Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu(227 views visite) Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A
Keywords Parole chiave: Antineoplastic Agent, Coordination Compound, Pancreatic Ribonuclease, Protein, Ruthenium, Article, Chemical Structure, Chemistry, Raman Spectrometry, X Ray Crystallography, Coordination Complexes, X-Ray, Molecular Structure, Spectrum Analysis, Coordination Complexes Chemistry, Proteins Chemistry, Pancreatic Chemistry, Ruthenium Chemistry,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, Napoli, Italy CNR Institute of Biostructures and Bioimages, Napoli, Italy CSGI (Consorzio per Lo Sviluppo Dei Sistemi A Grande Interfase), Florence, Italy
References Riferimenti: Ang, W.H., Casini, A., Sava, G., Dyson, P.J., (2011) J. Org. Chem., 696, p. 98
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, p. 219
Levina, A., Mitra, A., Lay, P.A., (2009) Metallomics, 1, p. 458
Levina, A., Lay, P.A., (2011) Dalton Trans., 40, p. 11675
Bergamo, A., Gaiddon, C., Schellens, J.H.M., Beijnen, J.H., Sava, G., (2012) J. Inorg. Biochem., 106, p. 90
Bergamo, A., Gava, B., Alessio, E., Mestroni, G., Serli, B., Cocchietto, M., Zorzet, S., Sava, G., (2002) Int. J. Oncol., 21, p. 1331
Casini, A., Temperini, C., Gabbiani, C., Supuran, C.T., Messori, L., (2010) ChemMedChem, 5, p. 1989
Smith, C.A., Sutherland-Smith, A.J., Keppler, B.K., Kratz, F., Baker, E.N., (1996) J. Biol. Inorg. Chem., 2, p. 424
Ascone, I., Messori, L., Casini, A., Gabbiani, C., Balerna, A., Dell'Unto, F., Castellano, A.C., (2008) Inorg. Chem., 47, p. 8629
Liu, M., Lim, Z.J., Gwee, Y.Y., Levina, A., Lay, P.A., (2010) Angew. Chem., 122, p. 1705
Levina, A., Aitken, J.B., Gwee, Y.Y., Lim, Z.J., Liu, M., Singharay, A.M., Wong, P.F., Lay, P.A., (2013) Chemistry, 19, p. 3609
Vergara, A., D'Errico, G., Montesarchio, D., Mangiapia, G., Paduano, L., Merlino, A., (2013) Inorg. Chem., 52, p. 4157
Mangiapia, G., D'Errico, G., Simeone, L., Irace, C., Radulescu, A., Di Pascale, A., Colonna, A., Paduano, L., (2012) Biomaterials, 33, p. 3770
Simeone, L., Mangiapia, G., Vitiello, G., Irace, C., Colonna, A., Ortona, O., Montesarchio, D., Paduano, L., (2012) Bioconjugate Chem., 23, p. 758
Balakrishnan, A.R., Ramasubbu, N., Varughese, K.I., Parthasarathy, R., (1997) Proc. Natl. Acad. Sci. U.S.A., 94, p. 9620
Merlino, A., Sica, F., Mazzarella, L., (2007) J. Phys. Chem. B, 111, p. 5483
Vitagliano, L., Merlino, A., Zagari, A., Mazzarella, L., (2000) Protein Sci., 9, p. 1217
George, G.N., Pickering, I.J., Pushie, M.J., Nienaber, K., Hackett, M.J., Ascone, I., Hedman, B., Lay, P.A., (2012) J. Synchrotron Radiat., 19, p. 875
Vergara, A., Merlino, A., Pizzo, E., D'Alessio, G., Mazzarella, L., (2008) Acta Crystallogr., Sect. D, 64, p. 167
Bouma, M., Nuijen, B., Jansen, M.T., Sava, G., Flaibani, A., Bult, A., Beijnen, J.H., (2002) Int. J. Pharm., 248, p. 239
Merlino, A., Fuchs, M.R., Pica, A., Balsamo, A., Dworkowski, F.S., Pompidor, G., Mazzarella, L., Vergara, A., (2013) Acta Crystallogr., Sect. D, 69, p. 137
Vergara, A., Vitagliano, L., Merlino, A., Sica, F., Marino, K., Verde, C., Di Prisco, G., Mazzarella, L., (2010) J. Biol. Chem., 285, p. 32568
Ang, W. H., Casini, A., Sava, G., Dyson, P. J., (2011) J. Org. Chem., 696, p. 98
Levina, A., Lay, P. A., (2011) Dalton Trans., 40, p. 11675
Smith, C. A., Sutherland-Smith, A. J., Keppler, B. K., Kratz, F., Baker, E. N., (1996) J. Biol. Inorg. Chem., 2, p. 424
Liu, M., Lim, Z. J., Gwee, Y. Y., Levina, A., Lay, P. A., (2010) Angew. Chem., 122, p. 1705
Balakrishnan, A. R., Ramasubbu, N., Varughese, K. I., Parthasarathy, R., (1997) Proc. Natl. Acad. Sci. U. S. A., 94, p. 9620
George, G. N., Pickering, I. J., Pushie, M. J., Nienaber, K., Hackett, M. J., Ascone, I., Hedman, B., Lay, P. A., (2012) J. Synchrotron Radiat., 19, p. 875
Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu
A Raman-assisted crystallographic study on the adduct between AziRu, a Ru(III) complex with high antiproliferative activity, and RNase A is presented. The protein structure is not perturbed significantly by the Ru label. The metal coordinates to ND atoms of His105 or of His119 imidazole rings, losing all of its original ligands but retaining octahedral, although distorted, coordination geometry. The AziRu binding inactivates the enzyme, suggesting that its antitumor action can be exerted by a mechanism of competitive inhibition.
Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(198 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
Chattopadhyay A, Cogdell R, Crespo-hernandez CE, Datta A, De A, Haacke S, Hariharan M, Helliwell J, Hughes A, Improta R, Jones M, Joseph J, Karsili T, Kohler B, Krishnan R, Kuriakose A, L , M , Markovitsi D, Medhi H, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schertler GFX, Schlichting I, Segarra-marti J, Swaminathan R, V , V , Van Grondelle R, Venkatraman RK, Venkatramani R, Watts A * Light induced charge and energy transport in nucleic acids and proteins: general discussion(115 visite) Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 153-180. Impact Factor:4.194 DettagliEsporta in BibTeXEsporta in EndNote
Chandra A, Cogdell R, Crespo-hernandez CE, Datta A, Giussani A, Haacke S, Helliwell J, Improta R, Jayasree RS, Jones M, Karsili T, Kohler B, L , M , Mandal I, Markovitsi D, Medhi H, Mishra PP, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schlichting I, Segarra-marti J, Sharma A, V , V , Van Grondelle R, Watts A * Light induced damage and repair in nucleic acids and proteins: general discussion(96 visite) Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 389-408. Impact Factor:4.194 DettagliEsporta in BibTeXEsporta in EndNote
Bhat V, Cogdell R, Crespo-hernández CE, Datta A, De A, Haacke S, Helliwell J, Improta R, Joseph J, Karsili T, Kohler B, Krishnan R, Mahil LM, Lewis F, Mandal I, Markovitsi D, Mishra PP, Paul S, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Sasikumar D, Schapiro I, Schertler GFX, Schlichting I, Segarra-martí J, Swaminathan R, Vishnu V, Van Grondelle R, Varghese R, Venkatramani R * Photocrosslinking between nucleic acids and proteins: general discussion(104 visite) Faraday Discussions, 2018; N/D: N/D-N/D. Impact Factor:3.427 DettagliEsporta in BibTeXEsporta in EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(211 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote