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Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (181 visite)

Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E

Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.

Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,

Impact factor: 3.06

Impact factor a 5 anni: 3.307


Parole chiave: Alzheimer, S Disease, Carnosine, Molecular Dynamics, Neuroprotective Agent, Nutraceutical Compounds, Protein-Protein Interactions, Amyloid, Amyloid Beta Protein[1-42], Collagen Fibril, Heptapeptide, Monomer, Thioflavine, Alzheimer Disease, Article, Circular Dichroism, Controlled Study, Drug Mechanism, Experimentation, Fluorescence Analysis, Hydrogen Bond, Hydrophobicity, Nuclear Magnetic Resonance, Priority Journal, Protein Aggregation, Protein Conformation, Protein Structure, Scanning Force Microscopy, Amyloid Beta-Peptides, Hydrogen Bonding, Hydrophobic And Hydrophilic Interactions, Magnetic Resonance Spectroscopy, Molecular Dynamics Simulation, Peptide Fragments, Static Electricity, Temperature, Amyloid Beta-Peptides Antagonists, Inhibitors Metabolism, Carnosine Chemistry Metabolism, Peptide Fragments Antagonists, Amyloid Beta Protein [1-42],

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874979750&partnerID=40&md5=56dd38794e109d4957604f5737133d86

Aggregation of the amyloid-β peptide (Aβ) into fibrillar structures is a hallmark of Alzheimer's disease. Thus, preventing self-assembly of the Aβ peptide is an attractive therapeutic strategy. Here, we used experimental techniques and atomistic simulations to investigate the influence of carnosine, a dipeptide naturally occurring in the brain, on Aβ aggregation. Scanning force microscopy, circular dichroism and thioflavin T fluorescence experiments showed that carnosine does not modify the conformational features of Aβ42 but nonetheless inhibits amyloid growth. Molecular dynamics (MD) simulations indicated that carnosine interacts transiently with monomeric Aβ42 by salt bridges with charged side chains, and van der Waals contacts with residues in and around the central hydrophobic cluster (17LVFFA21). NMR experiments on the nonaggregative fragment Aβ12-28 did not evidence specific intermolecular interactions between the peptide and carnosine, in agreement with MD simulations. However, a close inspection of the spectra revealed that carnosine interferes with the local propensity of the peptide to form backbone hydrogen bonds close to the central hydrophobic cluster (residues E22, S26 and N27). Finally, MD simulations of aggregation-prone Aβ heptapeptide segments show that carnosine reduces the propensity to form intermolecular backbone hydrogen bonds in the region 18-24. Taken together, the experimental and simulation results (cumulative MD sampling of 0.2 ms) suggest that, despite the inability of carnosine to form stable contacts with Aβ, it might block the pathway toward toxic aggregates by perturbing the hydrogen bond network near residues with key roles in fibrillogenesis. Dropping your H's/Ban the bond: Inspired by the body of evidence for a neuroprotective activity of carnosine, we investigated whether this dipeptide hinders Aβ42 growth in vitro. Our results indicate that despite the inability of carnosine to form stable contacts with Aβ, it might block aggregation by perturbing the propensity of the peptide to form H-bonds. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
*** IBB - CNR ***

Istituto di Biostrutture e Bioimmagini-UOS CT, Consiglio Nazionale delle Ricerche, V.le A. Doria 6, 95125 Catania, Italy

Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland

Dipartimento di Scienze Mediche e Biologiche, Università di Udine, Piazzale Kolbe 4, 33100 Udine, Italy

Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy
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Rivi re, C., Richard, T., Quentin, L., Krisa, S., M rillon, J. M., Monti, J. P., (2007) Bioorg. Med. Chem., 15, pp. 1160-1167

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Haberth r, U., Caflisch, A., (2008) J. Comput. Chem., 29, pp. 701-715

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Marion, D., W thrich, K., (1983) Biochem. Biophys. Res. Commun., 113, pp. 967-974

Hwang, T. L., Shaka, A. J., (1995) J. Magn. Reson. A, 112, pp. 275-279

Morris, K. F., Johnson, Jr. C. S., (1992) J. Am. Chem. Soc., 114, pp. 3139-3141

Jerschow, A., M ller, N., (1997) J. Magn. Reson., 125, pp. 372-375

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Barone D, Balasco N, Autiero I, Vitagliano L
* The dynamic properties of the Hepatitis C Virus E2 envelope protein unraveled by molecular dynamics (74 visite)
J Biomol Struct Dyn (ISSN: 1538-0254electronic, 0739-1102linking), 2016 Dec; N/D: 1-12.
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (79 visite)
Acs Med Chem Lett (ISSN: 1948-5875print, 1948-5875linking), 2016 Sep 26; 7(12): 1145-1150.
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Dubbioso R, Ranucci G, Esposito M, Di Dato F, Topa A, Quarantelli M, Matarazzo M, Santoro L, Manganelli F, Iorio R
* Subclinical neurological involvement does not develop if Wilson's disease is treated early (92 visite)
Parkinsonism Relat Disord (ISSN: 1873-5126electronic, 1353-8020linking, 1353-8020print), 2016 Mar; 24: 15-19.
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Sciuto S, Greco V, Rizzarelli E, Bellia F, Lanza V, Vaccaro S, Messina L
* Derivatives obtained from hyaluronic acid and carnosine (61 visite)
Google Patents, 2016 Feb 04; CA2951808A1: CA2951808-CA2951808.
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (148 visite)
Analytical And Bioanalytical Chemistry (ISSN: 1618-2642), 2016; 408(3): 849-854.
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Gaia O, Melillo P, Sirio C, D'Alterio FM, Prinster A, Testa F, Brunetti A, Simonelli F, Quarantelli M
* Cerebral Involvement in Stargardt's Disease: A VBM and TBSS Study (149 visite)
Invest Ophthalmol Vis Sci (ISSN: 1552-5783electronic, 0146-0404linking), 2015 Nov; 56(12): 7388-7397.
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Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (105 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2015 Jul 30; 16(8): 17422-17444.
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Santangelo G, Vitale C, Picillo M, Cuoco S, Moccia M, Pezzella D, Erro R, Longo K, Vicidomini C, Pellecchia MT, Amboni M, Brunetti A, Salvatore M, Barone P, Pappata S
* Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients (112 visite)
Parkinsonism Relat Disord (ISSN: 1353-8020, 1873-5126, 1353-8020linking), 2015 May; 21(5): 489-493.
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Autiero I, Saviano M, Langella E
* Conformational studies of chiral D-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach (145 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2015 Feb 16; 91: 109-117.
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Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
* Cognitive performances and DAT imaging in early Parkinson's disease with mild cognitive impairment: a preliminary study (125 visite)
Acta Neurologica Scandinavica (ISSN: 0001-6314, 1600-0404), 2015 Feb 3; 131(5): 275-281.
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Balasco N, Barone D, Vitagliano L
* Structural conversion of the transformer protein RfaH: new insights derived from protein structure prediction and molecular dynamics simulations (139 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic), 2015 Jan 12; 33(10): 2173-2179.
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Carbonniere P, Pouchan C, Improta R
* Intramolecular vibrational redistribution in the non-radiative excited state decay of uracil in the gas phase: An ab initio molecular dynamics study (120 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2015; 17(17): 11615-11626.
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Milardi D, Pappalardo M
* Molecular dynamics: New advances in drug discovery (106 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2015; 91: 1-3.
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Ribaldone DG, Garavagno M, Pellicano R, Bresso F, Fagoonee S, David E, Sapone N, Bonagura AG, Resegotti A, Astegiano M
* Prevalence and prognostic value of hepatic histological alterations in patients with Crohn's disease (116 visite)
Scand J Gastroenterol (ISSN: 1502-7708electronic, 0036-5521linking), 2015; 50(12): 1463-1468.
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Lolicato F, Raudino A, Milardi D, La Rosa C
* Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (165 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2015; 92: 876-881.
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Bellia F, Rizzarelli E, Vecchio G
* The chemistry of carnosine derivatives (87 visite)
Food And Nutritional Components In Focus (ISSN: 2045-1695), 2015; 2015-January(8): 61-83.
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Moccia M, Pappata S, Erro R, Picillo M, Vitale C, Amboni M, Longo K, Palladino R, Barone P, Pellecchia MT
* Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease (121 visite)
Acta Neurologica Scandinavica (ISSN: 1600-0404, 0001-6314), 2015; 131(2): 127-131.
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Moccia M, Pappata S, Picillo M, Erro R, Coda ARD, Longo K, Vitale C, Amboni M, Brunetti A, Capo G, Salvatore M, Barone P, Pellecchia MT
* Dopamine transporter availability in motor subtypes of de novo drug-naïve Parkinson's disease (115 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2014 Nov; 261(11): 2112-2118.
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (104 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2014 Feb; 131: 56-63.
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Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A
* A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia (93 visite)
J Alzheimers Dis (ISSN: 1387-2877, 1875-8908electronic, 1387-2877linking), 2014; 41(3): 709-714.
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Villari V, Attanasio F, Micali N
* Control of the structural stability of α-crystallin under thermal and chemical stress: The role of carnosine (123 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2014; 118(47): 13770-13776.
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Autiero I, Saviano M, Langella E
* Molecular Dynamics Simulations Of Pna-Pna And Pna-Dna Duplexes By The Use Of New Parameters Implemented In The Gromacs Package: A Conformational And Dynamics Study (120 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(5): 1868-1874.
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Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (119 visite)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
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De Rosa A, Pappata S, Pellegrino T, De Leva MF, Maddaluno G, Fiumara G, Carotenuto R, Petretta M, Filla A, De Michele G, Cuocolo A
* Reduced Cardiac 123i-Metaiodobenzylguanidine Uptake In Patients With Spinocerebellar Ataxia Type 2: A Comparative Study With Parkinson'S Disease (93 visite)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2013 Dec; 40(12): 1914-1921.
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Salvatore E, Quarantelli M, Russo C, Giorgio SM, Cervo A, Cocozza S, Di Maio L, Brunetti A, Filla A, De Michele G
* Default-Mode Network Alterations In Huntington'S Disease (100 visite)
Second Joint Limpe / Dismov Sin Meeting Rome, 2013 Nov; N/D: N/D-N/D.
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Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (117 visite)
Biochim Biophys Acta (ISSN: 0005-2736, 0006-3002e), 2013 Nov; 1828(11): 2637-2645.
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Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (112 visite)
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2013 Sep 19; 8(8): e72159-e72159.
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Erro R, Barone P, Vicidomini C, Picillo M, Pappata S
* Patients with Parkinson's disease and scans with (predominant) ipsilateral dopaminergic deficit (97 visite)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2013 Sep; 260(9): 2405-2406.
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McNeill A, Wu RM, Tzen KY, Aguiar PC, Arbelo JM, Barone P, Bhatia K, Barsottini O, Bonifati V, Bostantjopoulou S, Bressan R, Cossu G, Cortelli P, Felicio A, Ferraz HB, Herrera J, Houlden H, Hoexter M, Isla C, Lees A, Lorenzo-Betancor O, Mencacci NE, Pastor P, Pappata S, Pellecchia MT, Silveria-Moriyama L, Varrone A, Foltynie T, Schapira AH
* Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis (127 visite)
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2013 Jul 23; 8(7): e69190-e69190.
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Squeglia F, Romanò MF, Ruggiero A, Vitagliano L, De Simone A, Berisio R
* Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses (103 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jun 4; 104(11): 2530-2539.
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Mariconda M, Soscia E, Sirignano C, Smeraglia F, Soldati A, Balato G
* Long-Term Clinical Results And Mri Changes After Tendon Ball Arthroplasty For Advanced Kienbock'S Disease (112 visite)
J Hand Surg Eur Vol (ISSN: 2043-6289, 0266-7681, 2043-6289electronic), 2013 Jun; 38(5): 508-514.
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (141 visite)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (119 visite)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (139 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (139 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (111 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
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Erro R, Pappata S, Amboni M, Vicidomini C, Longo K, Santangelo G, Picillo M, Vitale C, Moccia M, Giordano F, Brunetti A, Pellecchia MT, Salvatore M, Barone P
* Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients (141 visite)
Parkinsonism Relat Disord (ISSN: 1873-5126, 1353-8020, 1873-5126electronic), 2012 Nov; 18(9): 1034-1038.
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Pascual B, Prieto E, Arbizu J, Marti-climent JM, Peñuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (120 visite) (PDF 136 visite)
(ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(9): 2817-2825.
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (142 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (180 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
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Caruso P, Causà M, Cimino P, Crescenzi O, D'Amore M, Improta R, Pavone M, Rega N
* Effects of molecular dynamics and solvation on the electronic structure of molecular probes (109 visite)
Theor Chem Acc (ISSN: 1432-881x), 2012 Apr; 131(4): 1211-1212.
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Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
* Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (94 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Jan 12; 116(1): 401-412.
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (204 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
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Pizzuti LM, Todaro P, Caleo A, Pace L, Vajro P
* Lymph node fine needle cytology in the diagnosis of infectious diseases and instrumental guides: Ultrasound and computed tomography (100 visite)
Infez Med (ISSN: 1124-9390), 2012; 20(SUPPL.3): 26-29.
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De Rosa A, Rinaldi C, Tucci T, Pappata S, Rossi F, Morra VB, Faggiano A, Colao A, De Michele G
* Co-existence of primary hyperparathyroidism and Parkinson's disease in three patients: An incidental finding? (129 visite)
Parkinsonism Relat Disord (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2011 Dec; 17(10): 771-773.
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (114 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (165 visite)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (133 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (124 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (108 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
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Grasso GI, Bellia F, Arena G, Vecchio G, Rizzarelli E
* Noncovalent interaction-driven stereoselectivity of copper(II) complexes with cyclodextrin derivatives of L- and D-carnosine (117 visite)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2011 Jun 6; 50(11): 4917-4924.
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (117 visite)
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (258 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (154 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (123 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
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Pappalardo G, Milardi D, Rizzarelli E, Sovago I
* The Inorganic Side of Alzheimer's Disease (110 visite)
Neurodegeneration (ISSN: 2041-3203), 2011; (7): N/D-N/D.
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (121 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
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Maurea S, Mollica C, Imbriaco M, Fusari M, Camera L, Salvatore M
* Magnetic resonance cholangiography with mangafodipir trisodium in Caroli's disease with pancreas involvement (109 visite)
Jop (ISSN: 1590-8577, 1590-0857), 2010 Sep 06; 11(5): 460-463.
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (118 visite)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
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Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
* Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (87 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 May 27; 114(20): 7002-7008.
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Cella L, Conson M, Liuzzi R, Caterino M, De Rosa N, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Radiation Induced Thyroid Disorders After Radiotherapy For Hodgkin S Disease: A Dosimetric Analysis (107 visite)
Radiotherapy And Oncology (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2010; 96: N/D-N/D.
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (132 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (113 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
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Giordano D, Boechi L, Vergara A, Marti MA, Samuni U, Dantsker D, Grassi L, Estrin DA, Friedman JM, Mazzarella L, Di Prisco G, Verde C
* The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species - oxygen-binding equilibria, kinetics and molecular dynamics (113 visite)
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(8): 2266-2277.
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De Rosa A, Criscuolo C, Mancini P, De Martino M, Giordano IA, Pappata S, Filla A, De Michele G
* Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy (58 visite)
Parkinsonism Relat Disord (ISSN: 1353-8020print, 1353-8020linking, 1873-5126electronic), 2009 Mar; 15(3): 242-244.
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (98 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (140 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
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Spinelli L, Nicolai E, Acampa W, Imbriaco M, Pisani A, Rao MA, Scopacasa F, Cianciaruso B, De Luca N, Cuocolo A
* Cardiac performance during exercise in patients with Fabry's disease (101 visite)
European Journal Of Clinical Investigation (ISSN: 0014-2972, 1365-2362), 2008 Dec; 38(12): 910-917.
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Milardi D, Pappalardo M, Pannuzzo M, Grasso DM, Rosa CL
* The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study (129 visite)
Chemical Physics Letters (ISSN: 0009-2614), 2008 Oct 1; 463(4-6): 396-399.
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De Simone A, Esposito L, Pedone C, Vitagliano L
* Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses (103 visite)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.
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De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (128 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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Esposito L, Paladino A, Pedone C, Vitagliano L
* Insights into structure, stability, and toxicity of monomeric and aggregated polyglutamine models from molecular dynamics simulations (102 visite)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 May 15; 94(10): 4031-4040.
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (108 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (127 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (241 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
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Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
* An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution (99 visite)
Chemical Physics Letters (ISSN: 0009-2614), 2007 Jul 6; 442(1-3): 110-118.
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (156 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
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Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (94 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (119 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (129 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
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Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
* MRI characterization of myocardial tissue in patients with Fabry's disease (114 visite)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
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Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (90 visite)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (101 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jan 12; 282(2): 831-835.
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Steered molecular dynamics studies reveal different unfolding pathways of prions from mammalian and non-mammalian species (99 visite)
New Journal Of Chemistry (ISSN: 1144-0546), 2007; 31(6): 901-905.
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Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (113 visite)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (154 visite)
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (147 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (117 visite)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (169 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (131 visite)
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2006; 26(43): 10949-10957.
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Varrone A, Pagani M, Salmaso D, Salvatore E, Sansone V, Nobili F, Rodriguez G, Barone P, Larsson SA, De Michele G, Filla A, Pappata S, Salvatore M
* Anterior Cingulate Hypoperfusion Can Differentiate Progressive Supranuclear Palsy From Parkinson's Disease; Voxel-Based Analysis And CBA-Based PCA Analysis Of 99mTc-ECD SPECT Data (110 visite)
European Journal Of Nuclear Medicine And Molecular Imaging, 2005 Sep; 32: N/D-N/D.
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (100 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (106 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2005 May 6; 280(18): 17953-17960.
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Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Sabbatini F, D'Amico P, Castiglione F
* Noninvasive diagnosis of small bowel Crohn's disease: Combined use of bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (100 visite)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic), 2005 Apr; 11(4): 376-382.
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Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (93 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (122 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (110 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (104 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
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Varrone A, Pappata S, Quarantelli M, Sansone V, Mollica C, Lore E, Carlomagno S, Iavarone A, Postiglione A, Alfano B, Salvatore M
* Partial volume effect correction of rCBF SPET studies in mild cognitive impairment and Alzheimer's disease (117 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
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Rispo A, Imbriaco M, Celentano L, Cozzolino A, Mainenti PP, Camera L, Di Girolamo E, De Falco T, Castiglione F
* Small bowel Crohn's disease: Comparison of enteroclysis, bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (110 visite)
Eur Rev Med Pharmacol Sci (ISSN: 1128-3602), 2004 Sep; 8(5): 219-224.
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (116 visite)
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2004 Jun 30; 24(26): 6021-6027.
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Pappalardo M, Milardi D, La Rosa C, Zannoni C, Rizzarelli E, Grasso D
* A molecular dynamics study on the conformational stability of PrP 180-193 helix II prion fragment (97 visite)
Chemical Physics Letters (ISSN: 0009-2614), 2004 Jun 1; 390(4-6): 511-516.
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Rendina D, Mossetti G, Soscia E, Sirignano C, Insabato L, Viceconti R, Ignarra R, Salvatore M, Nunziata V
* Giant cell tumor and Paget's disease of bone in one family: geographic clustering (95 visite)
Clinical Orthopaedics And Related Research (ISSN: 0009-921x), 2004 Apr; (421): 218-224.
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Castiglione F, Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Di Girolamo E, Mazzacca G
* Small bowel Crohn's disease: Enteroclysis, bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy at comparison (95 visite)
Gastroenterology (ISSN: 0016-5085), 2004 Apr; 126(4): N/D-N/D.
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (121 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
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Varrone A, Pappata S, Amboni M, Pellecchia M, Salvatore E, Salvatore M
* Imaging of dopaminergic dysfunction with [I-123]FP-CIT SPECT in early-onset Parkinson's disease (102 visite)
Mov Disord (ISSN: 0885-3185, 1531-8257), 2004; 19: N/D-N/D.
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Covelli E, Brunetti A, Tedeschi E, Sullo P, Mazzarella G, Nuzzo M, Lombardi E, Di Lauro A, Belfiore G
* Parkinson's disease - Correlation between MRI analyses, perfusion SPECT with I-123FP-CIT SPECT and the clinical stage of the disease (89 visite)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2003 May; 16: N/D-N/D.
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Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Free energy perturbation and molecular dynamics calculations of copper binding to azurin (102 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2003 Apr 30; 24(6): 779-785.
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Di Somma C, Pivonello R, Loche S, Faggiano A, Klain M, Salvatore M, Lombardi G, Colao A
* Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: A prospective study (106 visite)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Mar; 58(3): 302-308.
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Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (101 visite)
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (149 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (96 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (137 visite) (PDF 127 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (107 visite)
Rapid Commun Mass Spectrom (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
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La Mendola D, Sortino S, Rizzarelli E, Vecchiog
* Synthesis Of New Carnosine Derivatives Of R-Cyclodextrin And Their Hydroxyl Radical Scavanger Ability (83 visite)
Helvetica Chimica Acta, 2002; 85: 1633-1643.
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Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (112 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
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Pappata S, Varrone A, Caraco C, Soricelli A, Brunetti A, Milan G, Postiglione A, Alfano B, Salvatore M
* Voxel-based comparison of 99mTc-HMPAO SPECT images in Alzheimer and fronto-temporal dementia revealed distinct patterns of CBF alterations (97 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
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Camera L, Selva G, Puzziello A, Sparano L, Ignarra R, Quarantelli M
* [Castleman's disease: CT and MR findings in a case localized in the portocaval space] (91 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2001 Sep; 102(3): 186-188.
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Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (184 visite) (PDF 158 visite)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): 260-266.
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Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli E, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (181 visite)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): N/D-N/D.
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Cirillo LC, Camera L, Della Noce M, Castiglione F, Mazzacca G, Salvatore M
Accuracy of enteroclysis in Crohn's disease of the small bowel: A retrospective study (92 visite)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic), 2000; 10(12): 1894-1898.
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Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison Between Cortical Distribution Of I-123 Iomazenil And Tc-99m Hmpao In Patients With Alzheimer'S Disease Using Spect (89 visite)
Clin Nucl Med, 1999 Sep; 24(9): 660-665.
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Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (100 visite)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
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Messina G, Viceconti N, Trinti B
Diagnostic items and treatment of Plummer's disease: A study on 180 patients (101 visite)
Clinica Terapeutica (ISSN: 0009-9074), 1998 May; 149(3): 191-195.
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Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (93 visite)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
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Varrone A, Soricelli A, Postiglione A, Salvatore M, Lassen N
Benzodiazepine receptor distribution in Alzheimer's disease with (123)I-iomazenil by SPECT (102 visite)
Textbook Of Spect In Neurology And Psychiatry, 1997; N/D: N/D-N/D.
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Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (102 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 1996 Nov; 201: N/D-N/D.
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Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (92 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
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Soricelli A, Postiglione A, Mainenti PP, GrivetFojaja M, Discepolo A, Varrone A, Salvatore M, Lassen N
Preliminary evaluation of distribution volume for 123I-Iomazenil in Alzheimer's disease as a measure of neuronal loss (84 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
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NAPPI A, CUOCOLO A, MAROTTA T, FERRARA L, IAZZETTA N, PACE L, NICOLAI E, DEMICHELE G, SALVATORE M, CAMPANELLA G, POSTIGLIONE A
Usefulness of monitoring left ventricular function by an ambulatory radionuclide detector (VEST) in patients with Parkinson's disease and postural hypotension (78 visite)
Alzheimer S And Parkinson S Diseases (ISSN: 0099-9962), 1995; 44: N/D-N/D.
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SORICELLI A, TEDESCHI E, POSTIGLIONE A, GROSSI D, BRUNETTI A, ROMANO M, CASTELLI L, MAINENTI PP, SALVATORE M
BRAIN PERFUSION AT REST AND DURING COGNITIVE ACTIVATION IN PATIENTS WITH DEMENTIA OF ALZHEIMERS TYPE (100 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
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Nappi A, Cuocolo A, Iazzetta N, Ferrara LA, Marotta T, Pace L, Nicolai E, De Michele G, Campanella G, Salvatore M, Postiglione A
Ambulatory monitoring of left ventricular function in patients with Parkinson's disease and postural hypotension (105 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1994; 21(12): 1312-1317.
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Saviano M, Rossi F, Pavone V, Di Blasio B, Pedone C
Molecular dynamics simulation in vacuo and in solution of [Aib5, 6-D- Ala8] Cyclolinopeptide A: A conformational and comparative study (100 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 1992 Jun; 9(6): 1045-1060.
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