Conformational behavior of C(α, α)-diphenyl glycine: Extended conformation in tripeptides containing consecutive Dφg residues(334 views visite) Pavone V, Lombardi A, Saviano M, De Simone G, Nastri F, Maglio O, Omote Y, Yamanaka Y, Yamada T
Affiliations Affiliazioni: Ctro. Interuniversiterio di Ric., CEINGE-Biotecnologie Avanzate, Universita of Napoli Federico II, 80134 Napoli, Italy Department of Chemistry, Faculty of Science, Konan University, 658 Kobe, Japan Dipartimento di Chimica, Università di Napoli, Via Mezzocannone 4, I-80134 Napoli, Italy
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Conformational behavior of C(α, α)-diphenyl glycine: Extended conformation in tripeptides containing consecutive Dφg residues
Recent studies on the conformational preferences of the Dφg (C(α,α)- diphenylglycine) residue showed that this C(α,α)-disubstituted glycine has a structural versatility. In fact, depending on the nature of the following or preceding residue, Dφg can assume either folded or extended conformations. We have carried out the analysis of the conformational preferences of the Dφg residue in tripeptides containing consecutive Dφg residues. The crystal structures of Z-Dφg-Dφg-Dφg-OMe (a; Z = benzyloxycarbonyl; OMe = methyl ester), Z-Aib-Dφg-Dφg-OMe (b; Aib = α- aminoisobutyric acid), and Z-Ac3c-Dφg-Dφg-OMe (c; Ac3c = α-amino- cyclopropan carboxylic acid), are here reported. The Dφg residues adopt the fully extended conformation in the three tripeptides examined. Together with our previous findings on Dφg containing peptides, the structures of the peptides here examined, indicate that the presence of adjacent Dφg residue in the sequence further stabilizes the extended conformation. (C) 2000 John Wiley and Sons, Inc.
Conformational behavior of C(α, α)-diphenyl glycine: Extended conformation in tripeptides containing consecutive Dφg residues
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