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Trehalose Effects On Alpha-Crystallin Aggregates (153 visite)

Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E

(ISSN: 0006-291x), 2007 Mar 23; 354(4): 899-905.

Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,

Impact factor: 2.749

Impact factor a 5 anni: 2.802


Parole chiave: α-Crystallin, Aggregates, Chaperone Activity, Thermal Stability, Trehalose, Alpha Crystallin, Article, Controlled Study, Human, Inhibition Kinetics, Priority Journal, Protein Aggregation, Protein Structure, Stress, Thermostability, Alpha-Crystallins, Circular Dichroism, Microscopy, Atomic Force, Quaternary, Spectrometry, Fluorescence, Thiazoles,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846799235&partnerID=40&md5=3c58938e2d6a8e07a4109aa595ae3fa2

alpha-Crystallin in its native state is a large, heterogeneous, low-molecular weight (LMW) aggregate that under certain conditions may progressively became part of insoluble high-molecular weight (HMW) systems. These systems are supposed to play a relevant role in eye lens opacification and vision impairment. In this paper, we report the effects of trehalose on alpha-crystallin aggregates. The role of trehalose in alpha-crystallin stress tolerance, chaperone activity and thermal stability is studied. The results show that trehalose stabilizes the alpha-crystallin native structure, inhibits alpha-crystallin aggregation, and disaggregates preformed LMW systems not affecting its chaperone activity. (c) 2007 Elsevier Inc. All rights reserved
*** IBB - CNR ***

Istituto di Biostrutture e Bioimmagini (IBB), CNR, Catania, Italy

Consorzio Catania Ricerche, Italy

Dipartimento di Scienze Chimiche, Università di Catania, Italy

Dipartimento di Chimica Fisica, Università di Palermo, Italy
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Doss-Pepe, E. W., Carew, E. L., Koretz, J. F., Studies of the denaturation patterns of bovine alpha-crystallin using an ionic denaturant, guanidine hydrochloride and a non-ionic denaturant, urea (1998) Exp. Eye Res., 67, pp. 657-679

Spector, A., Li, L. K., Augusteyn, R. C., Schneider, A., Freund, T., Crystallin. The isolation and characterization of distinct macromolecular fractions (1971) Biochem. J., 124, pp. 337-343

Liang, J. J. -N., Akhtar, N. J., Human lens high-molecular-weight (-crystallin aggregates (2000) Biochem. Biophys. Res. Commun., 275, pp. 354-359

Thomson, J. A., Augusteyn, R. C., Alpha m-crystallin the native form of the protein? (1983) Exp. Eye Res., 37, pp. 367-377

Das, B. K., Liang, J. J. N., Chakrabarti, B., Heat-induced conformational change and increased chaperone activity of lens -crystallin (1997) Curr. Eye Res., 16, pp. 303-309

Burgio, M. R., Carin, J. K., Dow, C. C., Koretz, J. F., Correlation between the chaperone-like activity and aggregate size of -crystallin with increasing temperature (2000) Biochem. Biophys. Res. Commun., 268, pp. 426-432

Harding, J. J., Cataract, Alzheimer's disease, and other conformational diseases (1998) Curr. Opin. Ophthalmol., 9, pp. 10-13

Arguelles, J. C., Physiological roles of trehalose in bacteria and yeasts: a comparative analysis (2000) Arch. Microbiol., 174, pp. 217-224

Davies, J. E., Sovan, S., Rubinsztein, D. C., Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy (2006) Hum. Mol. Genet., 15, pp. 23-31

Sharp, L. K., Mallya, M., Kinghorn, K. J., Wang, Z., Crowther, D. C., Huntington, J. A., Belorgey, D., Lomas, D. A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS J., 273, pp. 2540-2552

Garcia, V. J., Martinez, L., Brice o-Valero, J. M., Shilling, C. M., (1997) Probe Microsc., 1, pp. 107-116

McFall-Ngai, M. J., Ding, L. L., Takemoto, L. J., Horwitz, J., Spatial and temporal mapping of the age-related changes in human lens crystallins (1985) Exp. Eye Res., 41, pp. 745-758

Chiou, S. H., Azari, P. J., Physicochemical characterization of alpha-crystallins from bovine lenses: hydrodynamic and conformational properties (1989) Protein Chem., 8, pp. 1-17

Lee, J. S., Satoh, H. S., Samejima, T., Wu, S. H., Chiou, S. H., Effect of heat induced structural perturbation of secondary and tertiary structures on the chaperone activity of -crystallin (1997) Biochem. Biophys. Res. Commun., 237, pp. 277-282

Liang, J. J. N., Sun, T. X., Akhtar, N. J., Heat-induced conformational change of human lens recombinant A- and B-crystallins (2000) Mol. Vis., 6, pp. 10-14

Beattie, G. M., Crowe, J. H., Lopez, A. D., Cirulli, V., Ricordi, C., Hayek, A., Trehalose: a cryoprotectant that enhances recovery and preserves function of human pancreatic islets after long-term storage (1997) Diabetes, 46, pp. 519-523

Beattie, G. M., Leibowitz, G., Lopez, A. D., Levine, F., Hayek, A., Protection from cell death in cultured human fetal pancreatic cells (2000) Cell Transplant., 9, pp. 431-438

Satpathy, G. R., Torok, Z., Bali, R., Dwyre, D. M., Little, E., Wolkers, WF., Tablin, F., Tsvetkova, N. M., Loading red blood cells with trehalose: a step towards biostabilization (2004) Cryobiology, 49, pp. 123-136

Steadman, B. L., Trautman, P. A., Lawson, E. Q., Raymond, M. J., Mood, D. A., Thomson, J. A., Middaugh, C. R., A differential scanning calorimetric study of the bovine lens crystallins (1989) Biochemistry, 28, pp. 9653-9658

Walsh, M. T., Sen, A. C., Chakrabarti, B., Micellar subunit assembly in a three-layer model of oligomeric alpha-crystallin (1991) J. Biol. Chem., 266, pp. 20079-20084

Surewicz, W. K., Olesen, P. R., On the thermal stability of alpha-crystallin: a new insight from infrared spectroscopy (1995) Biochemistry, 34, pp. 9655-9660

Timasheff, S. N., Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components (2002) Proc. Natl. Acad. Sci., 99, pp. 9721-9726

Kaushik, J. K., Bhat, R., Why is trehalose an exceptional protein stabilizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehalose (2003) J. Biol. Chem., 278, pp. 26458-26465

Lins, R. D., Pereira, C. S., H nenberger, P. H., Trehalose-protein interaction in aqueous solution (2004) Proteins, 55, pp. 177-186

Cesaro, A., Magaz, V., Migliardo, F., Sussich, F., Vadal, M., (2004) Physica B: Condensed Matter, 350 (1-3 SUPPL. 1), pp. e367-e370

H doux, A., Willart, J. F., Ionov, R., Affouard, F., Guinet, Y., Paccou, L., Lerbret, A., Descamps, M. J., Analysis of sugar bioprotective mechanisms on the thermal denaturation of lysozyme from Raman scattering and differential scanning calorimetry investigations (2006) Phys. Chem. B, 110, pp. 22886-22893

Magaz, S., Migliardo, F., Ramirez-Cuesta, A. J., Study on physical mechanisms of bioprotection (2006) Int. J. Phys. Sci., 1, pp. 75-80

Choi, Y., Cho, K. W., Jeong, K., Jung, S., Molecular dynamics simulations of trehalose as a 'dynamic reducer' for solvent water molecules in the hydration shell (2006) Carbohydr. Res., 341, pp. 1020-1028

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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (170 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (90 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (140 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (94 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
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De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (128 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (80 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (104 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (116 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (137 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (128 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
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Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (79 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (127 visite)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (119 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (88 visite)
Biophysical Chemistry (ISSN: 0301-4622), 2005 Jul 1; 116(2): 89-95.
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (94 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (74 visite)
Supramol Chem Supramolecular Chemistry (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (95 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (86 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (123 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (127 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
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Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
* Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (102 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (91 visite)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
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39 Records (36 escludendo Abstract e Conferenze).
Impact factor totale: 139.467 (136.159 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 152.69 (149.126 escludendo Abstract e Conferenze).







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