Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS(120 visite) Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
Novel benzyl- and phenyl-isothioureidic derivatives have been synthesised and evaluated as inhibitors of nitric oxide synthesis. induced in lipopolysaccharide (LPS)-activated J774.A1 macrophage cell line. The most potent iNOS inhibitor resulting was 1-methyl-3-phenyl-S-methyl isothiourea 5I. (C) 2004 Elsevier Ltd. All rights reserved.
56 Records (54 escludendo Abstract e Conferenze). Impact factor totale: 272.425 (252.076 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 289.023 (260.564 escludendo Abstract e Conferenze).