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Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (60 views)

Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R

J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2014 Sep 6; 136(31): 10838-10841.

DNA methylation, occurring at the 5 position of cytosine, is a natural process associated with mutational hotspots in skin tumors. By combining experimental techniques (optical spectroscopy, HPLC coupled to mass spectrometry) with theoretical methods (molecular dynamics, DFT/TD-DFT calculations in solution), we study trinucleotides with key sequences (TCG/T5mCG) in the UV-induced DNA damage. We show how the extra methyl, affecting the conformational equilibria and, hence, the electronic excited states, increases the quantum yield for the formation of cyclobutane dimers while reducing that of (6-4) adducts. © 2014 American Chemical Society.

Affiliations ▼
*** IBB - CNR Affiliation

Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, I-80134 Napoli, Italy

CNRS, IRAMIS, Laboratoire Francis Perrin, F-91191 Gif-sur-Yvette, France

INAC-LCIB, INAC-SCIB, LAN Université Grenoble Alpes, F-38000 Grenoble, France

Details ▼
Impact factor: 12.11, 5-year impact factor: 11.73

Paper type: Journal Article, Research Support, Non-U. S. Gov'T,

Keywords: Alkylation, Dimers, Electric Excitation, Mass Spectrometry, Molecular Dynamics, Computational Studies, Conformational Equilibrium, Electronic Excited State, Experimental Techniques, Natural Process, Optical Spectroscopy, Theoretical Methods, Uv-Induced Dna Damage, Dna Sequences,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84905674437&partnerID=40&md5=9d1060cdd3002d4df021987f61ddf5ae

References ▼
Klose, R.J., Bird, A.P., (2006) Trends Biochem. Sci., 31, p. 8

Friso, S., Choi, S.W., Dolnikowski, G.G., Selhub, J., (2002) Anal. Chem., 74, p. 4526

Denissenko, M.F., Chen, J.X., Tang, M.S., Pfeifer, G.P., (1997) Proc. Natl. Acad. Sci. U.S.A., 94, p. 3893

Pfeifer, G.P., You, Y.H., Besaratinia, A., (2005) Mutat. Res., 571, p. 19

Vu, B., Cannistraro, V.J., Sun, L., Taylor, J.S., (2006) Biochemistry, 45, p. 9327

Song, Q., Sherrer, S.M., Suo, Z., Taylor, J.S., (2012) J. Biol. Chem., 287, p. 8021

You, Y.H., Li, C., Pfeifer, G.P., (1999) J. Mol. Biol., 293, p. 493

Rochette, P.J., Lacoste, S., Therrien, J.P., Bastien, N., Brash, D.E., Drouin, R., (2009) Mutat. Res., 665, p. 7

Markovitsi, D., Gustavsson, T., Banyasz, A., (2010) Mutat. Res., 704, p. 21

Tommasi, S., Denissenko, M.F., Pfeifer, G.P., (1997) Cancer Res., 57, p. 4727

Cannistraro, V.J., Taylor, J.S., (2009) J. Mol. Biol., 392, p. 1145

Sharonov, A., Gustavsson, T., Marguet, S., Markovitsi, D., (2003) Photochem. Photobiol. Sci., 2, p. 362

Onidas, D., Markovitsi, D., Marguet, S., Sharonov, A., Gustavsson, T., (2002) J. Phys. Chem. B, 106, p. 11367

Lavery, R., Zakrzewska, K., Beveridge, D., Bishop, T.C., Case, D.A., Cheatham, T., Dixit, S., Sponer, J., (2010) Nucleic Acids Res., 38, p. 299

Banyasz, A., Douki, T., Improta, R., Gustavsson, T., Onidas, D., Vaya, I., Perron, M., Markovitsi, D., (2012) J. Am. Chem. Soc., 134, p. 14834

Improta, R., (2012) J. Phys. Chem. B, 116, p. 14261

Gustavsson, T., Improta, R., Markovitsi, D., (2010) J. Phys. Chem. Lett., 1, p. 2025

Law, Y.K., Azadi, J., Crespo-Hernandez, C.E., Olmon, E., Kohler, B., (2008) Biophys. J., 94, p. 3590

McCullagh, M., Hariharan, M., Lewis, F.D., Markovitsi, D., Douki, T., Schatz, G.C., (2010) J. Phys. Chem. B, 114, p. 5215

Boggio-Pasqua, M., Groenhof, G., Schafer, L.V., Grubmuller, H., Robb, M.A., (2007) J. Am. Chem. Soc., 129, p. 10996

Blancafort, L., Migani, A., (2007) J. Am. Chem. Soc., 129, p. 14540

Serrano-Perez, J.J., Gonzalez-Ramirez, I., Coto, P.B., Merchan, M., Serrano-Andres, L., (2008) J. Phys. Chem. B, 112, p. 14096

Desnous, C., Babu, B.R., McIriou, C., Mayo, J.U.O., Favre, A., Wengel, J., Clivio, P., (2008) J. Am. Chem. Soc., 130, p. 30

Hariharan, M., McCullagh, M., Schatz, G.C., Lewis, F.D., (2010) J. Am. Chem. Soc., 132, p. 15831

Douki, T., Cadet, J., (1994) Biochemistry, 33, p. 11942

Temiz, N.A., Donohue, D.E., Bacolla, A., Luke, B.T., Collins, J.R., (2012) PLoS One, 7, p. 35558

Klose, R. J., Bird, A. P., (2006) Trends Biochem. Sci., 31, p. 8

Friso, S., Choi, S. W., Dolnikowski, G. G., Selhub, J., (2002) Anal. Chem., 74, p. 4526

Denissenko, M. F., Chen, J. X., Tang, M. S., Pfeifer, G. P., (1997) Proc. Natl. Acad. Sci. U. S. A., 94, p. 3893

Pfeifer, G. P., You, Y. H., Besaratinia, A., (2005) Mutat. Res., 571, p. 19

You, Y. H., Li, C., Pfeifer, G. P., (1999) J. Mol. Biol., 293, p. 493

Rochette, P. J., Lacoste, S., Therrien, J. P., Bastien, N., Brash, D. E., Drouin, R., (2009) Mutat. Res., 665, p. 7

Law, Y. K., Azadi, J., Crespo-Hernandez, C. E., Olmon, E., Kohler, B., (2008) Biophys. J., 94, p. 3590

Serrano-Perez, J. J., Gonzalez-Ramirez, I., Coto, P. B., Merchan, M., Serrano-Andres, L., (2008) J. Phys. Chem. B, 112, p. 14096

Temiz, N. A., Donohue, D. E., Bacolla, A., Luke, B. T., Collins, J. R., (2012) PLoS One, 7, p. 35558

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* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (63 views)
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Oct 10; 283(41): 27799-27809.

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1 Records (1 excluding Abstracts and Conferences).
Total impact factor: 4.6 (4.6 excluding Abstracts and Conferences).
Total 5-year impact factor: 4.863 (4.863 excluding Abstracts and Conferences).

Your bibliography query: (([btitle, keywords, abstract] ALKYLATION AND [btitle, keywords, abstract] DIMERS)) AND NOT [id] = 11566

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