Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (246 views visite)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic), 1996 May 1; 236(2): 338-343.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 2.017, 5-year impact factor Impact factor a 5 anni: 3.039
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928765&partnerID=40&md5=bb0a9e4fa58c481690153ac801b23dfa
Keywords Parole chiave: Colchicine, Dactinomycin, Doxorubicin, Glycoprotein P, Iodine 125, Monoclonal Antibody, Vincristine, Antigen Antibody Complex, Article, Binding Competition, Binding Site, Dissociation Constant, Gene Expression, Human, Human Cell, Multidrug Resistance, Neuroblastoma Cell, Priority Journal, Protein Determination, Quantitative Diagnosis, Antibodies, Multiple, Neoplasm, Epitopes, Linear Models, Neoplasm Proteins, P-Glycoprotein, Reproducibility Of Results, Tumor Cells, Cultured,
Affiliations Affiliazioni:
Nuclear Medicine Research Laboratory, Mem. Sloan Kettering Cancer Center, New York, NY 10021, United States
Lab. of Cell. and Biochem. Genetics, Mem. Sloan Kettering Cancer Center, New York, NY 10021, United States
Fordham University, Bronx, NY 10458, United States
Inst. of Molec. and Cell. Biosci., University of Tokyo, Tokyo, Japan
References Riferimenti:
Hulme, E.C., (1992) Receptor-Ligand Interactions: a Practical Approach, , IRL Press, Oxfor
Hamada, H., Tsuruo, T., (1986) Proc. Natl. Acad. Sci. USA, 83, pp. 7785-7789
Tsuruo, T., (1988) Jpn. J. Cancer Res., 77, pp. 682-692
Riordan, J.R., Ling, V., (1985) Pharmacol. Ther., 28, pp. 51-75
Kartner, N., Evernden-Porelle, P., Bradley, G., Ling, V., (1985) Nature, 316, pp. 820-823
Fojo, A.T., Ueda, K., Slamon, D.J., Poplack, D.G., Gottesman, M.M., Pastan, I., (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S., Mori, S., (1988) Cancer Res., 48, pp. 1926-1929
Sugawara, I., Hamada, H., Tsuruo, T., Mon, S., (1990) Jpn. J. Cancer Res., 81, pp. 727-730
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I., Willingham, M.C., (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 7735-7738
Georges, E., Tsuruo, T., Ling, V., (1993) J. Biol. Chem., 268, pp. 1792-1798
Higgins, C.F., (1992) Annu. Rev. Cell. Biol., 8, pp. 67-113
Biedler, J.L., Casals, D., Chang, T.-D., Meyers, M.B., Spengler, B.A., Ross, R.A., (1991) Adv. Neuroblast. Res., 3, pp. 181-191
Fraker, P.J., Speck, J.C., (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-854
Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., Bunn, P.A., (1984) J. Immunol. Methods, 72, pp. 77-89
Laemmli, U.K., (1970) Nature, 227, p. 680
Badger, C.C., Krohn, K.A., Bernstein, I.D., (1987) Nucl. Med. Biol., 14 (6), pp. 605-610
Marquardt, D., (1963) Appl. Math., 11, pp. 431-441
Mehta, B.M., Levchenko, A., Patel, D.A., Tsuruo, T., Larson, S.M., (1995) Proc. Am. Assoc. Cancer Res., 36, p. 333
Georges, E., Bradley, G., Gariepy, J., Ling, V., (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 150-156
Munson, P.J., (1983) J. Receptor Res., 3, pp. 249-259
Del Vecchio, S., Reynolds, J.C., Carrasquillo, J.A., Blasberg, R.G., Neumann, R.D., Lotze, M.T., Bryant, G.J., Larson, S.M., (1989) Cancer Res., 49, pp. 2783-2789
Hulme, E. C., (1992) Receptor-Ligand Interactions: a Practical Approach, , IRL Press, Oxfor
Riordan, J. R., Ling, V., (1985) Pharmacol. Ther., 28, pp. 51-75
Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., Pastan, I., (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Higgins, C. F., (1992) Annu. Rev. Cell. Biol., 8, pp. 67-113
Biedler, J. L., Casals, D., Chang, T. -D., Meyers, M. B., Spengler, B. A., Ross, R. A., (1991) Adv. Neuroblast. Res., 3, pp. 181-191
Fraker, P. J., Speck, J. C., (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-854
Laemmli, U. K., (1970) Nature, 227, p. 680
Badger, C. C., Krohn, K. A., Bernstein, I. D., (1987) Nucl. Med. Biol., 14 (6), pp. 605-610
Mehta, B. M., Levchenko, A., Patel, D. A., Tsuruo, T., Larson, S. M., (1995) Proc. Am. Assoc. Cancer Res., 36, p. 333
Munson, P. J., (1983) J. Receptor Res., 3, pp. 249-259
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic), 1996 May 1; 236(2): 338-343.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.017, 5-year impact factor Impact factor a 5 anni: 3.039
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928765&partnerID=40&md5=bb0a9e4fa58c481690153ac801b23dfa
Keywords Parole chiave: Colchicine, Dactinomycin, Doxorubicin, Glycoprotein P, Iodine 125, Monoclonal Antibody, Vincristine, Antigen Antibody Complex, Article, Binding Competition, Binding Site, Dissociation Constant, Gene Expression, Human, Human Cell, Multidrug Resistance, Neuroblastoma Cell, Priority Journal, Protein Determination, Quantitative Diagnosis, Antibodies, Multiple, Neoplasm, Epitopes, Linear Models, Neoplasm Proteins, P-Glycoprotein, Reproducibility Of Results, Tumor Cells, Cultured,
Affiliations Affiliazioni:
Nuclear Medicine Research Laboratory, Mem. Sloan Kettering Cancer Center, New York, NY 10021, United States
Lab. of Cell. and Biochem. Genetics, Mem. Sloan Kettering Cancer Center, New York, NY 10021, United States
Fordham University, Bronx, NY 10458, United States
Inst. of Molec. and Cell. Biosci., University of Tokyo, Tokyo, Japan
References Riferimenti:
Hulme, E.C., (1992) Receptor-Ligand Interactions: a Practical Approach, , IRL Press, Oxfor
Hamada, H., Tsuruo, T., (1986) Proc. Natl. Acad. Sci. USA, 83, pp. 7785-7789
Tsuruo, T., (1988) Jpn. J. Cancer Res., 77, pp. 682-692
Riordan, J.R., Ling, V., (1985) Pharmacol. Ther., 28, pp. 51-75
Kartner, N., Evernden-Porelle, P., Bradley, G., Ling, V., (1985) Nature, 316, pp. 820-823
Fojo, A.T., Ueda, K., Slamon, D.J., Poplack, D.G., Gottesman, M.M., Pastan, I., (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S., Mori, S., (1988) Cancer Res., 48, pp. 1926-1929
Sugawara, I., Hamada, H., Tsuruo, T., Mon, S., (1990) Jpn. J. Cancer Res., 81, pp. 727-730
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I., Willingham, M.C., (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 7735-7738
Georges, E., Tsuruo, T., Ling, V., (1993) J. Biol. Chem., 268, pp. 1792-1798
Higgins, C.F., (1992) Annu. Rev. Cell. Biol., 8, pp. 67-113
Biedler, J.L., Casals, D., Chang, T.-D., Meyers, M.B., Spengler, B.A., Ross, R.A., (1991) Adv. Neuroblast. Res., 3, pp. 181-191
Fraker, P.J., Speck, J.C., (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-854
Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., Bunn, P.A., (1984) J. Immunol. Methods, 72, pp. 77-89
Laemmli, U.K., (1970) Nature, 227, p. 680
Badger, C.C., Krohn, K.A., Bernstein, I.D., (1987) Nucl. Med. Biol., 14 (6), pp. 605-610
Marquardt, D., (1963) Appl. Math., 11, pp. 431-441
Mehta, B.M., Levchenko, A., Patel, D.A., Tsuruo, T., Larson, S.M., (1995) Proc. Am. Assoc. Cancer Res., 36, p. 333
Georges, E., Bradley, G., Gariepy, J., Ling, V., (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 150-156
Munson, P.J., (1983) J. Receptor Res., 3, pp. 249-259
Del Vecchio, S., Reynolds, J.C., Carrasquillo, J.A., Blasberg, R.G., Neumann, R.D., Lotze, M.T., Bryant, G.J., Larson, S.M., (1989) Cancer Res., 49, pp. 2783-2789
Hulme, E. C., (1992) Receptor-Ligand Interactions: a Practical Approach, , IRL Press, Oxfor
Riordan, J. R., Ling, V., (1985) Pharmacol. Ther., 28, pp. 51-75
Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., Pastan, I., (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Higgins, C. F., (1992) Annu. Rev. Cell. Biol., 8, pp. 67-113
Biedler, J. L., Casals, D., Chang, T. -D., Meyers, M. B., Spengler, B. A., Ross, R. A., (1991) Adv. Neuroblast. Res., 3, pp. 181-191
Fraker, P. J., Speck, J. C., (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-854
Laemmli, U. K., (1970) Nature, 227, p. 680
Badger, C. C., Krohn, K. A., Bernstein, I. D., (1987) Nucl. Med. Biol., 14 (6), pp. 605-610
Mehta, B. M., Levchenko, A., Patel, D. A., Tsuruo, T., Larson, S. M., (1995) Proc. Am. Assoc. Cancer Res., 36, p. 333
Munson, P. J., (1983) J. Receptor Res., 3, pp. 249-259
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay
To date, all reported measurements of multidrug resistance have been semiquantitative. The purpose of the present study is to establish and validate the self-competitive binding assay technique utilizing monoclonal antibody for quantitative estimation of multidrug resistance in tumor cells. This technique is used for P-glycoprotein concentration measurement in BE(2)- C human neuroblastoma cell line and its sublines with primary resistance to colchicine and actinomycin D. Monoclonal antibody MRK-16 was used in this study. It was labeled with iodine-125 (125I) to trace the concentration of antibody-antigen complexes. The binding data were obtained by varying the concentration of the unlabeled antibody. The results were fitted to a model equation to estimate the number of binding sites and antibody-antigen dissociation constant. The P-glycoprotein concentration was significantly higher in the resistant sublines than in the sensitive line. The highest levels were achieved in actinomycin D-resistant cells: 2.1 x 106 binding sites/cell versus 5.4 x 104 binding sites/cell in the sensitive cells. The consistency of the results was verified by repeating the study three times for each cell line. The binding assay results were confirmed by Western blot experiments performed on the same cell lines.
To date, all reported measurements of multidrug resistance have been semiquantitative. The purpose of the present study is to establish and validate the self-competitive binding assay technique utilizing monoclonal antibody for quantitative estimation of multidrug resistance in tumor cells. This technique is used for P-glycoprotein concentration measurement in BE(2)- C human neuroblastoma cell line and its sublines with primary resistance to colchicine and actinomycin D. Monoclonal antibody MRK-16 was used in this study. It was labeled with iodine-125 (125I) to trace the concentration of antibody-antigen complexes. The binding data were obtained by varying the concentration of the unlabeled antibody. The results were fitted to a model equation to estimate the number of binding sites and antibody-antigen dissociation constant. The P-glycoprotein concentration was significantly higher in the resistant sublines than in the sensitive line. The highest levels were achieved in actinomycin D-resistant cells: 2.1 x 106 binding sites/cell versus 5.4 x 104 binding sites/cell in the sensitive cells. The consistency of the results was verified by repeating the study three times for each cell line. The binding assay results were confirmed by Western blot experiments performed on the same cell lines.
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay
No results. Nessun risultato. |
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay
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* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (415 visite)
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
Impact Factor: 2.345
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Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
* EANM/ESC guidelines for radionuclide imaging of cardiac function (501 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (512 visite)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (541 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (566 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (403 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (212 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Pace L, Salvatore M, Del Vecchio S
* Use of Tc-99m-Sestamibi scintigraphy in multiple myeloma (220 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2006 Mar; 47(3): 555-555.
Impact Factor: 4.986
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Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M
* Functional imaging of multidrug resistance in breast cancer (381 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2006; 21(SUPPL.1): 24-27.
Impact Factor: 0.313
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Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Salvatore B, Andretta C, Di Nuzzo C, Rotoli B, Salvatore M
* Washout of [99mTc] sestamibi in predicting response to chemotherapy in patients with multiple myeloma (350 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Sep; 49(3): 281-285.
Impact Factor: 1.724
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Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (550 visite) (PDF 177 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (425 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (228 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (406 visite)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (484 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
* Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (257 visite)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Impact Factor: 2.045
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (414 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (443 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (434 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Del Vecchio S, Ciarmiello A, Salvatore M
Scintigraphic detection of multidrug resistance in cancer (435 visite)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2000 Sep; 15(4): 327-337.
Impact Factor: 0.989
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (246 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (254 visite)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (402 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (303 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (229 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (286 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (523 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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Trischitta V, Benzi L, Brunetti A, Cecchetti P, Marchetti P, Vigneri R, Navalesi R
Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus (900 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1987 May; 64(5): 914-920.
Impact Factor: 4.575
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60 Records (56 escludendo Abstract e Conferenze).
Impact factor totale: 239.317 (221.487 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 263.271 (242.939 escludendo Abstract e Conferenze).
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Mercurio V, Cuomo A, Della Pepa R, Ciervo D, Cella L, Pirozzi F, Parrella P, Campi G, Franco R, Varricchi G, Abete P, Marone G, Petretta M, Bonaduce D, Pacelli R, Picardi M, Tocchetti CG
* What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients? (155 visite)
Antioxid Redox Signal (ISSN: 1523-0864linking, 1557-7716), 2019 Nov 20; 31 (15 ): 1166-1174.
Impact Factor: 7.581
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (433 visite)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
* Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin (393 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Mar 22; 7(1): 307-307.
Impact Factor: 4.122
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (408 visite)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (298 visite)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
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Rizzitelli S, Giustetto P, Cutrin JC, Delli Castelli D, Boffa C, Ruzza M, Menchise V, Molinari F, Aime S, Terreno E
* Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (419 visite)
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Impact Factor: 7.441
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (469 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (419 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (450 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (417 visite)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (292 visite)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (402 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (514 visite)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
* Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (499 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520.
Impact Factor: 5.48
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Accardo A, Tesauro D, Morelli G
* Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (440 visite)
Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493.
Impact Factor: 1.554
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (399 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (362 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (362 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (373 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (438 visite) (PDF 216 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (338 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (433 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (400 visite)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (403 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (502 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (387 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (348 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (321 visite)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (573 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (412 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (374 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (795 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (415 visite)
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
Impact Factor: 2.345
Dettagli Esporta in BibTeX Esporta in EndNote
Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
* EANM/ESC guidelines for radionuclide imaging of cardiac function (501 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (512 visite)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (541 visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (566 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (403 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (212 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Pace L, Salvatore M, Del Vecchio S
* Use of Tc-99m-Sestamibi scintigraphy in multiple myeloma (220 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2006 Mar; 47(3): 555-555.
Impact Factor: 4.986
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Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M
* Functional imaging of multidrug resistance in breast cancer (381 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2006; 21(SUPPL.1): 24-27.
Impact Factor: 0.313
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Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Salvatore B, Andretta C, Di Nuzzo C, Rotoli B, Salvatore M
* Washout of [99mTc] sestamibi in predicting response to chemotherapy in patients with multiple myeloma (350 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Sep; 49(3): 281-285.
Impact Factor: 1.724
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Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (550 visite) (PDF 177 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (425 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (228 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (406 visite)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (484 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
* Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (257 visite)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Impact Factor: 2.045
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (414 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (443 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (434 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Del Vecchio S, Ciarmiello A, Salvatore M
Scintigraphic detection of multidrug resistance in cancer (435 visite)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2000 Sep; 15(4): 327-337.
Impact Factor: 0.989
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (246 visite)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (254 visite)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (402 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (303 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (229 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (286 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (523 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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Trischitta V, Benzi L, Brunetti A, Cecchetti P, Marchetti P, Vigneri R, Navalesi R
Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus (900 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1987 May; 64(5): 914-920.
Impact Factor: 4.575
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60 Records (56 escludendo Abstract e Conferenze).
Impact factor totale: 239.317 (221.487 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 263.271 (242.939 escludendo Abstract e Conferenze).
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