Parole chiave: Intensity Modulation, Protons, X-Rays, Beam Therapy, Cancer Radiotherapy, Case Report, Child, Conference Paper, Controlled Study, Human, Prostate Cancer, Proton Radiation, Radiation Dose Distribution, Rhabdomyosarcoma, Tumor Volume, Dose-Response Relationship, Neoplasms, Second Primary, Organ Specificity, Prostatic Neoplasms, Radiation Dosage, Radiation Tolerance,
*** IBB - CNR *** Dipartimento di Scienze Fisiche, Università di Napoli, Napoli, Italy
Lomax, A., Intensity modulation methods for proton radiotherapy (1999) Phys Med Biol, 44, pp. 185-20
Bortfeld, T., Buerkelbach, J., Boesecke, R., Schlegel, W., Three-dimensional solution of the inverse problem in conformation radiotherapy (1992), pp. 503-508. , Breit A. ed. Advanced radiation therapy: Tumor response monitoring and treatment planning. Berlin. Springer VerlagLyman, J.T., Complication probability as assessed from dose-volume histograms (1985) Radiat Res, 104, pp. 513-519
Inverse planning and intensity modulated (IM) X-ray beam treatment techniques can achieve significant improvements in dose distributions comparable to those obtained with forward planned proton beams. However, intensity modulation can also be applied to proton beams and further optimization in dose distribution can reasonably be expected. A comparative planning exercise between IM X-rays and IM proton beams was carried out on two different tumor cases: a pediatric rhabdomyosarcoma and a prostate cancer. Both IM X-rays and IM protons achieved equally homogenous coverage of the target volume in the two tumor sites. Predicted NTCPs were equally low for both treatment techniques. Nevertheless, a reduced low-to-medium dose to the organs at risk and a lesser integral non-target mean dose for IM protons in the two cases favored the use of IM proton beams.
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(47 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(111 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote