Integrin Receptor Family: Promising Target For Therapeutic And Diagnostic Applications(100 visite) Zaccaro L, Del Gatto A, Pedone C, Saviano M
Current Topics In Biochemical Research (ISSN: 0972-4583), 2007; 9(2): 45-56.
Tipo di articolo: Journal Article,
Impact factor: 0, Impact factor a 5 anni: 0
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Integrins are a family of heterodimeric receptors present on multiple types of cell surface. They play a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate. The involvement of integrins in different signal pathways makes them an interesting target for therapeutic and diagnostic purposes.
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821 Records (743 escludendo Abstract e Conferenze). Impact factor totale: 2823.238 (2615.825 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2984.345 (2757.603 escludendo Abstract e Conferenze).
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