Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity (214 views visite)
Arkivoc (ISSN: 1424-6376), 2006; 6(VIII): 24-37.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 0.8, 5-year impact factor Impact factor a 5 anni: 1.221
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33744470562&partnerID=40&md5=736f517cf4e92d098c00f595b4211328
Keywords Parole chiave: Acetylation, Chromatin Remodelling, Gcn5, Yeast,
Affiliations Affiliazioni:
*** IBB - CNR ***
Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy
Dipartimento di Genetica e Biologia Molecolare, Universit degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy
Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, via Ponte Don Melillo, 84084 Fisciano (SA), Italy
Dipartimento di Patologia Generale, Seconda Universit degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy
Centro di Oncogenomica AIRC, CEINGE Biotecnologia Avanzata, Napoli, Italy
Istituto di Biologia e Patologia Molecolari CNR, Dip. Genetica e Biologia Molecolare, Universit degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy
References Riferimenti:
Davie, J.R., (1998) Curr. Opin. Genet. Dev., 8, p. 17
Kouzarides, T., (1999) Curr. Opin. Genet. Dev., 9, p. 40
Strahl, B.D., Allis, C.D., (2000) Nature, 403, p. 41
Pazin, M.J., Kadonaga, J.T., (1997) Cell, 89, p. 325
Glass, C.K., Rosenfeld, M.G., (2000) Genes Dev., 14, p. 121
Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., Richmond, T.J., (1998) Nature, 389, p. 251
Urnov, F.D., Wolffe, A., (2000) Emerg. Ther. Targets, 4, p. 665
Fischle, W., Wang, Y., Allis, C.D., (2003) Curr. Opin. Cell Biol., 15, p. 172
Akey, C.W., Luger, K., (2003) Curr. Opin. Struc. Biol., 13, p. 6
Roth, S.Y., Denu, J.M., Allis, C.D., (2001) Annu. Rev. Biochem., 70, p. 81
Sterner, D.E., Berger, S.L., (2000) Microbiol. Mol. Biol. Rev., 64, p. 435
Marmorstein, R., (2001) J. Mol. Biol., 311, p. 433
Schiltz, R.L., Mizzen, C.A., Vassilev, A., Cook, R.G., Allis, C.D., Nakatani, Y., (1999) J. Biol. Chem., 274, p. 1189
Lau, O.D., Courtney, A.D., Vassilev, A., Marzilli, L.A., Cotter, R.J., Nakatani, Y., Cole, P.A., (2000) J. Biol. Chem., 275, p. 21953
Grant, P.A., Duggan, L., Cote, J., Roberts, S.M., Brownell, J.E., Candau, R., Ohba, R., Workman, J.L., (1997) Genes Dev., 11, p. 1640
Grant, P.A., Eberharter, A., John, S., Cook, R.G., Turner, B.M., Workman, J.L., (1999) J. Biol. Chem., 274, p. 5895
Mai, A., Massa, S., Rotili, D., Cerbara, I., Valente, S., Pezzi, R., Simeoni, S., Ragno, R., (2005) Med. Res. Rev., 25, p. 261
Minucci, S., Pelicci, P.G., (2006) Nat. Rev. Cancer, 6, p. 38
Muraoka, M., Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Shitara, N., Chong, J.M., Iwama, T., Miyaki, M., (1996) Oncogene, 12, p. 1565
Sakakura, C., Hagiwara, A., Yasuoka, R., Fujita, Y., Nakanishi, M., Masuda, K., Kimura, A., Yamagishi, H., (2000) Int. J. Cancer, 89, p. 217
Puri, P.L., Sartorelli, V., Yang, X.J., Hamamori, Y., Ogryzko, V.V., Howard, B.H., Kedes, L., Levrero, M., (1997) Mol. Cell, 1, p. 35
Lehrmann, H., Pritchard, L.L., Harel-Bellan, A., (2002) Adv. Cancer Res., 86, p. 41
Zheng, Y., Thompson, P.R., Cebrat, M., Wang, L., Devlin, M.K., Alani, R.M., Cole, P.A., (2004) Methods Enzymol., 376, p. 188
Lau, O.D., Kundu, T.K., Soccio, R.E., Ait-Si-Ali, S., Khalil, E.M., Vassilev, A., Wolffe, A.P., Cole, P.A., (2000) Mol. Cell, 5, p. 589
Balasubramanyam, K., Swaminathan, V., Ranganathan, A., Kundu, T.K., (2003) J. Biol. Chem., 278, p. 19134
Biel, M., Kretsovali, A., Karatzali, E., Papamatheakis, J., Giannis, A., (2004) Angew. Chem. Int. Ed., 43, p. 3974
Stimson, L., Rowlands, M.G., Newbatt, Y.M., Smith, N.F., Raynaud, F.I., Rogers, P., Bavetsias, V., Aherne, G.W., (2005) Mol. Cancer Ther., 4, p. 1521
Massa, S., Mai, A., Sbardella, G., Esposito, M., Ragno, R., Loidl, P., Brosch, G., (2001) J. Med. Chem., 44, p. 2069
Ragno, R., Mai, A., Massa, S., Cerbara, I., Valente, S., Bottoni, P., Scatena, R., Brosch, G., (2004) J. Med. Chem., 47, p. 1351
Warrell Jr., R.P., Frankel, S.R., Miller Jr., W.H., Scheinberg, D.A., Itri, L.M., Hittelman, W.N., Vyas, R., Jakubowski, A.N., (1991) Engl. J. Med., 324, p. 1385
Han, J.W., Ahn, S.H., Park, S.H., Wang, S.Y., Bae, G.U., Seo, D.W., Known, H.K., Lee, H.W., (2000) Cancer Res., 60, p. 6068
Shute, R.E., Dunlap, B., Rich, D.H., (1987) J. Med. Chem., 30, p. 71
Ornaghi, P., Rotili, D., Sbardella, G., Mai, A., Filetici, P., (2005) Biochem. Pharmacol., 70, p. 911
Diana, G.D., McKinlay, M.A., Otto, M.J., Akullian, V., Oglesby, C., (1985) J. Med. Chem., 28, p. 1906
Ladner, D.W., (1986) Synthetic Commun., 16, p. 157
Ech-Chahad, A., Minassi, A., Berton, L., Appendino, G., (2005) Tetrahedron Lett., 46, p. 5113
Mori, K., Koseki, K., (1988) Tetrahedron, 44, p. 6013
Nyoung Kim, J., Mi Chung, Y., Jin Im, Y., (2002) Tetrahedron Lett., 43, p. 6209
Ma, Z., Hano, Y., Nomura, T., Chen, Y., (2004) Bioorg. Med. Chem. Lett., 14, p. 1193
Asao, N., Nogami, T., Lee, S., Yamamoto, Y., (2003) J. Amer. Chem. Soc., 125, p. 10921
Howe, L.A., Auston, D., Grant, P., John, S., Cook, R.G., Workman, J.L., Pillus, L., (2001) Genes Dev., 15, p. 3144
Arkivoc (ISSN: 1424-6376), 2006; 6(VIII): 24-37.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 0.8, 5-year impact factor Impact factor a 5 anni: 1.221
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33744470562&partnerID=40&md5=736f517cf4e92d098c00f595b4211328
Keywords Parole chiave: Acetylation, Chromatin Remodelling, Gcn5, Yeast,
Affiliations Affiliazioni:
*** IBB - CNR ***
Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy
Dipartimento di Genetica e Biologia Molecolare, Universit degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy
Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, via Ponte Don Melillo, 84084 Fisciano (SA), Italy
Dipartimento di Patologia Generale, Seconda Universit degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy
Centro di Oncogenomica AIRC, CEINGE Biotecnologia Avanzata, Napoli, Italy
Istituto di Biologia e Patologia Molecolari CNR, Dip. Genetica e Biologia Molecolare, Universit degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy
References Riferimenti:
Davie, J.R., (1998) Curr. Opin. Genet. Dev., 8, p. 17
Kouzarides, T., (1999) Curr. Opin. Genet. Dev., 9, p. 40
Strahl, B.D., Allis, C.D., (2000) Nature, 403, p. 41
Pazin, M.J., Kadonaga, J.T., (1997) Cell, 89, p. 325
Glass, C.K., Rosenfeld, M.G., (2000) Genes Dev., 14, p. 121
Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., Richmond, T.J., (1998) Nature, 389, p. 251
Urnov, F.D., Wolffe, A., (2000) Emerg. Ther. Targets, 4, p. 665
Fischle, W., Wang, Y., Allis, C.D., (2003) Curr. Opin. Cell Biol., 15, p. 172
Akey, C.W., Luger, K., (2003) Curr. Opin. Struc. Biol., 13, p. 6
Roth, S.Y., Denu, J.M., Allis, C.D., (2001) Annu. Rev. Biochem., 70, p. 81
Sterner, D.E., Berger, S.L., (2000) Microbiol. Mol. Biol. Rev., 64, p. 435
Marmorstein, R., (2001) J. Mol. Biol., 311, p. 433
Schiltz, R.L., Mizzen, C.A., Vassilev, A., Cook, R.G., Allis, C.D., Nakatani, Y., (1999) J. Biol. Chem., 274, p. 1189
Lau, O.D., Courtney, A.D., Vassilev, A., Marzilli, L.A., Cotter, R.J., Nakatani, Y., Cole, P.A., (2000) J. Biol. Chem., 275, p. 21953
Grant, P.A., Duggan, L., Cote, J., Roberts, S.M., Brownell, J.E., Candau, R., Ohba, R., Workman, J.L., (1997) Genes Dev., 11, p. 1640
Grant, P.A., Eberharter, A., John, S., Cook, R.G., Turner, B.M., Workman, J.L., (1999) J. Biol. Chem., 274, p. 5895
Mai, A., Massa, S., Rotili, D., Cerbara, I., Valente, S., Pezzi, R., Simeoni, S., Ragno, R., (2005) Med. Res. Rev., 25, p. 261
Minucci, S., Pelicci, P.G., (2006) Nat. Rev. Cancer, 6, p. 38
Muraoka, M., Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Shitara, N., Chong, J.M., Iwama, T., Miyaki, M., (1996) Oncogene, 12, p. 1565
Sakakura, C., Hagiwara, A., Yasuoka, R., Fujita, Y., Nakanishi, M., Masuda, K., Kimura, A., Yamagishi, H., (2000) Int. J. Cancer, 89, p. 217
Puri, P.L., Sartorelli, V., Yang, X.J., Hamamori, Y., Ogryzko, V.V., Howard, B.H., Kedes, L., Levrero, M., (1997) Mol. Cell, 1, p. 35
Lehrmann, H., Pritchard, L.L., Harel-Bellan, A., (2002) Adv. Cancer Res., 86, p. 41
Zheng, Y., Thompson, P.R., Cebrat, M., Wang, L., Devlin, M.K., Alani, R.M., Cole, P.A., (2004) Methods Enzymol., 376, p. 188
Lau, O.D., Kundu, T.K., Soccio, R.E., Ait-Si-Ali, S., Khalil, E.M., Vassilev, A., Wolffe, A.P., Cole, P.A., (2000) Mol. Cell, 5, p. 589
Balasubramanyam, K., Swaminathan, V., Ranganathan, A., Kundu, T.K., (2003) J. Biol. Chem., 278, p. 19134
Biel, M., Kretsovali, A., Karatzali, E., Papamatheakis, J., Giannis, A., (2004) Angew. Chem. Int. Ed., 43, p. 3974
Stimson, L., Rowlands, M.G., Newbatt, Y.M., Smith, N.F., Raynaud, F.I., Rogers, P., Bavetsias, V., Aherne, G.W., (2005) Mol. Cancer Ther., 4, p. 1521
Massa, S., Mai, A., Sbardella, G., Esposito, M., Ragno, R., Loidl, P., Brosch, G., (2001) J. Med. Chem., 44, p. 2069
Ragno, R., Mai, A., Massa, S., Cerbara, I., Valente, S., Bottoni, P., Scatena, R., Brosch, G., (2004) J. Med. Chem., 47, p. 1351
Warrell Jr., R.P., Frankel, S.R., Miller Jr., W.H., Scheinberg, D.A., Itri, L.M., Hittelman, W.N., Vyas, R., Jakubowski, A.N., (1991) Engl. J. Med., 324, p. 1385
Han, J.W., Ahn, S.H., Park, S.H., Wang, S.Y., Bae, G.U., Seo, D.W., Known, H.K., Lee, H.W., (2000) Cancer Res., 60, p. 6068
Shute, R.E., Dunlap, B., Rich, D.H., (1987) J. Med. Chem., 30, p. 71
Ornaghi, P., Rotili, D., Sbardella, G., Mai, A., Filetici, P., (2005) Biochem. Pharmacol., 70, p. 911
Diana, G.D., McKinlay, M.A., Otto, M.J., Akullian, V., Oglesby, C., (1985) J. Med. Chem., 28, p. 1906
Ladner, D.W., (1986) Synthetic Commun., 16, p. 157
Ech-Chahad, A., Minassi, A., Berton, L., Appendino, G., (2005) Tetrahedron Lett., 46, p. 5113
Mori, K., Koseki, K., (1988) Tetrahedron, 44, p. 6013
Nyoung Kim, J., Mi Chung, Y., Jin Im, Y., (2002) Tetrahedron Lett., 43, p. 6209
Ma, Z., Hano, Y., Nomura, T., Chen, Y., (2004) Bioorg. Med. Chem. Lett., 14, p. 1193
Asao, N., Nogami, T., Lee, S., Yamamoto, Y., (2003) J. Amer. Chem. Soc., 125, p. 10921
Howe, L.A., Auston, D., Grant, P., John, S., Cook, R.G., Workman, J.L., Pillus, L., (2001) Genes Dev., 15, p. 3144
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity
Starting from a yeast phenotypic screening performed on 21 chemically different substances we described the discovery of two small molecules as GCN5 inhibitors. The 2-methyl-3-carbethoxyquinoline 9 and its 2-desmethyl analogue 18 were able to significantly reduce the yeast cell growth, thus miming the effect of GCN5 deletion mutant. Tested to evaluate their effect on GCN5-dependent transcription of the HIS3 gene, 9 and 18 showed high inhibitory activity of gene transcription, more evident in activated conditions. Compound 9 was also able to reduce the acetylation levels of H3 and, to a lesser extent, H4 in yeast at 0.6 mM. In human leukemia U937 cells, at 1 mM concentration 9 showed 27% apoptosis induction, while 18 had just a little effect in the same conditions. Further studies on 9 and 18 will be performed to deepen their effects on GCN5-related phenomena.
Starting from a yeast phenotypic screening performed on 21 chemically different substances we described the discovery of two small molecules as GCN5 inhibitors. The 2-methyl-3-carbethoxyquinoline 9 and its 2-desmethyl analogue 18 were able to significantly reduce the yeast cell growth, thus miming the effect of GCN5 deletion mutant. Tested to evaluate their effect on GCN5-dependent transcription of the HIS3 gene, 9 and 18 showed high inhibitory activity of gene transcription, more evident in activated conditions. Compound 9 was also able to reduce the acetylation levels of H3 and, to a lesser extent, H4 in yeast at 0.6 mM. In human leukemia U937 cells, at 1 mM concentration 9 showed 27% apoptosis induction, while 18 had just a little effect in the same conditions. Further studies on 9 and 18 will be performed to deepen their effects on GCN5-related phenomena.
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity
No results. Nessun risultato. |
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity
Lama A, Annunziata C, Coretti L, Pirozzi C, Di Guida F, Nitrato Izzo A, Cristiano C, Mollica MP, Chiariotti L, Pelagalli A, Lembo F, Meli R, Mattace Raso G
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Lama A, Annunziata C, Coretti L, Pirozzi C, Di Guida F, Nitrato Izzo A, Cristiano C, Mollica MP, Chiariotti L, Pelagalli A, Lembo F, Meli R, Mattace Raso G
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Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
* RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer (172 visite)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jun 15; 24(12): 2886-2900.
Impact Factor: 6.488
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (206 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Magrì A, Tabbì G, Giuffrida A, Pappalardo G, Satriano C, Naletova I, Nicoletti VG, Attanasio F
* Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties (200 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016 Aug 27; 164: 59-69.
Impact Factor: 3.348
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Sandomenico A, Focà A, Sanguigno L, Caporale A, Focà G, Pignalosa A, Corvino G, Caragnano A, Beltrami AP, Antoniali G, Tell G, Leonardi A, Ruvo M
* Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen (335 visite) (PDF 204 visite)
Mabs-Austin (ISSN: 1942-0862), 2016 Aug; 8: 1575-1589.
Impact Factor: 4.881
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (338 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (319 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (396 visite)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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Poletto M, Di Loreto C, Marasco D, Poletto E, Puglisi F, Damante G, Tell G
* Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers (324 visite)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2012 Jul 20; 424(1): 34-39.
Impact Factor: 2.406
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (502 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (282 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
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Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (303 visite)
Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
Impact Factor: 7.836
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (456 visite)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (308 visite)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (248 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (368 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E
* Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region (431 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jan; 98(1): 133-143.
Impact Factor: 2.225
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17 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 94.601 (94.601 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 98.127 (98.127 escludendo Abstract e Conferenze).
Impact factor totale: 94.601 (94.601 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 98.127 (98.127 escludendo Abstract e Conferenze).
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