Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (430 views)
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.441, 5-year impact factor: 8.407
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921957698&partnerID=40&md5=b3ea740a30eba97245ac851bcc56ea81
Keywords: Chemotherapy, Drug Products, Fluorescence Microscopy, Medical Nanotechnology, Tumors, Ultrasonic Applications, Antitumor Drugs, Focused Ultrasound, Imaging Agent, Mri Contrasts, Theranostic Agents, Therapeutic Benefits, Therapeutic Outcomes, Translatability, Liposomes, Doxorubicin, Gadoteridol, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Confocal Microscopy, Contrast Enhancement, Contrast To Noise Ratio, Controlled Study, Drug Release, Ex Vivo Study, Female, In Vitro Study, In Vivo Study, Liposomal Delivery, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Priority Journal, Pulsed Low Intensity Non Focused Ultrasound,
Affiliations:
*** IBB - CNR ***
Center for Molecular Imaging, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52Torino, Italy
Center for Preclinical Imaging, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Ribes 5Colleretto Giacosa (TO), Italy
Institute for Biostructures and Bioimages (CNR), C/o Molecular Biotechnology Center, University of Torino, Italy
Biolab, Department of Electronics and Telecommunications, Politecnico di TorinoTorino, Italy
References:
Terreno, E., Uggeri, F., Aime, S., Image guided therapy: The advent of theranostic agents (2012) J. Control. Release, 161 (2), pp. 328-33
Prabhu, P., Patravale, V., The upcoming field of theranostic nanomedicine: An overview (2012) J. Biomed. Nanotechnol., 8 (6), pp. 859-882
Sumer, B., Gao, J.M., Theranostic nanomedicine for cancer (2008) Nanomedicine, 3 (2), pp. 137-140
Weissleder, R., Pittet, M.J., Imaging in the era of molecular oncology (2008) Nature, 452 (7187), pp. 580-589
Massoud, T.F., Gambhir, S.S., Molecular imaging in living subjects: Seeing fundamental biological processes in a new light (2003) Genes Dev., 17 (5), pp. 545-580
Weissleder, R., Molecular imaging: Exploring the next frontier (1999) Radiology, 212 (3), pp. 609-614
Jacobs, R.E., Cherry, S.R., Complementary emerging techniques: High-resolution PET and MRI (2001) Curr. Opin. Neurobiol., 11 (5), pp. 621-629
Manzoor, A.A., Overcoming limitations in nanoparticle drug delivery: Triggered, intravascular release to improve drug penetration into tumors (2012) Cancer Res., 72 (21), pp. 5566-5575
Lammers, T., Theranostic nanomedicine (2011) Acc. Chem. Res., 44 (10), pp. 1029-1038
Torchilin, V., Liposomes in drug delivery (2012) Fundamentals and Applications of Controlled Release Drug Delivery, pp. 289-328. , J. Siepmann, R.A. Siegel, M.J. Rathbone, Springer New York
Ponce, A.M., Hyperthermia mediated liposomal drug delivery (2006) Int. J. Hyperth., 22 (3), pp. 205-213
Koning, G.A., Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors (2010) Pharm. Res., 27 (8), pp. 1750-1754
Needham, D., A new temperature-sensitive liposome for use with mild hyperthermia: Characterization and testing in a human tumor xenograft model (2000) Cancer Res., 60 (5), pp. 1197-1201
Torres, E., Improved paramagnetic liposomes for MRI visualization of pH triggered release (2011) J. Control. Release, 154 (2), pp. 196-202
Kuppusamy, P., Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels (2002) Cancer Res., 62 (1), pp. 307-312
Mellal, D., Zumbuehl, A., Exit-strategies - Smart ways to release phospholipid vesicle cargo (2014) J. Mater. Chem. B, 2 (3), pp. 247-252
Zhu, L., Torchilin, V.P., Stimulus-responsive nanopreparations for tumor targeting (2013) Integr. Biol., 5 (1), pp. 96-107
Singh, R., Torti, S.V., Carbon nanotubes in hyperthermia therapy (2013) Adv. Drug Deliv. Rev., 65 (15), pp. 2045-2060
Bazrafshan, B., Temperature imaging of laser-induced thermotherapy (LITT) by MRI: Evaluation of different sequences in phantom (2014) Lasers Med. Sci., 29 (1), pp. 173-183
Kostrzewa, M., Microwave ablation of osteoid osteomas using dynamic MR imaging for early treatment assessment: Preliminary experience (2014) J. Vasc. Interv. Radiol., 25 (1), pp. 106-111
De Smet, M., Magnetic resonance guided high-intensity focused ultrasound mediated hyperthermia improves the intratumoral distribution of temperature-sensitive liposomal doxorubicin (2013) Investig. Radiol., 48 (6), pp. 395-405
Grull, H., Langereis, S., Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound (2012) J. Control. Release, 161 (2), pp. 317-327
Negussie, A.H., Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound (2011) Int. J. Hyperth., 27 (2), pp. 140-155
Ranjan, A., Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model (2012) J. Control. Release, 158 (3), pp. 487-494
Li, L., Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy (2013) J. Control. Release, 168 (2), pp. 142-150
Lanza, G.M., Assessing the barriers to image-guided drug delivery (2014) Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 6 (1), pp. 1-14
Fernando, R., MRI-guided monitoring of thermal dose and targeted drug delivery for cancer therapy (2013) Pharm. Res., 30 (11), pp. 2709-2717
Dewhirst, M.W., Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes (2013) Surgical Oncology Clinics of North America, 22 (3), pp. 545-561
McDaniel, J.R., Dewhirst, M.W., Chilkoti, A., Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia (2013) Int. J. Hyperth., 29 (6), pp. 501-510
Sharma, D., Chelvi, T.P., Ralhan, R., Thermosensitive liposomal taxol formulation: Heat-mediated targeted drug delivery in murine melanoma (1998) Melanoma Res., 8 (3), pp. 240-244
Papahadjopoulos, D., Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol (1973) Biochim. Biophys. Acta, 311 (3), pp. 330-348
Dicheva, B.M., Koning, G.A., Targeted thermosensitive liposomes: An attractive novel approach for increased drug delivery to solid tumors (2014) Expert Opin. Drug Deliv., 11 (1), pp. 83-100
Li, L., A novel two-step mild hyperthermia for advanced liposomal chemotherapy (2014) J. Control. Release, 174, pp. 202-208
Nakayama, M., Akimoto, J., Okano, T., Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting (2014) J. Drug Target., 22 (7), pp. 584-599
May, J.P., Li, S.D., Hyperthermia-induced drug targeting (2013) Expert Opin. Drug Deliv., 10 (4), pp. 511-527
Needham, D., Materials characterization of the low temperature sensitive liposome (LTSL): Effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin (2013) Faraday Discuss., 161, pp. 515-534
Langereis, S., Paramagnetic liposomes for molecular MRI and MRI-guided drug delivery (2013) NMR Biomed., 26 (7), pp. 728-744
Wang, S., Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors (2012) J. Control. Release, 162 (1), pp. 218-224
Chen, X.Y., Gambhlr, S.S., Cheon, J., Theranostic nanomedicine (2011) Acc. Chem. Res., 44 (10). , p. 841
Lin, C.Y., Ultrasound sensitive eLiposomes containing doxorubicin for drug targeting therapy (2014) Nanomedicine, 10 (1), pp. 67-76
Lin, H.Y., Thomas, J.L., Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound (2004) Langmuir, 20 (15), pp. 6100-6106
Evjen, T.J., In vivo monitoring of liposomal release in tumours following ultrasound stimulation (2013) Eur. J. Pharm. Biopharm., 84 (3), pp. 526-531
Giustetto, P., Release of a paramagnetic magnetic resonance imaging agent from liposomes triggered by low intensity non-focused ultrasound (2013) J. Med. Imaging Health Inform., 3 (3), pp. 356-366
Datta, S., Correlation of cavitation with ultrasound enhancement of thrombolysis (2006) Ultrasound Med. Biol., 32 (8), pp. 1257-1267
Schroeder, A., Kost, J., Barenholz, Y., Ultrasound, liposomes, and drug delivery: Principles for using ultrasound to control the release of drugs from liposomes (2009) Chem. Phys. Lipids, 162 (12), pp. 1-16
Yudina, A., Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes (2011) J. Control. Release, 155 (3), pp. 442-448
Schroeder, A., Controlling liposomal drug release with low frequency ultrasound: Mechanism and feasibility (2007) Langmuir, 23 (7), pp. 4019-4025
Afadzi, M., Mechanisms of the ultrasound-mediated intracellular delivery of liposomes and dextrans (2013) IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 60 (1), pp. 21-33
Staples, B.J., Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats (2009) Cancer Chemother. Pharmacol., 64 (3), pp. 593-600
Knodler, M., An analysis of toxicity in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) receiving cetuximab, fluorouracil and cisplatin alone or with docetaxel in a phase II clinical trial (CeFCiD) (2012) Onkologie, 35, p. 153
Fattahi, H., Magnetoliposomes as multimodal contrast agents for molecular imaging and cancer nanotheragnostics (2011) Nanomedicine, 6 (3), pp. 529-544
Aime, S., Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications (2009) Acc. Chem. Res., 42 (7), pp. 822-831
Terreno, E., Paramagnetic liposomes as innovative contrast agents for magnetic resonance (MR) molecular imaging applications (2008) Chem. Biodivers., 5 (10), pp. 1901-1912
Fossheim, S.L., Paramagnetic liposomes as MRI contrast agents: Influence of liposomal physicochemical properties on the in vitro relaxivity (1999) Magn. Reson. Imaging, 17 (1), pp. 83-89
Castelli, D.D., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord. Chem. Rev., 252 (2122), pp. 2424-2443
Rizzitelli, S., Giustetto, P., Boffa, C., Delli Castelli, D., Cutrin, J.C., Aime, S., Terreno, E., In vivo MRI visualization of release from liposomes triggered by local application of pulsed low intensity non focused ultrasound (2014) Nanomedicine, 10 (5), pp. 901-904
Barge, A., How to determine free Gd and free ligand in solution of Gd chelates. A technical note (2006) Contrast Media Mol. Imaging, 1 (5), pp. 184-188
Nanni, P., TS/A: A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma (1983) Clin. Exp. Metastasis, 1 (4), pp. 373-380
Steckner, M.C., Liu, B., Ying, L., A new single acquisition, two-image difference method for determining MR image SNR (2009) Med. Phys., 36 (2), pp. 662-671
Dietrich, O., Measurement of signal-to-noise ratios in MR images: Influence of multichannel coils, parallel imaging, and reconstruction filters (2007) J. Magn. Reson. Imaging, 26 (2), pp. 375-385
Henkelman, R.M., Measurement of signal intensities in the presence of noise in mr images (1985) Med. Phys., 12 (2), pp. 232-233
Castellano, G., Li, L.M., Cendes, F., Texture analysis of medical images (2004) Clin. Radiol., 59 (12), pp. 1061-1069
Haralick, R.M., Dinstein, I.H., Textural features for image classification (1973) IEEE Trans. Syst. Man Cybern., 3 (6), pp. 610-621. , SMC
Da, A.A.J.R., Quantification of histochemical staining by color deconvolution (2001) Anal. Quant. Cytol. Histol., 23 (4), pp. 291-299
Sumer, B., Gao, J. M., Theranostic nanomedicine for cancer (2008) Nanomedicine, 3 (2), pp. 137-140
Massoud, T. F., Gambhir, S. S., Molecular imaging in living subjects: Seeing fundamental biological processes in a new light (2003) Genes Dev., 17 (5), pp. 545-580
Jacobs, R. E., Cherry, S. R., Complementary emerging techniques: High-resolution PET and MRI (2001) Curr. Opin. Neurobiol., 11 (5), pp. 621-629
Manzoor, A. A., Overcoming limitations in nanoparticle drug delivery: Triggered, intravascular release to improve drug penetration into tumors (2012) Cancer Res., 72 (21), pp. 5566-5575
Ponce, A. M., Hyperthermia mediated liposomal drug delivery (2006) Int. J. Hyperth., 22 (3), pp. 205-213
Koning, G. A., Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors (2010) Pharm. Res., 27 (8), pp. 1750-1754
Negussie, A. H., Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound (2011) Int. J. Hyperth., 27 (2), pp. 140-155
Lanza, G. M., Assessing the barriers to image-guided drug delivery (2014) Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 6 (1), pp. 1-14
Dewhirst, M. W., Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes (2013) Surgical Oncology Clinics of North America, 22 (3), pp. 545-561
McDaniel, J. R., Dewhirst, M. W., Chilkoti, A., Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia (2013) Int. J. Hyperth., 29 (6), pp. 501-510
Dicheva, B. M., Koning, G. A., Targeted thermosensitive liposomes: An attractive novel approach for increased drug delivery to solid tumors (2014) Expert Opin. Drug Deliv., 11 (1), pp. 83-100
May, J. P., Li, S. D., Hyperthermia-induced drug targeting (2013) Expert Opin. Drug Deliv., 10 (4), pp. 511-527
Chen, X. Y., Gambhlr, S. S., Cheon, J., Theranostic nanomedicine (2011) Acc. Chem. Res., 44 (10). , p. 841
Lin, C. Y., Ultrasound sensitive eLiposomes containing doxorubicin for drug targeting therapy (2014) Nanomedicine, 10 (1), pp. 67-76
Lin, H. Y., Thomas, J. L., Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound (2004) Langmuir, 20 (15), pp. 6100-6106
Evjen, T. J., In vivo monitoring of liposomal release in tumours following ultrasound stimulation (2013) Eur. J. Pharm. Biopharm., 84 (3), pp. 526-531
Staples, B. J., Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats (2009) Cancer Chemother. Pharmacol., 64 (3), pp. 593-600
Fossheim, S. L., Paramagnetic liposomes as MRI contrast agents: Influence of liposomal physicochemical properties on the in vitro relaxivity (1999) Magn. Reson. Imaging, 17 (1), pp. 83-89
Castelli, D. D., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord. Chem. Rev., 252 (2122), pp. 2424-2443
Steckner, M. C., Liu, B., Ying, L., A new single acquisition, two-image difference method for determining MR image SNR (2009) Med. Phys., 36 (2), pp. 662-671
Henkelman, R. M., Measurement of signal intensities in the presence of noise in mr images (1985) Med. Phys., 12 (2), pp. 232-233
Haralick, R. M., Dinstein, I. H., Textural features for image classification (1973) IEEE Trans. Syst. Man Cybern., 3 (6), pp. 610-621. , SMC
Da, A. A. J. R., Quantification of histochemical staining by color deconvolution (2001) Anal. Quant. Cytol. Histol., 23 (4), pp. 291-299
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.441, 5-year impact factor: 8.407
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921957698&partnerID=40&md5=b3ea740a30eba97245ac851bcc56ea81
Keywords: Chemotherapy, Drug Products, Fluorescence Microscopy, Medical Nanotechnology, Tumors, Ultrasonic Applications, Antitumor Drugs, Focused Ultrasound, Imaging Agent, Mri Contrasts, Theranostic Agents, Therapeutic Benefits, Therapeutic Outcomes, Translatability, Liposomes, Doxorubicin, Gadoteridol, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Confocal Microscopy, Contrast Enhancement, Contrast To Noise Ratio, Controlled Study, Drug Release, Ex Vivo Study, Female, In Vitro Study, In Vivo Study, Liposomal Delivery, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Priority Journal, Pulsed Low Intensity Non Focused Ultrasound,
Affiliations:
*** IBB - CNR ***
Center for Molecular Imaging, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52Torino, Italy
Center for Preclinical Imaging, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Ribes 5Colleretto Giacosa (TO), Italy
Institute for Biostructures and Bioimages (CNR), C/o Molecular Biotechnology Center, University of Torino, Italy
Biolab, Department of Electronics and Telecommunications, Politecnico di TorinoTorino, Italy
References:
Terreno, E., Uggeri, F., Aime, S., Image guided therapy: The advent of theranostic agents (2012) J. Control. Release, 161 (2), pp. 328-33
Prabhu, P., Patravale, V., The upcoming field of theranostic nanomedicine: An overview (2012) J. Biomed. Nanotechnol., 8 (6), pp. 859-882
Sumer, B., Gao, J.M., Theranostic nanomedicine for cancer (2008) Nanomedicine, 3 (2), pp. 137-140
Weissleder, R., Pittet, M.J., Imaging in the era of molecular oncology (2008) Nature, 452 (7187), pp. 580-589
Massoud, T.F., Gambhir, S.S., Molecular imaging in living subjects: Seeing fundamental biological processes in a new light (2003) Genes Dev., 17 (5), pp. 545-580
Weissleder, R., Molecular imaging: Exploring the next frontier (1999) Radiology, 212 (3), pp. 609-614
Jacobs, R.E., Cherry, S.R., Complementary emerging techniques: High-resolution PET and MRI (2001) Curr. Opin. Neurobiol., 11 (5), pp. 621-629
Manzoor, A.A., Overcoming limitations in nanoparticle drug delivery: Triggered, intravascular release to improve drug penetration into tumors (2012) Cancer Res., 72 (21), pp. 5566-5575
Lammers, T., Theranostic nanomedicine (2011) Acc. Chem. Res., 44 (10), pp. 1029-1038
Torchilin, V., Liposomes in drug delivery (2012) Fundamentals and Applications of Controlled Release Drug Delivery, pp. 289-328. , J. Siepmann, R.A. Siegel, M.J. Rathbone, Springer New York
Ponce, A.M., Hyperthermia mediated liposomal drug delivery (2006) Int. J. Hyperth., 22 (3), pp. 205-213
Koning, G.A., Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors (2010) Pharm. Res., 27 (8), pp. 1750-1754
Needham, D., A new temperature-sensitive liposome for use with mild hyperthermia: Characterization and testing in a human tumor xenograft model (2000) Cancer Res., 60 (5), pp. 1197-1201
Torres, E., Improved paramagnetic liposomes for MRI visualization of pH triggered release (2011) J. Control. Release, 154 (2), pp. 196-202
Kuppusamy, P., Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels (2002) Cancer Res., 62 (1), pp. 307-312
Mellal, D., Zumbuehl, A., Exit-strategies - Smart ways to release phospholipid vesicle cargo (2014) J. Mater. Chem. B, 2 (3), pp. 247-252
Zhu, L., Torchilin, V.P., Stimulus-responsive nanopreparations for tumor targeting (2013) Integr. Biol., 5 (1), pp. 96-107
Singh, R., Torti, S.V., Carbon nanotubes in hyperthermia therapy (2013) Adv. Drug Deliv. Rev., 65 (15), pp. 2045-2060
Bazrafshan, B., Temperature imaging of laser-induced thermotherapy (LITT) by MRI: Evaluation of different sequences in phantom (2014) Lasers Med. Sci., 29 (1), pp. 173-183
Kostrzewa, M., Microwave ablation of osteoid osteomas using dynamic MR imaging for early treatment assessment: Preliminary experience (2014) J. Vasc. Interv. Radiol., 25 (1), pp. 106-111
De Smet, M., Magnetic resonance guided high-intensity focused ultrasound mediated hyperthermia improves the intratumoral distribution of temperature-sensitive liposomal doxorubicin (2013) Investig. Radiol., 48 (6), pp. 395-405
Grull, H., Langereis, S., Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound (2012) J. Control. Release, 161 (2), pp. 317-327
Negussie, A.H., Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound (2011) Int. J. Hyperth., 27 (2), pp. 140-155
Ranjan, A., Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model (2012) J. Control. Release, 158 (3), pp. 487-494
Li, L., Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy (2013) J. Control. Release, 168 (2), pp. 142-150
Lanza, G.M., Assessing the barriers to image-guided drug delivery (2014) Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 6 (1), pp. 1-14
Fernando, R., MRI-guided monitoring of thermal dose and targeted drug delivery for cancer therapy (2013) Pharm. Res., 30 (11), pp. 2709-2717
Dewhirst, M.W., Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes (2013) Surgical Oncology Clinics of North America, 22 (3), pp. 545-561
McDaniel, J.R., Dewhirst, M.W., Chilkoti, A., Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia (2013) Int. J. Hyperth., 29 (6), pp. 501-510
Sharma, D., Chelvi, T.P., Ralhan, R., Thermosensitive liposomal taxol formulation: Heat-mediated targeted drug delivery in murine melanoma (1998) Melanoma Res., 8 (3), pp. 240-244
Papahadjopoulos, D., Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol (1973) Biochim. Biophys. Acta, 311 (3), pp. 330-348
Dicheva, B.M., Koning, G.A., Targeted thermosensitive liposomes: An attractive novel approach for increased drug delivery to solid tumors (2014) Expert Opin. Drug Deliv., 11 (1), pp. 83-100
Li, L., A novel two-step mild hyperthermia for advanced liposomal chemotherapy (2014) J. Control. Release, 174, pp. 202-208
Nakayama, M., Akimoto, J., Okano, T., Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting (2014) J. Drug Target., 22 (7), pp. 584-599
May, J.P., Li, S.D., Hyperthermia-induced drug targeting (2013) Expert Opin. Drug Deliv., 10 (4), pp. 511-527
Needham, D., Materials characterization of the low temperature sensitive liposome (LTSL): Effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin (2013) Faraday Discuss., 161, pp. 515-534
Langereis, S., Paramagnetic liposomes for molecular MRI and MRI-guided drug delivery (2013) NMR Biomed., 26 (7), pp. 728-744
Wang, S., Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors (2012) J. Control. Release, 162 (1), pp. 218-224
Chen, X.Y., Gambhlr, S.S., Cheon, J., Theranostic nanomedicine (2011) Acc. Chem. Res., 44 (10). , p. 841
Lin, C.Y., Ultrasound sensitive eLiposomes containing doxorubicin for drug targeting therapy (2014) Nanomedicine, 10 (1), pp. 67-76
Lin, H.Y., Thomas, J.L., Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound (2004) Langmuir, 20 (15), pp. 6100-6106
Evjen, T.J., In vivo monitoring of liposomal release in tumours following ultrasound stimulation (2013) Eur. J. Pharm. Biopharm., 84 (3), pp. 526-531
Giustetto, P., Release of a paramagnetic magnetic resonance imaging agent from liposomes triggered by low intensity non-focused ultrasound (2013) J. Med. Imaging Health Inform., 3 (3), pp. 356-366
Datta, S., Correlation of cavitation with ultrasound enhancement of thrombolysis (2006) Ultrasound Med. Biol., 32 (8), pp. 1257-1267
Schroeder, A., Kost, J., Barenholz, Y., Ultrasound, liposomes, and drug delivery: Principles for using ultrasound to control the release of drugs from liposomes (2009) Chem. Phys. Lipids, 162 (12), pp. 1-16
Yudina, A., Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes (2011) J. Control. Release, 155 (3), pp. 442-448
Schroeder, A., Controlling liposomal drug release with low frequency ultrasound: Mechanism and feasibility (2007) Langmuir, 23 (7), pp. 4019-4025
Afadzi, M., Mechanisms of the ultrasound-mediated intracellular delivery of liposomes and dextrans (2013) IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 60 (1), pp. 21-33
Staples, B.J., Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats (2009) Cancer Chemother. Pharmacol., 64 (3), pp. 593-600
Knodler, M., An analysis of toxicity in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) receiving cetuximab, fluorouracil and cisplatin alone or with docetaxel in a phase II clinical trial (CeFCiD) (2012) Onkologie, 35, p. 153
Fattahi, H., Magnetoliposomes as multimodal contrast agents for molecular imaging and cancer nanotheragnostics (2011) Nanomedicine, 6 (3), pp. 529-544
Aime, S., Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications (2009) Acc. Chem. Res., 42 (7), pp. 822-831
Terreno, E., Paramagnetic liposomes as innovative contrast agents for magnetic resonance (MR) molecular imaging applications (2008) Chem. Biodivers., 5 (10), pp. 1901-1912
Fossheim, S.L., Paramagnetic liposomes as MRI contrast agents: Influence of liposomal physicochemical properties on the in vitro relaxivity (1999) Magn. Reson. Imaging, 17 (1), pp. 83-89
Castelli, D.D., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord. Chem. Rev., 252 (2122), pp. 2424-2443
Rizzitelli, S., Giustetto, P., Boffa, C., Delli Castelli, D., Cutrin, J.C., Aime, S., Terreno, E., In vivo MRI visualization of release from liposomes triggered by local application of pulsed low intensity non focused ultrasound (2014) Nanomedicine, 10 (5), pp. 901-904
Barge, A., How to determine free Gd and free ligand in solution of Gd chelates. A technical note (2006) Contrast Media Mol. Imaging, 1 (5), pp. 184-188
Nanni, P., TS/A: A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma (1983) Clin. Exp. Metastasis, 1 (4), pp. 373-380
Steckner, M.C., Liu, B., Ying, L., A new single acquisition, two-image difference method for determining MR image SNR (2009) Med. Phys., 36 (2), pp. 662-671
Dietrich, O., Measurement of signal-to-noise ratios in MR images: Influence of multichannel coils, parallel imaging, and reconstruction filters (2007) J. Magn. Reson. Imaging, 26 (2), pp. 375-385
Henkelman, R.M., Measurement of signal intensities in the presence of noise in mr images (1985) Med. Phys., 12 (2), pp. 232-233
Castellano, G., Li, L.M., Cendes, F., Texture analysis of medical images (2004) Clin. Radiol., 59 (12), pp. 1061-1069
Haralick, R.M., Dinstein, I.H., Textural features for image classification (1973) IEEE Trans. Syst. Man Cybern., 3 (6), pp. 610-621. , SMC
Da, A.A.J.R., Quantification of histochemical staining by color deconvolution (2001) Anal. Quant. Cytol. Histol., 23 (4), pp. 291-299
Sumer, B., Gao, J. M., Theranostic nanomedicine for cancer (2008) Nanomedicine, 3 (2), pp. 137-140
Massoud, T. F., Gambhir, S. S., Molecular imaging in living subjects: Seeing fundamental biological processes in a new light (2003) Genes Dev., 17 (5), pp. 545-580
Jacobs, R. E., Cherry, S. R., Complementary emerging techniques: High-resolution PET and MRI (2001) Curr. Opin. Neurobiol., 11 (5), pp. 621-629
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Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound
The main goal of this study was to assess the theranostic performance of a nanomedicine able to generate MRI contrast as a response to the release from liposomes of the antitumor drug Doxorubicin triggered by the local exposure to pulsed low intensity non focused ultrasounds (pLINFU). In vitro experiments showed that Gadoteridol was an excellent imaging agent for probing the release of Doxorubicin following pLINFU stimulation. On this basis, the theranostic system was investigated in vivo on a syngeneic murine model of TS/A breast cancer. MRI offered an excellent guidance for monitoring the pLINFU-stimulated release of the drug. Moreover, it provided: i) an in vivo proof of the effective release of the liposomal content, and ii) a confirmation of the therapeutic benefits of the overall protocol. Ex vivo fluorescence microscopy indicated that the good therapeutic outcome was originated from a better diffusion of the drug in the tumor following the pLINFU stimulus. Very interestingly, the broad diffusion of the drug in the tumor stroma appeared to be mediated by the presence of the liposomes themselves. The results of this study highlighted either the great potential of US-based stimuli to safely trigger the release of a drug from its nanocarrier or the associated significant therapeutic improvement. Finally, MRI demonstrated to be a valuable technique to support chemotherapy and monitoring the outcome. Furthermore, in this specific case, the theranostic agent developed has a high clinical translatability because the MRI agent utilized is already approved for human use. © 2015 Elsevier B.V. All rights reserved.
The main goal of this study was to assess the theranostic performance of a nanomedicine able to generate MRI contrast as a response to the release from liposomes of the antitumor drug Doxorubicin triggered by the local exposure to pulsed low intensity non focused ultrasounds (pLINFU). In vitro experiments showed that Gadoteridol was an excellent imaging agent for probing the release of Doxorubicin following pLINFU stimulation. On this basis, the theranostic system was investigated in vivo on a syngeneic murine model of TS/A breast cancer. MRI offered an excellent guidance for monitoring the pLINFU-stimulated release of the drug. Moreover, it provided: i) an in vivo proof of the effective release of the liposomal content, and ii) a confirmation of the therapeutic benefits of the overall protocol. Ex vivo fluorescence microscopy indicated that the good therapeutic outcome was originated from a better diffusion of the drug in the tumor following the pLINFU stimulus. Very interestingly, the broad diffusion of the drug in the tumor stroma appeared to be mediated by the presence of the liposomes themselves. The results of this study highlighted either the great potential of US-based stimuli to safely trigger the release of a drug from its nanocarrier or the associated significant therapeutic improvement. Finally, MRI demonstrated to be a valuable technique to support chemotherapy and monitoring the outcome. Furthermore, in this specific case, the theranostic agent developed has a high clinical translatability because the MRI agent utilized is already approved for human use. © 2015 Elsevier B.V. All rights reserved.
Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound
| ▼ Molecular imaging for personalized therapy in oncology |
Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound
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Impact Factor: 6.069
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (365 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (342 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (475 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F
* Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (332 views)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.
Impact Factor: 1.303
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Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (707 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (358 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (876 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (221 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (272 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (370 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (582 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (221 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Salvatore B, Andretta C, Di Nuzzo C, Rotoli B, Salvatore M
* Washout of [99mTc] sestamibi in predicting response to chemotherapy in patients with multiple myeloma (360 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Sep; 49(3): 281-285.
Impact Factor: 1.724
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (428 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (316 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (309 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (234 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (496 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (425 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (451 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P
* Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (435 views)
J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155.
Impact Factor: 1.573
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (476 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Danforth Dn JR, Aloj L, Carrasquillo JA, Bacharach SL, Chow C, Zujewski J, Whatley M, Galen B, Merino M, Neumann RD
* The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (261 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 2002; 75(2): 135-146.
Impact Factor: 3.132
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Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Sica G, Annunziata G, Califano C, Rotoli B, Salvatore M
* Wash-out of 99mTc-sestamibi (99mTc-MIBI) in evaluating response to chemotherapy in patients with multiple myeloma (MM) (279 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Pace L, Catalano L, Del Vecchio S, Di Gennaro F, De Renzo A, Sica G, Califano C, Tedesco N, Borrelli G, Rotoli B, Salvatore M
* Predictive value of technetium-99m sestamibi in patients with multiple myeloma and potential role in the follow-up (395 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Mar; 28(3): 304-312.
Impact Factor: 3.464
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Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (233 views) (PDF 217 views)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
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Colasanti A, Kisslinger A, Liuzzi R, Quarto M, Riccio P, Roberti G, Tramontano D, Villani F
Hypericin photosensitization of tumor and metastatic cell lines of human prostate (251 views)
J Photochem Photobiol B (ISSN: 1011-1344print, 1011-1344linking), 2000 Feb; 54(2-3): 103-107.
Impact Factor: 1.529
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (320 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Imbriaco M, De Iuri A, Camera L
Isolated uterine relapse in a child with acute lymphoblastic leukemia (208 views)
Ajr Am J Roentgenol (ISSN: 0361-803x), 1998 Oct; 171(4): 1166-1167.
Impact Factor: 2.179
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (431 views)
Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683.
Impact Factor: 8.228
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (303 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Gurrieri S, Rizzarelli E, Beach D, Bustamante C
Imaging of kinked configurations of DNA molecules undergoing orthogonal field alternating gel electrophoresis by fluorescence microscopy (530 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1990 Apr 3; 29(13): 3396-3401.
Impact Factor: 4.572
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Iaffaioli RV, Frasci G, Di Tuoro AS, Facchini G, Pacelli R, Scala S, Fasolino A, Bianco AR
Malignant lymphoma of the ovary: report on two cases and review of the literature (380 views)
Eur J Gynaecol Oncol (ISSN: 0392-2936), 1990; 11(3): 205-208.
Impact Factor: 0.397
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Iaffaioli RV, Frasci G, Tortora G, Ciardiello F, Nuzzo F, Scala S, Pacelli R, Bianco AR
Effect of thymic extract 'thymostimulin' on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer (537 views)
Thymus (ISSN: 0165-6090), 1988; 12(2): 69-75.
Impact Factor: 0.643
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* Default-Mode Network Connectivity Changes Correlate with Attention Deficits in ALL Long-Term Survivors Treated with Radio- and/or Chemotherapy (5 views)
Biology (ISSN: 2079-7737electronic), 2022 Mar 24; 11 (4 ): N/D-N/D.
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Ibarra LE, Camorani S, Agnello L, Pedone E, Pirone L, Chesta CA, Palacios RE, Fedele M, Cerchia L
* Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles (4 views)
Pharmaceutics (ISSN: 1999-4923linking), 2022 Mar 12; 14(3): N/D-N/D.
Impact Factor: 6.321
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Longo F, Perri F, Caponigro F, Della Vittoria Scarpati G, Guida A, Pavone E, Aversa C, Muto P, Giuliano M, Ionna F, Solla R
* Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck? (46 views)
Cancers (ISSN: 2072-6694linking), 2020 Sep 28; 12(10): N/D-N/D.
Impact Factor: 6.126
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D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
* New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer (128 views) (PDF 37 views)
Cancers (ISSN: 2072-6694linking), 2020 Jul 18; 12(7): 1952-1952.
Impact Factor: 6.126
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Smaldone G, Beneduce G, Incoronato M, Pane K, Franzese M, Coppola L, Cordella A, Parasole R, Ripaldi M, Nassa G, Soricelli A, Vitagliano L, Mirabelli P, Salvatore M
* KCTD15 is overexpressed in human childhood B-cell acute lymphoid leukemia (73 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Dec 27; 9(1): 20108-20108.
Impact Factor: 4.122
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Mercurio V, Cuomo A, Della Pepa R, Ciervo D, Cella L, Pirozzi F, Parrella P, Campi G, Franco R, Varricchi G, Abete P, Marone G, Petretta M, Bonaduce D, Pacelli R, Picardi M, Tocchetti CG
* What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients? (169 views)
Antioxid Redox Signal (ISSN: 1523-0864linking, 1557-7716), 2019 Nov 20; 31 (15 ): 1166-1174.
Impact Factor: 7.581
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Perri F, Della Vittoria Scarpati G, Caponigro F, Ionna F, Longo F, Buonopane S, Muto P, Di Marzo M, Pisconti S, Solla R
* Management of recurrent nasopharyngeal carcinoma: current perspectives (157 views)
Oncotargets Ther (ISSN: 1178-6930linking), 2019 Feb 26; 12: 1583-1591.
Impact Factor: 2.272
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Wang L, Bateman B, Zanetti-domingues L, Moores A, L , Astbury S, Spindloe C, Darrow M, C , Romano M, Needham S, R , Beis K, Rolfe D, J , Clarke D, T , Martin-fernandez M, L
* Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution (73 views)
Commun Biol, 2019 Feb 21; 2:74: N/D-N/D.
Impact Factor: 0
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Picardi M, Della Pepa R, Giordano C, Pugliese N, Mortaruolo C, Trastulli F, Grimaldi F, Zacheo I, Raimondo M, Sirignano C, Salvatore P, Pane F
* (1-3)-beta-D-Glucan serum increase and small-airway-invasive radiological findings as early signs of pulmonary aspergillosis in high-risk hematologic patients in the posaconazole era: preliminary observations (213 views) (PDF 7 views)
Ann Hematol (ISSN: 0939-5555, 0939-5555linking), 2019 Feb; 98(2): 527-531.
Impact Factor: 2.845
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De Simone G
* Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (208 views)
Expert Opin Ther Pat (ISSN: 1744-7674electronic, 1354-3776linking), 2019 Jan; 29(1): 1-6.
Impact Factor: 3.699
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Monti M, De Rosa V, Iommelli F, Carriero MV, Terlizzi C, Camerlingo R, Belli S, Fonti R, Di Minno G, Del Vecchio S
* Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (242 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
Impact Factor: 3.687
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Salvatore B, D'Amico D, Fonti R
* Metastasis to the Sellar/Suprasellar Region in a Patient With Endometrial Carcinoma Detected by 18F-FDG PET/CT (287 views)
Clin Nucl Med (ISSN: 1536-0229electronic, 0363-9762linking), 2018 May; 43(5): 363-364.
Impact Factor: 0.253
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Corrias G, Huicochea Castellanos S, Merkow R, Langan R, Balachandran V, Ragucci M, Carollo G, Mancini M, Saba L, Mannelli L
* Does Second Reader Opinion Affect Patient Management in Pancreatic Ductal Adenocarcinoma? (329 views)
Acad Radiol (ISSN: 1076-6332, 1878-4046electronic, 1076-6332linking), 2018; 25(7): 825-832.
Impact Factor: 2.128
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Gallicchio R, Nardelli A, Venetucci A, Capacchione D, Pelagalli A, Sirignano C, Mainenti P, Pedicini P, Guglielmi G, Storto G
* F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer (393 views) (PDF 6 views)
Eur J Radiol (ISSN: 0720-048x), 2017 Aug; 93: 107-113.
Impact Factor: 2.843
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Roviello GN, Iannitti R, Palumbo R, Simonyan H, Vicidomini C, Roviello V
* Lac-L-TTA, a novel lactose-based amino acid-sugar conjugate for anti-metastatic applications (304 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2017 May 06; 49(8): 1347-1353.
Impact Factor: 2.906
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Perri F, Addeo R, Conson M, Faiella A, Scarpati GDV, Torre G, Di Biase A, Romanelli P, Buonerba C, Di Lorenzo G, Daponte A, Caponigro F, Pisconti S, Pacelli R, Ravo V, Muto P, Solla R
* Locally advanced paranasal sinus carcinoma: A study of 30 patients (218 views)
Oncol Lett (ISSN: 1792-1074), 2017 Mar; 13(3): 1338-1342.
Impact Factor: 1.664
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Insabato L, Guadagno E, Natella V, Somma A, Bihl M, Pizzolorusso A, Mainenti PP, Apice G, Tornillo L
* An unusual association of malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like) and Ewing sarcoma (256 views)
Pathol Res Pract (ISSN: 0344-0338), 2015 Sep; 211(9): 688-692.
Impact Factor: 1.388
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (275 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (307 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
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Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (431 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
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Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (366 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (380 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S
* Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue (281 views)
Int J Surg Pathol (ISSN: 1066-8969), 2015; 23(3): 211-216.
Impact Factor: 0.782
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Formicola F, Riccardi A, Vigliar E, Biondi B, Accurso A, Del Vecchio W, Imbriaco M
* Multimetastatic medullary thyroid carcinoma to the breast: PET/CT--mammographic-US and MR findings (241 views)
Breast J (ISSN: 1075-122x), 2014 Nov; 20(6): 653-654.
Impact Factor: 1.411
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (382 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (369 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (451 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (305 views)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
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Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (328 views)
Neuro-Oncology (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (670 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1418 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of heart valve dysfunction in Hodgkin lymphoma survivors (348 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Oct 1; 87(2): 304-310.
Impact Factor: 4.176
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (408 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Maurea S, Fiumara G, Pellegrino T, Zampella E, Assante R, Mainenti PP, Cuocolo A
* MIBG molecular imaging for evaluating response to chemotherapy in patients with malignant pheochromocytoma: preliminary results (241 views)
Cancer Imaging (ISSN: 1470-7330, 1470-7330electronic, 1470-7330linking), 2013 Apr 15; 13: 155-161.
Impact Factor: 1.286
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Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G
* Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (264 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624.
Impact Factor: 3.578
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Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
* Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (463 views)
Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (469 views) (PDF 227 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
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Orditura M, Galizia G, Morgillo F, Martinelli E, Lieto E, Vitiello F, Di Martino N, Pacelli R, Renda A, Ciardiello F, De Vita F
* Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (379 views)
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Impact Factor: 2.057
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (414 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (323 views)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (320 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (454 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (423 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (377 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (365 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (342 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (475 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F
* Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (332 views)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.
Impact Factor: 1.303
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Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (707 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (358 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (876 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (221 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (272 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (370 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (582 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (221 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Salvatore B, Andretta C, Di Nuzzo C, Rotoli B, Salvatore M
* Washout of [99mTc] sestamibi in predicting response to chemotherapy in patients with multiple myeloma (360 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Sep; 49(3): 281-285.
Impact Factor: 1.724
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (428 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (316 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (309 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (234 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (496 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (425 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (451 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P
* Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (435 views)
J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155.
Impact Factor: 1.573
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (476 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Danforth Dn JR, Aloj L, Carrasquillo JA, Bacharach SL, Chow C, Zujewski J, Whatley M, Galen B, Merino M, Neumann RD
* The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (261 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 2002; 75(2): 135-146.
Impact Factor: 3.132
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Pace L, Catalano L, Del Vecchio S, De Renzo A, Fonti R, Sica G, Annunziata G, Califano C, Rotoli B, Salvatore M
* Wash-out of 99mTc-sestamibi (99mTc-MIBI) in evaluating response to chemotherapy in patients with multiple myeloma (MM) (279 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Pace L, Catalano L, Del Vecchio S, Di Gennaro F, De Renzo A, Sica G, Califano C, Tedesco N, Borrelli G, Rotoli B, Salvatore M
* Predictive value of technetium-99m sestamibi in patients with multiple myeloma and potential role in the follow-up (395 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Mar; 28(3): 304-312.
Impact Factor: 3.464
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Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (233 views) (PDF 217 views)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
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Colasanti A, Kisslinger A, Liuzzi R, Quarto M, Riccio P, Roberti G, Tramontano D, Villani F
Hypericin photosensitization of tumor and metastatic cell lines of human prostate (251 views)
J Photochem Photobiol B (ISSN: 1011-1344print, 1011-1344linking), 2000 Feb; 54(2-3): 103-107.
Impact Factor: 1.529
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (320 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Imbriaco M, De Iuri A, Camera L
Isolated uterine relapse in a child with acute lymphoblastic leukemia (208 views)
Ajr Am J Roentgenol (ISSN: 0361-803x), 1998 Oct; 171(4): 1166-1167.
Impact Factor: 2.179
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (431 views)
Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683.
Impact Factor: 8.228
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (303 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Gurrieri S, Rizzarelli E, Beach D, Bustamante C
Imaging of kinked configurations of DNA molecules undergoing orthogonal field alternating gel electrophoresis by fluorescence microscopy (530 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1990 Apr 3; 29(13): 3396-3401.
Impact Factor: 4.572
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Iaffaioli RV, Frasci G, Di Tuoro AS, Facchini G, Pacelli R, Scala S, Fasolino A, Bianco AR
Malignant lymphoma of the ovary: report on two cases and review of the literature (380 views)
Eur J Gynaecol Oncol (ISSN: 0392-2936), 1990; 11(3): 205-208.
Impact Factor: 0.397
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Iaffaioli RV, Frasci G, Tortora G, Ciardiello F, Nuzzo F, Scala S, Pacelli R, Bianco AR
Effect of thymic extract 'thymostimulin' on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer (537 views)
Thymus (ISSN: 0165-6090), 1988; 12(2): 69-75.
Impact Factor: 0.643
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78 Records (74 excluding Abstracts).
Total impact factor: 340.642 (323.737 excluding Abstracts).
Total 5 year impact factor: 342.846 (324.008 excluding Abstracts).
Total impact factor: 340.642 (323.737 excluding Abstracts).
Total 5 year impact factor: 342.846 (324.008 excluding Abstracts).
430 views. Last view on Wednesday 10 August 2022, 2:16:36
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