Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors
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Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (79 visite)

Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M

Rsc Advances (ISSN: 2046-2069), 2015; 5(13): 9965-9972.

Tipo di articolo: Journal Article,

Impact factor: 3.289

Impact factor a 5 anni: 3.485


Parole chiave: Amino Acids, Diagnosis, Enzyme Inhibition, Nitrogen Compounds, Proteins, Acetylated Amino Acids, Conformational Stabilities, Inhibition Activity, Serine Protease Inhibitor, Spatial Organization, Structural Insights, Structure Activity Study, Therapeutic Targets, Peptides, Click-Chemistry, ?-Hairpin Peptide, Serine-Protease,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921314759&partnerID=40&md5=fba895744a36582746d79ce8d464fe93

APEH catalyses the removal of N-terminal acetylated amino acids from proteins destined to be degraded and is now recognized as a new therapeutic target for several diseases. New APEH inhibitors having triazole-based structures have been recently reported. On this basis we have screened a set of click-generated cyclic peptides, previously investigated for peptide conformational stability studies, as possible novel enzyme inhibitors. We have found a clicked peptide, NHB3.3, that inhibits APEH activity and structure-activity studies highlighted that APEH inhibition is mediated by the spatial organization of the triazole ring and by its orientation and distance from the peptide scaffold, whose structural integrity, in turn, also plays a relevant role. In conclusion, our findings confirm that 1,2,3 triazoles are privileged pharmacophores for specific serine protease inhibitors and provide structural insights exploitable for modulating their inhibition activity. © The Royal Society of Chemistry 2015.
*** IBB - CNR ***

Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Via Mezzocannone 16Naples, Italy

CIRPEB-University of Naples Federico IINaples, Italy

Institute of Biosciensces and BioResources, National Research Council (CNR-IBBR)Naples, Italy

Istituto di Biostrutture e Bioimmagini

Istituto di Bioscienze e Biorisorse
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Vergara A, Montesarchio D, Russo Krauss I, Paduano L, Merlino A
Inorganic Chemistry (ISSN: 0020-1669, 1520-510xe), 2013; 52(19): 10714-10716.
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* Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (100 visite)
Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: 162674-162674.
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* Abnormal or delayed development of the posterior membranous area of the brain: Anatomy, ultrasound diagnosis, natural history and outcome of Blake's pouch cyst in the fetus (129 visite)
Paladini D, Quarantelli M, Pastore G, Sorrentino M, Sglavo G, Nappi C
Ultrasound Obstet Gynecol (ISSN: 0960-7692, 1469-0705), 2012 Mar; 39(3): 279-287.
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* Proteins as sponges: A statistical journey along protein structure organization principles (104 visite)
Paola LD, Paci P, Santoni D, Ruvo MD, Giuliani A
J Chem Inf Model American Chemical Society (ISSN: 1549-9596), 2012 Feb 27; 52(2): 474-482.
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* Abnormal Or Delayed Development Of The Area Membranacea Posterior Of The Brain: The Blake'S Pouch Cyst. Anatomy, Ultrasound Diagnosis, Natural History And Outcome In The Fetus (76 visite)
Paladini D, Quarantelli M, Pastore G, Sorrentino M, Sglavo G, Nappi C
Ultrasound Obstet Gynecol, 2012; 39: 279-287.
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* Lymph node fine needle cytology in the diagnosis of infectious diseases and instrumental guides: Ultrasound and computed tomography (79 visite)
Pizzuti LM, Todaro P, Caleo A, Pace L, Vajro P
Infez Med (ISSN: 1124-9390), 2012; 20(SUPPL.3): 26-29.
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* Site-specific protein double labeling by expressed protein ligation: applications to repeat proteins (62 visite)
De Rosa L, Cortajarena AL, Romanelli A, Regan L, D'Andrea LD
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2012; 10(2): 273-280.
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* Structural and Functional Aspects of Metal Binding Sites in Natural and Designed Metalloproteins (128 visite)
Maglio O, Nastri F, Lombardi A, Ciferri A, Perico A
Ionic Interactions In Nat And Synthetic Macromolecules John Wiley And Sons (ISSN: 9780-4705), 2012; N/D: 361-450.
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* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (99 visite)
Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
Biochim Biophys Acta (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
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* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (149 visite)
Monfregola L, De Luca S
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
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* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (84 visite)
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
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* Simultaneous non-functioning neuroendocrine carcinoma of the pancreas and extra-hepatic cholangiocarcinoma. A case of early diagnosis and favorable post-surgical outcome (58 visite)
Maurea S, Corvino A, Imbriaco M, Avitabile G, Mainenti P, Camera L, Galizia G, Salvatore M
Jop (ISSN: 1590-8577, 1590-0857), 2011 May 6; 12(3): 255-258.
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* Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (88 visite)
Pirone L, Correale S, De Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
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* Metal Ions and the Clearance of Misfolded Proteins (61 visite)
Grasso G, La Mendola D, Milardi D
Neurodegeneration (ISSN: 2041-3203), 2011; (7): N/D-N/D.
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* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (91 visite)
Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
Biochim Biophys Acta (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
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* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (74 visite)
Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
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* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (76 visite)
Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
Journal Of Chemical Physics, 2010; 114: 13830-13838.
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* Erratum: Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (Amino Acids DOI: 10. 1007/s00726-009-0324-x) (88 visite)
Roviello GN, Gröschel S, Pedone C, Diederichsen U
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010; 38(5): 1311-1312.
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* Ribosome Inactivating Proteins from P. dioica leaves (44 visite)
Parente A, Berisio R, Chambery A, Di Maro A
Springer Eds, 2010; N/D: N/D-N/D.
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* Prenatal 2D and 3D ultrasound diagnosis of diprosopus: Case report with post-mortem magnetic resonance images (MRI) and review of the literature (77 visite)
Maruotti GM, Paladini D, Napolitano R, Mazzarelli LL, Russo T, Quarantelli M, D'Armiento MR, Martinelli P
Prenat Diagn (ISSN: 0197-3851), 2009 Oct; 29(10): 992-994.
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* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (65 visite)
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
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* Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins (140 visite)
Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G
J Mol Biol Journal Of Molecular Biology (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 May 8; 388(3): 559-569.
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* Hemoproteins in the cold (87 visite)
Verde C, Giordano D, Russo R, Riccio A, Vergara A, Mazzarella L, Di Prisco G
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 67-73.
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* Peptides for tumour therapy and diagnosis: current status and future directions (156 visite)
Zaccaro L, Del Gatto A, Pedone C, Saviano M
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
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* Prenatal diagnosis of Seckel syndrome on 3-dimensional sonography and magnetic resonance imaging (64 visite)
Napolitano R, Maruotti GM, Quarantelli M, Martinelli P, Paladini D
Journal Of Ultrasound In Medicine (ISSN: 0278-4297, 1550-9613), 2009 Mar; 28(3): 369-374.
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* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (82 visite)
Merlino A, Vergara A, Sica F, Mazzarella L
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
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* A new and selective radiolabeled alpha(V)beta(3) peptide antagonist as tracer in tumor diagnosis (80 visite)
De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 439-440.
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* Automatic modeling based on cultural programming for osseointegration diagnosis (65 visite)
Arpaia P, Clemente F, Manna C, Montenero G
Vols 1 3i2mtc (ISSN: 1091-5281), 2009; N/D: 1278-1283.
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* Prion proteins leading to neurodegeneration (106 visite)
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
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* Diagnosis and therapeutic management of cystic dystrophy of the duodenal wall in heterotopic pancreas. A case report and revision of the literature (76 visite)
Galloro G, Napolitano V, Magno L, Diamantis G, Nardone G, Bruno M, Mollica C, Persico G
Jop (ISSN: 1590-8577, 1590-0857), 2008 Nov 03; 9(6): 725-732.
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* Five human phenylalanine hydroxylase proteins identified in mild hyperphenylalaninemia patients are disease-causing variants (76 visite)
Daniele A, Cardillo G, Pennino C, Carbone MT, Scognamiglio D, Esposito L, Correra A, Castaldo G, Zagari A, Salvatore F
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2008 Jun; 1782(6): 378-384.
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* Semisynthesis of dimeric proteins by expressed protein ligation (52 visite)
Ziaco B, Pensato S, D'Andrea LD, Benedetti E, Romanelli A
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2008 May 15; 10(10): 1955-1958.
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* Frontal Behavioural Inventory in the differential diagnosis of dementia (95 visite)
Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
Acta Neurologica Scandinavica (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
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* Improving the diagnosis of central hypothyroidism (73 visite)
Pezzino V, Sipione C, Vigneri R
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic, 0391-4097linking), 2008; 31(10): 939-939.
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* Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis (117 visite)
Catalano L, Del Vecchio S, Petruzziello F, Fonti R, Salvatore B, Martorelli C, Califano C, Caparrotti G, Segreto S, Pace L, Rotoli B
Annals Of Hematology (ISSN: 0939-5555), 2007 Jun; 86(6): 415-423.
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* Approximate values for force constant and wave number associated with a low-frequency concerted motion in proteins can be evaluated by a comparison of X-ray structures (62 visite)
Merlino A, Sica F, Mazzarella L
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2007 May 17; 111(19): 5483-5486.
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* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (75 visite)
Galdiero S, Galdiero M, Pedone C
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 63-82.
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* A new and selective radiolabeled alpha(v)beta 3 peptide antagonist as tracer in tumor diagnosis (69 visite)
Zaccaro L, Del Gatto A,  De Luca S, Ruvo M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(4): N/D-N/D.
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* Diiron-containing metalloproteins: Developing functional models (44 visite)
Maglio O, Nastri R, Torres O, Faiella V, Pavone WF, Degrado A, Lombardi M
Comptes Rendus Chimie, 2007; 10: 703-720.
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* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (96 visite)
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
J Chromatogr A (ISSN: 0021-9673), 2007; 1155(2): 172-179.
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* ODN-based drugs for targeting of extracellular proteins (51 visite)
Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
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* Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer (89 visite)
Garibaldi F, Cisbani E, Colilli S, Cusanno F, Fratoni R, Giuliani F, Gricia M, Lucentini M, Fratoni R, Lo Meo S, Magliozzi ML, Santanvenere F, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, Lanza RC, De Vincentis G, Scopinaro F
Nuclear Instruments And Methods In Physics Research Section A (ISSN: 0168-9002), 2006 Dec 20; 569(2SPEC.ISS.): 286-290.
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* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (73 visite)
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
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* Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (80 visite)
Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
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* Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (79 visite)
Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006; 65(2): 524-524.
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* High-resolution mini gamma camera for diagnosis and radio-guided surgery in diabetic foot infection (115 visite)
Scopinaro F, Capriotti G, Di Santo G, Capotondi C, Micarelli A, Massari R, Trotta C, Soluri A
Nuclear Instruments And Methods In Physics Research Section A, 2006; 569(2SPEC.ISS.): 269-272.
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* New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides (89 visite)
De Luca S, Della Moglie R, De Capua A, Morelli G
Tetrahedron Letters (ISSN: 0040-4039), 2005 Sep 26; 46(39): 6637-6640.
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* Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops (56 visite)
Maglio O, Nastri F, Calhoun JR, Lahr S, Wade H, Pavone V, Degrado WF, Lombardi A
J Biol Inorg Chem (ISSN: 0949-8257print, 0949-8257linking, 1432-1327electronic), 2005 Aug; 10(5): 539-549.
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* High resolution mini-gammacamera and 99mTc [HMPAO] - leukocytes for diagnosis of infection and radioguided surgery in diabetic foot (129 visite)
Soluri A, Massari R, Trotta C, Stella S, Cavaiola S, Capriotti G, Di Santo GP, Di Paolo ML, Mangano AM, Liberatore M, Micarelli A, Bruzzese A, Pasta V
Il Giornale Di Chirurgia (ISSN: 0391-9005), 2005 Jun; 26(6-7): 246-250.
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* Noninvasive diagnosis of small bowel Crohn's disease: Combined use of bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (77 visite)
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Sabbatini F, D'Amico P, Castiglione F
Inflammatory Bowel Dis (ISSN: 1078-0998), 2005 Apr; 11(4): 376-382.
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* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (104 visite)
Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
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* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (81 visite)
Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
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* Artificial diiron proteins: From structure to function (63 visite)
Calhoun JR, Nastri F, Maglio O, Pavone V, Lombardi A, Degrado WF
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(2-3): 264-278.
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* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (97 visite)
Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
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* Conformational conversion of prion proteins: Role synthetic PRP 173-195 fibrillogenic peptide (69 visite)
Tizzano B, Marasco D, Benedetti E, De Capua A, Palladino P, Pedone C, Perretta G, Rossi F, Ragone R, Ruvo M
Peptide Revolution, 2004; N/D: N/D-N/D.
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* TPR proteins: the versatile helix (70 visite)
D'Andrea LD, Regan L
Trends Biochem Sci Trends In Biochemical Sciences (ISSN: 0968-0004), 2003 Dec; 28(12): 655-662.
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* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (85 visite)
Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
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* Preorganization of molecular binding sites in designed diiron proteins (52 visite)
Maglio O, Nastri F, Pavone V, Lombardi A, Degrado WF
Proc Natl Acad Sci U S A (ISSN: 0027-8424print, 0027-8424linking), 2003 Apr 1; 100(7): 3772-3777.
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* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (77 visite)
Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Miniaturized metalloproteins: Application to iron-sulfur proteins (289 visite)
Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
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Pyramidalization of backbone carbonyl carbon atoms in proteins (79 visite)
Esposito L, Vitagliano L, Zagari A, Mazzarella L
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Oct; 9(10): 2038-2042.
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Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (79 visite)
Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
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Thermodynamic analysis of α-spectrin SH3 and two of its circular permutants with different loop lengths: Discerning the reasons for rapid folding in proteins (66 visite)
Martínez JC, Viguera AR, Berisio R, Wilmanns M, Mateo PL, Filimonov VV, Serrano L
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1999 Jan 12; 38(2): 549-559.
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Miniaturized Hemoproteins: A Covalent asymmetric Peptide-Porphyrin System (51 visite)
D’Andrea LD, Nastri F, Lombardi A, Maglio O, Pavone V
Peptides ’98, 1999; ConferenceBook: 304-305.
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L- and D-cysteine derivatives of β-cyclodextrin: Different molecular recognition properties of their copper(II) complexes for amino acids (91 visite)
Campagna T, Grasso G, Rizzarelli E, Vecchio G
Inorg Chim Acta (ISSN: 0020-1693), 1998; 275-276: 395-400.
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Miniaturized hemoproteins (60 visite)
Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
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Molecular Recognition of Amino Acids by Copper(II) Complexes of 6A, 6X-Diamino-6A, 6 X-dideoxy-β-cyclodextrin (X = B, C, D) (66 visite)
Bonomo RP, Pedotti S, Vecchio G, Rizzarelli E
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Nov 6; 35(23): 6873-6877.
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[Echotomography and color-Doppler in the diagnosis of thyroid carcinoma] (58 visite)
Messina G, Viceconti N, Trinti B
Ann Ital Med Int (ISSN: 0393-9340), 1996 Oct; 11(4): 263-267.
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Evaluation of brain perfusion with high resolution single photon emission tomography in the diagnosis of brain death (75 visite)
Soricelli A, Mainenti PP, Leone D, Discepolo A, Romano M, Varrone A, Servillo G, Serio S, Brunetti A, Salvatore M
Minerva Anestesiol (ISSN: 0375-9393), 1996 Jun; 62(6): 209-212.
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Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (55 visite)
Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
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Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (71 visite)
Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
J Mol Biol Journal Of Molecular Biology (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
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Correlative morphologic and functional imaging for diagnosis, staging and follow up in AIDS: an overview (65 visite)
Brunetti A, Soricelli A, Rotondo A, Alfano B, Raman R, Celentano L, Di Chiro G, Salvatore M
Q J Nucl Med (ISSN: 1125-0135, 0392-2020, 1124-3937), 1995 Sep; 39(3): 201-211.
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The diagnosis of nonfunctioning pheochromocytoma the role of I-123 MIBG imaging (57 visite)
Maurea S, Lastoria S, Cuocolo A, Celentano L, Salvatore M
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1995 Jan; 20(1): 22-24.
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Diagnosis and treatment of thymoma by octreotide (61 visite)
Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1995; 36(0): N/D-N/D.
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TC-99M SESTAMIBI SCINTIGRAPHY IN THE DIAGNOSIS OF PRIMARY BREAST-CANCER (52 visite)
LASTORIA S, VARRELLA P, MAINOLFI C, VERGARA E, MAUREA S, ACAMPA W, PICCOLO S, SALVATORE M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
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TC-99M MIBI IMAGING IN THE INITIAL DIAGNOSIS AND POST-SURGERY FOLLOW-UP OF PATIENTS WITH THYROID CANCER (57 visite)
MAUREA S, LASTORIA S, KLAIN M, GRIVETFOJAJA M, VARRELLA P, ACAMPA W, VERGARA E, MASTRO A, CONZO G, SALVATORE M
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
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Non coded C alpha, alpha-disubstituted amino acids. X-ray diffraction analysis of a dipeptide containing (S)-alpha-methylserine (72 visite)
Pavone V, Di Blasio B, Lombardi A, Maglio O, Isernia C, Pedone C, Benedetti E, Altmann E, Mutter M
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print, 0367-8377linking), 1993 Jan; 41(1): 15-20.
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Pt(II) Complexes of Amino Acids and Peptides. III. X-Ray Diffraction Study of trans-[Cl-(Ph3P)-Pt-(H-Aib-O-)] (60 visite)
Lombardi A, Maglio O, Pavone B, Di Blasio V, Saviano M, Nastri F, Pedone C, Benedetti E
Inorg Chim Acta, 1993; 204: 87-92.
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Diagnosis of coronary artery disease with Tc 99m-methoxy isobutil isonitrile and transesophageal pacing (76 visite)
SANTOMAURO M, CUOCOLO A, CELENTANO L, FERRARO S, PACE L, PAPPONE C, MADDALENA G, SALVATORE M, CHIARIELLO M
Angiology (ISSN: 0003-3197), 1992 Oct; 43(10): 818-825.
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Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (69 visite)
Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Inorg Chim Acta, 1992; 196: 241-246.
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Phylogenetic evolution of intermediate filament associated proteins in ependymal cells of several adult poikilotherm vertebrates (80 visite)
Lauro GM, Fonti R, Margotta V
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(2): 257-261.
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Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis (59 visite)
Manna R, Salvatore M, Scuderi F, Papa G, Marietti G, Greco AV, Ghirlanda G, Gambassi G
Diabetes Res (ISSN: 0265-5985), 1988 Nov; 9(3): 101-103.
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Novel insights on nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (36 visite)
Roviello G
Amino Acids, N/D; N/D: N/D-N/D.
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132 Records (118 escludendo Abstract e Conferenze).
Impact factor totale: 432.165 (384.76 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 433.452 (376.449 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Amino Acids" OR [btitle] "Diagnosis" OR [btitle] "Enzyme Inhibition" OR [btitle] "Nitrogen Compounds" OR [btitle] "Proteins") AND NOT [id] = 51997)







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