Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback
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Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (128 visite)

Mucci A, Dima D, Soricelli A, Volpe U, Bucci P, Frangou S, Prinster A, Salvatore M, Galderisi S, Maj M

Psychol Med (ISSN: 0033-2917), 2015 Jan 12; 45(8): 1765-1778.



Tipo di articolo: Journal Article,

Impact factor: 5.491, Impact factor a 5 anni: 5.969

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988258835&doi=10.1017%2fS0033291714002943&partnerID=40&md5=88fcadffbf1b15b682071af5b065f619

Parole chiave: Avolition, Deficit Schizophrenia, Dorsal Caudate, Reward Anticipation, Ventral Striatum, Adaptive Behavior, Adult, Brain, Brain Mapping, Female, Human, Motivation, Nuclear Magnetic Resonance Imaging, Pathophysiology, Psychological, Feedback,

Affiliazioni:

*** IBB - CNR ***
Department of Psychiatry,University of Naples SUN,Naples,Italy.
Psychosis Research Program,Department of Psychiatry,Icahn School of Medicine at Mount SinaiNew York,USA.
Biostructure and Bioimaging Institute,National Research Council,Naples,Italy.
Department of Biomorphological and Functional Studies,University of Naples 'Federico II',Naples,Italy.
MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, King's College London, United Kingdom


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Background The neurobiological underpinnings of avolition in schizophrenia remain unclear. Most brain imaging research has focused on reward prediction deficit and on ventral striatum dysfunction, but findings are not consistent. In the light of accumulating evidence that both ventral striatum and dorsal caudate play a key role in motivation, we investigated ventral striatum and dorsal caudate activation during processing of reward or loss in patients with schizophrenia. Method We used functional magnetic resonance imaging to study brain activation during a Monetary Incentive Delay task in patients with schizophrenia, treated with second-generation antipsychotics only, and in healthy controls (HC). We also assessed the relationships of ventral striatum and dorsal caudate activation with measures of hedonic experience and motivation. Results The whole patient group had lower motivation but comparable hedonic experience and striatal activation than HC. Patients with high avolition scores showed lower dorsal caudate activation than both HC and patients with low avolition scores. A lower dorsal caudate activation was also observed in patients with deficit schizophrenia compared to HC and patients with non-deficit schizophrenia. Dorsal caudate activity during reward anticipation was significantly associated with avolition, but not with anhedonia in the patient group. Conclusions These findings suggest that avolition in schizophrenia is linked to dorsal caudate hypoactivation. © Cambridge University Press 2015.
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Impact Factor: 2.315
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (194 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
Impact Factor: 4.101
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Landmann C, Dehaene S, Pappata S, Jobert A, Bottlaender M, Roumenov D, Le Bihan D
* Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task (163 visite)
Cereb Cortex (ISSN: 1047-3211), 2007 Apr; 17(4): 749-759.
Impact Factor: 6.519
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Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (190 visite) (PDF 147 visite)
J Neuroimaging (ISSN: 1051-2284), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
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Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL, Salvatore M, Bonavita V, Alfano B
* Brain atrophy and lesion load in a large population of patients with multiple sclerosis (198 visite) (PDF 170 visite)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2005 Jul 26; 65(2): 280-285.
Impact Factor: 5.065
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Buffon F, Molko N, Hervé D, Porcher R, Denghien I, Pappata S, Le Bihan D, Bousser MG, Chabriat H
* Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts (118 visite)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 0271-678xlinking), 2005 May; 25(5): 641-650.
Impact Factor: 4.786
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Galderisi S, Mucci A, Quarantelli M, Volpe U, Amati G, Alfano B, Maj M
* Structural and functional brain imaging findings in deficit and nondeficit schizophrenia (121 visite)
International Journal Of Neuropsychopharmacology (ISSN: 1461-1457), 2004 Jun; 7: N/D-N/D.
Impact Factor: 4.128
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Galderisi S, Del Zompo M, Invernizzi G, Pini S, Quarantelli M, Rossi A, Cassano P, Severino G, Stratta P, Vita A, Volpe U, Salvatore M, Maj M
* MRI, neuropsychological and genetic findings in deficit and non-deficit schizophrenia: A multicentre study (116 visite)
Eur Psychiat (ISSN: 0924-9338), 2004 Apr; 19: N/D-N/D.
Impact Factor: 1.191
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Amato U, Larobina M, Antoniadis A, Alfano B
* Segmentation of magnetic resonance brain images through discriminant analysis (287 visite) (PDF 151 visite)
J Neurosci Methods (ISSN: 0165-0270, 0165-0270linking, 1872-678xelectronic), 2003 Dec 30; 131(1-2): 65-74.
Impact Factor: 1.777
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Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (208 visite) (PDF 147 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2003 Feb; 18(2): 360-366.
Impact Factor: 6.192
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Pappata S, Dehaene S, Poline JB, Gregoire MC, Jobert A, Delforge J, Frouin V, Bottlaender M, Dolle F, Di Giamberardino L, Syrota A
* In Vivo detection of striatal dopamine release during reward: A PET study with [11C]raclopride and a single dynamic scan approach (163 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 16(4): 1015-1027.
Impact Factor: 5.624
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Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
* Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia (172 visite) (PDF 125 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 17(1): 373-384.
Impact Factor: 5.624
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Brunetti A, Tedeschi G, Di Costanzo A, Covelli EM, Aloj L, Bonavita S, Ciarmiello A, Alfano B, Salvatore M
White matter lesion detection in multiple sclerosis: Improved interobserver concordance with multispectral MRI display (164 visite) (PDF 142 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1997 Sep; 244(9): 586-590.
Impact Factor: 1.976
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Alfano B, Brunetti A
Advances in brain imaging: A new ethical challenge (120 visite) (PDF 198 visite)
Ann Ist Super Sanita (ISSN: 0021-2571), 1997; 33(4): 483-488.
Impact Factor: 0.343
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35 Records (30 escludendo Abstract e Conferenze).
Impact factor totale: 166.48 (154.188 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 184.775 (168.873 escludendo Abstract e Conferenze).







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