Parole chiave: Artificial Amino Acid, Light Scattering,
*** IBB - CNR *** Department of Pharmaceutical Chemistry, Yerevan State University, 1 A. Manoogian Str., Yerevan, 0025, Armenia Istituto di Biostrutture E Bioimmagini, CNR, Via Mezzocannone 16, Naples, I-80134, Italy Dipartimento di Scienze Chimiche, Università di Napoli 'Federico II', Naples, 80126, Italy Istituto Per L'Ambiente Marino Costiero, CNR, Calata Porta di Massa, Naples, 80133, Italy
In this work, we report the asymmetric synthesis and characterization of an artificial amino acid based on triazolyl-thione l-alanine, which was modified with a thiophenyl-substituted moiety, as well as in vitro studies of its nucleic acid-binding ability. We found, by dynamic light scattering studies, that the synthetic amino acid was able to form supramolecular aggregates having a hydrodynamic diameter higher than 200 nm. Furthermore, we demonstrated, by UV and CD experiments, that the heteroaromatic amino acid, whose enzymatic stability was demonstrated by HPLC analysis also after 24 h of incubation in human serum, was able to bind a RNA complex, which is a feature of biomedical interest in view of innovative antiviral strategies based on modulation of RNA-RNA molecular recognition.
25 Records (25 escludendo Abstract e Conferenze). Impact factor totale: 87.457 (87.457 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 89.511 (89.511 escludendo Abstract e Conferenze).