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Technetium-99m MIBI SPECT to identify viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction (99 visite)

Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Trimarco B, Salvatore M

Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1996; 92(3): 289-296.

Tipo di articolo: Journal Article,

Impact factor: 0.967

Impact factor a 5 anni: 1.448


Parole chiave: Coronary Artery Disease, Nitrates, Resting 99mtc-Mibi Tomography, Glyceryl Trinitrate, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Thallium 201, Adult, Aged, Article, Clinical Article, Diagnostic Accuracy, Echocardiography, Female, Heart Hemodynamics, Heart Scintiscanning, Human, Intravenous Drug Administration, Single Photon Emission Computer Tomography, Chronic Disease, Middle Aged, Myocardial Ischemia, Myocardial Revascularization, Radiopharmaceuticals, Technetium Tc 99m Sestamibi, Emission-Computed, Single-Photon, Ventricular Dysfunction,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029824535&partnerID=40&md5=c216a968ebe9bdb0b95885e08a9bc43c

Resting 99mTc-MIBI cardiac imaging may be poorly accurate in identifying the presence of viable myocardium in patients with chronic coronary artery disease (CAD). In this study, we directly compared the results of resting 99mTc-MIBI SPECT with initial (1 hr) and delayed (5 hrs) images with those of 99mTc-MIBI SPECT after nitroglycerine (NTG) administration in 31 patients with chronic CAD. All patients also underwent rest-redistribution thallium-201 ( 201Tl) SPECT. In 8 patients, echocardiography was performed before and after coronary revascularization (Rev). Of 682 myocardial segments, 197 showed a marked reduction (<50% of peak) in MIBI uptake on initial images. MIBI uptake (≤10%) was increased in 47 (24%) segments on delayed images (from 43 ± 8% to 60 ± 8%, p < 0.001) and in 54 (27%) segments after NTG (from 42 ± 8% to 60 ± 8%, p < 0.001). The results of delayed and NTG MIBI images were in agreement in most segments (n = 160, 81%). The results of delayed and NTG MIBI images were in disagreement in the remaining 37 (19%) segments. In particular, 15 segments showed reversible defects on delayed, but not on NTG MIBI images, while 22 on NTG, but not on delayed MIBI images. All the segments with reversible MIBI defects on delayed and/or NTG images were identified as viable on Tl-201. In the 8 pts examined before and after Rev, 83% of segments with reversible MIBI defects on delayed images and 87% of those with reversible defects after NTG showed functional recovery after Rev; furthermore, in these patients a significant improvement in global left ventricular function was observed after Rev, as shown by ejection fraction values (from 42 ± 7% to 47 ± 7%, p < 0.01). These comparative results show that resting delayed and NTG MIBI imaging provide similar information to identify viable myocardium and to predict functional recovery after coronary Rev in chronic CAD.
Cattedra di Medicina Nucleare, Centro per la Medicina Nucleare, CNR, Italy

I Clinica Medica, Univ. degli Studi Federico II, Istituto Nazionale dei Tumori, Napoli, Italy

Via Raffaele De Cesare, 7, 80132 Napoli NA, Italy
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Jones, R.H., Borges-Neto, S., Potts, J.M., Simultaneous measurement of myocardial perfusion and ventricular function during exercise from a single injection of technetium-99m sestamibi in coronary artery disease (1990) Am J Cardiol, 66, pp. 68E-71E

Liu, P.P., Technetium-99m-sestamibi. Another window on myocardial viability? (1991) J Nucl Med, 32, pp. 298-299

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Maurea, S., Cuocolo, A., Pace, L., Rest-injected thallium-201 redistribution and resting technetium-99m methoxy isobutyl isonitrile uptake in coronary artery disease: Relation to the seventy of coronary artery stenosis (1993) Eur J Nucl Med, 20, pp. 502-510

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Pozzoli, M.M.A., Fioretti, P.M., Salustri, A., Exercise echocardiography and technetium-99m MIBI single photon emission Computed Tomography in the detection of coronary artery disease (1991) Am J Cardiol, 67, pp. 350-355

Rahimtoola, S.H., The hibernating myocardium (1989) Am Heart J, 117, pp. 211-213

Rocco, T.P., Dilsizian, V., Strauss, H.W., Technetium-99m isonitrile myocardial uptake at rest. II. Relation to clinical markers of potential viability (1989) J Am Coll Cardiol, 14, pp. 1678-1684

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Sinusas, A.J., Bergin, J.D., Edwards, N.C., Redistribution of 99mTc sestamibi and 201Tl in the presence of a severe coronary artery stenosis (1994) Circulation, 89, pp. 2332-2341

Udelson, J.E., Coleman, P.S., Metherall, J., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc sestamibi (1994) Circulation, 89, pp. 2552-2561

Bisi, G., Sciagr, R., Santoro, G. M., Rest technetium-99m sestamibi tomography in combination with short-term administration of nitrates feasibility and reliability for prediction of postrevascularization outcome of asynergic territories (1994) J Am Coll Cardiol, 24, pp. 1282-1289

Gropler, R. J., Imaging to distinguish between viable and nonviable myocardium: Pathophysiologic basis and importance of positron emission tomography (1993) Am J Roentenol, 161, pp. 497-506

Henry, W. L., De Maria, A., Feigenbaum, H., (1982) Report of the American Society of Echocardiography Committee on Nomenclature and Standards: Identification of Myocardial Wall Segments, , Atti: American Society Echocardiography, Durham, North Carolina

Jones, R. H., Borges-Neto, S., Potts, J. M., Simultaneous measurement of myocardial perfusion and ventricular function during exercise from a single injection of technetium-99m sestamibi in coronary artery disease (1990) Am J Cardiol, 66, pp. 68E-71E

Liu, P. P., Technetium-99m-sestamibi. Another window on myocardial viability? (1991) J Nucl Med, 32, pp. 298-299

Marshall, R. C., Tillish, J. H., Phelps, M. E., Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, 18-F-labeled fluorodeoxyglucose and N-13 ammonia (1983) Circulation, 67, pp. 766-778

Okada, R. D., Glover, D., Gaffney, T., Myocardial kinetics of technetium-99m-hesakis-2-methoxy-2-methyl-propyl-isonitrile (1988) Circulation, 77, pp. 491-498

Pozzoli, M. M. A., Fioretti, P. M., Salustri, A., Exercise echocardiography and technetium-99m MIBI single photon emission Computed Tomography in the detection of coronary artery disease (1991) Am J Cardiol, 67, pp. 350-355

Rahimtoola, S. H., The hibernating myocardium (1989) Am Heart J, 117, pp. 211-213

Rocco, T. P., Dilsizian, V., Strauss, H. W., Technetium-99m isonitrile myocardial uptake at rest. II. Relation to clinical markers of potential viability (1989) J Am Coll Cardiol, 14, pp. 1678-1684

Sawada, S. G., Allman, K. C., Muzik, O., Positron emission tomography detects evidence of viability in rest technetium-99m sestamibi defects (1994) J Am Coll Cardiol, 23, pp. 92-98

Schelbert, H. R., Phelps, M. E., Hoffman, E., Regional myocardial blood flow, metabolism, and function assessed noninvasively with positron emission tomography (1980) Am J Cardiol, 80, pp. 1269-1277

Shiller, N. B., Shah, P. M., Crawford, M., American Society of Echocardiography Committe on Standards. Subcommittee on Quantitation of Two-dimensional Echocardiograms: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echo, 2, pp. 358-367

Sinusas, A. J., Bergin, J. D., Edwards, N. C., Redistribution of 99mTc sestamibi and 201Tl in the presence of a severe coronary artery stenosis (1994) Circulation, 89, pp. 2332-2341

Udelson, J. E., Coleman, P. S., Metherall, J., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc sestamibi (1994) Circulation, 89, pp. 2552-2561

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* Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease (95 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2005 Sep; 46(9): 1438-1443.
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Storto G, Vicario MLE, Pellegrino T, Cirillo L, Ragone N, Fontanella L, Petretta M, Bonaduce D, Cuocolo A
* Influence of Risk Factors on Tc-99m Sestamibi Estimated Coronary Flow Reserve in Patients with One-vessel Coronary Artery Disease (75 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
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Storto G, Cirillo P, Eufrasia Vicario ML, Pellegrino T, Sorrentino AR, Petretta M, Galasso G, De Sanctis V, Piscione F, Cuocolo A
* Estimation of coronary flow reserve by Tc-99m sestamibi imaging in patients with coronary artery disease: Comparison with the results of intracoronary Doppler technique (131 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2004 Nov; 11(6): 682-688.
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Ferro A, Acampa W, Petretta M, Ibello F, Salvatore M, Cuocolo A
* A prospective, multi-center trial to identify the prevalence of inducible ischemia in patients presenting with diabetes and without known coronary artery disease: Preliminary results (72 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
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Storto G, Pellegrino T, Cirillo P, Sorrentino A, Galasso G, Piscione F, Salvatore M, Cuocolo A
* Estimation of coronary flow reserve by Tc-99m sestamibi imaging in patients with coronary artery disease: Comparison with the results of intracoronary Doppler technique (91 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
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Imbriaco M, Ferro A, Storto G, Pellegrino T, Sica G, Cuocolo A
* Early and late effects of coronary artery bypass grafting on cardiac haemodynamics during daily physical activities in patients with coronary artery disease (92 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(6): 852-856.
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Dellegrottaglie S, Perrone-Filardi P, Pace L, Prastaro M, Della Morte AM, Ponticelli MP, Piscione F, Storto G, De Luca G, Salvatore M, Chiariello M
* Prediction of long-term effects of revascularization on regional and global left ventricular function by dobutamine echocardiography and rest TI-201 imaging alone and in combination in patients with chronic coronary artery disease (93 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Mar; 9(2): 174-182.
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Pace L, Filardi PP, Cuocolo A, Prastaro M, Acampa W, Dellegrottaglie S, Storto G, Della Morte AM, Piscione F, Chiariello M, Salvatore M
* Diagnostic accuracy of low-dose dobutamine echocardiography in predicting post-revascularisation recovery of function in patients with chronic coronary artery disease: Relationship to thallium-201 uptake (91 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Nov; 28(11): 1616-1623.
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Pace L, Perrone-Filardi P, Storto G, Della Morte AM, Dellegrottaglie S, Prastaro M, Crisci T, Ponticelli MP, Piscione F, Chiariello M, Salvatore M
Prediction of improvement in global left ventricular function in patients with chronic coronary artery disease and impaired left ventricular function: Rest thallium-201 SPET versus low-dose dobutamine echocardiography (82 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2000 Dec; 27(12): 1740-1746.
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Menna F, Acampa W, Florimonte L, Ferro A, Borrelli G, Mainolfi C, Cuocolo A
99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction (106 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 99(4): 258-263.
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Pace L, Perrone-Filardi P, Mainenti PP, Cuocolo A, Vezzuto P, Prastaro M, Varrone A, De Luca G, Soricelli A, Betocchi S, Chiariello M, Salvatore M
Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis (80 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Nov; 39(11): 1869-1874.
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Petretta M, Cuocolo A, Nicolai E, Acampa W, Salvatore M, Bonaduce D
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction (118 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Jul; 5(4): 378-386.
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Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Vezzuto P, Varrone A, Crisci T, Cuocolo A, Dellegrottaglie S, Piscione F, Chiariello M, Salvatore M
Combined evaluation of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the identification of viable myocardium in patients with chronic coronary artery disease (95 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1998 Jul; 25(7): 744-750.
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Acampa W, Cuocolo A, Sullo P, Varrone A, Nicolai E, Pace L, Petretta M, Salvatore M
Direct comparison of technetium 99m-sestamibi and technetium 99m-tetrofosmin cardiac single photon emission computed tomography in patients with coronary artery disease (99 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 May; 5(3): 265-274.
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Cuocolo A, Acampa W, Varrone A, Sullo P, Nicolai E, Pace L, Salvatore M
Direct comparison of technetium-99m labeled sestamibi and tetrofosmin cardiac tomography in patients with coronary artery disease (69 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): N/D-N/D.
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Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Cuocolo A, Varrone A, Vezzuto P, Crisci T, Soricelli A, Piscione F, Chiariello M, Salvatore M
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease (108 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Mar; 5(2): 153-160.
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Cuocolo A, Sullo P, Pace L, Nappi A, Gisonni P, Nicolai E, Trimarco B, Salvatore M
Adenosine coronary vasodilation in coronary artery disease: Technetium- 99m tetrofosmin myocardial tomography versus echocardiography (94 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jul; 38(7): 1089-1094.
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Marcassa C, Galli M, Cuocolo A, Scappellato F, Maurea S, Salvatore M
Rest-redistribution thallium-201 and rest technetium-99m-sestamibi SPECT in patients with stable coronary artery disease and ventricular dysfunction (88 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997; 38(3): 419-424.
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Nicolai E, Cuocolo A, Pace L, Maurea S, Nappi A, Imbriaco M, Morisco C, Argenziano L, Salvatore M
Assessment of systolic wall thickening using technetium-99m methoxyisobutylisonitrile in patients with coronary artery disease: relation to thallium-201 scintigraphy with re-injection (124 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1995 Sep; 22(9): 1017-1022.
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Maurea S, Cuocolo A, Nicolai E, Salvatore M
Improved detection of viable myocardium with thallium-201 reinjection in chronic coronary artery disease: comparison with technetium-99m-MIBI imaging (95 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Apr; 35(4): 621-624.
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Left ventricular dysfunction in coronary artery disease: Comparison between rest-redistribution thallium 201 and resting technetium 99m methoxyisobutyl isonitrile cardiac imaging (106 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1994 Jan; 1(1): 65-71.
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Cuocolo A, Maurea S, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Resting technetium-99m methoxyisobutylisonitrile cardiac imaging in chronic coronary artery disease: comparison with rest-redistribution thallium-201 scintigraphy (99 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Dec; 20(12): 1186-1192.
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Pace L, Cuocolo A, Maurea S, Nicolai E, Imbriaco M, Nappi A, Morisco C, Chiariello M, Trimarco B, Salvatore M
Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function (116 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1993 Oct; 34(10): 1688-1692.
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Morisco C, Chiariello M, Trimarco B, Salvatore M
Rest-injected thallium-201 redistribution and resting technetium-99m methoxyisobutylisonitrile uptake in coronary artery disease: relation to the severity of coronary artery stenosis (90 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Jun; 20(6): 502-510.
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SANTOMAURO M, CUOCOLO A, CELENTANO L, FERRARO S, PACE L, PAPPONE C, MADDALENA G, SALVATORE M, CHIARIELLO M
Diagnosis of coronary artery disease with Tc 99m-methoxy isobutil isonitrile and transesophageal pacing (92 visite)
Angiology (ISSN: 0003-3197), 1992 Oct; 43(10): 818-825.
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 Romano M, Betocchi S, Perrone-Filardi P, Cotecchia MR, Spinelli L, Salvatore M, Chiariello M, Condorelli M
Detecting coronary artery disease by radionuclide ventriculography: ejection time versus ejection fraction (65 visite)
Acta Cardiol (ISSN: 0001-5385), 1988; 43(3): 335-340.
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BETOCCHI S, PISCIONE F, PERRONE-FILARDI P, ALFANO B, GIUSTINO G, CAPPELLI-BIGAZZI M, SALVATORE M, CHIARIELLO M
EFFECTS OF VERAPAMIL ON LEFT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH CORONARY ARTERY DISEASE (85 visite)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 1988; 11(2SUPPL.A): N/D-N/D.
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53 Records (33 escludendo Abstract e Conferenze).
Impact factor totale: 181.524 (99.843 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 213.006 (122.826 escludendo Abstract e Conferenze).







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Ultimo aggiornamento: Monday 12 November 2018, 16:59:37