Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (374 views visite)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 8.535, 5-year impact factor Impact factor a 5 anni: 8.419
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529807&partnerID=40&md5=940d1a0b5a9a34825d4386fa3e3fd078
Keywords Parole chiave: Delivery Systems, Folate Receptor, Gadolinium Complexes, Low Concentrations, Mri Contrast Agents, Relaxometric Properties, Short Incubations, Structural Behaviors, Doping (additives), Gadolinium Compounds, Monomers, Organic Acids, Nanostructures,
Affiliations Affiliazioni:
*** IBB - CNR ***
CIRPeB, Department of Pharmacy, University of Naples Federico II, Via Mezzocannone, 16, 80134 Napoli, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy
References Riferimenti:
Young, I.R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P.A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
Li, J., Zheng, D., Bae, K.T., Woodard, P.K., Haacke, E.M., (1998) Invest. Radiol., 33, pp. 578-586
Mühler, A., (1998) Invest. Radiol., 33, pp. 709-714
Mühler, A., (1995) MAGMA, 3, pp. 21-33
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Mulder, W.J.M., Strijkers, G.J., Van Tilborg, G.A.F., Cormode, D.P., Fayad, Z.A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Accardo, A., Tesauro, D., Aloj, L., Pedone, C., Morelli, G., (2009) Coord. Chem. Rev., 253 (1718), pp. 2193-2213
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillen, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mulder, W.J.M., Van Der Schaft, D.W.J., Hautvast, P.A.I., Strijkers, G.J., Koning, G.A., Storm, G., Mayo, K.H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R.J.M.G.E., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Thijssen, V.L.J.L., Griffioen, A.W., (2007) Bioconjugate Chem., 18, pp. 785-790
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) ChemPhysChem, 8, pp. 2526-2538
Lipinski, M.J., Amirbekian, V., Frias, J.C., Aguinado, J.G.S., Mani, V., Briley-Saebo, K.C., Fuster, V., Fayad, Z.A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Amirbekian, V., Lipinski, M.J., Briley-Saebo, K.C., Amirbekian, S., Aguinado, J.G.S., Weinreb, D.B., Vucic, E., Fayad, Z.A., (2007) Proc. Natl. Acad. Sci. U. S. A., 104 (3), pp. 961-966
Yaghmur, A., Glatter, O., (2009) Adv. Colloid Interface Sci., 147-148, pp. 333-342
Liu, G., Conn, C.E., Waddington, L.J., Mudie, S.T., Drummond, C.J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C.E., Panchagnula, V., Weerawardena, A., Waddington, L.J., Kennedy, D.F., Drummond, C.J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M.J., De Campo, L., Waddington, L.J., Weerawardena, A., Kirby, N., Drummond, C.J., (2011) Soft Matter, 7, pp. 10994-11005
Accardo, A., Morisco, A., Gianolio, E., Tesauro, D., Mangiapia, G., Radulescu, A., Brandte, A., Morelli, G., (2011) J. Pept. Sci., 17, pp. 154-162
Schmitt, L., Dietrich, C., Tampe, R., (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Sharma, S.K., Lown, J.W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Dubochet, J., Adrian, M., Chang, J.J., Homo, J.C., Lepault, J., McDowall, A.W., Schultz, P., (1988) Q. Rev. Biophys., 21, pp. 129-228
Talmon, Y., (1996) Ber. Bunsenges. Phys. Chem., 100, pp. 364-372
Rank, A., Hauschild, S., Förster, S., Schubert, R., (2009) Langmuir, 25, pp. 1337-1344
Arena, F., Jebasingh, B.S., Gianolio, E., Stefania, R., Aime, S., (2011) Bioconjugate Chem., 22, pp. 2625-2635
Bradford, M.M., (1976) Anal. Biochem., 72, pp. 248-254
Gustafsson, J., Ljusberg-Wahren, H., Almgren, M., Larsson, K., (1997) Langmuir, 13, pp. 6964-6971
Spicer, P.T., Hayden, K.L., Lynch, M.L., Ofori-Boateng, A., Burns, J.L., (2001) Langmuir, 17 (13), pp. 5748-5756
Solomon, I., (1955) Phys. Rev., 99, pp. 559-565
Bloembergen, N., (1957) J. Chem. Phys., 27, pp. 572-573
Bloembergen, N., Morgan, L.O., (1961) J. Chem. Phys., 34, pp. 842-850
Aime, S., Botta, M., Fasano, M., Terreno, E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, p. 5. , ed. A. E. Merbach and E. Toth, John Wiley & Sons LTD
Bertini, I., Luchinat, C., (1996) Coord. Chem. Rev., 50, pp. 1-300
Kamaly, N., Kalber, T., Thanaou, M., Bell, D.J., Miller, A.D., (2009) Bioconjugate Chem., 20, pp. 648-655
Mangiapia, G., Vaccaro, M., D'Errico, G., Frielinghaus, H., Radulescu, A., Pipich, V., Carnerup, A.M., Paduano, L., (2011) Soft Matter, 7, pp. 10577-10580
Hilgenbrik, A.R., Low, P.S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E.I., Low, P.S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I.B., Shin, H., Garcia, A.L., Bunz, U.H.F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S.R., Zhou, R., Kung, H.F., Chen, I.W., (2004) Acad. Radiol., 11, pp. 996-1004
Ding, N., Lu, Y., Lee, R., Yang, C., Huang, L., Liu, J., Xiang, G., (2011) Int. J. Nanomed., 6, pp. 2513-2520
Low, P.S., Henne, W.A., Doorneweerd, D.D., (2008) Acc. Chem. Res., 41, pp. 120-129
Barauskas, J., Cervin, C., Jankunenc, M., Spandyreva, M., Ribokaite, K., Tiberg, F., Johnsson, M., (2010) Int. J. Pharm., 391, pp. 284-291
Murgia, S., Falchi, A.M., Mano, M., Lampis, S., Angius, R., Carnerup, A.M., Schmidt, J., Monduzzi, M., (2010) J. Phys. Chem. B, 114, pp. 3518-3525
Sahay, G., Batrakova, E.V., Kabanov, A.V., (2008) Bioconjugate Chem., 19, pp. 2023-2029
Li, X., Chen, D., Le, C., Zhu, C., Gang, Y., Hovgaard, L., Yang, M., (2011) Int. J. Nanomed., 6, pp. 3151-3162
Young, I. R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P. A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
M hler, A., (1998) Invest. Radiol., 33, pp. 709-714
M hler, A., (1995) MAGMA, 3, pp. 21-33
Mulder, W. J. M., Strijkers, G. J., Van Tilborg, G. A. F., Cormode, D. P., Fayad, Z. A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Mulder, W. J. M., Van Der Schaft, D. W. J., Hautvast, P. A. I., Strijkers, G. J., Koning, G. A., Storm, G., Mayo, K. H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R. J. M. G. E., Mulder, W. J. M., Nicolay, K., Mayo, K. H., Thijssen, V. L. J. L., Griffioen, A. W., (2007) Bioconjugate Chem., 18, pp. 785-790
Lipinski, M. J., Amirbekian, V., Frias, J. C., Aguinado, J. G. S., Mani, V., Briley-Saebo, K. C., Fuster, V., Fayad, Z. A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Liu, G., Conn, C. E., Waddington, L. J., Mudie, S. T., Drummond, C. J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C. E., Panchagnula, V., Weerawardena, A., Waddington, L. J., Kennedy, D. F., Drummond, C. J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M. J., De Campo, L., Waddington, L. J., Weerawardena, A., Kirby, N., Drummond, C. J., (2011) Soft Matter, 7, pp. 10994-11005
Sharma, S. K., Lown, J. W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Bradford, M. M., (1976) Anal. Biochem., 72, pp. 248-254
Spicer, P. T., Hayden, K. L., Lynch, M. L., Ofori-Boateng, A., Burns, J. L., (2001) Langmuir, 17 (13), pp. 5748-5756
Hilgenbrik, A. R., Low, P. S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E. I., Low, P. S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I. B., Shin, H., Garcia, A. L., Bunz, U. H. F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S. R., Zhou, R., Kung, H. F., Chen, I. W., (2004) Acad. Radiol., 11, pp. 996-1004
Low, P. S., Henne, W. A., Doorneweerd, D. D., (2008) Acc. Chem. Res., 41, pp. 120-129
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 8.535, 5-year impact factor Impact factor a 5 anni: 8.419
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529807&partnerID=40&md5=940d1a0b5a9a34825d4386fa3e3fd078
Keywords Parole chiave: Delivery Systems, Folate Receptor, Gadolinium Complexes, Low Concentrations, Mri Contrast Agents, Relaxometric Properties, Short Incubations, Structural Behaviors, Doping (additives), Gadolinium Compounds, Monomers, Organic Acids, Nanostructures,
Affiliations Affiliazioni:
*** IBB - CNR ***
CIRPeB, Department of Pharmacy, University of Naples Federico II, Via Mezzocannone, 16, 80134 Napoli, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy
References Riferimenti:
Young, I.R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P.A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
Li, J., Zheng, D., Bae, K.T., Woodard, P.K., Haacke, E.M., (1998) Invest. Radiol., 33, pp. 578-586
Mühler, A., (1998) Invest. Radiol., 33, pp. 709-714
Mühler, A., (1995) MAGMA, 3, pp. 21-33
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Mulder, W.J.M., Strijkers, G.J., Van Tilborg, G.A.F., Cormode, D.P., Fayad, Z.A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Accardo, A., Tesauro, D., Aloj, L., Pedone, C., Morelli, G., (2009) Coord. Chem. Rev., 253 (1718), pp. 2193-2213
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillen, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mulder, W.J.M., Van Der Schaft, D.W.J., Hautvast, P.A.I., Strijkers, G.J., Koning, G.A., Storm, G., Mayo, K.H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R.J.M.G.E., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Thijssen, V.L.J.L., Griffioen, A.W., (2007) Bioconjugate Chem., 18, pp. 785-790
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) ChemPhysChem, 8, pp. 2526-2538
Lipinski, M.J., Amirbekian, V., Frias, J.C., Aguinado, J.G.S., Mani, V., Briley-Saebo, K.C., Fuster, V., Fayad, Z.A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Amirbekian, V., Lipinski, M.J., Briley-Saebo, K.C., Amirbekian, S., Aguinado, J.G.S., Weinreb, D.B., Vucic, E., Fayad, Z.A., (2007) Proc. Natl. Acad. Sci. U. S. A., 104 (3), pp. 961-966
Yaghmur, A., Glatter, O., (2009) Adv. Colloid Interface Sci., 147-148, pp. 333-342
Liu, G., Conn, C.E., Waddington, L.J., Mudie, S.T., Drummond, C.J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C.E., Panchagnula, V., Weerawardena, A., Waddington, L.J., Kennedy, D.F., Drummond, C.J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M.J., De Campo, L., Waddington, L.J., Weerawardena, A., Kirby, N., Drummond, C.J., (2011) Soft Matter, 7, pp. 10994-11005
Accardo, A., Morisco, A., Gianolio, E., Tesauro, D., Mangiapia, G., Radulescu, A., Brandte, A., Morelli, G., (2011) J. Pept. Sci., 17, pp. 154-162
Schmitt, L., Dietrich, C., Tampe, R., (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Sharma, S.K., Lown, J.W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Dubochet, J., Adrian, M., Chang, J.J., Homo, J.C., Lepault, J., McDowall, A.W., Schultz, P., (1988) Q. Rev. Biophys., 21, pp. 129-228
Talmon, Y., (1996) Ber. Bunsenges. Phys. Chem., 100, pp. 364-372
Rank, A., Hauschild, S., Förster, S., Schubert, R., (2009) Langmuir, 25, pp. 1337-1344
Arena, F., Jebasingh, B.S., Gianolio, E., Stefania, R., Aime, S., (2011) Bioconjugate Chem., 22, pp. 2625-2635
Bradford, M.M., (1976) Anal. Biochem., 72, pp. 248-254
Gustafsson, J., Ljusberg-Wahren, H., Almgren, M., Larsson, K., (1997) Langmuir, 13, pp. 6964-6971
Spicer, P.T., Hayden, K.L., Lynch, M.L., Ofori-Boateng, A., Burns, J.L., (2001) Langmuir, 17 (13), pp. 5748-5756
Solomon, I., (1955) Phys. Rev., 99, pp. 559-565
Bloembergen, N., (1957) J. Chem. Phys., 27, pp. 572-573
Bloembergen, N., Morgan, L.O., (1961) J. Chem. Phys., 34, pp. 842-850
Aime, S., Botta, M., Fasano, M., Terreno, E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, p. 5. , ed. A. E. Merbach and E. Toth, John Wiley & Sons LTD
Bertini, I., Luchinat, C., (1996) Coord. Chem. Rev., 50, pp. 1-300
Kamaly, N., Kalber, T., Thanaou, M., Bell, D.J., Miller, A.D., (2009) Bioconjugate Chem., 20, pp. 648-655
Mangiapia, G., Vaccaro, M., D'Errico, G., Frielinghaus, H., Radulescu, A., Pipich, V., Carnerup, A.M., Paduano, L., (2011) Soft Matter, 7, pp. 10577-10580
Hilgenbrik, A.R., Low, P.S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E.I., Low, P.S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I.B., Shin, H., Garcia, A.L., Bunz, U.H.F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S.R., Zhou, R., Kung, H.F., Chen, I.W., (2004) Acad. Radiol., 11, pp. 996-1004
Ding, N., Lu, Y., Lee, R., Yang, C., Huang, L., Liu, J., Xiang, G., (2011) Int. J. Nanomed., 6, pp. 2513-2520
Low, P.S., Henne, W.A., Doorneweerd, D.D., (2008) Acc. Chem. Res., 41, pp. 120-129
Barauskas, J., Cervin, C., Jankunenc, M., Spandyreva, M., Ribokaite, K., Tiberg, F., Johnsson, M., (2010) Int. J. Pharm., 391, pp. 284-291
Murgia, S., Falchi, A.M., Mano, M., Lampis, S., Angius, R., Carnerup, A.M., Schmidt, J., Monduzzi, M., (2010) J. Phys. Chem. B, 114, pp. 3518-3525
Sahay, G., Batrakova, E.V., Kabanov, A.V., (2008) Bioconjugate Chem., 19, pp. 2023-2029
Li, X., Chen, D., Le, C., Zhu, C., Gang, Y., Hovgaard, L., Yang, M., (2011) Int. J. Nanomed., 6, pp. 3151-3162
Young, I. R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P. A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
M hler, A., (1998) Invest. Radiol., 33, pp. 709-714
M hler, A., (1995) MAGMA, 3, pp. 21-33
Mulder, W. J. M., Strijkers, G. J., Van Tilborg, G. A. F., Cormode, D. P., Fayad, Z. A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Mulder, W. J. M., Van Der Schaft, D. W. J., Hautvast, P. A. I., Strijkers, G. J., Koning, G. A., Storm, G., Mayo, K. H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R. J. M. G. E., Mulder, W. J. M., Nicolay, K., Mayo, K. H., Thijssen, V. L. J. L., Griffioen, A. W., (2007) Bioconjugate Chem., 18, pp. 785-790
Lipinski, M. J., Amirbekian, V., Frias, J. C., Aguinado, J. G. S., Mani, V., Briley-Saebo, K. C., Fuster, V., Fayad, Z. A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Liu, G., Conn, C. E., Waddington, L. J., Mudie, S. T., Drummond, C. J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C. E., Panchagnula, V., Weerawardena, A., Waddington, L. J., Kennedy, D. F., Drummond, C. J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M. J., De Campo, L., Waddington, L. J., Weerawardena, A., Kirby, N., Drummond, C. J., (2011) Soft Matter, 7, pp. 10994-11005
Sharma, S. K., Lown, J. W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Bradford, M. M., (1976) Anal. Biochem., 72, pp. 248-254
Spicer, P. T., Hayden, K. L., Lynch, M. L., Ofori-Boateng, A., Burns, J. L., (2001) Langmuir, 17 (13), pp. 5748-5756
Hilgenbrik, A. R., Low, P. S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E. I., Low, P. S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I. B., Shin, H., Garcia, A. L., Bunz, U. H. F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S. R., Zhou, R., Kung, H. F., Chen, I. W., (2004) Acad. Radiol., 11, pp. 996-1004
Low, P. S., Henne, W. A., Doorneweerd, D. D., (2008) Acc. Chem. Res., 41, pp. 120-129
Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
Highly ordered two or three dimensional mesophases in aqueous solution could be usefully obtained by using monoolein (MO) or diolein (DO) monomers. Nanostructures (also indicated as nanoparticles, NPs) of MO or DO containing different amounts (1%, 5%, 10% and 20%) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd) have been prepared and characterized for their relaxometric and structural behaviors. The nanostructure is found in the 110-200 nm range for all investigated systems, while the presence of the gadolinium containing monomer produces a partial loss of the cubic symmetry, as shown by Cryo-TEM images of NPs doped with 10% w/w of (C18)2DTPA(Gd). Gadolinium containing nanostructures display high relaxivity values (in the 10-15 mM-1 s-1 range at 25° and 20 MHz, with a further increase at 37 °C for DO based NPs), and interesting relaxometric properties for their possible use as MRI contrast agents. NPs containing 10% w/w of (C18)2DTPA(Gd) (MO3-NPs and DO3-NPs) have been also derivatized by introducing 3% wt of (C18)2-Peg3000-FA to obtain targeted aggregates (MO3-NP-FA, DO3-NP-FA). A preferential uptake efficiency of DO3-NP-FA in IGROV-1 cells with respect to DO-NPs without folic acid is observed, especially when cells are incubated with low concentrations of nanostructures or at short incubation times, thus indicating its potential use as a target-selective delivery system for MRI contrast agents on tumor cells overexpressing the folate receptor. This journal is © The Royal Society of Chemistry 2013.
Highly ordered two or three dimensional mesophases in aqueous solution could be usefully obtained by using monoolein (MO) or diolein (DO) monomers. Nanostructures (also indicated as nanoparticles, NPs) of MO or DO containing different amounts (1%, 5%, 10% and 20%) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd) have been prepared and characterized for their relaxometric and structural behaviors. The nanostructure is found in the 110-200 nm range for all investigated systems, while the presence of the gadolinium containing monomer produces a partial loss of the cubic symmetry, as shown by Cryo-TEM images of NPs doped with 10% w/w of (C18)2DTPA(Gd). Gadolinium containing nanostructures display high relaxivity values (in the 10-15 mM-1 s-1 range at 25° and 20 MHz, with a further increase at 37 °C for DO based NPs), and interesting relaxometric properties for their possible use as MRI contrast agents. NPs containing 10% w/w of (C18)2DTPA(Gd) (MO3-NPs and DO3-NPs) have been also derivatized by introducing 3% wt of (C18)2-Peg3000-FA to obtain targeted aggregates (MO3-NP-FA, DO3-NP-FA). A preferential uptake efficiency of DO3-NP-FA in IGROV-1 cells with respect to DO-NPs without folic acid is observed, especially when cells are incubated with low concentrations of nanostructures or at short incubation times, thus indicating its potential use as a target-selective delivery system for MRI contrast agents on tumor cells overexpressing the folate receptor. This journal is © The Royal Society of Chemistry 2013.
Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
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Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (345 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (265 visite)
Sci Rep (ISSN: 2045-2322linking), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
Dettagli Esporta in BibTeX Esporta in EndNote
Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (311 visite)
Eur J Pharm Sci (ISSN: 0928-0987, 0928-0987linking), 2018 Jan 1; 111: 177-185.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (270 visite)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (266 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
Dettagli Esporta in BibTeX Esporta in EndNote
Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (244 visite) (PDF 202 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (408 visite)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
Dettagli Esporta in BibTeX Esporta in EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (532 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
Dettagli Esporta in BibTeX Esporta in EndNote
Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (418 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
Dettagli Esporta in BibTeX Esporta in EndNote
Cohen SS, Riven I, Cortajarena AL, De Rosa L, D'Andrea LD, Regan L, Haran G
* Probing the molecular origin of native-state flexibility in repeat proteins (335 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015; 137(32): 10367-10373.
Impact Factor: 13.038
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (402 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
Dettagli Esporta in BibTeX Esporta in EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (412 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
Dettagli Esporta in BibTeX Esporta in EndNote
Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (381 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (464 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (387 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (496 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (379 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
Dettagli Esporta in BibTeX Esporta in EndNote
Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (782 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (489 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (339 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (226 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (535 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (566 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (418 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (388 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (260 visite)
J Chromatogr A (ISSN: 0021-9673), 2007; 1155(2): 172-179.
Impact Factor: 3.641
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (367 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
Dettagli Esporta in BibTeX Esporta in EndNote
Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (292 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (230 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (557 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (371 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (420 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
35 Records (32 escludendo Abstract e Conferenze).
Impact factor totale: 137.693 (131.78 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 141.086 (134.457 escludendo Abstract e Conferenze).
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (64 visite)
Angew Chem Int Ed Engl (ISSN: 1433-7851linking), 2021 Feb 19; 60(8): 4208-4214.
Impact Factor: 12.959
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (54 visite)
Chemistry (ISSN: 0947-6539linking), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (118 visite)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (345 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
Dettagli Esporta in BibTeX Esporta in EndNote
Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (265 visite)
Sci Rep (ISSN: 2045-2322linking), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
Dettagli Esporta in BibTeX Esporta in EndNote
Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (311 visite)
Eur J Pharm Sci (ISSN: 0928-0987, 0928-0987linking), 2018 Jan 1; 111: 177-185.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (270 visite)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
Dettagli Esporta in BibTeX Esporta in EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (266 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
Dettagli Esporta in BibTeX Esporta in EndNote
Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (244 visite) (PDF 202 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (408 visite)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
Dettagli Esporta in BibTeX Esporta in EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (532 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
Dettagli Esporta in BibTeX Esporta in EndNote
Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (418 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
Dettagli Esporta in BibTeX Esporta in EndNote
Cohen SS, Riven I, Cortajarena AL, De Rosa L, D'Andrea LD, Regan L, Haran G
* Probing the molecular origin of native-state flexibility in repeat proteins (335 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015; 137(32): 10367-10373.
Impact Factor: 13.038
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (402 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
Dettagli Esporta in BibTeX Esporta in EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (412 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
Dettagli Esporta in BibTeX Esporta in EndNote
Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (381 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (464 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (387 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (496 visite)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (379 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
Dettagli Esporta in BibTeX Esporta in EndNote
Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (782 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (489 visite)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (339 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (226 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (535 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (566 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
Dettagli Esporta in BibTeX Esporta in EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (418 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (388 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (260 visite)
J Chromatogr A (ISSN: 0021-9673), 2007; 1155(2): 172-179.
Impact Factor: 3.641
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (367 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
Dettagli Esporta in BibTeX Esporta in EndNote
Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (292 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (230 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (557 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (371 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (420 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
35 Records (32 escludendo Abstract e Conferenze).
Impact factor totale: 137.693 (131.78 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 141.086 (134.457 escludendo Abstract e Conferenze).
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