Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol (838 views visite)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1986; 29(6): 717-719.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 1.219, 5-year impact factor Impact factor a 5 anni: 2.258
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0022651542&partnerID=40&md5=3511ea7ddcf9866e5792683417b00aef
Keywords Parole chiave: Antihypertensive Activity, Cyclo-Oxygenase, Drug Interaction, Drug Metabolizing Enzymes, Oxprenolol, Prostaglandins, Sulphinpyrazone, Placebo, Sulfinpyrazone, Adverse Drug Reaction, Blood Pressure, Cardiovascular System, Clinical Article, Drug Therapy, Heart, Heart Rate, Human, Oral Drug Administration, Priority Journal, Adult, Cardiac Output, Clinical Trials, Double-Blind Method, Female, Middle Aged, Random Allocation,
Affiliations Affiliazioni:
Clinica Medica, Institute of Internal Medicine and Internal Diseases, 2nd Medical School, University of Naples, Naples, Italy
References Riferimenti:
Not available. Non disponibili.
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1986; 29(6): 717-719.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.219, 5-year impact factor Impact factor a 5 anni: 2.258
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0022651542&partnerID=40&md5=3511ea7ddcf9866e5792683417b00aef
Keywords Parole chiave: Antihypertensive Activity, Cyclo-Oxygenase, Drug Interaction, Drug Metabolizing Enzymes, Oxprenolol, Prostaglandins, Sulphinpyrazone, Placebo, Sulfinpyrazone, Adverse Drug Reaction, Blood Pressure, Cardiovascular System, Clinical Article, Drug Therapy, Heart, Heart Rate, Human, Oral Drug Administration, Priority Journal, Adult, Cardiac Output, Clinical Trials, Double-Blind Method, Female, Middle Aged, Random Allocation,
Affiliations Affiliazioni:
Clinica Medica, Institute of Internal Medicine and Internal Diseases, 2nd Medical School, University of Naples, Naples, Italy
References Riferimenti:
Not available. Non disponibili.
Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol
The interfering effect of sulphinpyrazone, a uricosuric agent which reduces the activity of cyclo-oxygenase, with the antihypertensive activity of oxprenolol, a non-cardioselective beta-blocker with sympathomimetic activity, has been evaluated. Ten patients with primary arterial hypertension of mild to moderate degree entered a randomized doubleblind cross-over study versus placebo. They were given oxprenolol + placebo or oxprenolol + sulphinpyrazone for 15 days, and then the treatments were crossed-over for a further 15 days. Oxprenolol significantly reduced blood pressure (161±3/101±1 vs 149±4/96±2 mmHg) and heart rate (72±3 vs 66±3 beats/min). During administration of the combination with sulphinpyrazone the blood pressure increased to its pretreatment level (156±5/101±2 mmHg). The effect of oxprenolol on heart rate was not influenced by the combined treatment (67±6 beats/min). The results may be explained by 1) sulphinpyrazone-induced inhibition of prostaglandin synthesis, which could interfere with the antihypertensive activity of oxprenolol, or 2) sulphinpyrazone-induced acceleration of the metabolism of oxprenolol. © 1986 Springer-Verlag.
The interfering effect of sulphinpyrazone, a uricosuric agent which reduces the activity of cyclo-oxygenase, with the antihypertensive activity of oxprenolol, a non-cardioselective beta-blocker with sympathomimetic activity, has been evaluated. Ten patients with primary arterial hypertension of mild to moderate degree entered a randomized doubleblind cross-over study versus placebo. They were given oxprenolol + placebo or oxprenolol + sulphinpyrazone for 15 days, and then the treatments were crossed-over for a further 15 days. Oxprenolol significantly reduced blood pressure (161±3/101±1 vs 149±4/96±2 mmHg) and heart rate (72±3 vs 66±3 beats/min). During administration of the combination with sulphinpyrazone the blood pressure increased to its pretreatment level (156±5/101±2 mmHg). The effect of oxprenolol on heart rate was not influenced by the combined treatment (67±6 beats/min). The results may be explained by 1) sulphinpyrazone-induced inhibition of prostaglandin synthesis, which could interfere with the antihypertensive activity of oxprenolol, or 2) sulphinpyrazone-induced acceleration of the metabolism of oxprenolol. © 1986 Springer-Verlag.
Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol
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Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol
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Impact Factor: 2.019
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Lauceri R, Purrello R, Shetty SJ, Vicente MGH
* Interactions of anionic carboranylated porphyrins with DNA [3] (276 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
Impact Factor: 6.079
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Ferrara LA, Iannuzzi R, Gaeta I, Mancini M, Guida L, Marotta T
Left ventricular hypertrophy and hypertension (319 visite)
Clin Exp Hypertens Informa Healthcare, 1996 Jul; 15(6): 1025-1032.
Impact Factor: 0
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (289 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Ferrara LA, Marotta T, Mancini Marcello, Fasano ML, Pasanisi F, Mancini M
Sulphinpyrazone-Induced Decrease In Antihypertensive Activity Of Beta-Blockers (148 visite)
Second European Meeting On Hypertension Milan, 1985 Dec; N/D: 171-171.
Impact Factor: 0
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Ferrara LA, Strazzullo P, Scillitani A, Mancini M, Gagliardi R
Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients (645 visite)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1985; 28(3): 241-244.
Impact Factor: 1.219
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De Simone G, Fasano ML, Di Lorenzo L, Lauria R, Russo L, Mancini M, Ferrara LA
Slow-Release Nifedipine Versus Placebo In The Treatment Of Arterial Hypertension (201 visite)
5th International Meeting Atherosclerosis And Cardiovascular Diseases Bologna, 1983; N/D: 176-176.
Impact Factor: 0
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1145 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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28 Records (22 escludendo Abstract e Conferenze).
Impact factor totale: 94.775 (73.828 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.967 (77.44 escludendo Abstract e Conferenze).
Impact factor totale: 94.775 (73.828 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.967 (77.44 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Massimiliano Sorbillo on in data Sunday 12 July 2020, 13:15:17
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