Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals
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Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (144 visite)

Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G

Clin Nutr (ISSN: 0261-5614), 2004 Jun; 23(3): 331-340.



Tipo di articolo: Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,

Impact factor: 2.019, Impact factor a 5 anni: 4.581

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042565671&partnerID=40&md5=66ee82f81e0bb8e68a433ce6d152373e

Parole chiave: Colonic Fermentation, Fructo-Oligosaccharides, Hyperlypidaemia, Lipid Metabolism, Apolipoprotein A1, Aspartame, Cholesterol, Dextrin, Fructose Oligosaccharide, Glucose, High Density Lipoprotein Cholesterol, Insulin, Low Density Lipoprotein Cholesterol, Maltose, Placebo, Short Chain Fatty Acid, Triacylglycerol, Very Low Density Lipoprotein Cholesterol, Adult, Article, Body Mass, Carbohydrate Diet, Carbohydrate Intake, Cholesterol Blood Level, Clinical Article, Coffee, Controlled Study, Diet Restriction, Fatty Acid Blood Level, Female, Glucose Blood Level, Glucose Metabolism, High Fiber Diet, Human, Hypercholesterolemia, Insulin Blood Level, Insulin Response, Lactobacillus Bifidus, Nutritional Parameters, Postprandial State, Protein Blood Level, Protein Diet, Standard, Statistical Significance, Triacylglycerol Blood Level, Blood Glucose, Cross-Over Studies, Double-Blind Method, Fasting, Volatile, Middle Aged, Postprandial Period, Triglycerides, Blood Glucose Metabolism, Biosynthesis, Pharmacology, Drug Therapy Metabolism, Chemistry Pharmacology,

Affiliazioni:

*** IBB - CNR ***
Institute of Food Science/Technology, National Reseach Council, Avellino, Italy
Cerestar Research/Development Center, Vilvoorde, Belgium
Nutri-Health, Rueil-Malmaison, France
Dept. of Clin./Experimental Medicine, Med. Sch. of University Federico II, Via S. Pansini 5, Naples 80131, Italy
Dept. of Clin. /Experimental Medicine, Med. Sch. of University Federico II, Via S. Pansini 5, Naples 80131, Italy


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Wolever, T.M., Spadafora, P.J., Cunnane, S.C., Pencharz, P.B., Propionate inhibits incorporation of colonic (1,2-13C) acetate into plasma lipids in humans (1995) Am. J. Clin. Nutr., 61, pp. 1241-1247

Cummings, J. H., Roberfroid, M. B., Anderson, H., A new took at dietary carbohydrate: Chemistry, physiology and health Eur (1997) J. Clin. Nutr., 51, pp. 417-42

Bouhnik, Y., Flouri, B., Riottot, M., Effects of fructo-oligosaccharides ingestion on fecal Bifidobacteria, and selected metabolic indexes of colon carcinogenesis in healthy humans (1996) Nutr. Cancer, 26, pp. 21-29

Cummings, J. H., Macfarlane, G. T., Englyst, H. N., Prebiotic digestion and fermentation (2001) Am. J. Clin. Nutr., 73, pp. 415S-420S

Wolever, T. M. S., Spadafora, P., Eshuis, H., Interaction between colonic acetate and propionate in humans (1991) Am. J. Clin. Nutr., 53, pp. 681-687

Alles, M. S., de Roos, N. M., Bakx, J. C., van de Lisdonk, E., Zock, P. L., Hautvast, J. G. A. J., Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes (1999) Am. J. Clin. Nutr., 69, pp. 64-69

Davidson, M. H., Maki, K. C., Synecki, C., Torri, S. A., Drennan, R., Evaluation of the influence of dietary inulin on serum lipids in adults with hypercholesterolemia (1998) Nutr. Res., 18, pp. 503-517

Jackson, K. G., Taylor, G. R. J., Clohessy, A. M., Williams, C. M., The effect of daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women (1999) Br. J. Nutr., 82, pp. 23-30

Causey, J. L., Feirtag, J. M., Gallaher, D. D., Tungland, B. C., Slavin, J. L., Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolaemic men (2000) Nutr. Res., 20, pp. 191-201

Marcovina, S. M., Albers, J. J., Henderson, L. O., Hannon, W. H., International Federation of Clinical Chemistry Standardization Project for measurements of Apolipoproteins A-1 and B. III. Comparability of Apolipoprotein A-1 values by use of International Reference Material (1993) Clin. Chem., 39, pp. 773-781

Luc, G., Bard, J. M., Arveiler, D., Lipoprotein (a) as a predictor of coronary heart disease: The prime study (2002) Atherosclerosis, 163, pp. 377-384

Lin, Y., Vonk, R. J., Slooff, M. J., Kuipers, F., Smit, M. J., Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes primary culture (1995) Br. J. Nutr., 74, pp. 197-207

Wolever, T. M., Spadafora, P. J., Cunnane, S. C., Pencharz, P. B., Propionate inhibits incorporation of colonic (1, 2-13C) acetate into plasma lipids in humans (1995) Am. J. Clin. Nutr., 61, pp. 1241-1247



Background: The intake of 10 g/day of short-chain-fructo-oligosaccharides (sc-FOS) has been shown to increase significantly bifidus counts and to produce high amounts of short-chain fatty acids (SCFA), presumed to influence glucose and lipid metabolism. Aim: To evaluate the effects of moderate intake of sc-FOS on glucose and lipid metabolism in individuals with mild hypercholesterolaemia. Design: A randomized double-blind sequential cross-over study. Subjects and methods: Thirty subjects of both genders (20 M/10 F), mean age 45.5±9.9 years (M±SD), BMI 26.6±2.2 kg/m2, with plasma cholesterol >5.17 and <7.76 mmol/l and plasma triglycerides <3.45 mmol/l, participated in the study. The study was performed after a wash-out period of 1 month and a run-in period of 1 month to stabilize patients on a standard diet (CHO 50%, fat 30%, protein 20%, fibre 20 g/day) plus placebo (maltodextrine plus aspartame 15 g/day). At the end of run-in, subjects were randomly assigned to receive sc-FOS (Actilight(R)) (10.6 g/day) or placebo (maltodextrine plus aspartame 15 g/day) with tea and/or coffee for a duration of 2 months and thereafter switched to the other treatment for additional 2 months. Plasma glucose, total and lipoprotein (VLDL, LDL, HDL) cholesterol and triglyceride concentrations were measured in the fasting state at the end of run-in and of each treatment period. At the end of the two treatment periods, patients consumed a standard test meal (protein 15%, carbohydrate 34%, fat 51%, kJ 3988) 1 h after the administration of 5.3 g of sc-FOS or placebo; plasma glucose, insulin, free fatty acid (FFA) and triglyceride responses to the test meal were evaluated. Results: No significant difference in fasting parameters was detected between the two treatments. After sc-FOS and placebo plasma cholesterol levels were, respectively, 6.47±0.70 and 6.44±0.78 mmol/l (n.s.) and plasma triglycerides were 1.53±0.71 and 1.56±0.53 mmol/l (n.s.). No significant differences were observed in cholesterol and triglyceride content of VLDL, LDL and HDL and in plasma Apo A1 levels; conversely, fasting plasma Lp(a) concentrations were significantly increased after sc-FOS (37±38 vs. 33±35 mg/dl; P<0.005). Postprandial responses of glucose, FFA and triglycerides were not significantly different between sc-FOS and placebo, while postprandial insulin response (incremental area) was significantly reduced after sc-FOS compared to placebo (14490±7416 vs. 17760±7710 pmol/l × 300 min; P<0.02). Conclusions: A moderate intake of sc-FOS has no major effects on lipid metabolism, both in the fasting and in the postprandial period, in individuals with mild hypercholesterolaemia. A small but significant increase of Lp(a) concentrations was observed with sc-FOS consumption together with a reduction of the postprandial insulin response; however, the clinical relevance of these small effects is unclear. © 2003 Elsevier Ltd. All rights reserved.
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (157 visite)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (149 visite)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
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Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (132 visite)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (153 visite)
Bba-Mol Basis Dis (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (117 visite)
Bba-Mol Basis Dis (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (141 visite)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Maurea S, Soricelli A, Salvatore M
* Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging (135 visite) (PDF 141 visite)
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2009; 2(1): 56-62.
Impact Factor: 0.643
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (101 visite)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (156 visite)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (223 visite)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (132 visite)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (145 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (130 visite)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (117 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (133 visite)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (262 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (122 visite)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (131 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Vicario MLE, Cirillo L, Storto G, Pellegrino T, Ragone N, Fontanella L, Petretta M, Bonaduce D, Cuocolo A
* Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease (118 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2005 Sep; 46(9): 1438-1443.
Impact Factor: 4.684
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Criscuolo C, Mancini P, Menchise V, Sacca F, De Michele G, Banfi S, Filla A
* Very late onset in ataxia oculomotor apraxia type I [1] (133 visite)
Ann Neurol (ISSN: 0364-5134), 2005 May; 57(5): 777-777.
Impact Factor: 7.571
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (143 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Maurea S, Salvatore M
* I-131 Nor-Cholesterol Nuclear imaging in Patients with Hypersecreting or Non-Hypersecreting Adrenal Adenomas (141 visite)
Trends In Cholesterol Research, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (146 visite) (PDF 141 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
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Clemente G, Mancini M, Nazzaro F, Lasorella G, Rivieccio A, Palumbo AM, Rivellese AA, Ferrara L, Giacco R
* Effects of different dairy products on postprandial lipemia (111 visite)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2003 Dec; 13(6): 377-383.
Impact Factor: 2.148
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (174 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (153 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Goodman M, Del Valle JR, Amino Y, Benedetti E
* Molecular basis of sweet taste in dipeptide taste ligands (79 visite)
Pure Appl Chem (ISSN: 0033-4545), 2002; 74(7): 1109-1116.
Impact Factor: 1.75
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Maurea S, Klain M, Mainolfi C, Ziviello M, Salvatore M
* The diagnostic role of radionuclide imaging in evaluation of patients with nonhypersecreting adrenal masses (104 visite) (PDF 141 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2001 Jun; 42(6): 884-892.
Impact Factor: 4.51
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (133 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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De Simone G, Galdiero S, Manco G, Lang D, Rossi M, Pedone C
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase (123 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Nov 10; 303(5): 761-771.
Impact Factor: 5.388
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (107 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Ferrara LA, Mancini M, Celentano A, Galderisi M, Iannuzzi R, Marotta T, Gaeta I
Early changes of the arterial carotid wall in uncomplicated primary hypertensive patients: Study by ultrasound high-resolution B-mode imaging (97 visite)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 1994 Sep; 14(8): 1290-1296.
Impact Factor: 5.317
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Postiglione A, Nappi A, Brunetti A, Soricelli A, Rubba P, Gnasso A, Cammisa M, Frusciante V, Cortese C, Salvatore M
Relative protection from cerebral atherosclerosis of young patients with homozygous familial hypercholesterolemia (105 visite)
Atherosclerosis (ISSN: 0021-9150, 1879-1484), 1991 Sep; 90(1): 23-30.
Impact Factor: 2.889
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (23 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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Greco AM, de Franciscis P, Bozza P, Salvatore M
Thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient Nath diet (118 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Dec 30; 55(24): 2589-2595.
Impact Factor: 0
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60 Records (57 escludendo Abstract e Conferenze).
Impact factor totale: 214.865 (203.619 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 209.049 (197.696 escludendo Abstract e Conferenze).







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