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 Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (193 visite) J Control Release (ISSN: 0168-3659, 1873-4995electronic, 0168-3659linking), 2015 Jan 24; 202: 21-30. Tipo di articolo: Journal Article, Impact factor: 7.441, Impact factor a 5 anni: 8.407 Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921957698&partnerID=40&md5=b3ea740a30eba97245ac851bcc56ea81 Parole chiave: Chemotherapy, Drug Products, Fluorescence Microscopy, Medical Nanotechnology, Tumors, Ultrasonic Applications, Antitumor Drugs, Focused Ultrasound, Imaging Agent, Mri Contrasts, Theranostic Agents, Therapeutic Benefits, Therapeutic Outcomes, Translatability, Liposomes, Doxorubicin, Gadoteridol, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Confocal Microscopy, Contrast Enhancement, Contrast To Noise Ratio, Controlled Study, Drug Release, Ex Vivo Study, Female, In Vitro Study, In Vivo Study, Liposomal Delivery, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Priority Journal, Pulsed Low Intensity Non Focused Ultrasound, Affiliazioni: *** IBB - CNR *** Center for Molecular Imaging, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52Torino, Italy Center for Preclinical Imaging, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Ribes 5Colleretto Giacosa (TO), Italy Institute for Biostructures and Bioimages (CNR), C/o Molecular Biotechnology Center, University of Torino, Italy Biolab, Department of Electronics and Telecommunications, Politecnico di TorinoTorino, Italy Riferimenti: Terreno, E., Uggeri, F., Aime, S., Image guided therapy: The advent of theranostic agents (2012) J. 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S., Molecular imaging in living subjects: Seeing fundamental biological processes in a new light (2003) Genes Dev., 17 (5), pp. 545-580 Jacobs, R. E., Cherry, S. R., Complementary emerging techniques: High-resolution PET and MRI (2001) Curr. Opin. Neurobiol., 11 (5), pp. 621-629 Manzoor, A. A., Overcoming limitations in nanoparticle drug delivery: Triggered, intravascular release to improve drug penetration into tumors (2012) Cancer Res., 72 (21), pp. 5566-5575 Ponce, A. M., Hyperthermia mediated liposomal drug delivery (2006) Int. J. Hyperth., 22 (3), pp. 205-213 Koning, G. A., Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors (2010) Pharm. Res., 27 (8), pp. 1750-1754 Negussie, A. H., Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound (2011) Int. J. Hyperth., 27 (2), pp. 140-155 Lanza, G. M., Assessing the barriers to image-guided drug delivery (2014) Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 6 (1), pp. 1-14 Dewhirst, M. W., Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes (2013) Surgical Oncology Clinics of North America, 22 (3), pp. 545-561 McDaniel, J. R., Dewhirst, M. W., Chilkoti, A., Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia (2013) Int. J. Hyperth., 29 (6), pp. 501-510 Dicheva, B. M., Koning, G. A., Targeted thermosensitive liposomes: An attractive novel approach for increased drug delivery to solid tumors (2014) Expert Opin. Drug Deliv., 11 (1), pp. 83-100 May, J. P., Li, S. D., Hyperthermia-induced drug targeting (2013) Expert Opin. Drug Deliv., 10 (4), pp. 511-527 Chen, X. Y., Gambhlr, S. S., Cheon, J., Theranostic nanomedicine (2011) Acc. Chem. Res., 44 (10). , p. 841 Lin, C. Y., Ultrasound sensitive eLiposomes containing doxorubicin for drug targeting therapy (2014) Nanomedicine, 10 (1), pp. 67-76 Lin, H. Y., Thomas, J. L., Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound (2004) Langmuir, 20 (15), pp. 6100-6106 Evjen, T. J., In vivo monitoring of liposomal release in tumours following ultrasound stimulation (2013) Eur. J. Pharm. Biopharm., 84 (3), pp. 526-531 Staples, B. J., Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats (2009) Cancer Chemother. Pharmacol., 64 (3), pp. 593-600 Fossheim, S. L., Paramagnetic liposomes as MRI contrast agents: Influence of liposomal physicochemical properties on the in vitro relaxivity (1999) Magn. Reson. Imaging, 17 (1), pp. 83-89 Castelli, D. D., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord. Chem. Rev., 252 (2122), pp. 2424-2443 Steckner, M. C., Liu, B., Ying, L., A new single acquisition, two-image difference method for determining MR image SNR (2009) Med. Phys., 36 (2), pp. 662-671 Henkelman, R. M., Measurement of signal intensities in the presence of noise in mr images (1985) Med. Phys., 12 (2), pp. 232-233 Haralick, R. M., Dinstein, I. H., Textural features for image classification (1973) IEEE Trans. Syst. Man Cybern., 3 (6), pp. 610-621. , SMC Da, A. A. J. R., Quantification of histochemical staining by color deconvolution (2001) Anal. Quant. Cytol. Histol., 23 (4), pp. 291-299 The main goal of this study was to assess the theranostic performance of a nanomedicine able to generate MRI contrast as a response to the release from liposomes of the antitumor drug Doxorubicin triggered by the local exposure to pulsed low intensity non focused ultrasounds (pLINFU). In vitro experiments showed that Gadoteridol was an excellent imaging agent for probing the release of Doxorubicin following pLINFU stimulation. On this basis, the theranostic system was investigated in vivo on a syngeneic murine model of TS/A breast cancer. MRI offered an excellent guidance for monitoring the pLINFU-stimulated release of the drug. Moreover, it provided: i) an in vivo proof of the effective release of the liposomal content, and ii) a confirmation of the therapeutic benefits of the overall protocol. Ex vivo fluorescence microscopy indicated that the good therapeutic outcome was originated from a better diffusion of the drug in the tumor following the pLINFU stimulus. Very interestingly, the broad diffusion of the drug in the tumor stroma appeared to be mediated by the presence of the liposomes themselves. The results of this study highlighted either the great potential of US-based stimuli to safely trigger the release of a drug from its nanocarrier or the associated significant therapeutic improvement. Finally, MRI demonstrated to be a valuable technique to support chemotherapy and monitoring the outcome. Furthermore, in this specific case, the theranostic agent developed has a high clinical translatability because the MRI agent utilized is already approved for human use. © 2015 Elsevier B.V. All rights reserved.
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Impact Factor: 5.008 Dettagli Esporta in BibTeX Esporta in EndNote Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S * Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue (113 visite) Int J Surg Pathol International Journal Of Surgical Pathology (ISSN: 1066-8969), 2015; 23(3): 211-216. Impact Factor: 0.782 Dettagli Esporta in BibTeX Esporta in EndNote Formicola F, Riccardi A, Vigliar E, Biondi B, Accurso A, Del Vecchio W, Imbriaco M * Multimetastatic medullary thyroid carcinoma to the breast: PET/CT--mammographic-US and MR findings (77 visite) Breast J (ISSN: 1075-122x, 1524-4741electronic), 2014 Nov; 20(6): 653-654. Impact Factor: 1.739 Dettagli Esporta in BibTeX Esporta in EndNote D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S * A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (111 visite) International Journal Of Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390. Impact Factor: 5.085 Dettagli Esporta in BibTeX Esporta in EndNote Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M * Exploitation of viral properties for intracellular delivery (135 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2014 Jul; 20(7): 468-478. Impact Factor: 1.546 Dettagli Esporta in BibTeX Esporta in EndNote Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G * Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (126 visite) Journal Of Bone And Mineral Metabolism (ISSN: 1435-5604, 0914-8779, 0914-8779linking), 2014 Jul; 32(4): 434-440. Impact Factor: 2.46 Dettagli Esporta in BibTeX Esporta in EndNote Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G * F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (112 visite) European Journal Of Haematology (ISSN: 0902-4441, 0902-4441linking), 2014 May; 92(5): 382-389. Impact Factor: 2.066 Dettagli Esporta in BibTeX Esporta in EndNote Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R * Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (121 visite) Acta Oncol Acta Oncologica (ISSN: 0284-186x, 1651-226x), 2014 May; 53(5): 613-619. Impact Factor: 2.997 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D * Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (108 visite) Colloid Polym Sci Springer Verlag (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127. Impact Factor: 1.865 Dettagli Esporta in BibTeX Esporta in EndNote Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R * Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (143 visite) Neuro Oncology Oxford University Press (ISSN: 1522-8517), 2014 May; 16(5): 748-753. Impact Factor: 6.776 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D * Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (199 visite) Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2014 Mar 27; 9(1): 1537-1557. Impact Factor: 4.383 Dettagli Esporta in BibTeX Esporta in EndNote Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M * Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (355 visite) Applied Microbiology And Biotechnology (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961. Impact Factor: 3.337 Dettagli Esporta in BibTeX Esporta in EndNote Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J * Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (690 visite) Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826. Impact Factor: 19.358 Dettagli Esporta in BibTeX Esporta in EndNote Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY * Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (181 visite) J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520. Impact Factor: 5.48 Dettagli Esporta in BibTeX Esporta in EndNote Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R * Multivariate normal tissue complication probability modeling of heart valve dysfunction in Hodgkin lymphoma survivors (151 visite) Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Oct 1; 87(2): 304-310. Impact Factor: 4.176 Dettagli Esporta in BibTeX Esporta in EndNote Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G * Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (137 visite) Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647. Impact Factor: 4.907 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Tesauro D, Morelli G * Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (141 visite) Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493. Impact Factor: 1.554 Dettagli Esporta in BibTeX Esporta in EndNote Maurea S, Fiumara G, Pellegrino T, Zampella E, Assante R, Mainenti PP, Cuocolo A * MIBG molecular imaging for evaluating response to chemotherapy in patients with malignant pheochromocytoma: preliminary results (106 visite) Cancer Imaging (ISSN: 1470-7330, 1470-7330electronic, 1470-7330linking), 2013 Apr 15; 13: 155-161. Impact Factor: 1.286 Dettagli Esporta in BibTeX Esporta in EndNote Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S * A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (153 visite) Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2013 Apr 2; 52(14): 3926-3930. Impact Factor: 11.336 Dettagli Esporta in BibTeX Esporta in EndNote Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L * Nanoparticles exposing neurotensin tumor-specific drivers (144 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204. Impact Factor: 1.862 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D * Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (159 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197. Impact Factor: 1.862 Dettagli Esporta in BibTeX Esporta in EndNote Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G * Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (92 visite) Analytical And Bioanalytical Chemistry (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624. Impact Factor: 3.578 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Ringhieri P, Tesauro D, Morelli G * Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (138 visite) New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534. Impact Factor: 3.159 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G * Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (156 visite) Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249. Impact Factor: 2.768 Dettagli Esporta in BibTeX Esporta in EndNote Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A * Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (173 visite) Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055. Impact Factor: 3.024 Dettagli Esporta in BibTeX Esporta in EndNote Lanzillo R, Quarantelli M, Bonavita S, Ventrella G, Lus G, Vacca G, Prinster A, Orefice G, Tedeschi G, Brescia Morra V * Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: A head-to-head retrospective study (115 visite) Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2012 Nov; 126(5): 306-314. Impact Factor: 2.474 Dettagli Esporta in BibTeX Esporta in EndNote Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R * Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (163 visite) (PDF 132 visite) Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808. Impact Factor: 4.524 Dettagli Esporta in BibTeX Esporta in EndNote Orditura M, Galizia G, Morgillo F, Martinelli E, Lieto E, Vitiello F, Di Martino N, Pacelli R, Renda A, Ciardiello F, De Vita F * Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (157 visite) Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136. Impact Factor: 2.057 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G * Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (146 visite) Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017. Impact Factor: 3.463 Dettagli Esporta in BibTeX Esporta in EndNote Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S * Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (117 visite) Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668. Impact Factor: 5.925 Dettagli Esporta in BibTeX Esporta in EndNote Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R * Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (122 visite) Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321. Impact Factor: 5.58 Dettagli Esporta in BibTeX Esporta in EndNote Cuocolo A Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (172 visite) Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300. Impact Factor: 1.724 Dettagli Esporta in BibTeX Esporta in EndNote Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S * Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (120 visite) Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669. Impact Factor: 6.169 Dettagli Esporta in BibTeX Esporta in EndNote Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G * Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (174 visite) Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685. Impact Factor: 3.151 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G * Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (181 visite) Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257. Impact Factor: 0 Dettagli Esporta in BibTeX Esporta in EndNote Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G * Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (115 visite) Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96. Impact Factor: 2.87 Dettagli Esporta in BibTeX Esporta in EndNote Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G * Hepatitis C virus infection in ocular adnexal lymphomas (80 visite) Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299. Impact Factor: 3.516 Dettagli Esporta in BibTeX Esporta in EndNote Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F * Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (103 visite) Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827. Impact Factor: 2.39 Dettagli Esporta in BibTeX Esporta in EndNote Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A * In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (165 visite) Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448. Impact Factor: 5.036 Dettagli Esporta in BibTeX Esporta in EndNote Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M * PET/CT in cancer research: From preclinical to clinical applications (172 visite) Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200. Impact Factor: 4.02 Dettagli Esporta in BibTeX Esporta in EndNote Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M * The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (105 visite) J Biol Chem Journal Of Biological Chemistry (ISSN: 1083-351x, 0021-9258), 2010 May 28; 285(22): 17123-17136. Impact Factor: 5.328 Dettagli Esporta in BibTeX Esporta in EndNote Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP * Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (142 visite) Plosone (ISSN: 1932-6203, 1932-6203electronic), 2010 Apr 8; 5(4): N/D-N/D. Impact Factor: 4.411 Dettagli Esporta in BibTeX Esporta in EndNote Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L * Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (112 visite) Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252. Impact Factor: 6.069 Dettagli Esporta in BibTeX Esporta in EndNote Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA * Cell recruitment and transfection in gene activated collagen matrix (114 visite) Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576. Impact Factor: 7.883 Dettagli Esporta in BibTeX Esporta in EndNote Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M * Bone mineral density in children, adolescents, and young adults with epilepsy (147 visite) Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146. Impact Factor: 4.052 Dettagli Esporta in BibTeX Esporta in EndNote Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V * Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (136 visite) Mol Cancer Ther Molecular Cancer Therapeutics (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717. Impact Factor: 4.953 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G * Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (114 visite) Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213. Impact Factor: 11.225 Dettagli Esporta in BibTeX Esporta in EndNote Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F * Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (118 visite) Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334. Impact Factor: 1.303 Dettagli Esporta in BibTeX Esporta in EndNote Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S * Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (120 visite) Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912. Impact Factor: 5.647 Dettagli Esporta in BibTeX Esporta in EndNote Storto G, Nicolai E, Salvatore M * [18F]FDG-PET-CT for early monitoring of tumor response: When and why (145 visite) Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180. Impact Factor: 1.724 Dettagli Esporta in BibTeX Esporta in EndNote Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G * Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (113 visite) J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250. Impact Factor: 1.807 Dettagli Esporta in BibTeX Esporta in EndNote Zaccaro L, Del Gatto A, Pedone C, Saviano M * Peptides for tumour therapy and diagnosis: current status and future directions (216 visite) Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795. Impact Factor: 4.708 Dettagli Esporta in BibTeX Esporta in EndNote Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M * 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (91 visite) Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D. Impact Factor: 4.532 Dettagli Esporta in BibTeX Esporta in EndNote Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A * Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (105 visite) Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633. Impact Factor: 6.594 Dettagli Esporta in BibTeX Esporta in EndNote Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R * Insights into cytochrome c-cardiolipin interaction. 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Impact Factor: 3.322 Dettagli Esporta in BibTeX Esporta in EndNote Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G * Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (128 visite) Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538. Impact Factor: 3.502 Dettagli Esporta in BibTeX Esporta in EndNote Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM * Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (224 visite) Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775. Impact Factor: 24.52 Dettagli Esporta in BibTeX Esporta in EndNote Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B * Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (132 visite) Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727. Impact Factor: 1.512 Dettagli Esporta in BibTeX Esporta in EndNote Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M * Nuclear imaging in cancer theranostics (194 visite) Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163. Impact Factor: 1.724 Dettagli Esporta in BibTeX Esporta in EndNote Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G * Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (145 visite) Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955. Impact Factor: 3.446 Dettagli Esporta in BibTeX Esporta in EndNote Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G * Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (137 visite) Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121. Impact Factor: 2.389 Dettagli Esporta in BibTeX Esporta in EndNote De Renzo A, Perna F, Persico M, Mainolfi C, Pace L * 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (85 visite) Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580. Impact Factor: 4.498 Dettagli Esporta in BibTeX Esporta in EndNote Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Salvatore B, Andretta C, Di Nuzzo C, Rotoli B, Salvatore M * Washout of [99mTc] sestamibi in predicting response to chemotherapy in patients with multiple myeloma (137 visite) Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Sep; 49(3): 281-285. Impact Factor: 1.724 Dettagli Esporta in BibTeX Esporta in EndNote Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F * The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (139 visite) J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2005 May 6; 280(18): 17953-17960. Impact Factor: 5.854 Dettagli Esporta in BibTeX Esporta in EndNote Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A * Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (110 visite) J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378. Impact Factor: 1.496 Dettagli Esporta in BibTeX Esporta in EndNote d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M * Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (131 visite) Int J Radiat Oncol Biol Phys (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738. Impact Factor: 4.285 Dettagli Esporta in BibTeX Esporta in EndNote Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M * Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (109 visite) Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830. Impact Factor: 0.996 Dettagli Esporta in BibTeX Esporta in EndNote Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A * ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (144 visite) J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032. Impact Factor: 5.873 Dettagli Esporta in BibTeX Esporta in EndNote Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M * Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (143 visite) Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887. Impact Factor: 3.324 Dettagli Esporta in BibTeX Esporta in EndNote Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C * Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (131 visite) Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461. Impact Factor: 2.045 Dettagli Esporta in BibTeX Esporta in EndNote Del Vecchio S, Zannetti A, Aloj L, Salvatore M * MIBI as prognostic factor in breast cancer (96 visite) Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50. Impact Factor: 2.222 Dettagli Esporta in BibTeX Esporta in EndNote Acampa W, Petretta M, Cuocolo A * Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (213 visite) Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330. Impact Factor: 1.903 Dettagli Esporta in BibTeX Esporta in EndNote Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P * Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (90 visite) J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155. Impact Factor: 1.573 Dettagli Esporta in BibTeX Esporta in EndNote Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R * Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (107 visite) Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616. Impact Factor: 3.542 Dettagli Esporta in BibTeX Esporta in EndNote Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M * Radiolabeling approaches for cholecystokinin B receptor imaging (147 visite) Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380. Impact Factor: 2.372 Dettagli Esporta in BibTeX Esporta in EndNote Danforth Dn JR, Aloj L, Carrasquillo JA, Bacharach SL, Chow C, Zujewski J, Whatley M, Galen B, Merino M, Neumann RD * The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (93 visite) Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 2002; 75(2): 135-146. Impact Factor: 3.132 Dettagli Esporta in BibTeX Esporta in EndNote Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Sica G, Annunziata G, Califano C, Rotoli B, Salvatore M * Wash-out of 99mTc-sestamibi (99mTc-MIBI) in evaluating response to chemotherapy in patients with multiple myeloma (MM) (91 visite) Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D. Impact Factor: 3.464 Dettagli Esporta in BibTeX Esporta in EndNote Pace L, Catalano L, Del Vecchio S, Di Gennaro F, De Renzo A, Sica G, Califano C, Tedesco N, Borrelli G, Rotoli B, Salvatore M * Predictive value of technetium-99m sestamibi in patients with multiple myeloma and potential role in the follow-up (118 visite) Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Mar; 28(3): 304-312. Impact Factor: 3.464 Dettagli Esporta in BibTeX Esporta in EndNote Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C * Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (90 visite) (PDF 128 visite) Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41. Impact Factor: 3.942 Dettagli Esporta in BibTeX Esporta in EndNote Colasanti A, Kisslinger A, Liuzzi R, Quarto M, Riccio P, Roberti G, Tramontano D, Villani F Hypericin photosensitization of tumor and metastatic cell lines of human prostate (64 visite) J Photochem Photobiol B (ISSN: 1011-1344print, 1011-1344linking), 2000 Feb; 54(2-3): 103-107. Impact Factor: 1.529 Dettagli Esporta in BibTeX Esporta in EndNote Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V From natural to synthetic multisite thrombin inhibitors (99 visite) Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39. Impact Factor: 2.331 Dettagli Esporta in BibTeX Esporta in EndNote Imbriaco M, De Iuri A, Camera L Isolated uterine relapse in a child with acute lymphoblastic leukemia (75 visite) Ajr Am J Roentgenol (ISSN: 0361-803x), 1998 Oct; 171(4): 1166-1167. Impact Factor: 2.179 Dettagli Esporta in BibTeX Esporta in EndNote Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (139 visite) Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683. Impact Factor: 8.228 Dettagli Esporta in BibTeX Esporta in EndNote Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (104 visite) Anal Biochem (ISSN: 0003-2697, 1096-0309electronic), 1996 May 1; 236(2): 338-343. Impact Factor: 2.017 Dettagli Esporta in BibTeX Esporta in EndNote Costanzo LL, De Guidi G, Giuffrida S, Sortino S, Condorelli G, Pappalardo G Antioxidant effect of copper(II) on photosensitized lipid peroxidation (100 visite) J Chem Res (ISSN: 0162-0134print, 0162-0134linking, 1873-3344), 1995 Feb; 57(2): 115-125. Impact Factor: 1.342 Dettagli Esporta in BibTeX Esporta in EndNote MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (129 visite) J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435. Impact Factor: 3.491 Dettagli Esporta in BibTeX Esporta in EndNote Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (73 visite) Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427. Impact Factor: 1.181 Dettagli Esporta in BibTeX Esporta in EndNote Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (67 visite) Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902. Impact Factor: 8.426 Dettagli Esporta in BibTeX Esporta in EndNote Gurrieri S, Rizzarelli E, Beach D, Bustamante C Imaging of kinked configurations of DNA molecules undergoing orthogonal field alternating gel electrophoresis by fluorescence microscopy (79 visite) Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1990 Apr 3; 29(13): 3396-3401. Impact Factor: 4.572 Dettagli Esporta in BibTeX Esporta in EndNote Iaffaioli RV, Frasci G, Di Tuoro AS, Facchini G, Pacelli R, Scala S, Fasolino A, Bianco AR Malignant lymphoma of the ovary: report on two cases and review of the literature (72 visite) Eur J Gynaecol Oncol (ISSN: 0392-2936), 1990; 11(3): 205-208. Impact Factor: 0.397 Dettagli Esporta in BibTeX Esporta in EndNote Iaffaioli RV, Frasci G, Tortora G, Ciardiello F, Nuzzo F, Scala S, Pacelli R, Bianco AR Effect of thymic extract 'thymostimulin' on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer (72 visite) Thymus (ISSN: 0165-6090), 1988; 12(2): 69-75. Impact Factor: 0.643 Dettagli Esporta in BibTeX Esporta in EndNote 116 Records (111 escludendo Abstract e Conferenze). Impact factor totale: 445.515 (427.268 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 479.774 (457.554 escludendo Abstract e Conferenze). 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