Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients
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Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients (86 visite)

Ferrara LA, Strazzullo P, Scillitani A, Mancini M, Gagliardi R

Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1985; 28(3): 241-244.



Tipo di articolo: Journal Article,

Impact factor: 1.219, Impact factor a 5 anni: 2.258

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0021884255&partnerID=40&md5=46d0365529b4b6e62e0d5c970c241b8b

Parole chiave: Antihypertensive Treatment, Hydrochlorothiazide + Amiloride, Hypertensive Patients, Muzolimine, Serum Potassium, Side-Effects, Hypertensive Agent, New Drug, Placebo, Adverse Drug Reaction, Blood Pressure, Cardiovascular System, Clinical Trial, Controlled Study, Drug Comparison, Drug Efficacy, Drug Therapy, Drug Tolerance, Human, Human Experiment, Methodology, Oral Drug Administration, Potassium Blood Level, Priority Journal, Adult, Drug Combinations, Female, Lipids, Middle Aged, Pyrazines, Pyrazoles,

Affiliazioni:

Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy
Medical Department, Bayer Italia S.p.A., Italy


Riferimenti:

Non disponibile.

Thiazide therapy is a widely used first line treatment for arterial hypertension. Its useful value, particularly in mild or moderate hypertension, is sometimes reduced by metabolic side-effects, as hypokalaemia and hyperuricaemia. In the present study the antihypertensive efficacy of a new, non-sulphonamide diuretic Bay g 2821 (muzolimine) was evaluated in comparison with the combination of hydrochlorothiazide-amiloride over a period of 4 weeks. A highly significant decrease in systolic and diastolic blood pressures was produced by both treatments. No decrease in serum potassium nor an increase in cholesterol, triglycerides, uric acid or glucose was detected during the 4 week treatment period. Subjective side-effects, such as headache and dizziness, were very rarely observed during Bay g 2821 treatment. The new diuretic appears, therefore, to be effective in the treatment of arterial hypertension without untoward side-effects. © 1985 Springer-Verlag.
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