Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol
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Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol (60 visite)

Ferrara LA, Mancini M, Marotta T, Pasanisi F, Fasano ML

Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1986; 29(6): 717-719.



Tipo di articolo: Journal Article,

Impact factor: 1.219, Impact factor a 5 anni: 2.258

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0022651542&partnerID=40&md5=3511ea7ddcf9866e5792683417b00aef

Parole chiave: Antihypertensive Activity, Cyclo-Oxygenase, Drug Interaction, Drug Metabolizing Enzymes, Oxprenolol, Prostaglandins, Sulphinpyrazone, Placebo, Sulfinpyrazone, Adverse Drug Reaction, Blood Pressure, Cardiovascular System, Clinical Article, Drug Therapy, Heart, Heart Rate, Human, Oral Drug Administration, Priority Journal, Adult, Cardiac Output, Clinical Trials, Double-Blind Method, Female, Middle Aged, Random Allocation,

Affiliazioni:

Clinica Medica, Institute of Internal Medicine and Internal Diseases, 2nd Medical School, University of Naples, Naples, Italy


Riferimenti:

Non disponibile.

The interfering effect of sulphinpyrazone, a uricosuric agent which reduces the activity of cyclo-oxygenase, with the antihypertensive activity of oxprenolol, a non-cardioselective beta-blocker with sympathomimetic activity, has been evaluated. Ten patients with primary arterial hypertension of mild to moderate degree entered a randomized doubleblind cross-over study versus placebo. They were given oxprenolol + placebo or oxprenolol + sulphinpyrazone for 15 days, and then the treatments were crossed-over for a further 15 days. Oxprenolol significantly reduced blood pressure (161±3/101±1 vs 149±4/96±2 mmHg) and heart rate (72±3 vs 66±3 beats/min). During administration of the combination with sulphinpyrazone the blood pressure increased to its pretreatment level (156±5/101±2 mmHg). The effect of oxprenolol on heart rate was not influenced by the combined treatment (67±6 beats/min). The results may be explained by 1) sulphinpyrazone-induced inhibition of prostaglandin synthesis, which could interfere with the antihypertensive activity of oxprenolol, or 2) sulphinpyrazone-induced acceleration of the metabolism of oxprenolol. © 1986 Springer-Verlag.
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