Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound
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Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (106 visite)

Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A

Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.



Tipo di articolo: Journal Article,

Impact factor: 3.585, Impact factor a 5 anni: 3.98

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84893276097&partnerID=40&md5=6ba50ce6078b2777e720fe9dcdca3ca6

Parole chiave: Adduct Formation, Bovine Pancreatic Ribonuclease, Cytotoxic, Dinuclear, Esi Mass Spectrometry, Mode Of Action, Model Proteins, X Ray Diffraction, Gold, Auoxo6, Auranofin, Gold Complex, Histidine, Ligand, Metallodrug, Peroxiredoxin, Prodrug, Thioredoxin Reductase, Unclassified Drug, Antineoplastic Activity, Cattle, Chemical Structure, Complex Formation, Conference Paper, Crystal Structure, Electrospray Mass Spectrometry, Enzyme Activity, Nonhuman, Priority Journal, Animals, Cell Death, Crystallography, X-Ray, Hydrolysis, Molecular, Saccharomyces Cerevisiae, Electrospray Ionization,

Affiliazioni:

*** IBB - CNR ***
Department of Chemistry Ugo Schiff, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte sant'Angelo, Via Cintia I-80126, Napoli, Italy
CNR Institute of Biostructures and Bioimages, Napoli, Italy


Riferimenti:

Sun, R.W.-Y., Lok, C.-N., Fong, T.T.-H., Li, C.K.-L., Yang, Z.F., Zou, T., Siu, A.F.-M., Che, C.-M., (2013) Chem. Sci., 4, p. 197

Zhang, J.-J., Sun, R.W.-Y., Che, C.-M., (2012) Chem. Commun., 48, p. 3388

Zhang, J.-J., Lu, W., Sun, R.W.-Y., Che, C.-M., (2012) Angew. Chem., Int. Ed., 51, p. 4882

Yan, J.J., Chow, A.L.-F., Leung, C.H., Sun, R.W.-Y., Ma, D.L., Che, C.-M., (2010) Chem. Commun., 46, p. 3893

Li, C.K.-L., Sun, R.W.-Y., Kui, S.C.-F., Zhu, N., Che, C.-M., (2006) Chem.-Eur. J., 12, p. 5253

Nobili, S., Mini, E., Landini, I., Gabbiani, C., Casini, A., Messori, L., (2010) Med. Res. Rev., 30, p. 550

Barnes, K.R., Lippard, S.J., (2004) Metal Ions Biol. Syst., Cisplatin and Related Anticancer Drugs: Recent Advances and Insights, 42, pp. 43-77. , ed. A. Sigel and H. Sigel, Marcel Dekker Inc., New York Basel Netherlands

Sun, R.W.-Y., Li, C.K.-L., Ma, D.-L., Yan, J.J., Lock, C.-N., Leung, C.-H., Zhu, N., Che, C.-M., (2010) Chem.-Eur. J., 16, p. 3097

Chow, K.H.-M., Sun, R.W.-Y., Lam, J.B.B., Li, C.K.-L., Xu, A., Ma, D.-L., Abagyan, R., Che, C.-M., (2010) Cancer Res., 70, p. 329

Lum, C.T., Yang, Z.F., Li, H.J., Sun, R.W.-Y., Fan, S.T., Poon, R.T., Lin, M.C.M., Kung, H.F., (2006) Int. J. Cancer, 118, p. 1527

Wang, Y., He, Q.Y., Sun, R.W.-Y., Che, C.-M., Chiu, J.F., (2005) Cancer Res., 65, p. 11553

Che, C.-M., Sun, R.W.-Y., Yu, W.-Y., Ko, C.-B., Zhu, N., Sun, H., (2003) Chem. Commun., p. 1718

Cattaruzza, L., Fregona, D., Mongiat, M., Ronconi, L., Fassina, A., Colombatti, A., Aldinucci, D., (2011) Int. J. Cancer, 128, p. 206

Milacic, V., Chen, D., Ronconi, L., Landis-Piwowar, K.R., Fregona, D., Dou, Q.P., (2006) Cancer Res., 66, p. 10478

Ronconi, L., Giovagnini, L., Marzano, C., Bettio, F., Graziani, R., Pilloni, G., Fregona, D., (2005) Inorg. Chem., 44, p. 1867

Giovagnini, L., Ronconi, L., Aldinucci, D., Lorenzon, D., Sitran, S., Fregona, D., (2005) J. Med. Chem., 48, p. 1588

De Vos, D., Ho, S.Y., Tiekink, E.R., (2004) Bioinorg. Chem. Appl., 2, p. 141

Zhang, C.X., Lippard, S.J., (2003) Curr. Opin. Chem. Biol., 7, p. 481

Rosenberg, B., Van Camp, L., Trosko, J.E., Mansour, V.H., (1969) Nature, 222, p. 385

Zou, J., Taylor, P., Dornan, J., Robinson, S.P., Walkinshaw, M.D., Sadler, P.J., (2000) Angew. Chem., Int. Ed., 39, pp. 2931-2934

Urig, S., Fritz-Wolf, K., Réau, R., Herold-Mende, C., Tóth, K., Davioud-Charvet, E., Becker, K., (2006) Angew. Chem., Int. Ed., 45, p. 1881

Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, p. 2099

Richards, F.M., Wyckoff, H.W., (1971) The Enzymes, 4, pp. 647-806. , ed. D. Boyer, Academic Press, San Diego

Raines, R.T., (1998) Chem. Rev., 98, p. 1045

Marshal, G.R., Fengand, J.A., Kuster, D.J., (2008) Biopolymers, 90, p. 259

D'Alessio, G., Riordan, J.F., (1997) Ribonucleases. Structures and Functions, , Academic Press, New York

Gutte, B., Merryfield, R.B., (1971) J. Biol. Chem., 246, p. 1922

Kartha, G., Bello, J., Harker, D., (1967) Nature, 213, p. 862

Merlino, A., Sica, F., Mazzarella, L., (2007) J. Phys. Chem., 111, p. 5483

Balakrishnan, R., Ramasubbu, N., Varughese, K.I., Parthasarathy, R., (1997) Proc. Natl. Acad. Sci. U. S. A., 94, p. 9620

Vergara, A., Montesarchio, D., Russo Krauss, I., Paduano, L., Merlino, A., (2013) Inorg. Chem., 52, p. 10714

Isab, A.A., Sadler, P.J., (1977) Biochim. Biophys. Acta, 492, p. 322

Maruyama, T., Sonokawa, S., Matsushita, H., Goto, M., (2007) J. Inorg. Biochem, 101, p. 180

Vitagliano, L., Merlino, A., Zagari, A., Mazzarella, L., (2000) Protein Sci., 9, p. 1217

Casini, A., Cinellu, M.A., Minghetti, G., Gabbiani, C., Coronnello, M., Mini, E., Messori, L., (2006) J. Med. Chem., 49, p. 5524

Cinellu, M.A., Maiore, L., Manassero, M., Casini, A., Arca, M., Fiebig, H.-H., Kelter, G., Messori, L., (2010) ACS Med. Chem. Lett., 1, p. 336

Messori, L., Scaletti, F., Massai, L., Cinellu, M.A., Gabbiani, C., Vergara, A., Merlino, A., (2013) Chem. Commun., 49, p. 10100

Mendes, F., Groessl, M., Nazarov, A.A., Tsybin, Y.O., Sava, G., Santos, I., Dyson, P.J., Casini, A., (2011) J. Med. Chem., 54, p. 2196

Kunitz, M., (1946) J. Biol. Chem., 164, p. 563

Merlino, A., Vitagliano, L., Ceruso, M.A., Di Nola, A., Mazzarella, L., (2002) Biopolymers, 65, p. 274

Sun, R. W. -Y., Lok, C. -N., Fong, T. T. -H., Li, C. K. -L., Yang, Z. F., Zou, T., Siu, A. F. -M., Che, C. -M., (2013) Chem. Sci., 4, p. 197

Zhang, J. -J., Sun, R. W. -Y., Che, C. -M., (2012) Chem. Commun., 48, p. 3388

Zhang, J. -J., Lu, W., Sun, R. W. -Y., Che, C. -M., (2012) Angew. Chem., Int. Ed., 51, p. 4882

Yan, J. J., Chow, A. L. -F., Leung, C. H., Sun, R. W. -Y., Ma, D. L., Che, C. -M., (2010) Chem. Commun., 46, p. 3893

Li, C. K. -L., Sun, R. W. -Y., Kui, S. C. -F., Zhu, N., Che, C. -M., (2006) Chem. -Eur. J., 12, p. 5253

Barnes, K. R., Lippard, S. J., (2004) Metal Ions Biol. Syst., Cisplatin and Related Anticancer Drugs: Recent Advances and Insights, 42, pp. 43-77. , ed. A. Sigel and H. Sigel, Marcel Dekker Inc., New York Basel Netherlands

Sun, R. W. -Y., Li, C. K. -L., Ma, D. -L., Yan, J. J., Lock, C. -N., Leung, C. -H., Zhu, N., Che, C. -M., (2010) Chem. -Eur. J., 16, p. 3097

Chow, K. H. -M., Sun, R. W. -Y., Lam, J. B. B., Li, C. K. -L., Xu, A., Ma, D. -L., Abagyan, R., Che, C. -M., (2010) Cancer Res., 70, p. 329

Lum, C. T., Yang, Z. F., Li, H. J., Sun, R. W. -Y., Fan, S. T., Poon, R. T., Lin, M. C. M., Kung, H. F., (2006) Int. J. Cancer, 118, p. 1527

Wang, Y., He, Q. Y., Sun, R. W. -Y., Che, C. -M., Chiu, J. F., (2005) Cancer Res., 65, p. 11553

Che, C. -M., Sun, R. W. -Y., Yu, W. -Y., Ko, C. -B., Zhu, N., Sun, H., (2003) Chem. Commun., p. 1718

De Vos, D., Ho, S. Y., Tiekink, E. R., (2004) Bioinorg. Chem. Appl., 2, p. 141

Zhang, C. X., Lippard, S. J., (2003) Curr. Opin. Chem. Biol., 7, p. 481

Bhabak, K. P., Bhuyan, B. J., Mugesh, G., (2011) Dalton Trans., 40, p. 2099

Richards, F. M., Wyckoff, H. W., (1971) The Enzymes, 4, pp. 647-806. , ed. D. Boyer, Academic Press, San Diego

Raines, R. T., (1998) Chem. Rev., 98, p. 1045

Marshal, G. R., Fengand, J. A., Kuster, D. J., (2008) Biopolymers, 90, p. 259

Isab, A. A., Sadler, P. J., (1977) Biochim. Biophys. Acta, 492, p. 322

Cinellu, M. A., Maiore, L., Manassero, M., Casini, A., Arca, M., Fiebig, H. -H., Kelter, G., Messori, L., (2010) ACS Med. Chem. Lett., 1, p. 336



The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
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Dettagli    Esporta in BibTeX    Esporta in EndNote

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Dettagli    Esporta in BibTeX    Esporta in EndNote

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Impact Factor: 2.983
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (163 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (137 visite)
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
Impact Factor: 4.819
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (155 visite)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
* The mode of action of anticancer gold-based drugs: a structural perspective (111 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
Impact Factor: 6.718
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (161 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Merlino A, Picone D, Ercole C, Balsamo A, Sica F
* Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease (100 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1108-1118.
Impact Factor: 3.142
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (108 visite)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (149 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (127 visite)
Bba-Mol Basis Dis (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (134 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Adinolfi M, Capasso D, Di Gaetano S, Iadonisi A, Leone L, Pastore A
* A straightforward synthetic access to symmetrical glycosyl disulfides and biological evaluation thereof (116 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2011 Sep 21; 9(18): 6278-6283.
Impact Factor: 3.696
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (190 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (80 visite)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (164 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (91 visite)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (177 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (119 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (137 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (96 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (144 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (96 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (119 visite)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarf MR
* Cytotoxicity Investigation On Cultured Human Blood Cells Treated With Single-Wall Carbon Nanoyubes (85 visite)
Sensors, 2008; 8: 488-499.
Impact Factor: 2.245
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (107 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (125 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (102 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Impact Factor: 3.415
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (170 visite)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (140 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (144 visite)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (119 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (106 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (150 visite)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (147 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (112 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (161 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Casella L, Monzani E, Gullotti M, Zoppellaro G, Pagliarin R, Bonomo RP, Tabbì G, Nardin G, Randaccio L
Synthetic Models For Biological Trinuclear Copper Clusters. Trinuclear And Dinuclear Complexes Derived From An Octadentate Tetraamin-Tetrabenzimidazole Ligand (115 visite)
Inorg Chim Acta, 1998; 282: 180-192.
Impact Factor: 0
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Monzani E, Quinti L, Perrotti A, Casella L, Gullotti M, Randaccio L, Geremia S, Nardin G, Faleschini P, Tabbì G
Tyrosinase Models. Synthesis, Structure, Catechol Oxidase Activity, And Phenol Monoxygenase Activity Of A Dinuclear Copper Complex Derived From A Triamino Pentabenzimidazole Ligand (99 visite)
Inorg Chem, 1998; 37: 553-562.
Impact Factor: 0
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (102 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (95 visite)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (115 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Veldman N, Spek AL, Tabbì G, Driessen WL, Reedijk J
A dinuclear nickel(II) compound: μ-{N, N, N′, N′-tetrakis[2-(3, 5-dimethyl-1-pyrazolyl)ethyl]-1, 2- ethylenediamine}-bis[aqua(nitrato-Ο, Ο + ′)nickel(II)] dinitrate dimethanol solvate (72 visite)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1996; 52(11): 2698-2701.
Impact Factor: 0.459
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (85 visite)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (113 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (92 visite)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (85 visite)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (142 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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77 Records (74 escludendo Abstract e Conferenze).
Impact factor totale: 281.263 (272.416 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 279.602 (270.93 escludendo Abstract e Conferenze).







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