Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy

Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy (165 visite)

Guaragna A, Roviello GN, D'Errico S, Paolella C, Palumbo G, D'Alonzo D

TETRAHEDRON LETT (ISSN: 0040-4039), 2015 Feb 4; 56(6): 775-778.

Tipo di articolo: Journal Article,

Impact factor: 2.347, Impact factor a 5 anni: 2.212

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921033943&partnerID=40&md5=603cc82bc5de785db1cb595be5153d45

Parole chiave: 5-Aminolevulinic Acid Methyl Ester, Folate Conjugates, Photodynamic Therapy, β-Amino Acids, Folic Acid, Photosensitizing Agent, Article, Conjugation, Solid Phase Synthesis, ?-Amino Acids,

Affiliazioni:

*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università Degli Studi di Napoli Federico II, via Cintia 21Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16Napoli, Italy
Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano 49Napoli, Italy
Universita degli Studi di Napoli Federico II

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Bareford, L. M., Swaan, P. W., (2007) Adv. Drug Delivery Rev., 59, pp. 748-758

Lee, D. Y., Li, K. C. P., (2011) Am. J. Roentgenol., 197, pp. 318-324

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The development of a novel tumor-targeting photosensitizer delivery system, with potential ability to selectively transport the photosensitizer prodrug 5-aminolevulinic acid methyl ester (MAL) into the tumor site has been herein described. Conjugation of MAL to folic acid (FA) via an unnatural beta-peptide linker has been carried out almost entirely by an efficient solid phase approach. This molecular system has been devised for possible applications in selective photodynamic diagnosis (PDD) and therapy (PDT). (C) 2014 Elsevier Ltd. All rights reserved.

Interrogazione effettuata: [atitle, keywords] "5-Aminolevulinic Acid Methyl Ester" OR [atitle, keywords] "Folate Conjugates" OR [atitle, keywords] "Photodynamic Therapy" OR [atitle, keywords] "β-Amino Acids" OR [atitle, keywords] "Folic Acid" OR [atitle, keywords] "Photosensitizing Agent" OR [atitle, keywords] "Conjugation"

Nessun risultato.

Interrogazione effettuata: [ptitle] "5-Aminolevulinic Acid Methyl Ester" OR [ptitle] "Folate Conjugates" OR [ptitle] "Photodynamic Therapy" OR [ptitle] "β-Amino Acids" OR [ptitle] "Folic Acid" OR [ptitle] "Photosensitizing Agent" OR [ptitle] "Conjugation"

Nessun risultato.

Interrogazione effettuata: [btitle, keywords] "5-Aminolevulinic Acid Methyl Ester" [btitle, keywords] "Folate Conjugates" [btitle, keywords] "Photodynamic Therapy" [btitle, keywords] "β-Amino Acids" [btitle, keywords] "Folic Acid" [btitle, keywords] "Photosensitizing Agent" [btitle, keywords] "Conjugation"

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