Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound(293 views visite) Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
Keywords Parole chiave: Adduct Formation, Bovine Pancreatic Ribonuclease, Cytotoxic, Dinuclear, Esi Mass Spectrometry, Mode Of Action, Model Proteins, X Ray Diffraction, Gold, Auoxo6, Auranofin, Gold Complex, Histidine, Ligand, Metallodrug, Peroxiredoxin, Prodrug, Thioredoxin Reductase, Unclassified Drug, Antineoplastic Activity, Cattle, Chemical Structure, Complex Formation, Conference Paper, Crystal Structure, Electrospray Mass Spectrometry, Enzyme Activity, Nonhuman, Priority Journal, Animals, Cell Death, Crystallography, X-Ray, Hydrolysis, Molecular, Saccharomyces Cerevisiae, Electrospray Ionization,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Chemistry Ugo Schiff, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte sant'Angelo, Via Cintia I-80126, Napoli, Italy CNR Institute of Biostructures and Bioimages, Napoli, Italy
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Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound
The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(227 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
130 Records (127 escludendo Abstract e Conferenze). Impact factor totale: 444.457 (435.61 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 449.399 (440.727 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:14:52 293 views visite. Last view on Ultima visita in data Sunday 28 March 2021, 10:03:01