Prognostic Value of Fluoro-D-glucose Uptake of Primary Tumor and Metastatic Lesions in Advanced Nonsmall Cell Lung Cancer(124 visite) Nguyen XC, Nguyen VK, Tran MT, Maurea S, Salvatore M
World Journal Of Nuclear Medicine (ISSN: 1450-1147), 2014 May; 13(2): 112-119.
Tipo di articolo: Journal Article,
Impact factor: 5.563, Impact factor a 5 anni: 6.119
Url: Non disponibile.
Parole chiave: 2-Deoxy-2-[18f]-Fluoro-D-Glucose, Nonsmall Cell Lung Cancer, Sum Of Maximum Standardized Uptake Value, Tumor Burden, 2-Deoxy-2- [18f] -Fluoro-D-Glucose,
*** IBB - CNR *** Unit of PET/CT and Cyclotron, Choray Hospital, Ho Chi Minh City, Vietnam.
To assess the prognostic value of maximum standardized uptake value (maxSUV) of the primary tumor (maxSUVpt), maxSUV of whole-body tumors (maxSUVwb) and sum of maximum standardized uptake value (sumaxSUV) measured by the sum of maxSUVs of the primary tumor, metastatic lymph nodes, and metastatic lesions per each organ on fluoro-D-glucose-positron emission tomography/computed tomography in advanced non-small cell lung cancer (NSCLC). Eighty-three patients (49 male, 34 female) with advanced NSCLC were enrolled. Seventeen patients had Stage IIIA, 21 Stage IIIB, and 45 Stage IV. maxSUVpt, maxSUVwb, sumaxSUV, age, gender, tumor-cell type, T stage, N stage, overall stage, primary tumor size, and specific treatment were analyzed for correlation with overall survival. Median follow-up duration was 13 months. Fifty patients were dead during a median follow-up time of 11 months and 33 patients were alive with a median time of 15 months. Univariate analysis revealed that overall survival was significantly correlated with sumaxSUV (≥35 vs.