Primary systemic amyloidosis with giant hepatomegaly and a swiftly progressive course (224 views visite)
J Clin Gastroenterol (ISSN: 0192-0790), 1997 Apr; 24(3): 173-175.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 0.936, 5-year impact factor Impact factor a 5 anni: 2.61
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030958389&partnerID=40&md5=dbb52df05e1834fcc9ff67a5981a6314
Keywords Parole chiave: Amyloidosis, Cholestasis, Hepatomegaly, Portal Hypertension, Alkaline Phosphatase, Aminotransferase, Adult, Aminotransferase Blood Level, Article, Ascites, Case Report, Esophagus Varices, Female, Human, Human Tissue, Priority Journal, Biopsy, Intrahepatic, Fatal Outcome, Liver, Liver Function Tests, Middle Aged,
Affiliations Affiliazioni:
Nuclear Medicine Department, University Federico II, Naples, Italy
Gastroenterology Unit, University Federico II, Naples, Italy
Corso Vittorio Emanuele, 670, 80122 Napoli, Italy
References Riferimenti:
Gertz, M.A., Kyle, R.A., Hepatic amyloidosis (primary [AL] immunoglobulin light chain): The natural history in 80 patients (1988) Am J Med, 85, pp. 73-8
Kyle, R.A., Gertz, M.A., Primary systemic amyloidosis: Clinical and laboratory features in 474 cases (1995) Semin Hematol, 32, pp. 45-59
Brandt, K., Cathacart, E.S., Cohen, A.S., A clinical analysis of the course and prognosis of forty-two patients with amyloidosis (1968) Am J Med, 44, pp. 955-969
Kyle, R.A., Greipp, P.R., Amyloidosis (AL): Clinical and laboratory features in 229 cases (1983) Mayo Clin Proc, 58, pp. 665-683
Merlini, G., Treatment of primary amyloidosis (1995) Semin Hematol, 32, pp. 60-79
Serra, L., Poppi, M.C., Criscuolo, M., Zandomenighi, R., Primary systemic amyloidosis with giant hepatomegaly and portal hypertension: A case report and a review of the literature (1993) Ital J Gastroenterol, 25, pp. 435-438
Bion, E., Brenard, R., Pariente, E.A., Sinusoidal portal hypertension in hepatic amyloidosis (1991) Gut, 32, p. 227
Rubinow, A., Koff, R.S., Cohen, A.S., Severe intrahepatic cholestasis in primary amyloidosis: A report of four cases and a review of the literature (1978) Am J Med, 64, pp. 937-946
Levy, M., Fryd, C.H., Eliakim, M., Intrahepatic obstructive jaundice due to amyloidosis of the liver: A case report and a review of the literature (1971) Gastroenterology, 61, pp. 234-238
Itescu, S., Hepatic amyloidosis: An unusual cause of ascites and portal hypertension (1984) Arch Intern Med, 144, pp. 2257-2259
Menke, D.M., Kyle, R.A., Fleming, C.R., Wolfe, J.T., Kurtin, P.J., Oldenburg, W.A., Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis (1993) Mayo Clin Proc, 68, pp. 763-767
Gertz, M. A., Kyle, R. A., Hepatic amyloidosis (primary [AL] immunoglobulin light chain): The natural history in 80 patients (1988) Am J Med, 85, pp. 73-8
Kyle, R. A., Gertz, M. A., Primary systemic amyloidosis: Clinical and laboratory features in 474 cases (1995) Semin Hematol, 32, pp. 45-59
Kyle, R. A., Greipp, P. R., Amyloidosis (AL): Clinical and laboratory features in 229 cases (1983) Mayo Clin Proc, 58, pp. 665-683
Levy, M., Fryd, C. H., Eliakim, M., Intrahepatic obstructive jaundice due to amyloidosis of the liver: A case report and a review of the literature (1971) Gastroenterology, 61, pp. 234-238
Menke, D. M., Kyle, R. A., Fleming, C. R., Wolfe, J. T., Kurtin, P. J., Oldenburg, W. A., Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis (1993) Mayo Clin Proc, 68, pp. 763-767
J Clin Gastroenterol (ISSN: 0192-0790), 1997 Apr; 24(3): 173-175.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 0.936, 5-year impact factor Impact factor a 5 anni: 2.61
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030958389&partnerID=40&md5=dbb52df05e1834fcc9ff67a5981a6314
Keywords Parole chiave: Amyloidosis, Cholestasis, Hepatomegaly, Portal Hypertension, Alkaline Phosphatase, Aminotransferase, Adult, Aminotransferase Blood Level, Article, Ascites, Case Report, Esophagus Varices, Female, Human, Human Tissue, Priority Journal, Biopsy, Intrahepatic, Fatal Outcome, Liver, Liver Function Tests, Middle Aged,
Affiliations Affiliazioni:
Nuclear Medicine Department, University Federico II, Naples, Italy
Gastroenterology Unit, University Federico II, Naples, Italy
Corso Vittorio Emanuele, 670, 80122 Napoli, Italy
References Riferimenti:
Gertz, M.A., Kyle, R.A., Hepatic amyloidosis (primary [AL] immunoglobulin light chain): The natural history in 80 patients (1988) Am J Med, 85, pp. 73-8
Kyle, R.A., Gertz, M.A., Primary systemic amyloidosis: Clinical and laboratory features in 474 cases (1995) Semin Hematol, 32, pp. 45-59
Brandt, K., Cathacart, E.S., Cohen, A.S., A clinical analysis of the course and prognosis of forty-two patients with amyloidosis (1968) Am J Med, 44, pp. 955-969
Kyle, R.A., Greipp, P.R., Amyloidosis (AL): Clinical and laboratory features in 229 cases (1983) Mayo Clin Proc, 58, pp. 665-683
Merlini, G., Treatment of primary amyloidosis (1995) Semin Hematol, 32, pp. 60-79
Serra, L., Poppi, M.C., Criscuolo, M., Zandomenighi, R., Primary systemic amyloidosis with giant hepatomegaly and portal hypertension: A case report and a review of the literature (1993) Ital J Gastroenterol, 25, pp. 435-438
Bion, E., Brenard, R., Pariente, E.A., Sinusoidal portal hypertension in hepatic amyloidosis (1991) Gut, 32, p. 227
Rubinow, A., Koff, R.S., Cohen, A.S., Severe intrahepatic cholestasis in primary amyloidosis: A report of four cases and a review of the literature (1978) Am J Med, 64, pp. 937-946
Levy, M., Fryd, C.H., Eliakim, M., Intrahepatic obstructive jaundice due to amyloidosis of the liver: A case report and a review of the literature (1971) Gastroenterology, 61, pp. 234-238
Itescu, S., Hepatic amyloidosis: An unusual cause of ascites and portal hypertension (1984) Arch Intern Med, 144, pp. 2257-2259
Menke, D.M., Kyle, R.A., Fleming, C.R., Wolfe, J.T., Kurtin, P.J., Oldenburg, W.A., Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis (1993) Mayo Clin Proc, 68, pp. 763-767
Gertz, M. A., Kyle, R. A., Hepatic amyloidosis (primary [AL] immunoglobulin light chain): The natural history in 80 patients (1988) Am J Med, 85, pp. 73-8
Kyle, R. A., Gertz, M. A., Primary systemic amyloidosis: Clinical and laboratory features in 474 cases (1995) Semin Hematol, 32, pp. 45-59
Kyle, R. A., Greipp, P. R., Amyloidosis (AL): Clinical and laboratory features in 229 cases (1983) Mayo Clin Proc, 58, pp. 665-683
Levy, M., Fryd, C. H., Eliakim, M., Intrahepatic obstructive jaundice due to amyloidosis of the liver: A case report and a review of the literature (1971) Gastroenterology, 61, pp. 234-238
Menke, D. M., Kyle, R. A., Fleming, C. R., Wolfe, J. T., Kurtin, P. J., Oldenburg, W. A., Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis (1993) Mayo Clin Proc, 68, pp. 763-767
Primary systemic amyloidosis with giant hepatomegaly and a swiftly progressive course
Although the involvement of the liver is common in systemic amyloidosis (AL), clinical features of hepatic dysfunction and liver chemistry abnormalities are often mild or absent. A mild increase in the serum alkaline phosphatase value is the most common finding. Hypertransaminasemia, hyperbilirubinemia, and portal hypertension with ascites and gastroesophageal varices occur late in the course of the disease and predict a short survival. We describe the case of a 58-year-old woman with AL, whose dramatic and unusual clinical picture, consisting of giant hepatomegaly, hypertransaminasemia, increase in alkaline phosphatase, esophageal varices, and ascites, was rapidly complicated by severe obstructive cholestasis.
Although the involvement of the liver is common in systemic amyloidosis (AL), clinical features of hepatic dysfunction and liver chemistry abnormalities are often mild or absent. A mild increase in the serum alkaline phosphatase value is the most common finding. Hypertransaminasemia, hyperbilirubinemia, and portal hypertension with ascites and gastroesophageal varices occur late in the course of the disease and predict a short survival. We describe the case of a 58-year-old woman with AL, whose dramatic and unusual clinical picture, consisting of giant hepatomegaly, hypertransaminasemia, increase in alkaline phosphatase, esophageal varices, and ascites, was rapidly complicated by severe obstructive cholestasis.
Primary systemic amyloidosis with giant hepatomegaly and a swiftly progressive course
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Impact Factor: 2.433
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Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (335 visite)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
Dettagli Esporta in BibTeX Esporta in EndNote
De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (212 visite)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
Dettagli Esporta in BibTeX Esporta in EndNote
Mainenti PP, Camera L, Nicotra S, Cantalupo T, Soscia E, Vizio DD, Insabato G, Salvatore M
* Splenic hypoperfusion as a sign of systemic amyloidosis (297 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Dec; 30(6): 768-772.
Impact Factor: 1.034
Dettagli Esporta in BibTeX Esporta in EndNote
Mainenti PP, Cantalupo T, Nicotra S, Camera L, Imbriaco M, Di Vizio D, Insabato L, Salvatore M
* Systemic amyloidosis: The CT sign of splenic hypoperfusion (276 visite)
Amyloid (ISSN: 1350-6129), 2004 Dec; 11(4): 281-282.
Impact Factor: 1.886
Dettagli Esporta in BibTeX Esporta in EndNote
Romano M, Giojelli A, Capuano G, Pomponi D, Salvatore M
* Partial splenic embolization in patients with idiopathic portal hypertension (272 visite)
Eur J Radiol (ISSN: 0720-048x), 2004 Mar; 49(3): 268-273.
Impact Factor: 1.745
Dettagli Esporta in BibTeX Esporta in EndNote
Mainenti PP, D'Agostino L, Soscia E, Romano M, Salvatore M
* Hepatic and splenic amyloidosis: Dual-phase spiral CT findings (290 visite)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Sep; 28(5): 688-690.
Impact Factor: 0.996
Dettagli Esporta in BibTeX Esporta in EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (597 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
Camera L, Selva G, Puzziello A, Sparano L, Ignarra R, Quarantelli M
* [Castleman's disease: CT and MR findings in a case localized in the portocaval space] (274 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2001 Sep; 102(3): 186-188.
Impact Factor: 1.368
Dettagli Esporta in BibTeX Esporta in EndNote
Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Isolation and characterization of human embryonic osteoblasts (416 visite)
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.
Impact Factor: 2.364
Dettagli Esporta in BibTeX Esporta in EndNote
26 Records (24 escludendo Abstract e Conferenze).
Impact factor totale: 66.244 (59.841 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 65.763 (59.027 escludendo Abstract e Conferenze).
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