Nail and distal interphalangeal joint in psoriatic arthritis(120 visite) Scarpa R, Soscia E, Peluso R, Atteno M, Manguso F, Del Puente A, Spano A, Sirignano C, Oriente A, Di Minno MN, Iervolino S, Salvatore M
Parole chiave: Distal Interphalangeal Joint, Psoriasis, Psoriatic Arthritis, Psoriatic Onychopathy, Adult, Aged, Article, Clinical Article, Controlled Study, Disease Association, Disease Course, Female, Finger Joint, Human, Human Tissue, Nail Disease, Nuclear Magnetic Resonance Imaging, Priority Journal, Middle Aged, Complications, Pathology,
Affiliazioni:
*** IBB - CNR *** Department of Clinical and Experimental Medicine, Rheumatology Research Unit, Italy Radiology Unit, University Federico II, Naples, Italy Biostructures and Bioimaging Institute, National Council of Research, Italy Department of Radiology, Biostructures and Bioimaging Institute, National Council of Research, Italy
Riferimenti:
Bauer, W., Bennett, G.A., Zeller, J.W., Pathology of joint lesions in patients with psoriasis and arthritis (1941) Trans Assoc Am Physicians, 56, pp. 349-35
Dawson, M.H., Tyson, T.L., Psoriasis arthropathica with observations on certain features common to psoriasis and rheumatoid arthritis (1938) Trans Assoc Am Physicians, 53, pp. 303-306
Sherman, M., Psoriatic arthritis: Observations of the clinical roentgenographic and pathological changes (1952) J Bone Joint Surg, 34, pp. 831-852
Scarpa, R., Manguso, F., Oriente, A., Peluso, R., Atteno, M., Oriente, P., Is the involvement of the distal interphalangeal joint in psoriatic patients related to nail psoriasis? (2004) Clin Rheumatol, 23, pp. 27-30
Rich, P., Scher, R.K., Nail Psoriasis Severity Index: A useful tool for evaluation of nail psoriasis (2003) J Am Acad Dermatol, 49, pp. 206-212
Drapé, J.L., Chevrolet, A., Bittoun, J., Ungual and subungual disease (2001) Fundamentals of Hand and Wrist Imaging, pp. 481-505. , Guglielmi G, Van Kuijk C, Genant HK, editors. Berlin: Springer
Fournie, B., Viraben, R., Durroux, R., Lassoued, S., Gay, R., Fournié, A., L'onycho-pachydermo-périostite psoriasique du gros orteil (1989) Rev Rhum Mal Ostéoartic, 56, pp. 579-582
Fournie, B., Granel, J., Bonnet, M., Fréquences des signes évocateurs d'un rhumatisme psoriasique dans l'atteinte radiologique des doigts et des orteils. A propos de 193 cas d'arthropathie psoriasique (1992) Rev Rhum Mal Ostéoartic, 59, pp. 177-180
McGonagle, D., Gibbon, W., Emery, P., Classification of inflammatory arthritis by enthesitis (1998) Lancet, 352, pp. 1137-1140
McGonagle, D., Conaghan, P.G., Emery, P., Psoriatic arthritis: A unified concept twenty years on (1999) Arthritis Rheum, 42, pp. 1080-1086
OBJECTIVE: To study distal interphalangeal (DIP) joints in patients with psoriatic arthritis (PsA) with or without onychopathy, using magnetic resonance imaging (MRI). METHODS: Twenty-three patients with PsA (9/14 F/M, median age 47 yrs), 12 with onychopathy (2/10 F/M, median age 44 yrs) and 11 without (7/4 F/M, median age 52 yrs), and 10 control subjects (5/5 F/M, median age 43.2 yrs) were enrolled. MRI of nail and distal phalanx (DP) including examination of DIP joints was carried out. MRI was performed with a surface coil in a 1.5 T device. For each selected finger, both longitudinal and axial scans were performed. The involvement of nail, DP, and DIP joint was scored. RESULTS: Nail thickening with or without surface irregularity occurred in 95.7% of cases (100% with onychopathy and 90.9% without). MRI nail involvement was more frequent in patients with clinical evidence of onychopathy than in those without (p = 0.003). Similarly, 95.7% of patients showed MRI abnormalities of DP (100% with onychopathy and 90.9% without). MRI DP abnormalities were more marked in patients with clinical evidence of onychopathy than in those without (p = 0.009). Involvement of DIP joints was present in 34.8% of cases (58.3% with onychopathy and 9.1% without), and onychopathic patients showed marked MRI DIP joint involvement in 5 cases and mild in 2, while patients without onychopathy showed minimal changes in one case (p = 0.03). Considering the entire group of patients, MRI involvement of DIP joints was always associated with MRI DP changes, and in no case was it present alone. CONCLUSION: MRI nail involvement was present in almost all patients with PsA studied, even in those without clinically evident onychopathy. MRI involvement of DP always overlapped with nail involvement, since it was present in all psoriatic cases showing MRI nail involvement. In contrast, MRI DIP joint involvement was almost exclusively in a lower percentage of the patients with clinical nail involvement and was always associated with MRI DP changes. Our results suggest that DIP joint involvement is always secondary to nail and DP involvement.
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(60 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(135 visite) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 DettagliEsporta in BibTeXEsporta in EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(136 visite) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 DettagliEsporta in BibTeXEsporta in EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(177 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(144 visite) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 DettagliEsporta in BibTeXEsporta in EndNote
