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Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (64 views)

Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R

J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2014 Sep 6; 136(31): 10838-10841.

Abstract
DNA methylation, occurring at the 5 position of cytosine, is a natural process associated with mutational hotspots in skin tumors. By combining experimental techniques (optical spectroscopy, HPLC coupled to mass spectrometry) with theoretical methods (molecular dynamics, DFT/TD-DFT calculations in solution), we study trinucleotides with key sequences (TCG/T5mCG) in the UV-induced DNA damage. We show how the extra methyl, affecting the conformational equilibria and, hence, the electronic excited states, increases the quantum yield for the formation of cyclobutane dimers while reducing that of (6-4) adducts. © 2014 American Chemical Society.

Affiliations ▼
*** IBB - CNR Affiliation

Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, I-80134 Napoli, Italy

CNRS, IRAMIS, Laboratoire Francis Perrin, F-91191 Gif-sur-Yvette, France

INAC-LCIB, INAC-SCIB, LAN Université Grenoble Alpes, F-38000 Grenoble, France

Details ▼
Impact factor: 12.113, 5-year impact factor: 11.726

Paper type: Journal Article, Research Support, Non-U. S. Gov'T,

Keywords: Alkylation, Dimers, Electric Excitation, Mass Spectrometry, Molecular Dynamics, Computational Studies, Conformational Equilibrium, Electronic Excited State, Experimental Techniques, Natural Process, Optical Spectroscopy, Theoretical Methods, Uv-Induced Dna Damage, Dna Sequences,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84905674437&partnerID=40&md5=9d1060cdd3002d4df021987f61ddf5ae

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Friso, S., Choi, S. W., Dolnikowski, G. G., Selhub, J., (2002) Anal. Chem., 74, p. 4526

Denissenko, M. F., Chen, J. X., Tang, M. S., Pfeifer, G. P., (1997) Proc. Natl. Acad. Sci. U. S. A., 94, p. 3893

Pfeifer, G. P., You, Y. H., Besaratinia, A., (2005) Mutat. Res., 571, p. 19

You, Y. H., Li, C., Pfeifer, G. P., (1999) J. Mol. Biol., 293, p. 493

Rochette, P. J., Lacoste, S., Therrien, J. P., Bastien, N., Brash, D. E., Drouin, R., (2009) Mutat. Res., 665, p. 7

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Temiz, N. A., Donohue, D. E., Bacolla, A., Luke, B. T., Collins, J. R., (2012) PLoS One, 7, p. 35558


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* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (66 views)
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
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1 Records (1 excluding Abstracts and Conferences).
Total impact factor: 5.52 (5.52 excluding Abstracts and Conferences).
Total 5-year impact factor: 5.575 (5.575 excluding Abstracts and Conferences).



Your bibliography query: (([btitle, keywords, abstract] ALKYLATION AND [btitle, keywords, abstract] DIMERS)) AND NOT [id] = 11566



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