Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
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Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (328 visite)

Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G

J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.



Tipo di articolo: Journal Article,

Impact factor: 8.535, Impact factor a 5 anni: 8.419

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529807&partnerID=40&md5=940d1a0b5a9a34825d4386fa3e3fd078

Parole chiave: Delivery Systems, Folate Receptor, Gadolinium Complexes, Low Concentrations, Mri Contrast Agents, Relaxometric Properties, Short Incubations, Structural Behaviors, Doping (additives), Gadolinium Compounds, Monomers, Organic Acids, Nanostructures,

Affiliazioni:

*** IBB - CNR ***
CIRPeB, Department of Pharmacy, University of Naples Federico II, Via Mezzocannone, 16, 80134 Napoli, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy


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Highly ordered two or three dimensional mesophases in aqueous solution could be usefully obtained by using monoolein (MO) or diolein (DO) monomers. Nanostructures (also indicated as nanoparticles, NPs) of MO or DO containing different amounts (1%, 5%, 10% and 20%) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd) have been prepared and characterized for their relaxometric and structural behaviors. The nanostructure is found in the 110-200 nm range for all investigated systems, while the presence of the gadolinium containing monomer produces a partial loss of the cubic symmetry, as shown by Cryo-TEM images of NPs doped with 10% w/w of (C18)2DTPA(Gd). Gadolinium containing nanostructures display high relaxivity values (in the 10-15 mM-1 s-1 range at 25° and 20 MHz, with a further increase at 37 °C for DO based NPs), and interesting relaxometric properties for their possible use as MRI contrast agents. NPs containing 10% w/w of (C18)2DTPA(Gd) (MO3-NPs and DO3-NPs) have been also derivatized by introducing 3% wt of (C18)2-Peg3000-FA to obtain targeted aggregates (MO3-NP-FA, DO3-NP-FA). A preferential uptake efficiency of DO3-NP-FA in IGROV-1 cells with respect to DO-NPs without folic acid is observed, especially when cells are incubated with low concentrations of nanostructures or at short incubation times, thus indicating its potential use as a target-selective delivery system for MRI contrast agents on tumor cells overexpressing the folate receptor. This journal is © The Royal Society of Chemistry 2013.
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (239 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (190 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (450 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (308 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (341 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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32 Records (30 escludendo Abstract e Conferenze).
Impact factor totale: 118.993 (117.339 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 124.034 (122.252 escludendo Abstract e Conferenze).







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Ultima modifica di Marco Comerci in data Sunday 12 July 2020, 13:14:55
328 visite. Ultima visita in data Monday 12 October 2020, 15:24:21