The mode of action of anticancer gold-based drugs: a structural perspective(288 views visite) Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
Keywords Parole chiave: Antineoplastic Agent, Cisplatin, Glutathione Reductase, Gold Derivative, Antineoplastic Activity, Article, Controlled Study, Crystal Structure, Drug Structure, Electrospray Mass Spectrometry, Enzyme Inhibition, X Ray Crystallography, Auranofin, Binding Sites, X-Ray, Drug Design, Models, Molecular, Molecular Structure, Muramidase, Organometallic Compounds, Protein Binding,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte sant'Angelo, Via cintia, I-80126 Napoli, Italy
References Riferimenti: Nobili, S., Mini, E., Landini, I., Gabbiani, C., Casini, A., Messori, L., (2010) Med. Res. Rev., 30, p. 55
Tanley, S.W.M., Schreurs, A.M., Kroon-Batenburg, L.M.J., Meredith, J., Prendergast, R., Walsh, D., Bryant, P., Helliwel, J.R., (2012) Acta Crystallogr., Sect. D, 68, p. 601
Gabbiani, C., Massai, L., Scaletti, F., Michelucci, E., Maiore, L., Cinellu, M.A., Messori, L., (2012) JBIC, J. Biol. Inorg. Chem., 17, p. 1293
Sun, R. W. -Y., Li, C. K. -L., Ma, D. -L., Yan, J. J., Lock, C. -N., Leung, C. -H., Zhu, N., Che, C. -M., (2010) Chem. -Eur. J., 16, p. 3097
Chow, K. H. -M., Sun, R. W. -Y., Lam, J. B. B., Li, C. K. -L., Xu, A., Ma, D. -L., Abagyan, R., Che, C. -M., (2010) Cancer Res., 70, p. 329
Lum, C. T., Yang, Z. F., Li, H. J., Sun, R. W. -Y., Fan, S. T., Poon, R. T., Lin, M. C. M., Kung, H. F., (2006) Int. J. Cancer, 118, p. 1527
Wang, Y., He, Q. Y., Sun, R. W. -Y., Che, C. -M., Chiu, J. F., (2005) Cancer Res., 65, p. 11553
Che, C. -M., Sun, R. W. -Y., Yu, W. -Y., Ko, C. -B., Zhu, N., Sun, H., (2003) Chem. Commun., p. 1718
De Vos, D., Ho, S. Y., Tiekink, E. R., (2004) Bioinorg. Chem. Appl., 2, p. 141
Sun, R. W. -Y., Lok, C. -N., Fong, T. T. -H., Li, C. K. -L., Yang, Z. F., Zou, T., Siu, A. F. -M., Che, C. -M., (2013) Chem. Sci., 4, p. 1979
Zhang, J. -J., Sun, R. W. -Y., Che, C. -M., (2012) Chem. Commun., 48, p. 3388
Zhang, J. -J., Lu, W., Sun, R. W. -Y., Che, C. -M., (2012) Angew. Chem., Int. Ed., 51, p. 4882
Yan, J. J., Chow, A. L. -F., Leung, C. H., Sun, R. W. -Y., Ma, D. L., Che, C. -M., (2010) Chem. Commun., 46, p. 3893
Li, C. K. -L., Sun, R. W. -Y., Kui, S. C. -F., Zhu, N., Che, C. -M., (2006) Chem. -Eur. J., 12, p. 5253
Cinellu, M. A., Maiore, L., Manassero, M., Casini, A., Arca, M., Fiebig, H. -H., Kelter, G., Messori, L., (2010) ACS Med. Chem. Lett., 1, p. 336
Zou, T., Lum, C. T., Chui, S. S. -Y., Che, C. -M., (2013) Angew. Chem., Int. Ed., 52, p. 2930
Baker, M. W., Barnard, P. J., Berners-Price, S. J., Brayshaw, S. K., Hickey, J. L., Skelton, B. W., White, A. H., (2006) Dalton Trans., p. 3708
Mirabelli, C. K., Sung, C. M., Zimmerman, J. P., Hill, D. T., Mong, S., Crooke, S. T., (1986) Biochem. Pharmacol., 35, p. 1427
Schuh, E., Pfl ger, C., Citta, A., Folda, A., Rigobello, M. P., Bindoli, A., Casini, A., Mohr, F., (2012) J. Med. Chem., 55, p. 5518
Panzner, M. J., Bilinovich, S. M., Youngs, W. J., Leeper, T. C., (2011) Chem. Commun., 47, p. 12479
Helliwell, J. R., Tanley, S. W., (2013) Acta Crystallogr., Sect. D, 69, p. 121
Tanley, S. W. M., Schreurs, A. M., Kroon-Batenburg, L. M. J., Meredith, J., Prendergast, R., Walsh, D., Bryant, P., Helliwel, J. R., (2012) Acta Crystallogr., Sect. D, 68, p. 601
The mode of action of anticancer gold-based drugs: a structural perspective
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
The mode of action of anticancer gold-based drugs: a structural perspective
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(206 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(284 visite) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 DettagliEsporta in BibTeXEsporta in EndNote
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(422 visite) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 DettagliEsporta in BibTeXEsporta in EndNote
Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A * MR Contrast Agents(230 visite) Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555. Impact Factor:1.784 DettagliEsporta in BibTeXEsporta in EndNote