99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction(154 visite) Menna F, Acampa W, Florimonte L, Ferro A, Borrelli G, Mainolfi C, Cuocolo A
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 99(4): 258-263.
Tipo di articolo: Journal Article,
Impact factor: 1.368, Impact factor a 5 anni: 1.47
Centro per la Med. Nucleare del CNR, Universita Federico II, Via Pansini 5, 80131 Napoli NA, Italy
Purpose. To investigate the role of technetium-99m (99mTc) tetrofosmin single-photon emission Computed Tomography (SPECT) associated with nitrate administration in the detection of hypoperfused but still viable myocardium in patients with chronic coronary artery disease and left ventricular (LV) dysfunction. Material and methods. Twenty-two patients (mean age 54±11 years) with coronary artery disease, previous myocardial infarction and LV dysfunction (LV ejection fraction 38±13%) were examined. On differente days all patients underwent 99mTc tetrofosmin (740 MBq) SPECT under control conditions at rest and after sublingual nitroglycerin administration (10 mg). Regional tetrofosmin activity was quantitatively measured in 22 myocardial segments per patient. In each segment, tracer uptake was expressed as a percentage of the region with the peak activity. Results. Under control conditions, 267 myocardial segments (55%) showed normal tetrofosmin uptake (>70% of peak activity), 107 segments (22%) showed a moderate reduction (51- 70%) and 110 segments (23%) a severe reduction (≤50%) in tracer uptake. Among the 110 segments with a severe reduction in tetrofosmin uptake 20 (18%) showed increased tracer uptake ≥10% of after nitrate administration (from 44±5% to 58±3%, p
131 Records (114 escludendo Abstract e Conferenze). Impact factor totale: 376.643 (312.725 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 450.991 (373.596 escludendo Abstract e Conferenze).