A hybrid mock circulatory system: development and testing of an electro-hydraulic impedance simulator
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A hybrid mock circulatory system: development and testing of an electro-hydraulic impedance simulator (212 views visite)

Kozarski M, Ferrari G, Clemente F, Gorczynska K, De Lazzari C, Darowski M, Mimmo R, Tosti G, Guaragno M

Int J Artif Organs (ISSN: 0391-3988, 0391-3988print), 2003 Jan; 26(1): 53-63.



Paper type Tipo di articolo: Journal Article, Comparative Study,

Impact factor: 0.964, 5-year impact factor Impact factor a 5 anni: 1.454

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0041312592&partnerID=40&md5=b3b3d62a20bfb7dbe7c62737c4bf1648

Keywords Parole chiave: Electro-Hydraulic Gyrator, Hybrid Model, Mock Circulatory System, Physical Model, Variable Elastance Model, Ventricular Model, Arterial Pressure, Article, Cardiovascular Parameters, Cardiovascular System, Data Analysis, Experimental Model, Flow Measurement, Health Care Cost, Heart Assist Device, Heart Cycle, Heart Hemodynamics, Heart Output, Heart Rate, Heart Ventricle Function, Heart Ventricle Volume, Hydraulic Conductivity, Impedance, Simulator, Vascular Resistance, Computer Simulation, Electric Impedance, Equipment Design, Heart-Assist Devices, Humans, Structural, Ventricular Function,

Affiliations Affiliazioni:

*** IBB - CNR ***
Inst. of Biocyber. and Biomed. Eng., PAN, Warsaw, Poland
Institute of Biomedical Technologies, CNR, Rome, Italy
Institute of Biocybernetics and Biomedical Engineering, PAN, Warsaw, Poland.,


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Mock circulatory systems are used to test mechanical assist devices and for training and research purposes; when compared to numerical models, however, they are not flexible enough and rather expensive. The concept of merging numerical and physical models, resulting in a hybrid one, is applied here to represent the input impedance of the systemic arterial tree, by a conventional windkessel model built out of an electro-hydraulic (E-H) impedance simulator added to a hydraulic section. This model is inserted into an open loop circuit, completed by another hybrid model representing the ventricular function. The E-H impedance simulator is essentially an electrically controlled flow source (a gear pump). Referring to the windkessel model, it is used to simulate the peripheral resistance and the hydraulic compliance, creating the desired input impedance. The data reported describe the characterisation of the E-H impedance simulator and demonstrate its behaviour when it is connected to a hybrid ventricular model. Experiments were performed under different hemodynamic conditions, including the presence of a left ventricular assist device (LVAD).
No results. Nessun risultato.
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* Early and late effects of coronary artery bypass grafting on cardiac haemodynamics during daily physical activities in patients with coronary artery disease (223 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(6): 852-856.
Impact Factor: 3.935
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Romano  M, Mainenti PP, Imbriaco M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease: diagnostic accuracy and interobserver agreement (220 visite)
European Journal Of Radiology (ISSN: 0720-048x), 2004 Jun; 50(3): 303-308.
Impact Factor: 1.745
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Clemente F, D'Avino E, Guaragno M, Menichetti A
* An on line technique to detect cardiac output variations and cardiovascular performances during abdominal aortic surgery (336 visite)
Journal Of Clinical Monitoring And Computing (ISSN: 1387-1307), 2004 Apr; 18(2): 81-87.
Impact Factor: 0.888
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Musumeci D, Roviello  GN, Sica D
* The oxidation of Δ2, Δ2, 4 and Δ4, 6 steroids with RuO4 (320 visite)
Steroids (ISSN: 0039-128x), 2004 Mar; 69(3): 173-179.
Impact Factor: 2.337
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (519 visite)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812.
Impact Factor: 0.023
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Ferro A, Duilio C, Santomauro M, Cuocolo A
* Walk test at increased levels of heart rate in patients with dual-chamber pacemaker and with normal or depressed left ventricular function (235 visite)
Eur Heart J (ISSN: 0195-668x), 2003 Dec; 24(23): 2123-2132.
Impact Factor: 5.997
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Ciampi Q, Betocchi S, Violante A, Lombardi R, Losi M, Storto G, Manganelli F, Tocchetti C, Aversa M, Pezzella E, Finizio F, Cuocolo A, Chiariello M
* Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: Comparison with normal subjects (235 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2003 Mar; 10(2): 154-160.
Impact Factor: 1.629
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Biondi B, Palmieri EA, Pagano L, Klain M, Scherillo G, Salvatore M, Fenzi G, Lombardi G, Fazio S
* Cardiovascular safety of acute recombinant human thyrotropin administration to patients monitored for differentiated thyroid cancer (314 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Jan; 88(1): 211-214.
Impact Factor: 5.873
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Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (347 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
Impact Factor: 1.377
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Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
* Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy (252 visite)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Impact Factor: 2.134
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Ciampi Q, Betocchi S, Lombardi R, Manganelli F, Storto G, Losi MA, Pezzella E, Finizio F, Cuocolo A, Chiariello M
* Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy (210 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2002 Jul 17; 40(2): 278-284.
Impact Factor: 6.278
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (249 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Manganelli F, Betocchi S, Ciampi Q, Storto G, Losi MA, Violante A, Briguori C, Tocchetti CG, Lombardi R, Cuocolo A, Chiariello M
* Myopia and IOP (253 visite)
Ann Ottalmol Clin Ocul, 2002 Jun 15; 115(10): 1053-1058.
Impact Factor: 0
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (233 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Ferro A, Salvatore M, Cuocolo A
* Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity (209 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001 Sep; 8(6): 669-676.
Impact Factor: 1.868
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (203 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (197 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Cuocolo A, Storto G, Izzo R, Iovino GL, Damiano M, Bertocchi F, Mann J, Trimarco B
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril (206 visite)
Journal Of Hypertension (ISSN: 0263-6352), 1999 Dec; 17(12): 1759-1766.
Impact Factor: 3.039
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Cittadini A, Fazio S, Strömer H, Cuocolo A, Sabatini D, Imbriaco M, Saccá L, Douglas PS
OPTIMAL DETERMINATION OF RIGHT-VENTRICULAR FILLING DYNAMICS IN SYSTEMIC HYPERTENSION (234 visite)
American Heart Journal (ISSN: 0002-8703), 1995 Nov; 130(5): 1074-1082.
Impact Factor: 1.993
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (263 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Ferrara LA, Mancini M, Iannuzzi R, Marotta T, Gaeta I, Pasanisi F, Postiglione A, Guida L
CAROTID DIAMETER AND BLOOD-FLOW VELOCITIES IN CEREBRAL-CIRCULATION IN HYPERTENSIVE PATIENTS (175 visite)
Stroke (ISSN: 0039-2499), 1995 Mar; 26(3): 418-421.
Impact Factor: 4.323
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Cuocolo A, Soricelli A, Pace L, Nicolai E, Castelli L, Nappi A, Imbriaco M, Morisco C, Ell PJ, Salvatore M
ADENOSINE TECHNETIUM-99M-METHOXY ISOBUTYL ISONITRILE MYOCARDIAL TOMOGRAPHY IN PATIENTS WITH CORONARY-ARTERY DISEASE - COMPARISON WITH EXERCISE (180 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Jul; 35(7): 1110-1115.
Impact Factor: 3.491
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Nappi A, Cuocolo A, Iazzetta N, Ferrara LA, Marotta T, Pace L, Nicolai E, De Michele G, Campanella G, Salvatore M, Postiglione A
Ambulatory monitoring of left ventricular function in patients with Parkinson's disease and postural hypotension (1073 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1994; 21(12): 1312-1317.
Impact Factor: 2.692
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Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano  M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (244 visite)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
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Pace L, Cuocolo A, Maurea S, Nicolai E, Imbriaco M, Nappi A, Morisco C, Chiariello M, Trimarco B, Salvatore M
Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function (236 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1993 Oct; 34(10): 1688-1692.
Impact Factor: 3.491
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PETRETTA M, BONADUCE D, CUOCOLO A, MORGANO G, NICOLAI E, PULCINO A, BIANCHI V, SALVATORE M
Incremental prognostic value of thallium imaging and coronary angiography in patients with a symptom-limited ECG stress test (233 visite)
Coron Artery Dis (ISSN: 0954-6928), 1993 Jul; 4(7): 637-644.
Impact Factor: 0.653
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Ferrara LA, Marotta T, Mainenti G, Borrelli R, Mancini M, Soro S
Resting blood pressure and cardiovascular response to sympathetic stimulation in adolescents (207 visite)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1992 Sep; 36(2): 197-201.
Impact Factor: 0.61
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Ferrara LA, Mancini M, De Simone GD, Turco S, Iovine C, Marotta T, Mainenti G, Mancini M
Responses of serum insulin and blood pressure to cold and handgrip in obese patients (248 visite)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1991 Sep; 32(3): 353-359.
Impact Factor: 0.61
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Alfano B, Bencivelli W, Bertolucci E, Bottigli U, Bucciolini M, Conti M, Del Guerra A, Messineo A, Milano F, Randaccio P, Renzi R, Rosso V, Russo P, Stefanini A.
Hardware/software simulator of a silicon detector for digital radiography (225 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 1990; 6(3-4): 239-241.
Impact Factor: 0.142
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Ferrara LA, Soro S, Mainenti G, Mancini M, Pisanti N, Borrelli R, Moscato TS
Body weight and cardiovascular response to sympathetic stimulation in childhood (426 visite)
Int J Obes (ISSN: 0307-0565), 1989; 13(3): 271-277.
Impact Factor: 2.476
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Mancini M, De Chiara S, Ferrara LA, Gallotta G, Postiglione A
TRANSCRANIAL DOPPLER EVALUATION OF CEREBROVASCULAR REACTIVITY TO ACETAZOLAMIDE IN NORMAL SUBJECTS (539 visite)
15th World Congress Angiology Rome, 1989; 20(4): 284-284.
Impact Factor: 0
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Romano  M, Betocchi S, Perrone-filardi P, Cotecchia MR, Spinelli L, Salvatore M, Chiariello M, Condorelli M
Detecting coronary artery disease by radionuclide ventriculography: ejection time versus ejection fraction (256 visite)
Acta Cardiol (ISSN: 0001-5385), 1988; 43(3): 335-340.
Impact Factor: 0.279
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Betocchi S, Cuocolo A, Pace L, Chiariello M, Trimarco B, Alfano B, Ricciardelli B, Salvatore M, Condorelli M
Effects of intravenous verapamil administration on left ventricular diastolic function in systemic hypertension (507 visite)
Am J Cardiol (ISSN: 0002-9149), 1987 Mar 1; 59(6): 624-629.
Impact Factor: 2.402
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Ferrara LA, Mancini M, Marotta T, Pasanisi F, Fasano ML
Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol (800 visite)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1986; 29(6): 717-719.
Impact Factor: 1.219
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64 Records (58 escludendo Abstract e Conferenze).
Impact factor totale: 161.869 (150.208 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 193.227 (172.744 escludendo Abstract e Conferenze).







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