A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction (255 views visite)
N-S Arch Pharmacol (ISSN: 0028-1298), 2015 Feb; 388(2): 257-269.
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Paper type Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.376, 5-year impact factor Impact factor a 5 anni: 2.226
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84905998753&partnerID=40&md5=99858e5e6387600c8f282b3b545c5c38
Keywords Parole chiave: Competitive Permeable Peptide (cpp), H-Prune, Nm23-H1, Prostate Cancer,
Affiliations Affiliazioni:
*** IBB - CNR ***
Centro di Ingegneria Genetica e Biotecnologia Avanzate (CEINGE), Naples, Italy.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli 'Federico II', Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Haemato-Oncology Laboratory, Department of Paediatrics, University of Padova, Padua, Italy
Dipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, Università di Napoli 'Federico II', Naples, Italy
DAI Dipartimento Assistenziale Medicina Trasfusionale, Azienda Ospedaliera Federico II, Naples, Italy
References Riferimenti:
Not available. Non disponibili.
N-S Arch Pharmacol (ISSN: 0028-1298), 2015 Feb; 388(2): 257-269.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.376, 5-year impact factor Impact factor a 5 anni: 2.226
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84905998753&partnerID=40&md5=99858e5e6387600c8f282b3b545c5c38
Keywords Parole chiave: Competitive Permeable Peptide (cpp), H-Prune, Nm23-H1, Prostate Cancer,
Affiliations Affiliazioni:
*** IBB - CNR ***
Centro di Ingegneria Genetica e Biotecnologia Avanzate (CEINGE), Naples, Italy.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli 'Federico II', Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Haemato-Oncology Laboratory, Department of Paediatrics, University of Padova, Padua, Italy
Dipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, Università di Napoli 'Federico II', Naples, Italy
DAI Dipartimento Assistenziale Medicina Trasfusionale, Azienda Ospedaliera Federico II, Naples, Italy
References Riferimenti:
Not available. Non disponibili.
A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction
Nm23-H1 is a metastasis suppressor gene whose overexpression is associated with both reduced cell motility in various cancers and increased metastatic potential in neuroblastomas, osteosarcomas, and hematological malignances. We previously reported that Nm23-H1 exerts tumor suppressor action in prostate cancer cells and that h-Prune, which is overexpressed in various tumor types, binds Nm23-H1. Moreover, blockage of the Nm23-H1/h-Prune interaction with a competitive permeable peptide (CPP) attenuates migration of breast and neuroblastoma cells. This series of events suggests that the Nm23-H1/h-Prune protein complex regulates cancer progression and that its specific impairment could be a new therapeutic strategy in oncology. We found that CPP leads to inhibition of the AKT/mTORv and NF-kBv signaling pathways and also activates apoptosis. To obtain a proof-of-concept of our hypothesis, we used a xenograft model of prostate cancer to evaluate whether impairment of this complex using CPP results in an anti-tumoral effect. Using a mouse orthotopic model with bioluminescent imaging, we show evidences that CPP reduces prostate cancer metastases formation. In conclusion, CPP being able to impair formation of the h-Prune/Nm23-H1 complex holds promise for the treatment of prostate cancer.
Nm23-H1 is a metastasis suppressor gene whose overexpression is associated with both reduced cell motility in various cancers and increased metastatic potential in neuroblastomas, osteosarcomas, and hematological malignances. We previously reported that Nm23-H1 exerts tumor suppressor action in prostate cancer cells and that h-Prune, which is overexpressed in various tumor types, binds Nm23-H1. Moreover, blockage of the Nm23-H1/h-Prune interaction with a competitive permeable peptide (CPP) attenuates migration of breast and neuroblastoma cells. This series of events suggests that the Nm23-H1/h-Prune protein complex regulates cancer progression and that its specific impairment could be a new therapeutic strategy in oncology. We found that CPP leads to inhibition of the AKT/mTORv and NF-kBv signaling pathways and also activates apoptosis. To obtain a proof-of-concept of our hypothesis, we used a xenograft model of prostate cancer to evaluate whether impairment of this complex using CPP results in an anti-tumoral effect. Using a mouse orthotopic model with bioluminescent imaging, we show evidences that CPP reduces prostate cancer metastases formation. In conclusion, CPP being able to impair formation of the h-Prune/Nm23-H1 complex holds promise for the treatment of prostate cancer.
A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction
No results. Nessun risultato. |
A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction
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* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (395 visite)
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Impact Factor: 5.078
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (399 visite)
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Dettagli Esporta in BibTeX Esporta in EndNote
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Dettagli Esporta in BibTeX Esporta in EndNote
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Dettagli Esporta in BibTeX Esporta in EndNote
Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (270 visite)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
Dettagli Esporta in BibTeX Esporta in EndNote
22 Records (19 escludendo Abstract e Conferenze).
Impact factor totale: 64.018 (52.622 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 62.179 (51.148 escludendo Abstract e Conferenze).
Impact factor totale: 64.018 (52.622 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 62.179 (51.148 escludendo Abstract e Conferenze).
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