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Collegamenti

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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New Conjugate Of Cyclodextrin Useful As Anti-Inflammatory And Anti-Tumoral Agents And For Preparation Of Medicaments With Colon Site-Specific Delivery (102 visite)

Rizzarelli E, Vecchio G, Puglisi A, La Mendola D, Pugliesi A

Am J Obstet Gynecol (ISSN: 0002-9378), 2015; 212(3): 413-413.



Tipo di articolo: Letter, Journal Article,

Impact factor: 4.681, Impact factor a 5 anni: 4.552

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84924765167&partnerID=40&md5=9fb50708bfa19fb257158eafc5cb56f5

Parole chiave: 25 Hydroxyvitamin D, Calcifediol, Estradiol, Gonadotropin, Vitamin D Binding Protein, 25-Hydroxyvitamin D, Blastocyst, Embryo Development, Ethnicity, Fertilization In Vitro, Hormonal Therapy, Hormone Substitution, Human, Infertility, Letter, Menstrual Cycle, Oocyte Donation, Ploidy, Pregnancy Outcome, Priority Journal, Self Report, Vitamin Blood Level, Analogs And Derivatives, Embryo Transfer, Female, Nidation, Pregnancy Rate, Embryo Implantation,

Affiliazioni:

*** IBB - CNR ***
Division of Reproductive Endocrinology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States
Reproductive Medicine Associates of New Jersey, 140 Allen Rd., Basking Ridge, NJ, United States
Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States



Riferimenti:

Fabris, A., Pacheco, A., Cruz, M., Puente, J.M., Fatemi, H., Garcia-Velasco, J.A., Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients (2014) Fertil Steril, 102, pp. 1608-161

Ozkan, S., Jindal, S., Greenseid, K., Replete vitamin D stores predict reproductive success following in vitro fertilization (2010) Fertil Steril, 94, p. 1314

Du, H., Daftary, G.S., Lalwani, S.I., Taylor, H.S., Direct regulation of HOXA10 by 1, 25-(OH)2 D3 in human myelomonocytic cells and human endometrial stromal cells (2005) Mol Endocrinol, 19, pp. 2222-2233

Shastri, S., Werner, M., Devkota, B., Taylor, D., Treff, N., Scott, R., Comparison of clinical outcomes between genetically similar groups of in vitro fertilization patients (2012) Fertil Steril, 98, p. S26



NOVELTY - A conjugate of cyclodextrin (I) is new. USE - For the preparation of medicaments with colon site-specific delivery (claimed). ADVANTAGE - The (S) -etodolac conjugate of beta -cyclodextrin is potent cyclooxygenase (COX) inhibitor. The beta -cyclodextrin etodolac conjugates allow to suitably target the drug. The optically pure etodolac conjugates is advantageous in terms of activity/side effects ratio. The solubility of the mixture of the diastereomers of the conjugate of cyclodextrin, markedly more water-soluble than etodolac itself, where the two isolated diastereomers show different solubilities in water, higher in the case of the R-etodolac conjugate (6. 8 g/l). The conjugate of beta -cyclodextrin shows excellent anti-inflammatory and anti-tumoral activity. DETAILED DESCRIPTION - A conjugate of cyclodextrin of formula (I), is new. Y1=acyl residue of is (R) or (S) 1, 8-diethyl-1, 3, 4, 9-tetrahydropyran (3, 4-b) indole-1-acetic acid (etodolac). An INDEPENDENT CLAIM is included for a pharmaceutical compositions containing conjugate of cyclodextrin of formula (Ib) in admixture with carriers
Nessun risultato.
Nessun risultato.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Simonetti I, Trovato P, Verde F, Tarotto L, Della Casa R, Lonardo MC, Vallone G, Caprio MG
* A rare case of hydrometrocolpos from persistent urogenital sinus in patient affected by adrenogenital syndrome (59 visite)
J Ultrasound (ISSN: 1876-7931electronic, 1876-7931linking, 1971-3495), 2018 Mar 3; 21(3): 249-252.
Impact Factor: 1.547
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (132 visite)
Molecular Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (147 visite)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (121 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (112 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (130 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Tauchmanova L, Pivonello R, De Martino MC, Rusciano A, De Leo M, Ruosi C, Mainolfi C, Lombardi G, Salvatore M, Colao A
* Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism (110 visite)
Eur J Endocrinol (ISSN: 0804-4643), 2007 Sep; 157(3): 359-366.
Impact Factor: 3.239
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Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (308 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (154 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (122 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, Lombardi G, Rossi R
* Andrenocortical carcinomas: Twelve-year prospective experience (96 visite)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Impact Factor: 1.952
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (122 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (122 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (82 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
Dettagli    Esporta in BibTeX    Esporta in EndNote



14 Records (13 escludendo Abstract e Conferenze).
Impact factor totale: 70.082 (64.967 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 58.371 (52.867 escludendo Abstract e Conferenze).







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