Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution(132 visite) Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
*** IBB - CNR *** Department of Medicine, University of Naples, Naples, Italy Department of Metabolic Diseases, University of Naples, Naples, Italy Department of Gastroenterology, University of Naples, Naples, Italy Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Institute of Biostructure and Bioimage, National Research Council, Naples, Italy SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy Institute of Food Sciences, National Research Council, Avellino, Italy Department of Biomorphological and Functional Science, Federico II University, Naples, Italy
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Luyckx, F. H., Desaive, C., Thiry, A., Dewe, W., Scheen, A. J., Gielen, J. E., Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty (1998) Int J Obes Relat Metab Disord, 22, pp. 222-226
Silverman, J. F., O'Brien, K. F., Long, S., Leggett, N., Khazanie, P. G., Pories, W. J., Liver pathology in morbidly obese patients with and without diabetes (1990) Am J Gastroenterol, 85, pp. 1349-1355
Kelley, D. E., McKolanis, T. M., Hegazi, R. A., Kuller, L. H., Kalhan, S. C., Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance (2003) Am J Physiol Endocrinol Metab, 285, pp. E906-E916
DeFronzo, R. A., Tobin, J. D., Andres, R., Glucose clamp technique: a method for quantifying insulin secretion and resistance (1979) Am J Physiol, 237, pp. E214-E223
Palmeira, C. M., Rolo, A. P., Berthiaume, J., Bjork, J. A., Wallace, K. B., Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis (2007) Toxicol Appl Pharmacol, 225, pp. 214-220
Caldwell, S. H., Swerdlow, R. H., Khan, E. M., Iezzoni, J. C., Hespenheide, E. E., Parks, J. K., Mitochondrial abnormalities in non-alcoholic steatohepatitis (1999) J Hepatol, 31, pp. 430-434
Korenblat, K. M., Fabbrini, E., Mohammed, B. S., Klein, S., Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects (2008) Gastroenterology, 134, pp. 1369-1375
Tushuizen, M. E., Bunck, M. C., Pouwels, P. J., Bontemps, S., Mari, A., Diamant, M., Lack of association of liver fat with model parameters of beta-cell function in men with impaired glucose tolerance and type 2 diabetes (2008) Eur J Endocrinol, 159, pp. 251-257
Dubois, S. G., Heilbronn, L. K., Smith, S. R., Albu, J. B., Kelley, D. E., Ravussin, E., Decreased expression of adipogenic genes in obese subjects with type 2 diabetes (2006) Obesity (Silver Spring), 14, pp. 1543-1552
Kim, J. Y., Van De Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Obesity-associated improvements in metabolic profile through expansion of adipose tissue (2007) J Clin Invest, 117, pp. 2621-2637
BACKGROUND: Fatty liver is commonly associated with insulin-resistant conditions, often related to increased abdominal visceral fat. Our objective was to elucidate the specific roles of obesity, type 2 diabetes mellitus, insulin-resistance and abdominal fat distribution.; MATERIALS AND METHODS: The study population comprised 13 diabetic obese (DO), 10 nondiabetic obese (NDO), and nine normal-weight control (C) men aged 28-65years, with normal plasma triglyceride levels. DO were in good glycaemic control (HbA1c = 6·8 ± 0·8%) (M ± SD) with diet (n = 8) or diet + metformin (n = 5). Liver fat content was measured by (1) H-magnetic resonance spectroscopy, abdominal fat distribution by magnetic resonance imaging and insulin sensitivity by hyperinsulinaemic euglycaemic clamp.; RESULTS: DO and NDO subjects had similar whole-body insulin resistance, BMI and waist circumference, higher than those of C subjects (P < 0·001). DO had more liver fat (11·9 ± 7·0%) than NDO (5·2 ± 2·8%, P < 0·05) and C (1·6 ± 1·0%, P < 0·001). Abdominal fat was greater in DO and NDO than in C (visceral: DO 3184 ± 843, NDO 2843 ± 1378 vs. C 1212 ± 587 cm(3), P < 0·001; subcutaneous: DO 4029 ± 362, NDO 5197 ± 1398 vs. C 2312 ± 626 cm(3), P < 0·001), visceral fat being not significantly different between the two obese groups, and subcutaneous fat significantly less in DO than in NDO (P < 0·05).; CONCLUSIONS: Type 2 diabetes is associated with increased fat accumulation in the liver, independent of obesity and whole-body insulin resistance. The increased liver fat in DO patients may be part of an altered regional fat distribution that includes an inadequate subcutaneous fat storing capacity, rather than simply being a consequence of increased abdominal visceral content. 2010 The Authors. European Journal of Clinical Investigation 2010 Stichting European Society for Clinical Investigation Journal Foundation.
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(24 visite) Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026. Impact Factor:0.913 DettagliEsporta in BibTeXEsporta in EndNote
128 Records (122 escludendo Abstract e Conferenze). Impact factor totale: 485.169 (467.05 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 501.803 (485.902 escludendo Abstract e Conferenze).
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