The relationship between cerebral vascular disease and parkinsonism: The VADO study (452 views visite)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 3.274, 5-year impact factor Impact factor a 5 anni: 3.361
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862186620&partnerID=40&md5=8ac74d57946a36ba076d24e7978dbdff
Keywords Parole chiave: Dopamine Transporter Spect Imaging, Mr Imaging, Parkinson, S Disease, Vascular Parkinsonism, Levodopa, Adult, Article, Basal Ganglion, Cerebrovascular Disease, Clinical Feature, Cohort Analysis, Cross-Sectional Study, Differential Diagnosis, Disease Severity, Drug Response, Female, Frontal Lobe, Human, Hypertension, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Parkinson Disease, Priority Journal, Protein Binding, Risk Factor, Single Photon Emission Computer Tomography, Vascular Lesion, 80 And Over, Antiparkinson Agents, Cerebrovascular Disorders, Cohort Studies, Corpus Striatum, Cross-Sectional Studies, Dopamine Plasma Membrane Transport Proteins, Middle Aged, Parkinsonian Disorders, Severity Of Illness Index, Emission-Computed, Single-Photon,
Affiliations Affiliazioni:
*** IBB - CNR ***
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy
Department for Parkinson's disease, IRCCS San Camillo, Venice and University of Padua, Italy
University Parthenope, Naples, Italy
IDC Hermitage-Capodimonte, Naples, Italy
Neurodegenerative Diseases Center, University of Salerno, Salerno, Italy
Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
Department of Neurosciences, University of Pisa, Italy
Neurology Unit, Annunziata Hospital, Cosenza, Italy
Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
Department of Nuclear Medicine, Ospedali Riuniti, Bergamo, Italy
Division of Nuclear Medicine, Ferrara, Italy
Hospital, Ferrara, Italy
Department of Endocrinological and Metabolic Sciences, Section of Clinical Neurophysiology Nuclear medicine, University of Genoa, Italy
Department of Radiological Sciences Nuclear Medicine, University of Messina, Italy
Nuclear Medicine, IRCCS-Ospedale Maggiore, Milan, Italy
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
IRCCS San Raffaele La Pisana, Rome, Italy
Hospital, Turin, Italy
References Riferimenti:
Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., The accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathologic study (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-18
Rektor, I., Rektorova, I., Kubova, D., Vascular parkinsonism - an update (2006) J Neurol Sci, 248, pp. 185-191
Fitzgerald, P.M., Jankovic, J., Lower body parkinsonism: evidence for vascular etiology (1989) Mov Disord, 4, pp. 249-260
Winikates, J., Jankovic, J., Clinical correlates of vascular parkinsonism (1999) Arch Neurol, 56, pp. 98-102
Zijlmans, J.C., Daniel, S.E., Hughes, A.J., Révész, T., Lees, A.J., Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis (2004) Mov Disord, 19 (6), pp. 630-640
Zijlmans, J., Katzenschlager, R., Daniel, S., Lees, A., The L-dopa response in vascular parkinsonism (2004) J Neurol Neurosurg Psychiatry, 75, pp. 545-547
Awad, I.A., Spetzler, R.F., Hodak, J.A., Awad, C.A., Carey, R., Incidental subcortical lesions identified on magnetic resonance imaging in the elderly, I: correlation with age and cerebrovascular risk factors (1986) Stroke, 17, pp. 1084-1089
Booij, J., Speelman, J.D., Horstink, M.W., Wolters, E.C., The clinical benefit of imaging striatal transporters with [123I]FP-CIT SPECT in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism (2001) Eur J Nucl Med, 28, pp. 266-272
Gerschlager, W., Bencsits, G., Pirker, W., Bloem, B.R., Asenbaum, S., Prayer, D., [ 123I]beta-CIT SPECT distinguishes vascular parkinsonism from Parkinson's disease (2002) Mov Disord, 17, pp. 518-523
Eerola, J., Tienari, P.J., Kaakkola, S., Nikkinen, P., Launes, J., How useful is [123I]beta- CIT SPECT in clinical practice? (2005) J Neurol Neurosurg Psychiatry, 76, pp. 1211-1216
Scherfler, C., Schwarz, J., Antonini, A., Grosset, D., Valldeoriola, F., Marek, K., Role of DAT-SPECT in the diagnostic work up of Parkinsonism (2007) Mov Disord, 22 (9), pp. 1229-1238
Gelb, D.J., Oliver, E., Gilman, S., Diagnostic criteria for Parkinson's disease (1999) Arch Neurol, 56, pp. 33-39
Grosset, K., Needleman, F., Macphee, G., Grosset, D., Switching from ergot to nonergot dopamine agonists in Parkinson's disease: a clinical series and five-drug dose conversion table (2004) Mov Disord, 19 (11), pp. 1370-1374
Fahn, S., Elton, R.L., Unified Parkinson's disease rating scale (1987) Recent developments in Parkinson's disease, 2, pp. 153-164. , Macmillan Health Care Information, Florham Park, NJ., Members of the UPDRS Development Committee
Hoehn, M.M., Yahr, M.D., Parkinsonism: onset, progression and mortality (1967) Neurology, 17 (5), pp. 427-442
Piccini, P., Pavese, N., Canapicchi, R., Paoli, C., Del Dotto, P., Puglioli, M., White matter hyperintensities in Parkinson's disease (1995) Arch Neurol, 52, pp. 191-194
Litvan, I., Bhatia, K.P., Burn, D.J., Goetz, C.G., Lang, A.E., McKeith, I., Movement Disorders Society Scientific issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders (2003) Mov Disord, 18 (5), pp. 467-486
Scheltens, P., Barkhof, F., Leys, D., Pruvo, J.P., Nauta, J.J., Vermersch, P., A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging (1993) J Neurol Sci, 114, pp. 7-12
Kapeller, P., Barber, R., Vermeulen, R.J., Adèr, H., Scheltens, P., Freidl, W., Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements (2003) Stroke, 34, pp. 441-445
Ottaviani, S., Tinazzi, M., Pasquin, I., Nothdurfter, W., Tomelleri, G., Fincati, E., Comparative analysis of visual and semi-quantitative assessment of striatal [(123)I]FP-CIT-SPET binding in Parkinson's disease (2006) Neurol Sci, 27 (6), pp. 397-401
Yamanouchi, H., Nagura, H., Neurological signs and frontal white matter lesions in vascular parkinsonism. A clinicopathologic study (1997) Stroke, 28, pp. 965-969
Rampello, L., Alvano, A., Battaglia, G., Raffaele, R., Vecchio, I., Malaguerra, M., Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism (2005) J Neurol, 252, pp. 1045-1049
van Swieten, J.C., van den Hout, J.H.W., van Ketel, B.A., Hijdra, A., Wokke, J.H., van Gijn, J., Periventricular lesions in the white matter on magnetic resonance imaging in the elderly (1991) Brain, 114, pp. 761-774
Zijlmans, J., Evans, A., Fontes, F., Katzenschlager, R., Gacinovic, S., Lees, A.J., [ 123I] FP-CIT SPECT study in vascular parkinsonism and Parkinson's disease (2007) Mov Disord, 22 (9), pp. 1278-1285
Lorberboym, M., Djaldetti, R., Melamed, E., Sadeh, M., Lampl, Y., 123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism (2004) J Nucl Med, 45 (10), pp. 1688-1693
Alarcón, F., Zijlmans, J.C., Dueñas, G., Cevallos, N., Post-stroke movement disorders: report of 56 patients (2004) J Neurol Neurosurg Psychiatry, 75 (11), pp. 1568-1574
Forno, L.S., Reaction of the substantia nigra to massive basal ganglia infarction (1983) Acta Neuropathol, 62 (1-2), pp. 96-102
Peralta, C., Werner, P., Holl, B., Kiechl, S., Willeit, J., Seppi, K., Parkinsonism following striatal infarcts: incidence in a prospective stroke unit cohort (2004) J Neural Transm, 111, pp. 1473-1483
Kahn, U., Porteous, L., Hassan, A., Markus, H.S., Risk factor profile of cerebral small vessel disease and its subtypes (2007) J Neurol Neurosurg Psychiatry, 78, pp. 702-706
Rektor, I., Goldemund, D., Sheardova, K., Rektorova, I., Michalcova, Z., Dufek, M., Vascular pathology in patients with idiopathic Parkinson's disease (2009) Parkinsonism Relat Disord, 15, pp. 24-29
Hughes, A. J., Daniel, S. E., Kilford, L., Lees, A. J., The accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathologic study (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-18
Fitzgerald, P. M., Jankovic, J., Lower body parkinsonism: evidence for vascular etiology (1989) Mov Disord, 4, pp. 249-260
Zijlmans, J. C., Daniel, S. E., Hughes, A. J., R v sz, T., Lees, A. J., Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis (2004) Mov Disord, 19 (6), pp. 630-640
Awad, I. A., Spetzler, R. F., Hodak, J. A., Awad, C. A., Carey, R., Incidental subcortical lesions identified on magnetic resonance imaging in the elderly, I: correlation with age and cerebrovascular risk factors (1986) Stroke, 17, pp. 1084-1089
Gelb, D. J., Oliver, E., Gilman, S., Diagnostic criteria for Parkinson's disease (1999) Arch Neurol, 56, pp. 33-39
Hoehn, M. M., Yahr, M. D., Parkinsonism: onset, progression and mortality (1967) Neurology, 17 (5), pp. 427-442
van Swieten, J. C., van den Hout, J. H. W., van Ketel, B. A., Hijdra, A., Wokke, J. H., van Gijn, J., Periventricular lesions in the white matter on magnetic resonance imaging in the elderly (1991) Brain, 114, pp. 761-774
Alarc n, F., Zijlmans, J. C., Due as, G., Cevallos, N., Post-stroke movement disorders: report of 56 patients (2004) J Neurol Neurosurg Psychiatry, 75 (11), pp. 1568-1574
Forno, L. S., Reaction of the substantia nigra to massive basal ganglia infarction (1983) Acta Neuropathol, 62 (1-2), pp. 96-102
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 3.274, 5-year impact factor Impact factor a 5 anni: 3.361
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862186620&partnerID=40&md5=8ac74d57946a36ba076d24e7978dbdff
Keywords Parole chiave: Dopamine Transporter Spect Imaging, Mr Imaging, Parkinson, S Disease, Vascular Parkinsonism, Levodopa, Adult, Article, Basal Ganglion, Cerebrovascular Disease, Clinical Feature, Cohort Analysis, Cross-Sectional Study, Differential Diagnosis, Disease Severity, Drug Response, Female, Frontal Lobe, Human, Hypertension, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Parkinson Disease, Priority Journal, Protein Binding, Risk Factor, Single Photon Emission Computer Tomography, Vascular Lesion, 80 And Over, Antiparkinson Agents, Cerebrovascular Disorders, Cohort Studies, Corpus Striatum, Cross-Sectional Studies, Dopamine Plasma Membrane Transport Proteins, Middle Aged, Parkinsonian Disorders, Severity Of Illness Index, Emission-Computed, Single-Photon,
Affiliations Affiliazioni:
*** IBB - CNR ***
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy
Department for Parkinson's disease, IRCCS San Camillo, Venice and University of Padua, Italy
University Parthenope, Naples, Italy
IDC Hermitage-Capodimonte, Naples, Italy
Neurodegenerative Diseases Center, University of Salerno, Salerno, Italy
Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
Department of Neurosciences, University of Pisa, Italy
Neurology Unit, Annunziata Hospital, Cosenza, Italy
Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
Department of Nuclear Medicine, Ospedali Riuniti, Bergamo, Italy
Division of Nuclear Medicine, Ferrara, Italy
Hospital, Ferrara, Italy
Department of Endocrinological and Metabolic Sciences, Section of Clinical Neurophysiology Nuclear medicine, University of Genoa, Italy
Department of Radiological Sciences Nuclear Medicine, University of Messina, Italy
Nuclear Medicine, IRCCS-Ospedale Maggiore, Milan, Italy
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
IRCCS San Raffaele La Pisana, Rome, Italy
Hospital, Turin, Italy
References Riferimenti:
Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., The accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathologic study (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-18
Rektor, I., Rektorova, I., Kubova, D., Vascular parkinsonism - an update (2006) J Neurol Sci, 248, pp. 185-191
Fitzgerald, P.M., Jankovic, J., Lower body parkinsonism: evidence for vascular etiology (1989) Mov Disord, 4, pp. 249-260
Winikates, J., Jankovic, J., Clinical correlates of vascular parkinsonism (1999) Arch Neurol, 56, pp. 98-102
Zijlmans, J.C., Daniel, S.E., Hughes, A.J., Révész, T., Lees, A.J., Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis (2004) Mov Disord, 19 (6), pp. 630-640
Zijlmans, J., Katzenschlager, R., Daniel, S., Lees, A., The L-dopa response in vascular parkinsonism (2004) J Neurol Neurosurg Psychiatry, 75, pp. 545-547
Awad, I.A., Spetzler, R.F., Hodak, J.A., Awad, C.A., Carey, R., Incidental subcortical lesions identified on magnetic resonance imaging in the elderly, I: correlation with age and cerebrovascular risk factors (1986) Stroke, 17, pp. 1084-1089
Booij, J., Speelman, J.D., Horstink, M.W., Wolters, E.C., The clinical benefit of imaging striatal transporters with [123I]FP-CIT SPECT in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism (2001) Eur J Nucl Med, 28, pp. 266-272
Gerschlager, W., Bencsits, G., Pirker, W., Bloem, B.R., Asenbaum, S., Prayer, D., [ 123I]beta-CIT SPECT distinguishes vascular parkinsonism from Parkinson's disease (2002) Mov Disord, 17, pp. 518-523
Eerola, J., Tienari, P.J., Kaakkola, S., Nikkinen, P., Launes, J., How useful is [123I]beta- CIT SPECT in clinical practice? (2005) J Neurol Neurosurg Psychiatry, 76, pp. 1211-1216
Scherfler, C., Schwarz, J., Antonini, A., Grosset, D., Valldeoriola, F., Marek, K., Role of DAT-SPECT in the diagnostic work up of Parkinsonism (2007) Mov Disord, 22 (9), pp. 1229-1238
Gelb, D.J., Oliver, E., Gilman, S., Diagnostic criteria for Parkinson's disease (1999) Arch Neurol, 56, pp. 33-39
Grosset, K., Needleman, F., Macphee, G., Grosset, D., Switching from ergot to nonergot dopamine agonists in Parkinson's disease: a clinical series and five-drug dose conversion table (2004) Mov Disord, 19 (11), pp. 1370-1374
Fahn, S., Elton, R.L., Unified Parkinson's disease rating scale (1987) Recent developments in Parkinson's disease, 2, pp. 153-164. , Macmillan Health Care Information, Florham Park, NJ., Members of the UPDRS Development Committee
Hoehn, M.M., Yahr, M.D., Parkinsonism: onset, progression and mortality (1967) Neurology, 17 (5), pp. 427-442
Piccini, P., Pavese, N., Canapicchi, R., Paoli, C., Del Dotto, P., Puglioli, M., White matter hyperintensities in Parkinson's disease (1995) Arch Neurol, 52, pp. 191-194
Litvan, I., Bhatia, K.P., Burn, D.J., Goetz, C.G., Lang, A.E., McKeith, I., Movement Disorders Society Scientific issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders (2003) Mov Disord, 18 (5), pp. 467-486
Scheltens, P., Barkhof, F., Leys, D., Pruvo, J.P., Nauta, J.J., Vermersch, P., A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging (1993) J Neurol Sci, 114, pp. 7-12
Kapeller, P., Barber, R., Vermeulen, R.J., Adèr, H., Scheltens, P., Freidl, W., Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements (2003) Stroke, 34, pp. 441-445
Ottaviani, S., Tinazzi, M., Pasquin, I., Nothdurfter, W., Tomelleri, G., Fincati, E., Comparative analysis of visual and semi-quantitative assessment of striatal [(123)I]FP-CIT-SPET binding in Parkinson's disease (2006) Neurol Sci, 27 (6), pp. 397-401
Yamanouchi, H., Nagura, H., Neurological signs and frontal white matter lesions in vascular parkinsonism. A clinicopathologic study (1997) Stroke, 28, pp. 965-969
Rampello, L., Alvano, A., Battaglia, G., Raffaele, R., Vecchio, I., Malaguerra, M., Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism (2005) J Neurol, 252, pp. 1045-1049
van Swieten, J.C., van den Hout, J.H.W., van Ketel, B.A., Hijdra, A., Wokke, J.H., van Gijn, J., Periventricular lesions in the white matter on magnetic resonance imaging in the elderly (1991) Brain, 114, pp. 761-774
Zijlmans, J., Evans, A., Fontes, F., Katzenschlager, R., Gacinovic, S., Lees, A.J., [ 123I] FP-CIT SPECT study in vascular parkinsonism and Parkinson's disease (2007) Mov Disord, 22 (9), pp. 1278-1285
Lorberboym, M., Djaldetti, R., Melamed, E., Sadeh, M., Lampl, Y., 123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism (2004) J Nucl Med, 45 (10), pp. 1688-1693
Alarcón, F., Zijlmans, J.C., Dueñas, G., Cevallos, N., Post-stroke movement disorders: report of 56 patients (2004) J Neurol Neurosurg Psychiatry, 75 (11), pp. 1568-1574
Forno, L.S., Reaction of the substantia nigra to massive basal ganglia infarction (1983) Acta Neuropathol, 62 (1-2), pp. 96-102
Peralta, C., Werner, P., Holl, B., Kiechl, S., Willeit, J., Seppi, K., Parkinsonism following striatal infarcts: incidence in a prospective stroke unit cohort (2004) J Neural Transm, 111, pp. 1473-1483
Kahn, U., Porteous, L., Hassan, A., Markus, H.S., Risk factor profile of cerebral small vessel disease and its subtypes (2007) J Neurol Neurosurg Psychiatry, 78, pp. 702-706
Rektor, I., Goldemund, D., Sheardova, K., Rektorova, I., Michalcova, Z., Dufek, M., Vascular pathology in patients with idiopathic Parkinson's disease (2009) Parkinsonism Relat Disord, 15, pp. 24-29
Hughes, A. J., Daniel, S. E., Kilford, L., Lees, A. J., The accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathologic study (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-18
Fitzgerald, P. M., Jankovic, J., Lower body parkinsonism: evidence for vascular etiology (1989) Mov Disord, 4, pp. 249-260
Zijlmans, J. C., Daniel, S. E., Hughes, A. J., R v sz, T., Lees, A. J., Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis (2004) Mov Disord, 19 (6), pp. 630-640
Awad, I. A., Spetzler, R. F., Hodak, J. A., Awad, C. A., Carey, R., Incidental subcortical lesions identified on magnetic resonance imaging in the elderly, I: correlation with age and cerebrovascular risk factors (1986) Stroke, 17, pp. 1084-1089
Gelb, D. J., Oliver, E., Gilman, S., Diagnostic criteria for Parkinson's disease (1999) Arch Neurol, 56, pp. 33-39
Hoehn, M. M., Yahr, M. D., Parkinsonism: onset, progression and mortality (1967) Neurology, 17 (5), pp. 427-442
van Swieten, J. C., van den Hout, J. H. W., van Ketel, B. A., Hijdra, A., Wokke, J. H., van Gijn, J., Periventricular lesions in the white matter on magnetic resonance imaging in the elderly (1991) Brain, 114, pp. 761-774
Alarc n, F., Zijlmans, J. C., Due as, G., Cevallos, N., Post-stroke movement disorders: report of 56 patients (2004) J Neurol Neurosurg Psychiatry, 75 (11), pp. 1568-1574
Forno, L. S., Reaction of the substantia nigra to massive basal ganglia infarction (1983) Acta Neuropathol, 62 (1-2), pp. 96-102
The relationship between cerebral vascular disease and parkinsonism: The VADO study
Background: The observation of gait abnormalities, parkinsonism and vascular lesions in elderly patients is often reported as vascular parkinsonism (VP). However the status of striatal dopamine transporter (DAT) and the effects of brain vascular lesions on motor features and levodopa responsiveness are poorly defined. Methods: We recorded clinical features, chronic response to levodopa and vascular risk factors in a cross-sectional cohort of consecutive elderly patients with possible Parkinson's disease (PD) or VP recruited in 20 centers in Italy. Results: We included a total of 158 patients. Onset of motor symptoms was asymmetric in 93 (59%) and symmetric in 65 patients (41%). Symmetric motor onset was associated with greater disease severity. Chronic levodopa response was positive in 75 (47.8%) and negative in 82 patients (52.2%). A negative response to levodopa was associated with greater frequency of symmetric onset of motor symptoms, worst disease severity, absence of dyskinesia and greater number of vascular risk factors. Frontal lobe showed largest vascular load. Striatal DAT was normal in 48 (30.4%) and abnormal in 110 (69.6%) patients. Patients with normal DAT binding showed higher vascular load at MRI. Significant predictive factors of worst disease severity and negative response to levodopa were hypertension, vascular lesions in basal ganglia/periventricular regions, and normal DAT uptake. Conclusions: Multiple cerebral vascular lesions modify clinical presentation and severity in patients with parkinsonism and this is underlined by specific risk factors primarily hypertension. Striatal DAT assessment is helpful in identifying patients where therapy benefit is less likely. © 2012 Elsevier Ltd.
Background: The observation of gait abnormalities, parkinsonism and vascular lesions in elderly patients is often reported as vascular parkinsonism (VP). However the status of striatal dopamine transporter (DAT) and the effects of brain vascular lesions on motor features and levodopa responsiveness are poorly defined. Methods: We recorded clinical features, chronic response to levodopa and vascular risk factors in a cross-sectional cohort of consecutive elderly patients with possible Parkinson's disease (PD) or VP recruited in 20 centers in Italy. Results: We included a total of 158 patients. Onset of motor symptoms was asymmetric in 93 (59%) and symmetric in 65 patients (41%). Symmetric motor onset was associated with greater disease severity. Chronic levodopa response was positive in 75 (47.8%) and negative in 82 patients (52.2%). A negative response to levodopa was associated with greater frequency of symmetric onset of motor symptoms, worst disease severity, absence of dyskinesia and greater number of vascular risk factors. Frontal lobe showed largest vascular load. Striatal DAT was normal in 48 (30.4%) and abnormal in 110 (69.6%) patients. Patients with normal DAT binding showed higher vascular load at MRI. Significant predictive factors of worst disease severity and negative response to levodopa were hypertension, vascular lesions in basal ganglia/periventricular regions, and normal DAT uptake. Conclusions: Multiple cerebral vascular lesions modify clinical presentation and severity in patients with parkinsonism and this is underlined by specific risk factors primarily hypertension. Striatal DAT assessment is helpful in identifying patients where therapy benefit is less likely. © 2012 Elsevier Ltd.
The relationship between cerebral vascular disease and parkinsonism: The VADO study
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The relationship between cerebral vascular disease and parkinsonism: The VADO study
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Impact Factor: 4.48
Dettagli Esporta in BibTeX Esporta in EndNote
Fusari M, Maurea S, Imbriaco M, Mollica C, Avitabile G, Soscia F, Camera L, Salvatore M
* Comparison between multislice CT and MR imaging in the diagnostic evaluation of patients with pancreatic masses (305 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2010 Apr; 115(3): 453-466.
Impact Factor: 1.618
Dettagli Esporta in BibTeX Esporta in EndNote
Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
* MRI characterization of myocardial tissue in patients with Fabry's disease (522 visite)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
Impact Factor: 2.47
Dettagli Esporta in BibTeX Esporta in EndNote
Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (311 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
Dettagli Esporta in BibTeX Esporta in EndNote
Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (330 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
Dettagli Esporta in BibTeX Esporta in EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (603 visite)
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Impact Factor: 0.023
Dettagli Esporta in BibTeX Esporta in EndNote
Molko N, Pappata S, Mangin JF, Poupon C, Vahedi K, Jobert A, LeBihan D, Bousser MG, Chabriat H
* Diffusion tensor imaging study of subcortical gray matter in CADASIL (360 visite)
Stroke (ISSN: 0039-2499), 2001 Sep; 32(9): 2049-2054.
Impact Factor: 5.33
Dettagli Esporta in BibTeX Esporta in EndNote
Imbriaco M, Sodano A, Riccardi A, Del Vecchio S, Panza M, Limite G, Pace U, Forestieri P, Petrella M, Salvatore G
Accuracy of dynamic contrast-enhanced MR imaging in patients with indeterminate mammograms (195 visite)
European Journal Of Cancer (ISSN: 0959-8049), 1998 Sep; 34: N/D-N/D.
Impact Factor: 2.743
Dettagli Esporta in BibTeX Esporta in EndNote
BRUNETTI A, COVELLI E, CASTELLI L, CARACO C, ARPAIA M, ALFANO B, TEDESCHI E, SALVATORE M
Multiparametric and dynamic MR imaging of sellar disease - Preliminary results (283 visite)
Neuroradiology 1994, 1994; N/D: N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Postiglione A, Nappi A, Brunetti A, Soricelli A, Rubba P, Gnasso A, Cammisa M, Frusciante V, Cortese C, Salvatore M
Relative protection from cerebral atherosclerosis of young patients with homozygous familial hypercholesterolemia (282 visite)
Atherosclerosis (ISSN: 0021-9150, 1879-1484), 1991 Sep; 90(1): 23-30.
Impact Factor: 2.889
Dettagli Esporta in BibTeX Esporta in EndNote
Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (319 visite)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
Dettagli Esporta in BibTeX Esporta in EndNote
19 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 44.2 (41.457 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 49.208 (45.18 escludendo Abstract e Conferenze).
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Russo C, Pontillo G, Saccà F, Riccio E, Cocozza S, Pane C, Tedeschi E, Pisani A, Pappata S
* Nonvascular Parkinsonism in Fabry Disease: Results From Magnetic Resonance and Dopamine Transporter Imaging (11 visite)
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Impact Factor: 2.923
Dettagli Esporta in BibTeX Esporta in EndNote
D'Antuono F, Mainenti PP, Mollica C, Camera L, Galizia G, Brunetti A, Maurea S
* Comparison Between Multidetector CT and High-Field 3T MR Imaging in Diagnostic and Tumour Extension Evaluation of Patients with Cholangiocarcinoma (159 visite)
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Impact Factor: 0.42
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Impact Factor: 2.147
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
* Appearance of hepatocellular carcinoma on gadoxetic acid-enhanced hepato-biliary phase MR imaging: a systematic review (241 visite)
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Dettagli Esporta in BibTeX Esporta in EndNote
Peluso S, De Rosa A, Antenora A, Lieto M, Criscuolo C, Barbieri F, Pappata S, De Michele G
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Impact Factor: 3.794
Dettagli Esporta in BibTeX Esporta in EndNote
Maurea S, Mainenti PP, Tambasco A, Imbriaco M, Mollica C, Laccetti E, Camera L, Liuzzi R, Salvatore M
* Diagnostic accuracy of MR imaging to identify and characterize focal liver lesions: comparison between gadolinium and superparamagnetic iron oxide contrast media (261 visite)
Quant Imaging Med Surg (ISSN: 2223-4292, 2223-4292print, 2223-4306linking), 2014 Jun; 4(3): 181-189.
Impact Factor: 3.105
Dettagli Esporta in BibTeX Esporta in EndNote
Romeo V, Maurea S, Guarino S, Sirignano C, Mainenti PP, Picardi M, Salvatore M
* A case of lower-neck cystic lymphangioma: correlative US, CT and MR imaging findings (243 visite) (PDF 4 visite)
Quant Imaging Med Surg (ISSN: 2223-4292, 2223-4292print, 2223-4306linking), 2013 Aug; 3(4): 224-227.
Impact Factor: 3.105
Dettagli Esporta in BibTeX Esporta in EndNote
Alfano B, Comerci M, Larobina M, Prinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti A, Salvatore M
* An MRI digital brain phantom for validation of segmentation methods (460 visite) (PDF 652 visite)
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Salvatore E, Di Maio L, Filla A, Ferrara AM, Rinaldi C, Sacca F, Peluso S, Macchia PE, Pappata S, De Michele G
* Benign hereditary chorea: Clinical and neuroimaging features in an Italian family (328 visite)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2010 Jul 30; 25(10): 1491-1496.
Impact Factor: 4.48
Dettagli Esporta in BibTeX Esporta in EndNote
Fusari M, Maurea S, Imbriaco M, Mollica C, Avitabile G, Soscia F, Camera L, Salvatore M
* Comparison between multislice CT and MR imaging in the diagnostic evaluation of patients with pancreatic masses (305 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2010 Apr; 115(3): 453-466.
Impact Factor: 1.618
Dettagli Esporta in BibTeX Esporta in EndNote
Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
* MRI characterization of myocardial tissue in patients with Fabry's disease (522 visite)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
Impact Factor: 2.47
Dettagli Esporta in BibTeX Esporta in EndNote
Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (311 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
Dettagli Esporta in BibTeX Esporta in EndNote
Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (330 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
Dettagli Esporta in BibTeX Esporta in EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (603 visite)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812.
Impact Factor: 0.023
Dettagli Esporta in BibTeX Esporta in EndNote
Molko N, Pappata S, Mangin JF, Poupon C, Vahedi K, Jobert A, LeBihan D, Bousser MG, Chabriat H
* Diffusion tensor imaging study of subcortical gray matter in CADASIL (360 visite)
Stroke (ISSN: 0039-2499), 2001 Sep; 32(9): 2049-2054.
Impact Factor: 5.33
Dettagli Esporta in BibTeX Esporta in EndNote
Imbriaco M, Sodano A, Riccardi A, Del Vecchio S, Panza M, Limite G, Pace U, Forestieri P, Petrella M, Salvatore G
Accuracy of dynamic contrast-enhanced MR imaging in patients with indeterminate mammograms (195 visite)
European Journal Of Cancer (ISSN: 0959-8049), 1998 Sep; 34: N/D-N/D.
Impact Factor: 2.743
Dettagli Esporta in BibTeX Esporta in EndNote
BRUNETTI A, COVELLI E, CASTELLI L, CARACO C, ARPAIA M, ALFANO B, TEDESCHI E, SALVATORE M
Multiparametric and dynamic MR imaging of sellar disease - Preliminary results (283 visite)
Neuroradiology 1994, 1994; N/D: N/D-N/D.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Postiglione A, Nappi A, Brunetti A, Soricelli A, Rubba P, Gnasso A, Cammisa M, Frusciante V, Cortese C, Salvatore M
Relative protection from cerebral atherosclerosis of young patients with homozygous familial hypercholesterolemia (282 visite)
Atherosclerosis (ISSN: 0021-9150, 1879-1484), 1991 Sep; 90(1): 23-30.
Impact Factor: 2.889
Dettagli Esporta in BibTeX Esporta in EndNote
Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (319 visite)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
Dettagli Esporta in BibTeX Esporta in EndNote
19 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 44.2 (41.457 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 49.208 (45.18 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:14:58
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