A hybrid mock circulatory system: development and testing of an electro-hydraulic impedance simulator(108 visite) Kozarski M, Ferrari G, Clemente F, Gorczynska K, De Lazzari C, Darowski M, Mimmo R, Tosti G, Guaragno M
*** IBB - CNR *** Inst. of Biocyber. and Biomed. Eng., PAN, Warsaw, Poland Institute of Biomedical Technologies, CNR, Rome, Italy Institute of Biocybernetics and Biomedical Engineering, PAN, Warsaw, Poland.,
Riferimenti:
Geertsema, A.A., Rakhorst, G., Mihaylov, D., Blanksma, P.K., Verkerke, G.J., Development of a numerical simulation model of the cardiovascular system (1997) Int J Artif Organs, 21, pp. 1297-130
Zhou, J., Armstrong, G.P., Medvedev, A.L., Smith, W.A., Golding, L.A., Thomas, J.D., Numeric modeling of the cardiovascular system with a left ventricular assist device (1999) ASAIO J, 45, pp. 83-89
Pantalos, G.M., Sharp, M.K., Woodruff, S.J., Influence of gravity on cardiac performance (1998) Ann Biomed Eng, 26, pp. 931-943
Bowles, C.T., Shah, S.S., Nishimura, K., Development of mock circulation models for the assessment of counter pulsation systems (1991) Cardiovasc Res, 11, pp. 901-908
Schima, H., Baumgartner, H., Spitaler, F., Kuhn, P., Wolner, E., A modular mock circulation for hydromechanical studies on valves, stenoses, vascular grafts and cardiac assist devices (1992) Int J Artif Organs, 15, pp. 417-421
Knierbein, B., Reul, H., Eilers, R., Lange, M., Kaufmann, R., Rau, C., Compact mock loops of the systemic and pulmonary circulation for blood pump testing (1992) Int J Artif Organs, 15, pp. 40-48
Woodard, J.C., Rock, S.M., Portner, P.M., A sophisticated electromechanical ventricular simulator for ventricular assist system testing (1991) ASAIO Trans, 37, pp. M210-M211
Mihaylov, D., Rakhorst, G., Van Der Plaats, A., In vivo and in vitro experience with the PUCA-II, a single-valved pulsatile catheter-pump (2000) Int J Artif Organs, 23, pp. 697-702
Clemente, F., Ferrari, G., De Lazzari, C., Tosti, G., Technical standards for medical devices: Assisted circulation devices (1997) Technology and Health Care, 5, pp. 19-34
Sagawa, K., Maughan, L., Suga, H., Sunagawa, K., (1988) Cardiac Contraction and the Pressure-Volume Relationship, , New York: Oxford University Press
Ferrari, G., Kozarski, M., De Lazzari, C., A hybrid (numerical-physical) model of the left ventricle (2001) Int J Artif Organs, 24, pp. 456-462
Donovan F.M., Jr., Design of a hydraulic analog of the circulatory system for evaluating artificial hearts (1975) Biomaterials Med Devices Artif Organs, 3, pp. 439-449
Rosenberg, G., Phillips, W.M., Landis, D.L., Pierce, W.S., Design and evaluation of the Pennsylvania State University mock circulatory system (1981) ASAIO J, 4, pp. 41-49
Gilbert, J.C., Glantz, S.A., Determinants of left ventricular filling and of the diastolic pressure-volume relation (1989) Circ Res, 64, pp. 827-852
Westerhof, N., Elzinga, G., Sipkema, P., An artificial arterial system for pumping hearts (1971) J Appl Physiol, 31, pp. 776-781
Mitra, S.K., (1969) Analysis and Synthesis of Linear Active Networks, , New York: John Wiley & Sons
Ferrari, G., Górczyńska, K., De Lazzari, C., Evaluation of influence of LVAD assistance on haemodynamics and ventricular energetics in closed-loop mock circulatory system (1998) Biocybernetics and Biomedical Engineering, 18, pp. 19-34
Geertsema, A. A., Rakhorst, G., Mihaylov, D., Blanksma, P. K., Verkerke, G. J., Development of a numerical simulation model of the cardiovascular system (1997) Int J Artif Organs, 21, pp. 1297-130
Pantalos, G. M., Sharp, M. K., Woodruff, S. J., Influence of gravity on cardiac performance (1998) Ann Biomed Eng, 26, pp. 931-943
Bowles, C. T., Shah, S. S., Nishimura, K., Development of mock circulation models for the assessment of counter pulsation systems (1991) Cardiovasc Res, 11, pp. 901-908
Woodard, J. C., Rock, S. M., Portner, P. M., A sophisticated electromechanical ventricular simulator for ventricular assist system testing (1991) ASAIO Trans, 37, pp. M210-M211
Donovan F. M., Jr., Design of a hydraulic analog of the circulatory system for evaluating artificial hearts (1975) Biomaterials Med Devices Artif Organs, 3, pp. 439-449
Gilbert, J. C., Glantz, S. A., Determinants of left ventricular filling and of the diastolic pressure-volume relation (1989) Circ Res, 64, pp. 827-852
Mitra, S. K., (1969) Analysis and Synthesis of Linear Active Networks, , New York: John Wiley & Sons
Ferrari, G., G rczy ska, K., De Lazzari, C., Evaluation of influence of LVAD assistance on haemodynamics and ventricular energetics in closed-loop mock circulatory system (1998) Biocybernetics and Biomedical Engineering, 18, pp. 19-34
Mock circulatory systems are used to test mechanical assist devices and for training and research purposes; when compared to numerical models, however, they are not flexible enough and rather expensive. The concept of merging numerical and physical models, resulting in a hybrid one, is applied here to represent the input impedance of the systemic arterial tree, by a conventional windkessel model built out of an electro-hydraulic (E-H) impedance simulator added to a hydraulic section. This model is inserted into an open loop circuit, completed by another hybrid model representing the ventricular function. The E-H impedance simulator is essentially an electrically controlled flow source (a gear pump). Referring to the windkessel model, it is used to simulate the peripheral resistance and the hydraulic compliance, creating the desired input impedance. The data reported describe the characterisation of the E-H impedance simulator and demonstrate its behaviour when it is connected to a hybrid ventricular model. Experiments were performed under different hemodynamic conditions, including the presence of a left ventricular assist device (LVAD).
7 Records (6 escludendo Abstract e Conferenze). Impact factor totale: 17.204 (15.171 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 13.702 (11.687 escludendo Abstract e Conferenze).
ibb.cnr.it