Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging
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Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (115 visite)

D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G

Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.



Tipo di articolo: Journal Article,

Impact factor: 5.361, Impact factor a 5 anni: 5.397

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77951622977&partnerID=40&md5=0197784a9f4f3c1c0364eb8176933242

Parole chiave: Biosensors, Dna Sensing, Genomic Dna, Pcr-Free, Peptide Nucleic Acids, Surface-Plasmon Resonance, Biosensing, Certified Reference Materials, Detection Methods, Direct Detection, Dna Detection, Enhanced Surface, Genetically Modified, Labeling Steps, Selectivity And Sensitivity, Target Sequences, Ultrasensitive Detection, Biomolecules, Dna Sequences, Nanoparticles, Polymerase Chain Reaction, Surface Plasmon Resonance, Complementary Dna, Analytic Method, Controlled Study, Dna Determination, Gene Amplification, Gene Targeting, Image Enhancement, Sensitivity Analysis, Base Sequence, Recombinant, Gold, Metal Nanoparticles, Plants, Soybeans,

Affiliazioni:

*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, I-95125 Catania, Italy
Dipartimento di Chimica Organica ed Industriale, Università di Parma, Viale G.P. Usberti 17/a, I-43100 Parma, Italy
Neotron S.p.a., Stradello Aggazzotti 104, I-41010 Modena, Italy
Scuola Superiore di Catania, C/o Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, Catania, Italy
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy


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Technologies today available for the DNA detection rely on a combination of labeled probes hybridized to target sequences which are amplified by polymerase chain reaction (PCR). Direct detection methods that eliminate the requirement for both PCR and labeling steps could afford faster, cheaper and simpler devices for the analysis of small amounts of unamplified DNA. In this work we describe the results obtained in the ultrasensitive detection of non-amplified genomic DNA. We analyzed certified reference materials containing different amounts of genetically modified DNA by using a detection method which combines the nanoparticle-enhanced surface plasmon resonance imaging (SPRI) biosensing to the peptide nucleic acids (PNAs) improved selectivity and sensitivity in targeting complementary DNA sequences. The method allowed us to obtain a 41 zM sensitivity in targeting genomic DNA even in the presence of a large excess of non-complementary DNA. (C) 2010 Elsevier B.V. All rights reserved.
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Impact Factor: 4.104
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (106 visite)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Musumeci D, Roviello  GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (111 visite)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (97 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (112 visite)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (99 visite)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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46 Records (38 escludendo Abstract e Conferenze).
Impact factor totale: 119.517 (108.778 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 123.724 (108.911 escludendo Abstract e Conferenze).







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