Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients (645 views visite)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1985; 28(3): 241-244.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 1.219, 5-year impact factor Impact factor a 5 anni: 2.258
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0021884255&partnerID=40&md5=46d0365529b4b6e62e0d5c970c241b8b
Keywords Parole chiave: Antihypertensive Treatment, Hydrochlorothiazide + Amiloride, Hypertensive Patients, Muzolimine, Serum Potassium, Side-Effects, Hypertensive Agent, New Drug, Placebo, Adverse Drug Reaction, Blood Pressure, Cardiovascular System, Clinical Trial, Controlled Study, Drug Comparison, Drug Efficacy, Drug Therapy, Drug Tolerance, Human, Human Experiment, Methodology, Oral Drug Administration, Potassium Blood Level, Priority Journal, Adult, Drug Combinations, Female, Lipids, Middle Aged, Pyrazines, Pyrazoles,
Affiliations Affiliazioni:
Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy
Medical Department, Bayer Italia S.p.A., Italy
References Riferimenti:
Not available. Non disponibili.
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1985; 28(3): 241-244.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.219, 5-year impact factor Impact factor a 5 anni: 2.258
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0021884255&partnerID=40&md5=46d0365529b4b6e62e0d5c970c241b8b
Keywords Parole chiave: Antihypertensive Treatment, Hydrochlorothiazide + Amiloride, Hypertensive Patients, Muzolimine, Serum Potassium, Side-Effects, Hypertensive Agent, New Drug, Placebo, Adverse Drug Reaction, Blood Pressure, Cardiovascular System, Clinical Trial, Controlled Study, Drug Comparison, Drug Efficacy, Drug Therapy, Drug Tolerance, Human, Human Experiment, Methodology, Oral Drug Administration, Potassium Blood Level, Priority Journal, Adult, Drug Combinations, Female, Lipids, Middle Aged, Pyrazines, Pyrazoles,
Affiliations Affiliazioni:
Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy
Medical Department, Bayer Italia S.p.A., Italy
References Riferimenti:
Not available. Non disponibili.
Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients
Thiazide therapy is a widely used first line treatment for arterial hypertension. Its useful value, particularly in mild or moderate hypertension, is sometimes reduced by metabolic side-effects, as hypokalaemia and hyperuricaemia. In the present study the antihypertensive efficacy of a new, non-sulphonamide diuretic Bay g 2821 (muzolimine) was evaluated in comparison with the combination of hydrochlorothiazide-amiloride over a period of 4 weeks. A highly significant decrease in systolic and diastolic blood pressures was produced by both treatments. No decrease in serum potassium nor an increase in cholesterol, triglycerides, uric acid or glucose was detected during the 4 week treatment period. Subjective side-effects, such as headache and dizziness, were very rarely observed during Bay g 2821 treatment. The new diuretic appears, therefore, to be effective in the treatment of arterial hypertension without untoward side-effects. © 1985 Springer-Verlag.
Thiazide therapy is a widely used first line treatment for arterial hypertension. Its useful value, particularly in mild or moderate hypertension, is sometimes reduced by metabolic side-effects, as hypokalaemia and hyperuricaemia. In the present study the antihypertensive efficacy of a new, non-sulphonamide diuretic Bay g 2821 (muzolimine) was evaluated in comparison with the combination of hydrochlorothiazide-amiloride over a period of 4 weeks. A highly significant decrease in systolic and diastolic blood pressures was produced by both treatments. No decrease in serum potassium nor an increase in cholesterol, triglycerides, uric acid or glucose was detected during the 4 week treatment period. Subjective side-effects, such as headache and dizziness, were very rarely observed during Bay g 2821 treatment. The new diuretic appears, therefore, to be effective in the treatment of arterial hypertension without untoward side-effects. © 1985 Springer-Verlag.
Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients
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Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients
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Dettagli Esporta in BibTeX Esporta in EndNote
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Dettagli Esporta in BibTeX Esporta in EndNote
Cuocolo A, Esposito S, Volpe M, Celentano L, Brunetti A, Salvatore M
Renal artery stenosis detection by combined Gates' technique and captopril test in hypertensive patients (238 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1989; 30(1): 51-56.
Impact Factor: 3.491
Dettagli Esporta in BibTeX Esporta in EndNote
Ferrara LA, Marotta T, Fasano ML, Pasanisi F, Mancini M, Soro S
Relationship Between Characteristics Of Patients And Changes In Blood Pressure During Antihypertensive Treatment (186 visite)
Third European Meeting On Hypertension Milan Italy, 1987; N/D: 168-168.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Mancini M, Pisanti N, Capone D, Fasano ML, Ferrara LA
Salt Intake And Sympathetic Responsiveness In Hypertensive Patients (184 visite)
International Symposium On Nutritional And Metabolic Aspect Of Arterial Hypertension Anacapri, 1985 Apr; N/D: N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Strazzullo P, Ferrara LA, Galletti F, Mancini M, Mastranzo P
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Recent Advances In Diuretic Therapy Andreucci Ve Ed Excerpta Medica, 1983; N/D: 328-334.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
20 Records (15 escludendo Abstract e Conferenze).
Impact factor totale: 46.861 (43.688 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 52.171 (48.988 escludendo Abstract e Conferenze).
Impact factor totale: 46.861 (43.688 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 52.171 (48.988 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Massimiliano Sorbillo on in data Sunday 12 July 2020, 13:15:17
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