9, pp. 550-562
Yuan, T. L., Canntley, L. C., PI3K pathway alteration in cancer: Variation on a theme (2008) Oncogene, 27, pp. 5497-5510
Arteaga, C. L., Sliwkowski, M. X., Osborne, C. K., Perez, E. A., Puglisi, F., Gianni, L., Treatment of HER2-positive breast cancer: Current status and future prospective (2011) Nat Rev Clin Oncol, 9, pp. 16-32
Di Fiore, P. P., Pierce, J. H., Kraus, M. H., Segatto, O., King, C. R., Aaronson, S. A., ErbB-2 is a potent oncogene when overexpressed in NIH73T3 cells (1987) Science, 237, pp. 178-182
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., McGuire, W. L., Human breast cancer: Correlation of relapse and survival with amplified HER-2/neu oncogene (1987) Science, 235, pp. 177-182
Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Studies of HER2/neu proto-oncogene in human breast and ovarian cancer (1989) Science, 244, pp. 707-712
Cho, H. S., Mason, K., Ramyar, K. X., Stanley, A. M., Gabelli, S. B., Denney Jr., D. W., Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab (2003) Nature, 421, pp. 756-760
Molina, M. A., Codony-Servat, J., Albanell, J., Rojo, F., Arribas, J., Baselga, J., Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells (2001) Cancer Res, 61, pp. 4744-4749
Hudis, C. A., Trastuzumab-mechanism of action and use in clinical practice (2007) N Engl J Med, 357, pp. 39-51
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpress HER2 (2001) N Engl J Med, 344, pp. 783-792
Hellyer, N. J., Cheng, K., Koland, J. G., ErbB3 (HER3) interaction with the p85 regolatory subunit of phosphoinositide3-kinase (1988) Biochem J, 333, pp. 757-763
Sergina, N. V., Rausch, M., Wang, D., Blair, J., Hann, B., Shokat, K. M., Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 (2007) Nature, 445, pp. 347-441
Hynes, N. E., Lane, H. A., ERBB receptors and cancer: The complexity of targeted inhibitors (2005) Nat Rev Cancer, 5, pp. 341-354
Siegel, P. M., Ryan, E. D., Cardiff, R. D., Muller, W. J., Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer (1999) EMBO J, 18, pp. 2149-2164
Cook, R. S., Garrett, R. T., Sanchez, V., Stanford, J. C., Young, C., Chakrabarty, A., ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis (2011) Cancer Res, 71, pp. 3941-3951
Engelman, J. A., Luo, J., Cantley, L. C., The evolution of phosphatidilinositol 3-kinase of growth and metabolism (2006) Nat Rev Cancer, 7, pp. 606-619
Saal, L. H., Holm, K., Maurer, M., Memeo, L., Su, T., Wang, X., PIK3CA mutations correlate with hormone receptor, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast cancer (2005) Cancer Res, 65, pp. 2554-2559
Zhu, S., Lee, D. A., Li, S., IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors (2010) J Immunol, 184, pp. 2348-2354
Sanchez, C. G., Ma, C. X., Crowder, R. J., Guintoli, T., Phommaly, C., Gao, F., Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer (2011) Breast Cancer Res, 13, pp. R21
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Tipo di articolo: Journal Article, Abstract, Conference,
Impact factor: 6.044, Impact factor a 5 anni: 6.044
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871250346&partnerID=40&md5=bd670025334313e76f1c52cd79ff9401
Parole chiave: Breast Cancer, Cell Signaling, Growth Factors And Receptors, Oncogenes, Tumor Promotion And Progression, Epidermal Growth Factor Receptor 2, Insulin Receptor Substrate 1, Liposome, Mitogen Activated Protein Kinase 1, P 1257, Phosphatidylinositol 3 Kinase, Phosphatidylinositol 3 Kinase Inhibitor, Phosphopeptide 1257, Protein P85, Trastuzumab, Unclassified Drug, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antineoplastic Activity, Apoptosis, Article, Cancer Cell Culture, Cell Death, Cell Proliferation, Controlled Study, Drug Efficacy, Electroporation, Enzyme Activity, Enzyme Inhibition, Enzyme Phosphorylation, Female, Gene Overexpression, Human, Human Cell, Human Tissue, In Vitro Study, In Vivo Gene Transfer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Function, Protein Protein Interaction, Protein Targeting, Treatment Response, Tumor Growth, Tumor Volume, Antineoplastic Agents, Breast Neoplasms, Catalytic Domain, Down-Regulation, Enzyme Inhibitors, Insulin Receptor Substrate Proteins, Scid, Phosphatidylinositol 3-Kinases, Protein Binding, Proto-Oncogene Proteins C-Akt, Erbb-3,
Affiliazioni:
*** IBB - CNR ***
Department of Experimental Oncology, Regina National Elena Cancer Institute, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro 156, 0158 Rome, Italy
Regina Elena National Cancer Institute, SAFU, Via delle Messi d'Oro 156, Rome, Italy
Department of Pathology, Regina Elena Cancer Institute, Via E. Chianesi 54, Rome, Italy
Department of Biological Sciences, CIRPeB, University of Naples 'Federico II' and IBB CNR, Via Giovanni Paladino 39, Naples, Italy
Department of Oncology, Regina Elena Cancer Institute, Via E. Chianesi 54, Rome, Italy
Riferimenti:
Liu, P., Cheng, H., Roberts, T.M., Zhao, J.J., Targeting the phosphoinositide 3-kinase pathway in cancer (2009) Nat Rev Drug Discov, 8, pp. 627-64
Engelman, J.A., Targeting signaling in cancer: Opportunities, challenges and limitation (2009) Nat Rev Cancer, 9, pp. 550-562
Yuan, T.L., Canntley, L.C., PI3K pathway alteration in cancer: Variation on a theme (2008) Oncogene, 27, pp. 5497-5510
Willems, L., Tamburini, J., Chapuis, N., Lacombe, C., Mayeux, P., Bouscary, D., PI3K and mTOR signaling pathways in cancer: New data on targeted therapies (2012) Curr Oncol Rep, 14, pp. 129-138
Lou, J., Manning, B.D., Cantley, L.C., Targeting the PI3K-Akt pathway in human cancer: Rationale and promise (2003) Cancer Cell, 4, pp. 257-262
Arteaga, C.L., Sliwkowski, M.X., Osborne, C.K., Perez, E.A., Puglisi, F., Gianni, L., Treatment of HER2-positive breast cancer: Current status and future prospective (2011) Nat Rev Clin Oncol, 9, pp. 16-32
Di Fiore, P.P., Pierce, J.H., Kraus, M.H., Segatto, O., King, C.R., Aaronson, S.A., ErbB-2 is a potent oncogene when overexpressed in NIH73T3 cells (1987) Science, 237, pp. 178-182
Slamon, D.J., Clark, G.M., Wong, S.G., Levin, W.J., Ullrich, A., McGuire, W.L., Human breast cancer: Correlation of relapse and survival with amplified HER-2/neu oncogene (1987) Science, 235, pp. 177-182
Slamon, D.J., Godolphin, W., Jones, L.A., Holt, J.A., Wong, S.G., Keith, D.E., Studies of HER2/neu proto-oncogene in human breast and ovarian cancer (1989) Science, 244, pp. 707-712
Segatto, O., Lonardo, F., Helin, K., Wexler, D., Fazioli, F., Rhee, S.G., ErbB-2 autophosphorylation is required for mitogenic action and high affinity substrate coupling (1992) Oncogene, 7, pp. 1339-1346
Cho, H.S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney Jr., D.W., Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab (2003) Nature, 421, pp. 756-760
Molina, M.A., Codony-Servat, J., Albanell, J., Rojo, F., Arribas, J., Baselga, J., Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells (2001) Cancer Res, 61, pp. 4744-4749
Hudis, C.A., Trastuzumab-mechanism of action and use in clinical practice (2007) N Engl J Med, 357, pp. 39-51
Slamon, D.J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpress HER2 (2001) N Engl J Med, 344, pp. 783-792
Marty, M., Cognetti, F., Maraninchi, D., Snyder, R., Mauriac, L., Tubiana-Hulin, M., Randomized phase II Trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with epidermal growth factor-2-positive metastatic breast cancer administrated as first line treatment: The M77001 Study Group (2005) J Clin Oncol, 23, pp. 4265-4274
Oakman, C., Sapino, C., Marchiò, C., Pestrin, M., Biganzoli, L., Di Leo, A., Chemotherapy with and without trastuzumab (2010) Ann Oncol, 21, pp. vii112-vii119
Normanno, N., Bianco, C., De Luca, A., Maiello, M.R., Salomon, D.S., Target-based agents against ErbB receptors and their ligands: A novel approach to cancer treatment (2003) Endocr Relat Cancer, 10, pp. 1-21
Yarden, Y., Sliwkowski, M.X., Untangling the ErbB signaling network (2001) Nat. Rev. Mol Cell Biol, 2, pp. 127-137
Wallasch, C., Weiss, F.U., Nierderfellner, G., Jallal, B., Issing, W., Ullrich, A., Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3 (1995) EMBO J, 14, pp. 4267-4275
Hellyer, N.J., Cheng, K., Koland, J.G., ErbB3 (HER3) interaction with the p85 regolatory subunit of phosphoinositide3-kinase (1988) Biochem J, 333, pp. 757-763
Sergina, N.V., Rausch, M., Wang, D., Blair, J., Hann, B., Shokat, K.M., Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 (2007) Nature, 445, pp. 347-441
Berns, K., Horlings, H.M., Hennessy, B.T., Madiredjo, M., Hijmans, E.M., Beelen, K., A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer (2007) Cancer Cell, 12, pp. 395-402
Hynes, N.E., Lane, H.A., ERBB receptors and cancer: The complexity of targeted inhibitors (2005) Nat Rev Cancer, 5, pp. 341-354
Holbro, T., Beerli, R.R., Maurer, F., Koziczak, M., Barbas III, C.F., Hynes, N.E., The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB-2 requires ErbB3 to drive breast cancer tumor cell proliferation (2003) Proc Natl Acad Sci USA, 100, pp. 8933-8938
Siegel, P.M., Ryan, E.D., Cardiff, R.D., Muller, W.J., Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer (1999) EMBO J, 18, pp. 2149-2164
Cook, R.S., Garrett, R.T., Sanchez, V., Stanford, J.C., Young, C., Chakrabarty, A., ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis (2011) Cancer Res, 71, pp. 3941-3951
Folgiero, V., Avetrani, P., Bon, G., Di Carlo, S.E., Fabi, A., Nisticò, C., Induction of ErbB-3 expression by a6b4 integrin contributes to Tamoxifen resistance in ERb1-negative breast carcinoma (2008) PLoS ONE, 3, pp. e1592
Vivanco, I., Sawyers, C.L., The phosphatydilinositol 3-kinase Akt pathway in human cancer (2002) Nat Rev Cancer, 2, pp. 489-551
Engelman, J.A., Luo, J., Cantley, L.C., The evolution of phosphatidilinositol 3-kinase of growth and metabolism (2006) Nat Rev Cancer, 7, pp. 606-619
Suenaga, A., Takada, N., Hatakeyama, M., Ichikawa, M., Yu, X., Tomii, K., Novel Mechanism of interaction of p85 subunit of phosphatidylinositol 3-kinase and ErbB3 receptor-derived phosphotyrosyl peptides (2005) J Biol Chem, 280, pp. 1321-1326
Songyang, Z., Shoelson, S.E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W.G., SH2 domains recognize specific phosphopeptide sequences (1993) Cell, 72, pp. 767-778
Damiano, V., Garofalo, S., Rosa, R., Bianco, R., Caputo, R., Gelardi, T., A novel toll-like receptor agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action (2009) Clin Cancer Res, 15, pp. 6921-6930
Defazio, A., Chiew, Y.E., Sini, R.L., Janes, P.W., Sutherland, R.L., Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cancer cell lines (2000) Int J Cancer, 87, pp. 487-498
Folgiero, V., Bachelder, R.E., Bon, G., Sacchi, A., Falcioni, R., Mercurio, A.M., The alpha6beta4 integrin can regulate ErbB-3 expression: Implications for alpha6beta4 signaling and function (2007) Cancer Res, 67, pp. 1645-1652
Saal, L.H., Holm, K., Maurer, M., Memeo, L., Su, T., Wang, X., PIK3CA mutations correlate with hormone receptor, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast cancer (2005) Cancer Res, 65, pp. 2554-2559
Huang, X., Gao, L., Wang, S., McManaman, J.L., Thor, A.D., Yang, X., Heterodimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-I receptor in breast cancer cells resistant to Trastuzumab (2010) Cancer Res, 70, pp. 1204-1214
Zhang, S., Huang, W.C., Li, P., Guo, H., Poh, S.B., Brady, S.W., Combating Trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways (2001) Nature Med, 17, pp. 461-470
Zhu, S., Lee, D.A., Li, S., IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors (2010) J Immunol, 184, pp. 2348-2354
Sanchez, C.G., Ma, C.X., Crowder, R.J., Guintoli, T., Phommaly, C., Gao, F., Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer (2011) Breast Cancer Res, 13, pp. R21
Engelman, J. A., Targeting signaling in cancer: Opportunities, challenges and limitation (2009) Nat Rev Cancer, 9, pp. 550-562
Yuan, T. L., Canntley, L. C., PI3K pathway alteration in cancer: Variation on a theme (2008) Oncogene, 27, pp. 5497-5510
Arteaga, C. L., Sliwkowski, M. X., Osborne, C. K., Perez, E. A., Puglisi, F., Gianni, L., Treatment of HER2-positive breast cancer: Current status and future prospective (2011) Nat Rev Clin Oncol, 9, pp. 16-32
Di Fiore, P. P., Pierce, J. H., Kraus, M. H., Segatto, O., King, C. R., Aaronson, S. A., ErbB-2 is a potent oncogene when overexpressed in NIH73T3 cells (1987) Science, 237, pp. 178-182
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., McGuire, W. L., Human breast cancer: Correlation of relapse and survival with amplified HER-2/neu oncogene (1987) Science, 235, pp. 177-182
Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Studies of HER2/neu proto-oncogene in human breast and ovarian cancer (1989) Science, 244, pp. 707-712
Cho, H. S., Mason, K., Ramyar, K. X., Stanley, A. M., Gabelli, S. B., Denney Jr., D. W., Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab (2003) Nature, 421, pp. 756-760
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The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing one of the mechanisms of resistance to therapies. Therefore, the identification of inhibitors of PI3K components represents one of the main goals to produce therapeutic agents. Here, we evaluated the efficacy of a phosphopeptide 1257 (P-1257) that targeting p85 strongly inhibits PI3K activity. We tested the effects of P-1257 administration in vitro and in vivo using BC cells expressing different levels of ErbB-2 and resistant or responsive to Trastuzumab. We demonstrated that inhibition of p85 activity by P-1257 induces cell death and sensitizes JIMT-1 and KPL-4 ErbB-2-overexpressing BC cells to Trastuzumab treatment. It is noteworthy that P-1257 delivery in vivo by electroporation or liposomes significantly inhibits the proliferation of tumor cells engrafted at subcutaneous and visceral sites. Overall, our data indicate that the p85 subunit is a valid target for therapeutic approaches and suggest that the structure of the peptide used in our study could be utilized for the development of novel drugs to apply in combination with therapies that fail to cure BCs with high PI3K activity. © 2012 Macmillan Publishers Limited All rights reserved.
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Nucl Instrum Meth A (ISSN: 0168-9002), 2006 Dec 20; 569(2SPEC.ISS.): 286-290.
Impact Factor: 1.185
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Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M
* Functional imaging of multidrug resistance in breast cancer (283 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2006; 21(SUPPL.1): 24-27.
Impact Factor: 0.313
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (365 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (255 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (210 visite)
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
Impact Factor: 1.888
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (274 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (227 visite)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (277 visite)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (427 visite)
Breast Cancer (ISSN: 9783-540367802), 2004 Jun; 1: 71-81.
Impact Factor: 0.635
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (358 visite) (PDF 146 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (397 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (228 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (288 visite)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (379 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
Dettagli Esporta in BibTeX Esporta in EndNote
Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (233 visite)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (310 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (230 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (317 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (318 visite)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Fonti R, Limite G, Sodano A, Riccardi A, Forestieri P, De Cristofaro G, Pettinato G, Salvatore M
* Sentinel lymph node identification in breast cancer patients (236 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2002 Apr; 103(4): 370-377.
Impact Factor: 1.368
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Danforth Dn JR, Aloj L, Carrasquillo JA, Bacharach SL, Chow C, Zujewski J, Whatley M, Galen B, Merino M, Neumann RD
* The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (202 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 2002; 75(2): 135-146.
Impact Factor: 3.132
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Fonti R, Caraco C, Salvatore M
* 99mTc-MIBI uptake and Bcl-2 overexpression in untreated breast cancer patients (261 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (238 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (243 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (281 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Ciarmiello A, Zannetti A, Fonti R, Botti G, D'Aiuto G, Salvatore M
Efflux rate of Tc-99m-MIBI and apoptosis in untreated breast cancer patients (239 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
Impact Factor: 3.617
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Del Vecchio S, Damiano M, Borrelli G, Di Gennaro F, Imbriaco M, Panico L, Bifano D, Pettinato G, Salvatore M
Washout of Tc-99m-MIBI and prognostic factors in untreated breast cancer patients (205 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
Impact Factor: 3.617
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Formisano C, Limite G, Lamberti M, Fonti R, Forestieri P
Lymph node mapping and sentinel lymph node biopsy for evaluation of axillary lymph node status in early invasive breast cancer. Our experience (252 visite)
Przegl Lek (ISSN: 0033-2240print, 0033-2240linking), 2000; 57Suppl5: 113-115.
Impact Factor: 0
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Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli M
Urokinase receptor interacts with alpha(v)beta(5) vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (263 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1999 Oct 15; 59(20): N/D-N/D.
Impact Factor: 8.614
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Del Vecchio S, Damiano M, Zannetti A, Di Gennaro F, Imbriaco M, Salvatore M
Fractional retention of 99mTc-MIBI and proliferation in untreated breast cancer (229 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1999 Sep; 26(9): N/D-N/D.
Impact Factor: 3.239
Dettagli Esporta in BibTeX Esporta in EndNote
Salvatore M, Del Vecchio S
Dynamic imaging: Scintimammography (277 visite)
Eur J Radiol Elsevier Sci Ireland Ltd (ISSN: 0720-048x), 1998 May; 27(SUPPL.2): S259-S259.
Impact Factor: 0.537
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (234 visite)
Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683.
Impact Factor: 8.228
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Mansi L, Rambaldi PF, Cuccurullo V, Pecori B, Quarantelli M, Fallanca F, Del Vecchio E
Diagnostic and prognostic role of 99mTc-Tetrofosmin in breast cancer (180 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1997 Sep; 41(3): 239-250.
Impact Factor: 2.125
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (322 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (345 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (262 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Lastoria S, Varrella P, Mainolfi C, Piccolo S, Acampa W, Apicella A, Muto P, Thomas R, DAiuto G, Panico R, Salvatore M
Fluorine-18 PET imaging of primary breast cancer: Preliminary results (139 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
Vecchio SD, Ciarmiello A, Potena MI, Carriero MV, Mainolfi C, Botti G, Thomas R, Cerra M, D'Aiuto G, Tsuruo T, Salvatore M
In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients (226 visite)
Eur J Nucl Med (ISSN: 0340-6997print, 0340-6997linking), 1997 Feb; 24(2): 150-159.
Impact Factor: 5.036
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Lastoria S, Varrella P, Thomas R, DAiuto G, Acampa W, Vergara E, Piccolo S, Muto P, Salvatore M
Planning and monitoring the treatment in breast cancer by scintimammography with Tc-99m MIBI (196 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
Varrella P, Lastoria S, Vergara E, Acampa W, Maurea S, Salvatore M
Tc-99m MIBI Scintimammography for monitoring tumor response in patients with advanced breast cancer (154 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995; 36(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (302 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (175 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Stoppelli MP, Del Vecchio S, Franco P, Massa O, Fonti R, Salvatore M
Comparative distribution of urokinase receptor and urokinase in human breast cancer (199 visite)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1994; 35(0): N/D-N/D.
Impact Factor: 0
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (309 visite)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Della Ragione F, Oliva A, Palumbo R, Russo GL, Gragnaniello V, Zappia V
Deficiency of 5'-deoxy-5'-methylthioadenosine phosphorylase activity in malignancy. Absence of the protein in human enzyme-deficient cell lines (174 visite)
Biochem J (ISSN: 0264-6021print, 0264-6021linking, 1470-8728electronic), 1992 Jan 15; 281(Pt2): 533-538.
Impact Factor: 3.579
Dettagli Esporta in BibTeX Esporta in EndNote
D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (427 visite)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Iaffaioli RV, Frasci G, Tortora G, Ciardiello F, Nuzzo F, Scala S, Pacelli R, Bianco AR
Effect of thymic extract 'thymostimulin' on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer (400 visite)
Thymus (ISSN: 0165-6090), 1988; 12(2): 69-75.
Impact Factor: 0.643
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (2066 visite)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
97 Records (75 escludendo Abstract e Conferenze).
Impact factor totale: 344.683 (275.001 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 356.198 (267.812 escludendo Abstract e Conferenze).
Impact factor totale: 344.683 (275.001 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 356.198 (267.812 escludendo Abstract e Conferenze).
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